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基于智能手机图像颜色参数的土壤有机质估测

土壤通报 2024年第4期55卷 932-943页

作者：郭倩王会利王晓晴杨华蕾张美薇曾令涛崔宇培徐富义孙孝林中山大学地理科学与规划学院广东广州510275 广西壮族自治区林业科学研究院广西南宁530002 本溪满族自治县农业综合发展服务中心辽宁本溪117100

【目的】应用深度学习模型开展基于智能手机图像颜色参数的土壤有机质估测,并评价应用效果。【方法】在自制光学暗室中拍摄728个风干、过筛后的土壤样本,对所得图像进行预处理后得到其红色(R)、绿色(G)、蓝色(B)、色调(H)、饱和度(S)和... 详细信息

【目的】应用深度学习模型开展基于智能手机图像颜色参数的土壤有机质估测,并评价应用效果。【方法】在自制光学暗室中拍摄728个风干、过筛后的土壤样本,对所得图像进行预处理后得到其红色(R)、绿色(G)、蓝色(B)、色调(H)、饱和度(S)和明度(V)六个颜色通道的中值和均值,分别建立卷积神经网络(CNN)、长短期记忆网络(LSTM)和随机森林(RF)模型,并使用基于树形结构Parzen估计器的贝叶斯方法进行参数优化,进而估测土壤有机质(SOM)含量,并对估测结果的准确度进行五折交叉验证。【结果】CNN、LSTM和RF三种模型均有着良好的估测准确度,决定系数(R2)范围为0.732~0.856,均方根误差(RMSE)范围为4.721~6.455 g kg^(-1),一致性相关系数(CCC)范围为0.843~0.917;其中,基于全部颜色参数的RF模型有着最优的估测效果,且R值、V值是该模型中最重要的参数;总体上,估测准确度的排序为RF略优于CNN,而CNN又略优于LSTM。【结论】CNN和LSTM在基于智能手机图像颜色参数估测土壤有机质中有着良好的准确度,但在小样本量的情况下,CNN、LSTM模型的准确度略低于RF。

关键词：智能手机土壤有机质卷积神经网络长短期记忆网络随机森林

基于多特征交互融合的老挝语无监督音素分割方法

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计算机工程与科学 2024年第5期46卷 937-944页

作者：李新洁王文君董凌赖华余正涛高盛祥昆明理工大学信息工程与自动化学院云南昆明650500 昆明理工大学云南省人工智能重点实验室云南昆明650500

针对现有方法对老挝语声调变化以及音频多样性考虑不足导致音素分割不准确的问题,提出一种多特征交互融合的老挝语无监督音素分割方法。先对自监督特征、频谱特征以及音高特征进行独立编码,避免单一特征的不足;再基于注意力机制渐进融... 详细信息

针对现有方法对老挝语声调变化以及音频多样性考虑不足导致音素分割不准确的问题,提出一种多特征交互融合的老挝语无监督音素分割方法。先对自监督特征、频谱特征以及音高特征进行独立编码,避免单一特征的不足;再基于注意力机制渐进融合多种独立特征,使模型更全面地捕捉老挝语的声调变化和音素边界的信息;最后采用可学习框架优化音素分割模型。实验结果表明,相比基线方法,在老挝语音素分割任务上所提方法的R-value值提升了27.88%。

关键词：无监督学习特征融合老挝语音素分割语音表征

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颗粒状碳酸氧镧去除水体中氟的性能

应用化学 2024年第2期41卷 297-307页

作者：张涛李思莹李俊乐邵思羽吴传栋凌梅吕东伟王威哈尔滨工业大学环境学院哈尔滨150090 哈尔滨工业大学水资源国家工程研究中心有限公司哈尔滨150090 广东粤海水务投资有限公司深圳518021

针对传统吸附剂对氟吸附能力不高的问题,采用氧化镧(La_(2)O_(3))活化制备颗粒状碳酸氧镧(La_(2)O_(2)CO_(3))材料。La_(2)O_(2)CO_(3)对氟离子具有很强的吸附性能,在一个较宽的pH值区间(3.0~10.0)内,具有较好的除氟性能,氟离子去除率在... 详细信息

针对传统吸附剂对氟吸附能力不高的问题,采用氧化镧(La_(2)O_(3))活化制备颗粒状碳酸氧镧(La_(2)O_(2)CO_(3))材料。La_(2)O_(2)CO_(3)对氟离子具有很强的吸附性能,在一个较宽的pH值区间(3.0~10.0)内,具有较好的除氟性能,氟离子去除率在94.5%~98.0%。吸附结果表明,La_(2)O_(2)CO_(3)对氟离子的吸附行为遵循Langmuir模型,是吸热过程。25℃时,其饱和吸附容量达到了22.47 mg/g,相较于传统La_(2)O_(3)材料吸附容量提升约5倍。吸附动力学遵循准二级动力学模型,主要为化学吸附。通过NaOH水溶液对La_(2)O_(2)CO_(3)实现了再生,当NaOH浓度为1.0 mol/L时,脱附率可以达到90.3%,实现了吸附剂的重复利用。

关键词： La_(2)O_(2)CO_(3) 吸附剂水中除氟热力学动力学再生

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复方地黄颗粒对帕金森病阴虚动风证6-OHDA模型大鼠黑质α-syn、VAPB、PTPIP51表达的影响

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中国药理学通报 2024年第6期40卷 1179-1186页

作者：孙光洁王行玲吕子微何建成梁建庆甘肃中医药大学基础医学院甘肃兰州730000 上海中医药大学基础医学院上海201203

目的观察复方地黄颗粒对帕金森病(Parkinson’s disease,PD)大鼠黑质α-syn、VAPB、PTPIP51表达的影响,并探讨其潜在作用机制。方法构建6-羟基多巴胺(6-OHDA)PD大鼠模型,成模大鼠随机分为Model组、Madopar组、CLD组、CMD组、CHD组,NC组... 详细信息

目的观察复方地黄颗粒对帕金森病(Parkinson’s disease,PD)大鼠黑质α-syn、VAPB、PTPIP51表达的影响,并探讨其潜在作用机制。方法构建6-羟基多巴胺(6-OHDA)PD大鼠模型,成模大鼠随机分为Model组、Madopar组、CLD组、CMD组、CHD组,NC组不做任何处理,SO组注射抗坏血酸,每组13只。检测大鼠神经行为学变化;Western blot、RT-PCR、免疫组化检测黑质α-syn、VAPB、PTPIP51表达;HE染色观察黑质组织病理形态变化;透射电镜观察黑质细胞线粒体超微结构;ELISA检测各组黑质组织ATP含量变化。结果与NC组和SO组比,Model组大鼠旋转圈数和爬杆时间增加,α-syn表达升高,VAPB、PTPIP51表达降低,神经元细胞数量减少、胞体皱缩,线粒体肿胀,线粒体嵴消失,ER-线粒体接触距离变大,ATP含量降低;与Model组相比,Madopar组和CLD组、CMD组、CHD组大鼠旋转圈数和爬杆时间减少,α-syn表达降低,VAPB、PTPIP51表达升高,神经元损伤程度减轻,线粒体形态有所改善,ATP含量增加,呈量效差异性,Madopar组和CHD组相对疗效较佳且差异无统计学意义。结论复方地黄颗粒能够减轻PD大鼠行为症状,并可能通过下调α-syn表达,上调PTPIP51、VAPB表达,改善线粒体功能,从而发挥治疗PD的作用。

关键词：帕金森病阴虚动风证复方地黄颗粒 α-syn VAPB PTPIP51

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微塑料与肺表面活性物质相互作用

中国环境科学 2024年第1期44卷 474-481页

作者：蒋凡殊曹妍张林丰师伟萌宋浩然王浩骏杨艳琳赵群李杰李曼焘昆明理工大学环境科学与工程学院云南昆明650500

选择聚氯乙烯(PVC)和聚乙烯(PE)为代表性微塑料,探究了微塑料与肺表面活性物质(LS)间的相互作用机制.结果表明,PVC和PE对LS活性组分具有显著的吸附作用,其对磷脂组分的吸附率可分别达到49.33%和47.00%,从而造成LS表面张力的升高和表面压... 详细信息

选择聚氯乙烯(PVC)和聚乙烯(PE)为代表性微塑料,探究了微塑料与肺表面活性物质(LS)间的相互作用机制.结果表明,PVC和PE对LS活性组分具有显著的吸附作用,其对磷脂组分的吸附率可分别达到49.33%和47.00%,从而造成LS表面张力的升高和表面压力-表面积等温线(π-A)的内缩.与LS接触后,微塑料的表面形貌和Zeta电位也发生了变化,PVC和PE的Zeta电位绝对值分别降低了5.61和5.20mV,进一步影响了微塑料的分散状态和沉降能力.因此,当微塑料通过呼吸系统进入肺部环境时,其不仅能造成LS界面化学性质的显著变化,其自身性质也受到影响,可能诱导更严重的健康危害.

关键词：微塑料肺表面活性物质界面性质肺健康

Transformer-Based Macroscopic Regulation for High-Speed Railway Timetable Rescheduling

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IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1822-1833页

作者： wei Xu Chen Zhao jie Cheng Yin wang Yiqing Tang tao Zhang Zhiming Yuan Yisheng Lv Fei-Yue wang Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Signal&Communication Research Institute China Academy Railway SciencesBeijing 100081China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China IEEE State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China

Unexpected delays in train operations can cause a cascade of negative consequences in a high-speed railway *** such cases,train timetables need to be ***,timely and efficient train timetable rescheduling is still a challenging problem due to its modeling difficulties and low optimization *** paper presents a Transformer-based macroscopic regulation approach which consists of two stages including Transformer-based modeling and policy-based ***,the relationship between various train schedules and operations is described by creating a macroscopic model with the Transformer,providing the better understanding of overall operation in the high-speed railway ***,a policy-based approach is used to solve a continuous decision problem after macro-modeling for fast *** experiments on various delay scenarios are *** results demonstrate the effectiveness of the proposed method in comparison to other popular methods.

关键词： High-speed railway reinforcement learning train timetable rescheduling Transformer

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中药干预糖尿病溃疡相关信号通路研究进展

中国实验方剂学杂志 2024年第2期30卷 212-220页

作者：魏晓涛何志军刘涛魏金凤李金鹏宋渊陈杰王海刚何元旭甘肃中医药大学兰州730000 甘肃省中医院兰州730000 酒钢医院甘肃嘉峪关735100 甘肃省第二人民医院兰州730000 甘肃中医药大学第四附属医院兰州730000

糖尿病溃疡创面是一种以创面迁延难愈为特点的糖尿病慢性严重并发症之一,临床上多见于足部、下肢的溃疡。糖尿病溃疡因其较大的治疗难度、漫长的治疗过程及较高的致残率、致死率,给患者带来了巨大经济及心理压力,严重影响患者的生活质... 详细信息

糖尿病溃疡创面是一种以创面迁延难愈为特点的糖尿病慢性严重并发症之一,临床上多见于足部、下肢的溃疡。糖尿病溃疡因其较大的治疗难度、漫长的治疗过程及较高的致残率、致死率,给患者带来了巨大经济及心理压力,严重影响患者的生活质量。故而如何帮助糖尿病溃疡创面快速愈合,降低致残率、致死率,保护肢体功能,提高生命质量,是当今医学领域研究的重要课题和热点。糖尿病溃疡发病机制复杂,以微循环障碍、周围神经病变、炎症及感染、细胞过度凋亡为主,涉及创面炎症反应、肉芽组织增生及再上皮化等生理过程。既往国内外大量研究发现,中药可在中医辨证论治、内外治相结合理论指导下,调控磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、Wnt/β-连环蛋白(β-catenin)、核转录因子-κB(NF-κB)、Notch、核因子E2相关因子2(Nrf2)、转化生长因子-β(TGF-β)/Smad等信号通路,调节异常葡萄糖代谢,改善微循环,抑制炎症及氧化应激反应,调控细胞增殖及过度凋亡,促进创面组织生长,达到促进糖尿病溃疡创面快速愈合的治疗目的。因此,该文通过对近年来中药单体或中药复方调控上述信号通路及关键蛋白分子表达,促进糖尿病溃疡创面快速愈合相关研究进展进行了总结,旨在为中药促进糖尿病溃疡创面愈合的深入研究和临床应用提供思路及理论依据。

关键词：糖尿病溃疡创面愈合信号通路中药

Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients With Metabolic Syndrome

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International Journal of Dermatology And Venereology 2024年第03期

作者： Song Cui-Hao wang Rui Zhao Zhen-Kai Zhang Yuan Sun jie Zhang Xu Ding Xiang-Yu Bai Jia Liang Xiao-Qiang wei Xuan-Jin Liu Xiao-ling Yang tao Liang Xin-Lin Li Cheng-Xin Lin Bi-Wen Department of Dermatology PLA General Hospital Beijing China Department of Clinical Laboratory PLA General Hospital Beijing China Department of Dermatology Southern Medical University Guangzhou Guangdong China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with ***: From January 2021 to June 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins’ concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting afterin vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chisquare test. Correlations were evaluated by Pearson correlation ***: The serum lepti

关键词： psoriasis metabolic syndrome leptin autophagy keratinocyte differentiation signal pathway PI3K/AKT/mTOR

Synthesis and characterization of magnetic and luminescent Fe_3O_4/CdTe nanocomposites using aspartic acid as linker

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Chinese Chemical Letters 2011年第2期22卷 233-236页

作者： Xiu ling wang Lu wei Guan Hong tao Meng Qiong Huang School of Chemistry Chemical Engineering and Materials Science Suzhou University Suzhou 215123 China School of Chemical and Biological Engineering Suzhou University of Science and Technology Suzhou 215009 China Yantai Entry-exit Inspection and Quarantine Bureau Yantai 264000 China Received 3 June 2010

In this study,the preparation of a new kind of magnetic and luminescent Fe3O4/CdTe nanocomposites was demonstrated. Superparamagnetic Fe3O4 nanoparticles were first synthesized by hydrothermal coprecipitation of ferric and ferrous ions,followed by the modification of their surfaces with tetramethylammonium hydroxide（TMAOH） and the chemical activation with aspartic *** surface-modified Fe3O4 nanoparticles were then covalently coated with CdTe quantum dots（QDs）,which were modified with mercaptoacetic acid（MPA）,to form the Fe3O4/CdTe magnetic and luminescent nanocomposites through the coordination of the amino groups on the surfaces of Fe3O4 and the carboxyl groups on CdTe *** structure and properties of as-synthesized nanocomposites were *** was indicated that the nanocomposites possessed structure with an average diameter of 40- 50 nm,yellow-green emission feature and room temperature *** the fluorescence and UV-vis absorption spectra of the nanocomposites showed a blue shift comparing with those of CdTe *** mechanism of the blue shift was *** nanocomposites retained the ferromagnetic property with a saturation magnetization of 8.9 emu/g.

关键词： Fe3O4/CdTe nanocomposites Luminescent Magnetic Synthesis Aspartic acid