检索结果-南通市图书馆

维普期刊数据库博看期刊

Suggestions on Improving China’s Breakthrough Therapy Designation System

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Social Pharmacy 2024年第3期19卷 232-236页

作者： wang Zuguang Chen Yuwen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD *** A comparative research method was used to study the content and implementation effect of BTD system in China and the relevant policies and implementation of the same procedures of drug regulatory authorities in the United States,Japan and the European ***,the differences in policies and implementation results among these countries were analyzed to provide suggestions for the implementation and optimization of this system in *** and Conclusion China’s BTD system is implemented late and a small number of drugs has been *** the same time,there are problems such as insufficient guidance and communication from the agency to applicants,a broad application condition,single review mode,and lack of full-time *** the agencies and the applicants have limited experience due to the short implementation time of BTD system in *** are still some problems despite we have learned a lot from the experience of other drug regulatory ***,based on our national conditions,we should strengthen the guidance of evaluation agency to applicants,optimize the eligibility criteria of BTD system,introduce the rolling review,and increase the number of professional liaisons,which can accelerate the development and marketing process of drugs with obvious clinical value,and finally to address unmet medical need.

关键词： breakthrough therapy designation(BTD) expedited program system optimization

Association of creatine kinase with Alzheimer’s disease pathology:A cross-sectional study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第1期137卷 117-119页

作者： Yutong wang Peiyang Gao Hongman Liu Tingyu wang Jiaming Fan Tingbo Jiang Alzheimer’s Disease Neuroimaging Initiative(ADNI) Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Institute for Cardiovascular Science of Soochow University SuzhouJiangsu 215000China Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandong 266071China Cardiac Function Department the Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong 271000China Department of Cardiac Surgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China 不详

To the Editor:Creatine kinase(CK),also called creatine phosphokinase,is primarily located in the cytoplasm and *** can be used to diagnose cardiac diseases such as myocardial infarction,viral myocarditis,and pericarditis because it is a vital kinase directly related to intracellular energy operation,muscle contraction,and adenosine triphosphate(ATP)*** studies have confirmed in recent years that serum biomarkers such as elevated CK are associated with Alzheimer’s disease(AD)and its related pathological protein.[1]Previous research indicated that systemic conditions,particularly cardiovascular and cerebrovascular diseases,are significant risk factors for cognitive impairment,and dysfunction of peripheral organs may also contribute to cognitive decline and AD.[2]However,the connection between CK and AD remains ***,to investigate the association between CK and cerebrospinal fluid(CSF)AD pathology biomarkers,we analyzed data from the Alzheimer’s Disease Neuroimaging Initiative(ADNI),a global multi-centered database.

关键词： Alzheimer pathology organs

Coarsening behavior of γ' particles in a nickel-base superalloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2009年第2期28卷 197-201页

作者： Li, Hongyu zuo, Lingli Song, Xiping wang, Yanli Chen, Guoliang State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

The coarsening behavior of γ particles in a nickel-base superalloy FGH95 was investigated by means of experimental observations and growth kinetics calculations. The results show that when aging at 1000,1080 and 1140°C for different times,the relation of average particle size to time obeys the cube law ( a /2)3= kt,where k is 15.49 × 103,77.5 × 103 and 230.04 × 103 nm3/min,respectively. The particle size distributions are better fit to the LSW theoretical distributions when aging at 1000°C within 1440 min....

关键词： nickel-base superalloys γ particles coarsening behavior particle size distribution activation energy

Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-wang Lu Zhao-Li Ding Rui Mao Gui-Gang Zhao Yu-Qi He Xiao-Lu Li Jiang Liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

Adsorption removal of roxarsone, arsenite(Ⅲ),and arsenate(Ⅴ) using iron-modified sorghum straw biochar and its kinetics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geochimica 2021年第3期40卷 409-418页

作者： Shuyan Zang Yingying zuo Juan wang Xiuming Liu Mario Alberto Gomez Lan wei Liaoning Engineering Research Center for Treatment and Recycling of Industrially Discharged Heavy Metals Shenyang University of Chemical TechnologyShenyang 110142China Shenyang University of Chemical Technology Shenyang 110142China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Arsenic(As)contamination in groundwater is a major problem in many countries,which causes serious health *** this paper,a novel method has been developed for the simultaneous removal of ROX and As(Ⅲ/Ⅴ)using the modified sorghum straw biochar(MSSB).The MSSB was characterized by X-ray diffraction,scanning electron microscopy,Fourier Transform Infrared,and Brunauer–Emmet–Teller(BET)surface *** removal performance of MSSB for ROX,arsenite[As(Ⅲ)],and arsenate(As(Ⅴ))was investigated using batch *** pH of 5,the arsenic concentration of 1.0 mg/L,adsorbent dose of 1.0 g/L,the maximum adsorptioncapacities of ROX,As(Ⅲ),and As(Ⅴ)were 12.4,5.3,and 23.0 mg/g,*** adsorption behaviors were fit well with the Langmuir and the pseudo-second-order rate *** results showed that MSSB acted as a highly effective adsorbent to simultaneously remove the composite pollution system consisted of ROX and As(Ⅲ/Ⅴ)in aqueous solutions,providing a promising method in environmental restoration applications.

关键词： Roxarsone Arsenic Arsenate Sorghum straw biochar Adsorption

在线全文

学校读者我要写书评

暂无评论

我国煤矿重特大事故统计分析及对策建议

中国安全科学学报 2024年第9期34卷 9-18页

作者：王海军齐庆杰梁运涛齐庆新刘英杰孙祚煤炭科学研究总院有限公司北京100013

为揭示近年来我国煤矿事故特征,有针对性地提出事故防范对策建议,首先,收集整理2013—2023年全国重特大煤矿事故,分析事故发生的年份、类型、月份、省份和原因等方面;其次,以内蒙古新井煤业“2·22”特别重大坍塌事故为例,基于“2-4”模... 详细信息

为揭示近年来我国煤矿事故特征,有针对性地提出事故防范对策建议,首先,收集整理2013—2023年全国重特大煤矿事故,分析事故发生的年份、类型、月份、省份和原因等方面;其次,以内蒙古新井煤业“2·22”特别重大坍塌事故为例,基于“2-4”模型(24Model)分析导致事故发生的原因;最后,结合以上分析和研究结果提出符合我国现阶段煤矿安全生产形势的事故预防对策与建议。结果表明:煤矿重特大事故发生起数和死亡人数呈整体下降趋势,且进入“十二五”规划以来,我国煤矿安全生产水平明显提高;瓦斯事故仍是我国煤矿主要事故,占事故总起数的51%;每年第4季度是煤矿事故高发期,占事故总起数的30.43%;受地质条件和赋存情况影响,煤炭主要产区发生事故较多;人的不安全行为导致的事故占比高达74%;当个体层面和组织层面存在隐患且双重预防措施不到位时,易发生事故;从安全监管、科技兴安、队伍建设、安全文化等4个维度提出降低煤矿安全事故的对策建议。

关键词：煤矿重特大事故统计分析 “2-4”模型(24Model) 事故原因不安全行为

霍山黄芽提取物对棕榈酸诱导下细胞脂质积累和炎症反应的影响

在线全文

学校读者我要写书评

暂无评论

浙江大学学报（农业与生命科学版） 2024年第4期50卷 633-645页

作者：左欣欣陈蔚丁乐佳施羽萱周继红刘仲华王岳飞浙江大学农业与生物技术学院茶叶研究所浙江杭州310058 湖南农业大学茶学教育部重点实验室/国家植物功能成分利用工程技术研究中心/植物功能成分利用省部共建协同创新中心湖南长沙410128

本研究比较分析了4个不同等级(特一级、特二级、一级、二级)霍山黄芽的主要生化成分和抗氧化活性差异,并选取特一级霍山黄芽,基于棕榈酸诱导的小鼠正常肝细胞AML-12(alpha mouse liver 12)、小鼠神经小胶质细胞BV-2、人肾皮质近曲小管... 详细信息

本研究比较分析了4个不同等级(特一级、特二级、一级、二级)霍山黄芽的主要生化成分和抗氧化活性差异,并选取特一级霍山黄芽,基于棕榈酸诱导的小鼠正常肝细胞AML-12(alpha mouse liver 12)、小鼠神经小胶质细胞BV-2、人肾皮质近曲小管上皮细胞HK-2(human kidney-2)、人胃腺癌细胞(human gastric adenocarcinoma,AGS)细胞模型,研究霍山黄芽提取物(Huoshanhuangya tea extract, HTE)对脂质积累和促炎细胞因子的影响。结果表明:特一级霍山黄芽的可溶性糖质量分数最低,咖啡碱质量分数、儿茶素类质量分数与游离氨基酸总量最高,且抗氧化活性最强;一定质量浓度的HTE处理后,棕榈酸诱导的AML-12、BV-2、HK-2、AGS细胞的细胞活力显著增加,棕榈酸诱导的脂质积累得到改善,棕榈酸诱导的AML-12、BV-2、HK-2细胞中肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)的释放水平明显降低。进一步探究其作用机制发现,HTE使BV-2细胞中炎症信号通路Toll样受体4(Toll-like receptor 4, TLR4)和核因子-κB RelA(nuclear factor-κB RelA, NF-κB p65)基因的表达下调,表明其可能通过抑制TLR4/NF-κB信号通路的活化来缓解棕榈酸诱导的BV-2细胞炎症损伤。

关键词：黄茶饱和脂肪酸抗氧化活性脂质积累促炎细胞因子

Bioinspired Multifunctional Self-Sensing Actuated Gradient Hydrogel for Soft-Hard Robot Remote Interaction

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第4期16卷 139-152页

作者： He Liu Haoxiang Chu Hailiang Yuan Deliang Li weisi Deng Zhiwei Fu Ruonan Liu Yiying Liu Yixuan Han Yanpeng wang Yue Zhao Xiaoyu Cui Ye Tian College of Medicine and Biological Information Engineering Northeastern UniversityShenyang 110169People’s Republic of China Foshan Graduate School of Innovation Northeastern UniversityFoshan 528300People’s Republic of China

The development of bioinspired gradient hydrogels with self-sensing actuated capabilities for remote interaction with soft-hard robots remains a challenging endeavor. Here, we propose a novel multifunctional self-sensing actuated gradient hydrogel that combines ultrafast actuation and high sensitivity for remote interaction with robotic hand. The gradient network structure, achieved through a wettability difference method involving the rapid precipitation of MoO_(2) nanosheets, introduces hydrophilic disparities between two sides within hydrogel. This distinctive approach bestows the hydrogel with ultrafast thermo-responsive actuation(21° s^(-1)) and enhanced photothermal efficiency(increase by 3.7 ℃ s^(-1) under 808 nm near-infrared). Moreover, the local cross-linking of sodium alginate with Ca^(2+) endows the hydrogel with programmable deformability and information display capabilities. Additionally, the hydrogel exhibits high sensitivity(gauge factor 3.94 within a wide strain range of 600%), fast response times(140 ms) and good cycling stability. Leveraging these exceptional properties, we incorporate the hydrogel into various soft actuators, including soft gripper, artificial iris, and bioinspired jellyfish, as well as wearable electronics capable of precise human motion and physiological signal detection. Furthermore, through the synergistic combination of remarkable actuation and sensitivity, we realize a self-sensing touch bioinspired tongue. Notably, by employing quantitative analysis of actuation-sensing, we realize remote interaction between soft-hard robot via the Internet of Things. The multifunctional self-sensing actuated gradient hydrogel presented in this study provides a new insight for advanced somatosensory materials, self-feedback intelligent soft robots and human–machine interactions.

关键词： Self-sensing Gradient structure Bioinspired actuator Hydrogel sensor Remote interaction

Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第10期15卷 918-931页

作者： Hui-Si Yang Yue-Xiang Zheng Xue Bai Xiu-Ying He Ting-Hua wang Department of Neurology and National Traditional Chinese Medicine Clinical Research Base The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Anesthesiology Institute of Neurological DiseaseWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Anesthesiology Institute of Neurological DiseaseTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional ***,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka *** evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal ***,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.

关键词： Urine-derived stem cells Urine-derived induced pluripotent stem cells Neurological diseases Musculoskeletal diseases Treatment prospect