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Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： wang Lu-ming ZHANG Wen-lan LYU Nuan suo Yan-rong YANG Lin YU Bin JIANG Xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human ***-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to ***-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque *** paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

On the Optimal Initial Inner-Core Size for Tropical Cyclone Intensification: An Idealized Numerical Study

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ADVANCES IN ATMOSPHERIC SCIENCES 2024年第11期41卷 2141-2155页

作者： Fei, rong wang, Yuqing Wuxi Univ Sch Atmospher Sci & Remote Sensing Wuxi 214105 Peoples R China Chinese Acad Meteorol Sci State Key Lab Severe Weather Beijing 100081 Peoples R China Univ Hawaii Manoa Int Pacific Res Ctr Sch Ocean & Earth Sci & Technol Dept Atmospher Sci Honolulu HI 96822 USA

Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones (TCs). In this study, with the initial inner-core size (i.e., the radius of maximum wind-RMW) varied from 20-180 km in idealized simulations using two different numerical models, we found a nonmonotonic dependence of the lifetime maximum intensification rate (LMIR) on the inner-core size. Namely, there is an optimal inner-core size for the LMIR of a TC. Tangential wind budget analysis shows that, compared to large TCs, small TCs have large inward flux of absolute vorticity due to large absolute vorticity inside the RMW. However, small TCs also suffer from strong lateral diffusion across the eyewall, which partly offsets the positive contribution from large inward flux of absolute vorticity. These two competing processes ultimately lead to the TC with an intermediate initial inner-core size having the largest LMIR. Results from sensitivity experiments show that the optimal size varies in the range of 40-120 km and increases with higher sea surface temperature, lower latitude, larger horizontal mixing length, and weaker initial TC intensity. The 40-120 km RMW corresponds to the inner-core size most commonly found for intensifying TCs in observations, suggesting the natural selection of initial TC size for intensification. This study highlights the importance of accurate representation of TC inner-core size to TC intensity forecasts by numerical weather prediction models.

关键词： tropical cyclones intensification inner-core size idealized simulations SURFACE EXCHANGE COEFFICIENTS PART II BOUNDARY-LAYER INTENSITY DYNAMICS

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li wang Guo-rong WAN Min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

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医疗机构放射性污染物的豁免与清洁解控

中国辐射卫生 2005年第3期14卷 182-183页

作者：王荣锁山东省辐射环境管理站山东济南250117

目的结合当前辐射环境管理现状,探讨医疗机构放射性污染物的豁免与清洁解控的范围、程序和方法。方法依据国家标准《电离辐射防护与辐射源安全基本标准》(BBS)。结果对常用概念加以定义和解释;阐述放射性污染物的豁免与清洁解控的一般... 详细信息

目的结合当前辐射环境管理现状,探讨医疗机构放射性污染物的豁免与清洁解控的范围、程序和方法。方法依据国家标准《电离辐射防护与辐射源安全基本标准》(BBS)。结果对常用概念加以定义和解释;阐述放射性污染物的豁免与清洁解控的一般要求及其基本准则;按照不同应用类型概略列出了应豁免的源及其豁免水平。结论豁免与清洁解控是辐射环境管理的一个重要环节。可大大节省社会管理资源,进一步降低和减少医疗机构在审查管理、安全保卫及放射性废物处置中的经营成本。

关键词：环境保护放射性豁免清洁解控

Explosion resistance performance of reinforced concrete box girder coated with polyurea:Model test and numerical simulation

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Defence Technology（防务技术） 2024年第3期33卷 1-18页

作者： Guangpan Zhou rong wang Mingyang wang Jianguo Ding Yuye Zhang School of Science Nanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina State Key Laboratory of Explosion and Impact and Disaster Prevention and Mitigation Army Engineering University of PLANanjing 210007JiangsuChina

To study the anti-explosion protection effect of polyurea coating on reinforced concrete box girder,two segmental girder specimens were made at a scale of 1:3,numbered as G(without polyurea coating)and PCG(with polyurea coating).The failure characteristics and dynamic responses of the specimens were compared through conducting explosion *** reliability of the numerical simulation using LS-DYNA software was verified by the test *** effects of different scaled distances,reinforcement ratios,concrete strengths,coating thicknesses and ranges of polyurea were *** results show that the polyurea coating can effectively enhance the anti-explosion performance of the *** top plate of middle chamber in specimen G forms an elliptical penetrating hole,while that in specimen PCG only shows a very slight local *** peak vertical displacement and residual displacement of PCG decrease by 74.8% and 73.7%,respectively,compared with those of specimen *** the TNT explosion with small equivalent,the polyurea coating has a more significant protective effect on reducing the size of *** the increase of TNT equivalent,the protective effect of polyurea on reducing girder displacement becomes more *** optimal reinforcement ratio,concrete strength,thickness and range of polyurea coating were also drawn.

关键词： Explosive load Explosion resistance performance Model test Polyurea Concrete box girder Numerical simulation

Transcriptional regulation in the development and dysfunction of neocortical projection neurons

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Neural Regeneration Research 2024年第2期19卷 246-254页

作者： Ningxin wang rong Wan Ke Tang Precise Genome Engineering Center School of Life SciencesGuangzhou UniversityGuangzhouGuangdong ProvinceChina

Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal *** development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and *** processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural *** generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.

关键词： autism spectrum disorders cognition differentiation excitatory circuits intellectual disability neocortex neurodevelopmental disorders projection neuron specification transcriptional regulation

GNN-based temporal knowledge reasoning for UAV mission planning systems

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 12-25页

作者： Chai rong Duan Xiaofang wang Lixuan School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Unmanned aerial vehicles(UAVs)are increasingly applied in various mission scenarios for their versatility,scalability and *** UAV mission planning systems(UMPSs),an efficient mission planning strategy is essential to meet the requirements of UAV ***,rapidly changing environments and unforeseen threats pose challenges to UMPSs,making efficient mission planning *** address these challenges,knowledge graph technology can be utilized to manage the complex relations and constraints among UAVs,missions,and *** paper investigates knowledge graph application in UMPSs,exploring its modeling,representation,and storage concepts and ***,the construction of a specialized knowledge graph for UMPS is ***,the paper delves into knowledge reasoning within UMPSs,emphasizing its significance in timely updates in the dynamic environment.A graph neural network(GNN)-based approach is proposed for knowledge reasoning,leveraging GNNs to capture structural information and accurately predict missing entities or relations in the knowledge *** relation reasoning,path information is also incorporated to improve the accuracy of *** account for the temporal dynamics of the environment in UMPS,the influence of timestamps is captured through the attention *** effectiveness and applicability of the proposed knowledge reasoning method are verified via simulations.

关键词： unmanned aerial vehicle mission planning knowledge graph knowledge reasoning graph neural network

Provenance of the Lower Jurassic pyroclastic sediments in the Zigui Basin:Implication for crustal thickening in the eastern Qinling orogenic belt

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Science China Earth Sciences 2024年第1期67卷 196-207页

作者： rong CHAI Jianghai YANG Yuansheng DU Chengshan wang School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100023China School of Earth Sciences China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Geological Sciences Beijing 100037China

The Late Triassic witnessed significant collisional orogenic events in the Qinling orogenic belt,accompanied by magma underplating and tectonic *** processes potentially resulted in substantial crustal thickening and uplift of the Qinling ***,due to the absence of igneous rock records from this period in the eastern section of the Qinling orogen,the changes in crustal thickness during this orogenic process have not been thoroughly investigated.A series of foreland basins emerged during the Early Mesozoic to the south of the East Qinling orogenic *** basins have preserved clastic sedimentary rocks derived from the uplift and erosion of the orogenic *** sedimentary records serve as crucial records to reconstruct the evolutionary history of the Qinling *** further clarify the collisional orogenic process of the Qinling orogenic belt,this study conducted in situ volcanic lithic fragment geochemistry,detrital zircon U-Pb chronology and trace element composition analysis on the sandstones of the Lower Jurassic Tongzhuyuan Formation in the Zigui *** results suggest that the sandstones,which exhibit a significant abundance of volcanic lithic fragments,has a characteristic detrital zircon age group of 250–200 Ma,indicating a major provenance from the Triassic volcanic *** with regional correlation and paleocurrent analysis,the detrital zircon U-Pb age data show that the source area of volcanic rocks should be in the Qinling orogenic belt to the north of the *** interpretation is further supported by the Triassic granitic rocks exposed in the western part of the orogenic belt,representing the magmatism during the Triassic collisional orogenesis in the Qinling *** on the co-varying relationships between present-day crust thickness with the chemical compositions of granite rocks and zircons,the La/Yb ratio of volcanic lithic fragments in the Tongzhuyuan Formation and the Eu/Eu*ratio of detrital zircon

关键词： Qinling orogenic belt Zigui Basin Late Triassic Detrital zircons Crustal thickening

对建设行业企业参与校企合作的层次性及对策研究

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成人教育 2009年第3期29卷 7-9页

作者：王锁荣常州建设高等职业技术学校江苏常州213016

建设职业教育教学"校企合作"的成效由其层次性决定,而参与"校企合作"的建设行业企业的层次是决定建设职业教育教学"校企合作"层次高低的重要因素之一。文章通过对影响参与"校企合作"的建设行业企业层次的两大因素——能力和积极性分析,... 详细信息

建设职业教育教学"校企合作"的成效由其层次性决定,而参与"校企合作"的建设行业企业的层次是决定建设职业教育教学"校企合作"层次高低的重要因素之一。文章通过对影响参与"校企合作"的建设行业企业层次的两大因素——能力和积极性分析,就如何提高建设职业教育教学"校企合作"层次,从建设职业院校和建设行政主管部门两方面提出对策建议。

关键词：建设职业院校建设行业企业校企合作层次性能力积极性