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Biomedical and Environmental Sciences 2024年第4期37卷 432-435页

作者： XIA Xian LI Guo Ming TANG Yi wang si quan HE Fei JIANG Yong Zhong YANG Hong Mei JIANG Hong Lin LYU Jing MAO Ling Feng Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization Hubei Normal UniversityHuangshi 430070HubeiChina Hubei Provincial Center for Disease Control and Prevention Wuhan 430079HubeiChina Joint Research Center for Molecular Diagnosis of Severe Infection in Children Binjiang Institute of Zhejiang UniversityHangzhou 310058ZhejiangChina

Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(***),which occurs in people of all ages and is most dangerous for young children,especially *** introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic.

关键词： Pertussis dangerous Hubei

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犬特应性皮炎及其治疗药物的研究进展

中国兽药杂志 2024年第3期58卷 72-78页

作者：董颖波王思权王龙王萌萌刘艳海赵艳兵刘永旺张海彬郭大伟南京农业大学动物医学院南京210095 新瑞鹏宠物医疗集团有限公司南京210019 南京农业大学教学动物医院南京210095

犬特应性皮炎是一种具有遗传倾向的过敏性皮肤病。由于近年来我国养犬数量不断增加,犬特应性皮炎成为宠物临床上的常见疾病,严重危害了宠物犬的身体健康。该病病因复杂,大致可概括为遗传因素、环境因素、皮肤屏障功能失调、免疫功能失... 详细信息

犬特应性皮炎是一种具有遗传倾向的过敏性皮肤病。由于近年来我国养犬数量不断增加,犬特应性皮炎成为宠物临床上的常见疾病,严重危害了宠物犬的身体健康。该病病因复杂,大致可概括为遗传因素、环境因素、皮肤屏障功能失调、免疫功能失调和微生物菌群失调五个方面,且由于其临床症状与其他过敏反应、炎症反应相似,难以确诊,需要通过多种临床反应共同判定。随着小动物诊疗的不断发展,犬特应性皮炎治疗在以往基础疗法上又增加了使用抗炎止痒药物、JAK通路抑制药物、生物制品药物和PDE-4选择性抑制剂等治疗方式。对近年来犬特应性皮炎的病因、临床症状、诊断方法和治疗方法方面的研究进展进行了综述,以期为犬特应性皮炎的治疗提供借鉴和参考。

关键词：犬特应性皮炎临床症状诊断治疗

A survey on facial image deblurring

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Computational Visual Media 2024年第1期10卷 3-25页

作者： Bingnan wang Fanjiang Xu quan Zheng Institute of Software Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

When a facial image is blurred,it significantly affects high-level vision tasks such as face *** purpose of facial image deblurring is to recover a clear image from a blurry input image,which can improve the recognition accuracy,***,general deblurring methods do not perform well on facial ***,some face deblurring methods have been proposed to improve performance by adding semantic or structural information as specific priors according to the characteristics of the facial *** this paper,we survey and summarize recently published methods for facial image deblurring,most of which are based on deep ***,we provide a brief introduction to the modeling of image ***,we summarize face deblurring methods into two categories:model-based methods and deep learning-based ***,we summarize the datasets,loss functions,and performance evaluation metrics commonly used in the neural network training *** show the performance of classical methods on these datasets and metrics and provide a brief discussion on the differences between model-based and learning-based ***,we discuss the current challenges and possible future research directions.

关键词： facial image deblurring model-based deep learning-based semantic or structural prior

Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-quan wang Xiao-Long Wu Jing Zhang si-Ting wang Yong-Juan Sang Kang Li Chao-Fan Yang Fei Sun Chao-Jun Li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang University School of Medicine HangzhouZhejiang 310016China Department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China Liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： single-cell RNA-seq single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

Strong shock propagation for the finite-source circular blast in a confined domain

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1071-1084页

作者： Qihang MA Kaileong CHONG Bofu wang quan ZHOU Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China Shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

The circular explosion wave produced by the abrupt discharge of gas from a high-temperature heat source serves as a crucial model for addressing explosion phenomena in compressible *** reflection of the primary shock and its propagation within a confined domain are studied both theoretically and numerically in this *** the assumption of strong shock,the scaling law governing propagation of the main shock is *** dimensionless frequency of reflected shock propagation is associated with the confined *** numerical simulation for the circular explosion problem in a confined domain is performed for *** the influence of confinement,the principal shock wave systematically undergoes reflection within the domain until it weakens,leading to the non-monotonic attenuation of kinetic energy in the explosion fireball and periodic oscillations of the fireball volume with a certain *** simulation results indicate that the frequency of kinetic energy attenuation and the volume oscillation of the explosive fireball align consistently with the scaling law.

关键词： explosion confinement main shock frequency

A New Industrial Intrusion Detection Method Based on CNN-BiLSTM

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Computers, Materials & Continua 2024年第6期79卷 4297-4318页

作者： Jun wang Changfu si Zhen wang Qiang Fu College of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China

Nowadays,with the rapid development of industrial Internet technology,on the one hand,advanced industrial control systems(ICS)have improved industrial production ***,there are more and more cyber-attacks targeting industrial control *** ensure the security of industrial networks,intrusion detection systems have been widely used in industrial control systems,and deep neural networks have always been an effective method for identifying cyber *** intrusion detection methods still suffer from low accuracy and a high false alarm ***,it is important to build a more efficient intrusion detection *** paper proposes a hybrid deep learning intrusion detection method based on convolutional neural networks and bidirectional long short-term memory neural networks(CNN-BiLSTM).To address the issue of imbalanced data within the dataset and improve the model’s detection capabilities,the Synthetic Minority Over-sampling Technique-Edited Nearest Neighbors(SMOTE-ENN)algorithm is applied in the preprocessing *** algorithm is employed to generate synthetic instances for the minority class,simultaneously mitigating the impact of noise in the majority *** approach aims to create a more equitable distribution of classes,thereby enhancing the model’s ability to effectively identify patterns in both minority and majority *** the experimental phase,the detection performance of the method is verified using two data *** results show that the accuracy rate on the CICIDS-2017 data set reaches 97.7%.On the natural gas pipeline dataset collected by Lan Turnipseed from Mississippi State University in the United States,the accuracy rate also reaches 85.5%.

关键词： Intrusion detection convolutional neural network bidirectional long short-term memory neural network multi-head self-attention mechanism

Rheological Behaviors of Polymers with Nanoparticles Tethered at Each End

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Chinese Journal of Polymer Science 2024年第3期42卷 400-406,I0009页

作者： Song-Qi Zhang Wen-Qing wang Jia-Ping Lin Li-quan wang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The polymer with nanoparticles tethered at each end is a unique model for unraveling the effect of chain ends on the polymer dynamics. We investigated the rheological behavior of this kind of polymer by using nonequilibrium molecular dynamics simulation. The effect of polymer lengths and nanoparticle radii on the complex moduli and viscosity was examined. The dependence of complex moduli on the frequency becomes less pronounced as the polymer is short or the nanoparticle is large. The shear thinning behavior was revealed for these systems, and the scaling exponent of complex viscosity with respect to the frequency was found to change from-1/2 to-3/4 as the polymer shortens or the nanoparticle enlarges. The rheological behavior was further explained by analyzing the mean square distance of nanoparticles. The simulation results were compared with the existing experimental finding, showing an agreement. The work provides information for understanding the chain end effect on polymer rheology.

关键词： Polymer rheology Modulus Viscosity Molecular dynamics

Epidemiological features of seasonal influenza transmission among 11 climate zones in Chinese mainland

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Infectious Diseases of Poverty 2024年第1期13卷 27-41页

作者： Xiaohan si Liping wang Kerrie Mengersen Wenbiao Hu Ecosystem Change and Population Health Research Group School of Public Health and Social WorkQueensland University of TechnologyBrisbaneQLD 4059Australia Information Center Chinese Center for Disease Control and PreventionBeijing 102206China School of Mathematical Sciences Queensland University of TechnologyBrisbaneQLD 4000Australia

Background Previous studies provided some evidence of meteorological factors influence seasonal influenza transmission patterns varying across regions and latitudes. However, research on seasonal influenza activities based on climate zones are still in lack. This study aims to utilize the ecological-based Koppen Geiger climate zones classification system to compare the spatial and temporal epidemiological characteristics of seasonal influenza in Chinese mainland and assess the feasibility of developing an early warning *** Weekly influenza cases number from 2014 to 2019 at the county and city level were sourced from China National Notifiable Infectious Disease Report Information System. Epidemic temporal indices, time series seasonality decomposition, spatial modelling theories including Moran’s/ and local indicators of spatial association were applied to identify the spatial and temporal patterns of influenza *** All climate zones had peaks in Winter-Spring season. Arid, desert, cold (BWk) showed up the first peak. Only Tropical, savannah (Aw) and Temperate, dry winter with hot summer (Cwa) zones had unique summer peak. Temperate, no dry season and hot summer (Cfa) zone had highest average incidence rate (IR) at 1.047/100,000. The Global Moran’s/ showed that average IR had significant clustered trend (z = 53.69,P < 0.001), with local Moran’s/ identified high-high cluster in Cfa and Cwa. IR differed among three age groups between climate zones (0-14 years old:F = 26.80,P < 0.001;15-64 years old:F = 25.04,P < 0.001;Above 65 years old:F = 5.27,P < 0.001). Age group 0-14 years had highest average IR in Cwa and Cfa (IR= 6.23 and 6.21) with unique dual peaks in winter and spring season showed by seasonality *** Seasonal influenza exhibited distinct spatial and temporal patterns in different climate zones. Seasonal influenza primarily emerged in BWk, subsequently in Cfa and Cwa. Cfa, Cwa and BSk pose high risk for seasonal

关键词： Seasonal influenza Koppen Geiger climate zones classification system Chinese mainland Seasonality decomposition Local indicators of spatial association

State Estimation of Drive-by-Wire Chassis Vehicle Based on Dual Unscented Particle Filter Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 99-113页

作者： Zixu wang Chaoning Chen quan Jiang Hongyu Zheng Chuyo Kaku State Key Laboratory of Automotive simulation and Control Jilin UniversityChangchun 130022China Jiangsu Chaoli Electric Co.Ltd. Zhenjiang 212321China

Accurate vehicle dynamic information plays an important role in vehicle driving ***,due to the characteristics of high mobility and multiple controllable degrees of freedom of drive-by-wire chassis vehicles,the current mature application of traditional vehicle state estimation algorithms can not meet the requirements of drive-by-wire chassis vehicle state *** paper proposes a state estimation method for drive-by-wire chassis vehicle based on the dual unscented particle filter algorithm,which make full use of the known advantages of the four-wheel drive torque and steer angle parameters of the drive-by-wire chassis *** the dual unscented particle filter algorithm,two unscented particle filter transfer information to each other,observe the vehicle state information and the tire force parameter information of the four wheels respectively,which reduce the influence of parameter uncertainty and model parameter changes on the estimation accuracy during *** performance with the dual unscented particle filter algorithm,which is analyzed in terms of the time-average square error,is superior of the unscented Kalman filter *** effectiveness of the algorithm is further verified by driving simulator *** this paper,a vehicle state estimator based on dual unscented particle filter algorithm was proposed for the first time to improve the estimation accuracy of vehicle parameters and states.

关键词： Drive-by-wire chassis vehicle Vehicle state estimation Dual unscented particle filter Tire force estimation Unscented particle filter

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng si Yue-Yue wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

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