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Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju wang Lv-hui Sun Xu wang qinghua Wu Aimei Liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan430070China College of Life Science Yangtze UniversityJingzhou 434025China

T-2 toxin is one of the most widespread and toxic fungal toxins in food and *** can cause gastrointestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxicity in humans and animals.T-2 toxin is physicochemically stable and does not readily degrade during food and feed ***,suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent *** agents against the organ toxicity of T-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively *** this review,we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification *** appropriate targets to antagonize T-2 toxin toxicity is also an important *** review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

关键词： T-2 toxin Organ toxicity Protective agent Detoxification mechanism

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Mitochondrial transplantation ameliorates hippocampal damage following status epilepticus

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Animal Models and Experimental Medicine 2023年第1期6卷 41-50页

作者： Xiaoxia Jia qinghua wang Jianlun Ji Wenchun Lu Zhidong Liu Hao Tian Lin Guo Yun wang Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhouChina Psychology Laboratory School of ManagementXuzhou Medical UniversityXuzhouChina Department of Pharmacy The Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina Agro-Products Processing Research Institute Yunnan Academy of Agricultural SciencesKunmingChina

Background:Hippocampal damage caused by status epilepticus(SE)can bring about cognitive decline and emotional disorders,which are common clinical comorbidities in patients with *** is therefore imperative to develop a novel therapeutic strat-egy for protecting hippocampal damage after *** dysfunction is one of contributing factors in *** the therapeutic benefits of mitochondrial replenishment by exogenous mitochondria,we hypothesized that transplantation of mitochondria would be capable of ameliorating hippocampal damage following ***:Pilocarpine was used to induced SE in ***-generated cognitive de-cline and emotional disorders were determined using novel object recognition,the tail suspension test,and the open field ***-induced hippocampal pathology was assessed by quantifying loss of neurons and activation of microglia and *** metabolites underlying mitochondrial transplantation were determined using ***:The results showed that peripheral administration of isolated mitochon-dria could improve cognitive deficits and depressive and anxiety-like *** mitochondria blunted the production of reactive oxygen species,pro-liferation of microglia and astrocytes,and loss of neurons in the *** metabonomic profiles showed that mitochondrial transplantation altered multiple metabolic pathways such as sphingolipid signaling pathway and carbon *** potential affected metabolites,mitochondrial transplantation decreased levels of sphingolipid(d18:1/18:0)and methylmalonic acid,and elevated levels of D-fructose-1,***:To the best of our knowledge,these findings provide the first direct ex-perimental evidence that artificial mitochondrial transplantation is capable of amelio-rating hippocampal damage following *** new findings support mitochondrial transplantation as a promising therapeutic strategy for epilepsy-associated psychiat-ric and cogniti

关键词： cognitive deficit emotional disorders hippocampal damage mitochondrial transplantation status epilepticus

Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

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BIOCELL 2022年第4期46卷 989-998页

作者： LONGJU QI XIAOYING XU BIN LI BO CHANG SHENGCUN wang CHUN LIU LIUCHENG WU XIAODI ZHOU qinghua wang Affiliated Nantong Hospital 3 of Nantong University Nantong UniversityNantong226001China Comparative Medicine Institution of Nantong University Nantong UniversityNantong226001China Department of Gynecology and Obstetrics Hai’an Hospital Affiliated to Nantong UniversityNantong UniversityNantong226001China Department of Paediatric Affiliated Hospital of Nantong UniversityNantong UniversityNantong226001China Department of Internal Cardiovascular Medicine the 6th People’s Hospital of Nantong CityNantong226001China

Excessive fat ectopically deposited in the non-adipose tissues is considered as one of the leading causes of *** aim of this study was to investigate the role of Dihydroartemisinin(DHA)in palmitate(PAL)-incubated H9c2 cells(lipotoxicity-induced cell injury model).Cell viability of PAL-treated cells was determined by MTT assay,and apoptotic regulators were examined by qRT-PCR and western blot analysis,in the absence or in the presence of DHA,*** levels of miR-133b and Sirt1 were also evaluated by qRT-PCR and western blotting *** decreased the viability of H9c2 cells and enhanced the expression of apoptotic *** reversed the effect of PAL on cell viability and lowed the level of Caspase3 and *** also lowered the expression of miR-133b,while enhanced the expression of ***1 was revealed as target of miR-133b through transcriptional regulation and the process was affected by *** partially protected against the PAL-induced lipotoxicity by influencing the expression of miR-133b that hindered the activity of *** may be used as a potential treatment in clinical management for lipotoxicity induced heart complications.

关键词： microRNA-133b Palmitate acid Cardiomyocytes Sirt1 Dihydroaretemisinin

基于核磁共振的CO 2驱喉道动用界限——以朝阳沟油田为例

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石油地质与工程 2024年第4期38卷 90-94,100页

作者：白振强皮彦夫王清华宋文波朱琦东北石油大学石油工程学院黑龙江大庆163318 中国石油大庆油田勘探开发研究院黑龙江大庆163000

依据核磁共振基本原理,通过孔隙的简化,推导出核磁共振T_(2)驰豫时间与孔隙喉道半径关系,利用数值差值和最小二乘基本方法,结合高压压汞岩心孔喉分布,将核磁共振T_(2)图谱转换为岩心孔喉半径分布。在此基础上,利用岩心驱替过程中含油饱... 详细信息

依据核磁共振基本原理,通过孔隙的简化,推导出核磁共振T_(2)驰豫时间与孔隙喉道半径关系,利用数值差值和最小二乘基本方法,结合高压压汞岩心孔喉分布,将核磁共振T_(2)图谱转换为岩心孔喉半径分布。在此基础上,利用岩心驱替过程中含油饱和度的变化,信号幅度同步变化的基本规律,分析水驱和CO_(2)驱不同孔喉半径的信号幅度变化曲线,判断出不同开发方式下的最小孔喉动用界限。研究表明,朝阳沟油田特低渗透区块为亲水特性,低压水驱岩样采出程度28.0%,高压水驱岩样采出程度30.0%,非混相气驱岩样的采出程度为48%,混相气驱岩样的采出程度为64%;水驱主要动用孔隙中喉半径大于1.00μm孔的可动油,非混相驱替不可动用的最小孔喉半径为0.15μm,混相驱没有提高喉道动用界限,但是驱替效率却大幅度提高;CO_(2)驱替出原油中的轻质组分,残余油黏度变大,不可动流体在原有的基础上增加了1/3~3/4,核磁共振图谱发生左移现象。研究结论为CO_(2)驱开发方案提供重要的参考依据。

关键词： CO_(2)驱核磁共振高压压汞喉道半径动用界限

护理本科生反思洞察力与人文关怀能力相关研究

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卫生职业教育 2024年第18期42卷 76-79页

作者：廖伟司马琪琪徐梦悦李娜王庆华滨州医学院护理学院山东滨州256699

分析护理本科生反思洞察力和人文关怀能力现状,并探讨二者之间的关系。结果表明,护理本科生自我反思与洞察力处于中等偏上水平,人文关怀能力为中等水平,且二者关系呈正相关。护理教育者应注重培养学生的自我反思意识,提升洞察力水平,促... 详细信息

分析护理本科生反思洞察力和人文关怀能力现状,并探讨二者之间的关系。结果表明,护理本科生自我反思与洞察力处于中等偏上水平,人文关怀能力为中等水平,且二者关系呈正相关。护理教育者应注重培养学生的自我反思意识,提升洞察力水平,促进其人文关怀能力的提升。

关键词：护理本科生自我反思洞察力人文关怀能力

塔西南山前地区柯克亚周缘叶探1井油气勘探重大突破及意义

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中国石油勘探 2024年第4期29卷 1-16页

作者：王清华杨海军李勇蔡振忠杨宪彰谢会文陈才孙春燕中国石油塔里木油田公司中国石油天然气集团有限公司超深层复杂油气藏勘探开发技术研发中心新疆维吾尔自治区超深层复杂油气藏勘探开发工程研究中心新疆超深油气重点实验室

塔西南山前西昆仑冲断带柯东构造带叶探1井在二叠系普斯格组获得重大突破,标志着塔西南山前地区发现一个重要的勘探接替层系。结合区域地质资料,根据野外露头、钻井、地震等综合研究,对柯克亚周缘二叠系普斯格组的成藏条件进行再认识。... 详细信息

塔西南山前西昆仑冲断带柯东构造带叶探1井在二叠系普斯格组获得重大突破,标志着塔西南山前地区发现一个重要的勘探接替层系。结合区域地质资料,根据野外露头、钻井、地震等综合研究,对柯克亚周缘二叠系普斯格组的成藏条件进行再认识。研究认为,研究区内二叠系普斯格组发育陆相湖泊—三角洲沉积体系,上段发育半深湖—深湖相烃源岩,面积1.0×10^(4)km^(2),厚度最大达到800m,集中段有机质丰度为0.92%~1.16%,以菌藻类生源为主,有机质类型主要为Ⅱ型,有机质丰度高;普斯格组下段发育三角洲前缘、滨浅湖沙坝优质砂岩储层,砂体厚度为42.5~63m,砂地比为27%~47%,是一套分布较广的区域性储层,与普斯格组上段泥岩组成优质储盖组合;柯克亚周缘发育印支期、喜马拉雅期两期构造变形,古生界叠瓦冲断、强烈逆掩叠置,圈闭成排成带,喜马拉雅期进一步挤压抬升改造,局部复杂化,形成的叠瓦冲断带为勘探有利区。根据普斯格组天然气干燥系数分析,折算Ro为1.31%~1.42%,与下盘烃源岩成熟度相当,表明油气来自下盘逆掩叠置烃源岩,经历早油晚气的成藏过程,成藏具有“逆掩叠置下盘供烃、下生上储、断裂输导”的特点。综合分析认为该地区二叠系普斯格组圈闭成排成带分布,已发现圈闭9个,面积301km^(2),天然气资源量约为2930×10^(8)m^(3),凝析油资源量约为2×10^(8)t,具有较好的勘探前景。

关键词：塔西南山前地区柯克亚周缘二叠系普斯格组叶探1井重大发现成藏条件

Conservation genomics provides insights into genetic resilience and adaptation of the endangered Chinese hazelnut, Corylus chinensis

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Plant Diversity 2024年第3期46卷 294-308页

作者： Zhen Yang Lisong Liang Weibo Xiang Lujun wang qinghua Ma Zhaoshan wang Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China National Engineering Research Center of Eco-Environment Protection for Yangtze River Economic Belt China Three Gorges CorporationBeijing 100083China Rare Plants Research Institute of Yangtze River China Three Gorges CorporationYichang 443133China Research Institute of Economic Forest Cultivation and Processing Anhui Academy of ForestryHefei 230031China

Global climate change has increased concerns regarding biodiversity ***,many key conservation issues still required further research,including demographic history,deleterious mutation load,adaptive evolution,and putative *** we generated the first chromosome-level genome of the endangered Chinese hazelnut,Corylus chinensis,and compared the genomic signatures with its sympatric widespread ***-C yunnanensis *** found large genome rearrangements across all Corylus species and identified species-specific expanded gene families that may be involved in *** genomics revealed that both *** and the *** complex had diverged into two genetic lineages,forming a consistent pattern of southwestern-northern *** size of the narrow southwestern lineages of both species have decreased continuously since the late Miocene,whereas the widespread northern lineages have remained stable(***) or have even recovered from population bottlenecks(*** complex) during the *** with ***-C. yunnanensis complex,*** showed significantly lower genomic diversity and higher inbreeding ***,*** carried significantly fewer deleterious mutations than ***-C. yunnanensis complex,as more effective purging selection reduced the accumulation of homozygous *** also detected signals of positive selection and adaptive introgression in different lineages,which facilitated the accumulation of favorable variants and formation of local ***,both types of selection and exogenous introgression could have mitigated inbreeding and facilitated survival and persistence of ***,our study provides critical insights into lineage differentiation,local adaptation,and the potential for future recovery of endangered trees.

关键词： Conservation genomics Demographic history Inbreeding Genetic load Runs of homozygosity Local adaptation

重症监护病房护士道德勇气与道德困境相关性分析

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卫生职业教育 2024年第8期42卷 67-71页

作者：魏肖星韩海霞王庆华郑丹丹滨州医学院护理学院山东滨州256603 滨州医学院附属医院山东滨州256600

为了解重症监护病房(ICU)护士道德勇气与道德困境现状,并探讨其相关性,便利选取山东省某省属三级甲等医院ICU护士208名作为研究对象,所有研究对象均采用护士道德勇气量表、护士道德困境量表进行评估。研究显示,ICU护士道德勇气和道德困... 详细信息

为了解重症监护病房(ICU)护士道德勇气与道德困境现状,并探讨其相关性,便利选取山东省某省属三级甲等医院ICU护士208名作为研究对象,所有研究对象均采用护士道德勇气量表、护士道德困境量表进行评估。研究显示,ICU护士道德勇气和道德困境具有显著相关性,提示医院相关职能部门应对其现状重点关注,应用较高的道德敏感度引导其辨析显存的伦理情景,脱离道德困扰。

关键词： ICU护士道德困境道德勇气

Chatter suppression techniques in milling processes:A state of the art review

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Chinese Journal of Aeronautics 2024年第7期37卷 1-23页

作者： Zhenmin LI qinghua SONG Peijian JIN Zhanqiang LIU Bing wang Haifeng MA Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China

Chatter in the machining system can result in a decrease in tool life,poor surface finish,conservative cutting parameters,*** many review papers promoting the understanding and research of this area,chatter suppression techniques are generally discussed within limited pages in the framework of comprehensive chatter-related *** recent years,the developments of smart materials,advanced sensing techniques,and more effective control strategies have led to some new progress in chatter ***,the widely used thin-walled parts present more and more severe machining challenges in their milling *** the above deficiencies,this paper summarizes the current state of the art in milling chatter *** classifications of chatter suppression techniques are proposed according to the working principle and control *** on the new classified framework,the mechanism and comparisons of different chatter suppression strategies are ***,the current challenges and potential tendencies of milling chatter suppression techniques are ***,integration,compactness,adaptability to workpiece geometry,and the collaboration of multiple control methods are predicted to be important trends in the future.

关键词： Active control Chatter suppression Damping Milling Regenerative effect

Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1204-1215页

作者： Ling-Ling Wu Qinxin Zhao qinghua wang Qingyang Zhang Feiya Yang Bo Zheng Hai-Yu Hu Nianzeng Xing State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Urology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Fluorescence-guided surgery(FGS)with tumor-targeted imaging agents,particularly those using the near-infrared wavelength,has emerged as a real-time technique to highlight the tumor location and margins during a surgical *** accurate visualization of prostate cancer(PCa)boundary and lymphatic metastasis,we developed a new approach involving an efficient self-quenched near-infrared fluorescence probe,Cy-KUE-OA,with dual PCa-membrane ***-KUE-OA specifically targeted the prostate-specific membrane antigen(PSMA),anchored into the phospholipids of the cell membrane of PCa cells and consequently showed a strong Cy7-de-quenching *** dual–membrane-targeting probe allowed us to detect PSMA-expressing PCa cells both in vitro and in vivo and enabled clear visualization of the tumor boundary during fluorescence-guided laparoscopic surgery in PCa mouse ***,the high PCa preference of Cy-KUE-OA was confirmed on surgically resected patient specimens of healthy tissues,PCa,and lymph node *** together,our results serve as a bridge between preclinical and clinical research in FGS of PCa and lay a solid foundation for further clinical research.

关键词： Activated probe Small molecule nanoparticle Self-assembly Dual-targeting Near-infrared Prostate cancer Fluorescence-guided surgery Metastases