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Synchronization Stability in Weighted Complex Networks with Coupling Delays

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Communications in Theoretical Physics 2009年第4期51卷 684-690页

作者： wang qing-yun DUAN Zhi-Sheng CHEN Guan-Rong LU Qi-Shao School of Statistics and Mathematics Inner Mongolia Finance and Economics College Huhhot 010051 China State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871 China Department of Electronic Engineering City University of Hong Kong Hong Kong SAR China School of Science Beijing University of Aeronautics and Astronautics Beijing 100083 China

Realistic networks display not only a complex topological structure, but also a heterogeneous distribution of weights in connection strengths. In addition, the information spreading through a complex network is often associated with time delays due to the finite speed of signal transmission over a distance. Hence, the weighted complex network with coupling delays have meaningful implications in real world, and resultantly gains increasing attention in various fields of science and engineering. Based on the theory of asymptotic stability of linear time-delay systems, synchronization stability of the weighted complex dynamical network with coupling delays is investigated, and simple criteria are obtained for both delay-independent and delay-dependent stabilities of synchronization states. The obtained criteria in this paper encompass the established results in the literature as special cases. Some examples are given to illustrate the theoretical results.

关键词： weighted complex networks coupling delays synchronization stability

Phenolic compounds from the aqueous extract of Acacia catechu

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Chinese Chemical Letters 2011年第11期22卷 1331-1334页

作者： Xing Cui Li Li Xin Yang Hong qing wang Ruo yun Chen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

From the aqueous extract of Acacia catechu,two new phenolic compounds（3R,4R）-3-（3,4-dihydroxyphenyl）-4-hydroxycy-clohexanone （1） and（4R）-5-（1-（3,4-dihydrophenyl）-3-oxobutyl）-dihydrofuran-2（3H）-one（2） w... 详细信息

关键词： Acacia catechu Phenolic compounds Free-radical scavenging activity

Association of Lysosome Associated Protein Transmembrane 4 Beta Gene Polymorphism with the Risk of Pancreatic Cancer

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Chinese Journal of Cancer Research 2010年第4期22卷 291-295页

作者： Shan wang qing-yun Zhang Key Laboratory of Carcinogenesis and Translational Research（Ministry of Education） Clinical Laboratory Peking University Cancer Hospital ＆ Institute Beijing 100142 China

Objective： Lysosome associated protein transmembrane 4 beta （LAPTM4B） was originally identified as a gene in human hepatocellular carcinoma （HCC）. It was successfully cloned by fluorescence differential display, rapid amplification of cDNA ends （RACE） and reverse transcription polymerase chain reaction （RT-PCR）. Previous study showed that the novel gene played an important role in the occurrence, development, migration and prognosis of tumors. Pancreatic cancer is an aggressive malignancy with the majority of patients dying within one year after diagnosis. This study tries to find out the relationship between lysosome associated protein transmembrane 4 beta gene polymorphism and the susceptibility of pancreatic cancer. Methods： A case-control study was conducted in China, including 58 pancreatic cancer cases and 156 healthy controls. Human genomic DNA was used as the template, polymerase chain reaction （PCR） was used to detect the distribution of LAPTM4B genotype. Analyses Odds ratio （OR） and corresponding 95% confidence interval （95%CI） with logistic regression were performed. Results： Two alleles of LAPTM4B generated three kinds of genotypes in population, ＊1/1, ＊1/2, and ＊2/2. The genotype frequency of ＊1/1, ＊1/2 and ＊2/2 in the pancreatic cancer group were 41.4%, 44.8% and 13.8% respectively, which were not significantly different from those of healthy group （47.4%, 42.9%, 9.6%）（P=0.773, P=0.291）. Also the ＊2 allele frequency of LAPTM4B among pancreatic cancer had no significantly difference with the controls （P=0.354）. When compared to the ＊1 allele, the people with ＊2 allele had no increased risk of pancreatic cancer. Conclusion： The gene polymorphism of LAPTM4B may not influence the susceptibility of pancreatic cancer.

关键词： Polymorphism Lysosome associated protein transmembrane 4 beta Pancreatic cancer Susceptibility

Application of Computed Tomographic Colonography in Diagnosis of Colonic Polyps

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Chinese Medical Sciences Journal 2009年第1期24卷 36-40页

作者： Ming-wei Qin Wei-dong Pan Guan-ning Cong yun wang yun-qing Zhang Ji-xiang Liang Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To assess the clinical values of computed tomographic colonography （CTC） in diagnosis of colonic polyps. Methods Forty-two patients who were clinically suspicious of colonic polyps or underwent colonic polyps screening received examinations with both CTC and conventional colonoscopy. Sixteen- or 64-slice spiral computed tomography and professional imaging processing techniques were used for evaluation. Per-polyp and per-patient results were analyzed. Those by per-polyp were subsequently divided into ≥10 mm group, 5-10 mm group, and ≤5 mm group. Sensitivity, positive predictive value （PPV）, specificity, negative predictive value （NPV）, and accuracy were calculated using statistical method for diagnostic studies, with conventional colonoscopy as a gold standard. Results Ninety and 61 polyps were found by CTC and conventional colonoscopy, respectively. The per-polyp sensitivity/PPV were 80.3%/55.6% in total, and 100%/92.9%, 93.8%/65.2%, and 68.8%/ 41.5% in the ≥10 mm group, 5-10 mm group, and ≤5 turn group, respectively. The per-patient sensitivity, PPV, specificity, NPV, and accuracy were 97.1%, 89.5%, 42.9%, 75.0%, and 88.1%, respectively. Conclusion CTC can clearly reveal the morphology of colonic polyps and be used as a routine monitoring method for the clinical diagnosis of polyps.

关键词： colonic polyp X-ray computed tomography colonoscopy

Determination of PDCD5 in Peripheral Blood Serum of Cancer Patients

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Chinese Journal of Cancer Research 2011年第3期23卷 224-228页

作者： Yue wang Guo-hong wang qing-yun Zhang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Clinical LaboratoryPeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：Programmed cell death 5 （PDCD5） is an apoptosis related gene and plays an important role in the pathogenesis and development of *** PDCD5 is present in peripheral blood serum has not been *** aim of this study is to determine the contents of PDCD5 protein in peripheral blood serum of cancer patients,as well as normal ***：ELISA was used to detect the serum PDCD5 concentrations in 100 normal persons,83 patients with breast cancer,74 patients with gastrointestinal tract cancer and 41 patients with lung *** results were statistically analyzed and ***：PDCD5 could be detected in peripheral blood serum in both normal subjects and cancer *** serum PDCD5 contents in normal persons ranged from 3.8 to 6.1 ng/ml with a median of 4.70±0.68 ng/*** cancer patients the PDCD5 levels were 4.59±0.90,4.79±1.14 and 10.43±22.34 ng/ml for breast cancer,gastrointestinal cancer and lung cancer patients *** was no statistically significant difference between the serum PDCD5 concentrations of normal persons and cancer ***：PDCD5 is present in peripheral *** PDCD5 levels in cancer patients are not statistically different from that of normal persons,though decreased expression of PDCD5 in malignant tissues has been found.

关键词： PDCD5 Apoptosis Cancer patients ELISA

USING OF MULTISLICE HELICAL CT COLONOGRAPHY IN PATIENTS WITH MALIGNANT LESIONS OF COLON

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Chinese Medical Sciences Journal 2005年第3期20卷 171-175页

作者： Ming-wei Qin Wei-dong Pan Guan-ning Cong yun wang yun-qing Zhang Wen-bin Mou Zheng-yu Jin Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objoctive To investigate the techniques and clinical applications ofmultislice helical computed tomography （CT） colonography in colonic lesions. Methods Fifty-nine patients with malignant lesions of colon underwent volume scanning using multislice helical CT. Four types of reconstruction including CT virtual colonoscopy （CTVC）, shaded surface display （SSD）, Raysum, and multiple planar reconstruction （MPR） were used for image post-processing. The results were compared with those of colonoscopy and pathology. Results Multislice helical CT colonography detected 54 colorectal carcinomas, 4 adenomas with focal carcinoma, 1 non-Hodgkin＇s lymphoma （NHL）. The lesions＇ number, size, location, morphology, stricture of intestinal cavity, infiltration, and metastasis were shown satisfactorily by multislice helical CT colonography. Whole colon could be shown in all patients. CT colonography displayed 4 synchronous colonic tumors, 1 ascending colon carcinoma combined with left renal carcinoma among 54 patients with colonic carcinomas. The accuracy of location of CT colonography was 100%. There were 9 cases that CT showed the tumor location was different from the finding of conventional colonoscopy, while all of the CT location were proven exact by operation. CT colonography also displayed the infiltration of serous layer and fatty tissue in 45 cases; 21 cases matched the pathological results in all the 24 cases of suspicious lymph node metastasis, the sensitivity was 87.5%, the specificity was 90.6%; 9 cases hepatic metastasis, 2 ovarian metastasis, and 1 double adrenal gland metastasis. Conclusions Multislice helical CT colonography is effective in preoperative diagnosis, location, stage, and making treatment plan of colorectal carcinoma. It can display the portion not seen during colonoscopy and may have an adjunctive role.

关键词： tomography, X-ray computed colorectal neoplasms image processing, computer assisted

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交通发展中的技术及技术含量的判断

交通运输系统工程与信息 2019年第6期19卷 1-5页

作者：王庆云北京交通大学中国综合交通研究中心

交通运输与技术是需要深入探究的系统工程问题.从技术与经济发展关系的角度入手,解读了新技术的应用与交通运输发展的关系;系统分析了交通运输中的技术、技术含量、技术含量判断方法等,指出新技术的应用要以提高运输效率和质量为目的;... 详细信息

交通运输与技术是需要深入探究的系统工程问题.从技术与经济发展关系的角度入手,解读了新技术的应用与交通运输发展的关系;系统分析了交通运输中的技术、技术含量、技术含量判断方法等,指出新技术的应用要以提高运输效率和质量为目的;从系统工程的角度分析,得出交通运输系统的关键技术主要体现在交通基础设施、运输工具、装载设备、运输组织管理和服务水平等5个方面.最后简要介绍了交通运输领域部分新技术的应用情况.

关键词：系统工程交通新技术关键技术技术含量判断交通运输系统

Effect of Wenhua Juanbi Recipe(温化蠲痹方) on Expression of Receptor Activator of Nuclear Factor Kappa B Ligand,Osteoprotegerin,and Tumor Necrosis Factor Receptor Superfamily Member 14 in Rats with Collagen-Induced Arthritis

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Chinese Journal of Integrative Medicine 2017年第3期23卷 208-214页

作者： LIU Xi-de wang yun-qing CAI Long YE Li-hong wang Fang FENG Ying-ying Department of Arthropathy Zhejiang Provincial Hospital of Integrated Traditional and Western Medicine Hangzhou 310003 China Zhejiang University of Traditional Chinese Medicine Hangzhou 310003 China

Objective： To study the effect of Wenhua Juanbi Recipe（温化蠲痹方, WJR） on expression of receptor activator of nuclear factor kappa B ligand（RANKL）, osteoprotegerin（OPG）, and tumor necrosis factor receptor superfamily member 14（TNFRSF14, also known as LIGHT） in rats with collagen-induced arthritis（CIA）. Methods： CIA rats were generated by subcutaneous injection of bovine collagen type-Ⅱ at the tail base. Sixty CIA rats were randomly assigned（10 animals/group） to： model, methotrexate（MTX）-treated（0.78 mg/kg body weight）, and WJR-treated（22.9 g/kg） groups. Healthy normal rats（n=10） were used as the normal control. Treatments or saline were administered once daily by oral gavage. Rats were sacrificed at day 28 post-treatment and knee synovium and peripheral blood serum were collected. Toe swelling degree and expression of RANKL, OPG, and LIGHT were determined by Western blot and immunohistochemistry. Results： Compared with the normal group, toe swelling degree was significantly increased in the model group（P〈0.01）. After treatment, toe swelling degree decreased significantly in the WJR and MTX groups compared with the model group（P〈0.01）. Compared with the normal group, expression of RANKL and LIGHT were significantly increased and OPG significantly decreased in peripheral blood and synovium of the model group（P〈0.01）. Conversely, RANKL and LIGHT expression were significantly reduced and OPG increased in the WJR and MTX groups compared with the model group（P〈0.01）. No statistically significant difference existed between WJR and MTX groups. Conclusion： WJR likely acts by reducing RANKL expression and increasing OPG expression, thus inhibiting RANKL/RANK interaction and reducing LIGHT expression, thereby inhibiting osteoclast formation/activation to block bone erosion.

关键词： Wenhua Juanbi Recipe collagen-induced arthritis receptor activator of nuclear factor kappa B ligand osteoprotegerin tumor necrosis factor receptor superfamily member 14 synovium peripheral blood Chinese medicine

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综合交通网规划中的系统工程思想及实践

交通运输系统工程与信息 2008年第1期8卷 11-16页

作者：王庆云国家发展和改革委员会交通运输司北京100844

综述了国际范围内国家综合交通网络研究的最近进展,结合新中国建立以来第一个全国性的、综合衔接铁路、公路、水路、民航及管道各运输方式的总体空间布局规划——综合交通网发展规划的制订为背景,系统分析了其编制与出台过程.作者根据... 详细信息

综述了国际范围内国家综合交通网络研究的最近进展,结合新中国建立以来第一个全国性的、综合衔接铁路、公路、水路、民航及管道各运输方式的总体空间布局规划——综合交通网发展规划的制订为背景,系统分析了其编制与出台过程.作者根据多年的综合交通系统规划与管理经验,从系统工程方法论角度,剖析了我国改革开放以来交通系统工程学科理论研究与实践中遇到的难题,研究提出了在综合交通网络规划中应注意的技术关键问题.

关键词：综合交通网交通系统工程交通规划发展规划