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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui wang Hanyue Zhang Xiou wang Sijia Zhou Bo Ma Yan Luan Xin wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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CYCLIC　VOLTAMMETRY　STUDY　ON　ANTIMALARIAL　MECHANISM　OF　ARTEMISININ（QINGHAOSU）DERIVATIVES

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Chinese Chemical Letters 1996年第7期7卷 623-626页

作者： Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y wang, QM Li, Q Ji, RY Zhuang, qk CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

Cyclic voltammetry method waws used to determine the cyclic voltammogram of artemisininderivatives and reduction potentials(RPs)of these compounds were obtained. Combining the determinationresults of Zhang and co-workers,QSAR analysis was performed between the activity and reductionpotentials(RPs),which illustrated the antimalarial mechanism of artemisinin analogs, The experimentalresult verified and tested our previous theoretical calculation results.

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A novel splicing mutation IVS7-2A>C of the ADAR1 gene in Chinese family with dyschromatosis symmetrica hereditaria

A novel splicing mutation IVS7-2A>C of the ADAR1 gene in Chi...

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湖北省遗传学会第八次代表大会暨学术讨论会

作者： Jingmin Wen~1,Hanyang Xu~1,Guohua Yang~1,Yong Gao~1,Mugen Liu~1,qk wang~(1,2),Jingyu Liu~(1*) 1 Key Laboratory of Molecular Biophysics of the Ministry of Education,Center for Human Genome Research,College of Life Science and Technology,Huazhong University of Science and Technology, Wuhan,430074,Hubei,P.R.China 2 Department of Molecular Cardiology,Lerner Research Institute, The Cleveland Clinic Foundation,Case Western Reserve University,44195,Cleveland,Ohio,USA

Dyschromatosis symmetrica hereditaria(DSH) is a rare autosomal dominantly inherited dermatosis and characterized by a mixture of hyperpigmented and hypopigmented macules on the back of hands and *** DSH locus was mapped to chromosome 1q21 and subsequently pathogenic mutations were identified in the adenosine deaminase acting on RNA1(ADAR1) gene in 2003.A large Chinese family with autosomal dominance DSH was *** analysis revealed linkage of the family to the *** exons and exon-intron boundaries of ADAR1 were PCR-amplified and sequenced with DNA samples from the *** fragment length polymorphism(RFLP) analysis for intron 7-exon 8 boundary of ADAR1 was performed in all family members and 100 normal control subjects.A novel splicing mutation IVS7-2A>C was detected in the ADAR1 *** mutation was present in other affected family members,but not in other normal family members and 100 normal *** in vitro splicing assay using HeLa cells transfected with expression vectors containing the normal or the mutant ADAR1 minigenes consisting of genomic fragments spanning exon 7 to exon 10 showed that the IVS7-2A>C mutation caused abnormal splicing,leading to severely truncated ADAR1 *** results indicate that the novel IVS7-2A>C mutation in the ADAR1 gene is responsible for DSH in the Chinese family,this study expands the spectrum of ADAR1 gene mutations associated with DSH,which have further improved our understanding on the role of ADAR1 in DSH. A Novel a B-Crystallin Mutation Associated with

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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(qk)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide qk was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-qk was found to control the delivery of qk by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-qk promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-qk may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation qk peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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A novel insertion mutation of FRMD7 gene causes X-linked idiopathic congenital nystagmus with progression nerve deafness in a large Chinese family

A novel insertion mutation of FRMD7 gene causes X-linked idi...

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湖北省遗传学会第八次代表大会暨学术讨论会

作者： Cui X~1,Yang K~2,Gao Y~1,wang Y~2,Dai X~1,Xu H~1,wang Q~1,Yang T~1,Jiang M~3,Zhang Z~2,Jin X~2, Sheng T~2,Liu M~1,wang qk~(1,4),Liu JY~(1*) 1 Key Laboratory of Molecular Biophysics of Ministry of Education,Center for Human Genome Research,Huazhong University of Science and Technology,Wuhan,430074,China 2 College of Preclincal Medicine,Yanbian University,Yanji,133000 3 College of Clinical Medicine,Yanbian University,Yanji,133000 4 Center for Cardiovascular Genetics,Department of Molecular Cardiology, Lerner Research Institute,Cleveland,Ohio,44195,USA

Nystagmus consists of involuntary to and fro eye movements and it can have a severe effect on vision and social *** nystagmus(CN) is a common(frequency of 1/1,500 live births) and genetically heterogeneous form of developmental nystagmus that usually presents at birth or within the first few months of *** inheritance models for CN are X-linked dominant,X-linked recessive, autosomal dominant and autosomal recessive forms.X-linked inheritance is likely the most common *** loci for autosomal dominant CN have been identified on 6pl2(NYS2),7p11.2(NYS3) and 13q31-q33(NY54).NYS4 involves vestibulocerebellar dysfunction and is clinically distinct from CN. X-linked CN has been associated with two physically independent loci(both symbolized NYS1) that map to Xp11.4-p11.3and *** addition,a locus for infantile periodic alternating nystagmus (NYS5),which often accompanies albinism,has been assigned to chromosome *** et al. identified multiple mutations in FRMD7 gene localizing to Xq26-27and responsible for a major part of X-linked CN(NYS1).This has also been confirmed by others.

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高校教师代表作评价真正实施了吗——基于高校教师职称评审办法的文本分析

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教育发展研究 2025年第1期045卷 67-75页

作者：汪燕唐智松西南大学教育学部四川开放大学

推行代表作评价制度是新时代我国教育评价改革的的重要方向。为此，各高校纷纷启动了学术评价改革，开始探索不同形式的代表作评价方案。但当前高校教师代表作评价实施情况究竟如何？文章基于42所高校最新的教师职称评审文件分析发现，... 详细信息

推行代表作评价制度是新时代我国教育评价改革的的重要方向。为此，各高校纷纷启动了学术评价改革，开始探索不同形式的代表作评价方案。但当前高校教师代表作评价实施情况究竟如何？文章基于42所高校最新的教师职称评审文件分析发现，虽然表面上看，代表作评价制度在高校得到了更大范围的推广，但大多数高校实施的“代表作评价”改革还未触及学术评价的根本。当前高校代表作评价的推行还受到传统学术交流制度、人脉圈子文化、评审专家资源、智能技术应用水平等制度、文化、资源以及技术障碍的影响。基于此，需打破以期刊为中心的传统科研交流系统，并利用数智技术开辟兼顾学术自由与管理效率且保障评价过程客观、公正、可行的新渠道。

关键词：代表作评价学术评价阻碍因素数智赋能

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与急性冠状动脉综合征相关的DNA甲基化基因组学分析

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中华高血压杂志 2017年第6期25卷 524-524页

作者：刘莉叶鹏 Li J Zhu X Yu K Jiang H Zhang Y Deng S Cheng L Liu X Zhong J Zhang X He M Chen W Yuan J Gao M Bai Y Han X Liu B Luo X Mei W He X Sun S Zhang L Zeng H Sun H Liu C Guo Y Zhang B Zhang Z Huang J Pan A Yuan Y Angileri F Ming B Zheng F Zeng Q Mao X Peng Y Mao Y Ye P wang qk Qi L Hu FB Liang L Wu T

急性冠状动脉综合征（acute coronary syndrome,ACS）是全球死亡的主要原因。免疫功能在ACS发展中起着至关重要的作用,表观遗传调控对这种疾病中的血液免疫细胞的调节作用尚没有研究报道过。该研究应用循环免疫细胞进行表观基因组分析,... 详细信息

急性冠状动脉综合征（acute coronary syndrome,ACS）是全球死亡的主要原因。免疫功能在ACS发展中起着至关重要的作用,表观遗传调控对这种疾病中的血液免疫细胞的调节作用尚没有研究报道过。该研究应用循环免疫细胞进行表观基因组分析,以确定ACS中异常分化的甲基化基因。

关键词：急性冠状动脉综合征 DNA甲基化基因组学分表观遗传调控免疫细胞甲基化基因免疫功能

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对罗夏测验中自我知觉记分的效度检验

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中国组织工程研究与临床康复 2007年第48期11卷 9768-9770页

作者：郭庆科陈雪霞王炜丽辽宁师范大学心理学系辽宁省大连市116029

目的:通过与罗夏评定量表RRS的对比研究,验证罗夏墨迹测验中自我知觉记分的效度。方法:①对象:某大学教育学院2004级心理学专业,学前教育专业,教育学专业的63名本科生。其中男生15名,女生48名;平均年龄21.2岁。受试者对测试知情同意。... 详细信息

目的:通过与罗夏评定量表RRS的对比研究,验证罗夏墨迹测验中自我知觉记分的效度。方法:①对象:某大学教育学院2004级心理学专业,学前教育专业,教育学专业的63名本科生。其中男生15名,女生48名;平均年龄21.2岁。受试者对测试知情同意。②测试方法:个别测试罗夏墨迹测验,根据罗夏综合系统的解释统计出H、H%、ECI等9个与自我概念有关的指标,并让熟悉的人根据RRS的内容对63名学生的自我知觉分别做出评定,分自我中心、自信、自我评价客观性3个分量表记分。再计算出罗夏墨迹测验的9项自我知觉记分与RRS的3个评定量表间的相关。结果:63名均进入结果分析。罗夏测验中关于自我知觉的测量指标纯H、H%、解剖学内容Ay+Xy、性内容Sx与自我概念的评定间出现了有意义的相关;指标自我中心指数ECI、形状距离反应FD、阴影距离反应sumV、病理内容MOR与自我概念的评定间则没有出现相关,均值差异检验结果亦不显著。结论:罗夏墨迹技术中的指标纯H、H%、An+Xy、Sx适合测量正常人的自我概念,在临床诊断中有重要价值,指标ECI、FD、sumV、MOR则需要进一步研究。

关键词：罗夏墨迹技术罗夏评定量表大学生自我知觉

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关注肺健康,实现COPD防治关口前移

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中华全科医学 2025年第2期23卷 194-197,214页

作者：王妍闫巍北京市海淀区玉渊潭社区卫生服务中心北京100142 首都医科大学附属复兴医院全科医学科北京100038

慢性阻塞性肺疾病(COPD,简称慢阻肺)是最常见的慢性呼吸系统疾病,具有高发病率、高致残率、高死亡率的特点,被认为是世界各地发病率和死亡率的主要原因之一,给个人、家庭、社会带来沉重的经济负担和照护负担。慢阻肺所带来的沉重疾病负... 详细信息

慢性阻塞性肺疾病(COPD,简称慢阻肺)是最常见的慢性呼吸系统疾病,具有高发病率、高致残率、高死亡率的特点,被认为是世界各地发病率和死亡率的主要原因之一,给个人、家庭、社会带来沉重的经济负担和照护负担。慢阻肺所带来的沉重疾病负担,已被广泛认为是一个重要的全球公共卫生问题,而广泛的诊断不足和误诊导致患者得不到治疗或治疗不当,更加剧了慢阻肺的防控形势。慢阻肺是一种常见的、可预防和可治疗的疾病,目前认为早期发现、早期诊断和尽早干预应是慢性阻塞性肺疾病防治的努力方向,并且可以产生非常积极且显著的公共卫生影响。然而,随着近年来人口老龄化加剧以及慢阻肺的发病率逐年上升,当前慢阻肺的全球诊疗现状并不乐观。在我国,居民对慢阻肺的认知度低下,基层医务人员对慢阻肺的相关知识和防治技能掌握欠缺,严重影响了慢阻肺的早期规范化防治。本文叙述了我国慢阻肺防治现状,提出关注肺健康,对有慢性咳嗽、气促等呼吸道症状及有慢阻肺高危因素的人群实行早期筛查、早期诊断、早期干预、及时转诊,与三级综合医院呼吸专科医生协同,共同完成对其闭环管理,实现肺部健康,以期为慢阻肺的早期预防、早期诊断以及及时和适当的治疗干预提供参考并打开新的机会之窗。

关键词：肺健康慢性阻塞性肺疾病筛查与管理早期

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Congruent elliptic curves with non-trivial Shafarevich-Tate groups： Distribution part

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Science China Mathematics 2017年第4期60卷 593-612页

作者： wang ZhangJie Yau Mathematical Sciences Center Tsinghua University Beijing 100084 China

Given a large positive number x and a positive integer k, we denote by qk(x) the set of congruent elliptic curves E(n): y2= z3- n2 z with positive square-free integers n x congruent to one modulo eight,having k prime factors and each prime factor congruent to one modulo four. We obtain the asymptotic formula for the number of congruent elliptic curves E(n)∈ qk(x) with Mordell-Weil ranks zero and 2-primary part of Shafarevich-Tate groups isomorphic to(Z/2Z)2. We also get a lower bound for the number of E(n)∈ qk(x)with Mordell-Weil ranks zero and 2-primary part of Shafarevich-Tate groups isomorphic to(Z/2Z)4. The key ingredient of the proof of these results is an independence property of residue symbols. This property roughly says that the number of positive square-free integers n x with k prime factors and residue symbols(quadratic and quartic) among its prime factors being given compatible values does not depend on the actual values.

关键词： Shafarevich-Tate group distribution congruent elliptic curve multiplicative number theory num-ber field independence property residue symbol

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