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电子电路基础课程的一体化教学模式分析

集成电路应用 2024年第6期41卷 380-381页

作者：陈欣郑秋菊王妮刘旭瑞重庆移通学院通信与信息工程学院重庆401520 公共大数据安全技术重庆市重点实验室重庆401420

阐述从电子电路基础课程出发,探讨一体化教学模式的设计与应用,通过跨学科整合、基于问题驱动学习、组织合作学习项目,培养学生的综合素质和解决问题的能力。

关键词：电子电路基础一体化教学模式教学设计

直肠癌术后肛周感染血常规变化及VEGF和sTREM-1与PGE2的预测价值

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中华医院感染学杂志 2024年第7期34卷 1045-1049页

作者：王妮刘占伦贺屹巍陈燕京韩玉孙素娇桂晗晔王双河北省中医院消化肿瘤外科河北石家庄050000 河北省中医院肿瘤科河北石家庄050000 河北省中医院脾胃病科河北石家庄050000 河北省中医院心胸外科河北石家庄050000

目的探究直肠癌术后患者肛周感染血常规变化情况及血管内皮生长因子(VEGF)、可溶性髓系细胞触发受体1(sTREM-1)、前列腺素E2(PGE2)的预测价值。方法回顾性选取2019年2月-2023年2月河北省中医院60例直肠癌术后发生肛周感染患者的临床资... 详细信息

目的探究直肠癌术后患者肛周感染血常规变化情况及血管内皮生长因子(VEGF)、可溶性髓系细胞触发受体1(sTREM-1)、前列腺素E2(PGE2)的预测价值。方法回顾性选取2019年2月-2023年2月河北省中医院60例直肠癌术后发生肛周感染患者的临床资料作为研究组,选取82例同期直肠癌术后未发生肛周感染患者的临床资料作为对照组。统计并分析两组患者的临床资料,比较两组患者血常规指标变化,比较两组患者VEGF、sTREM-1、PGE2水平,采用受试者工作特征(ROC)曲线分析VEGF、sTREM-1、PGE2单独及联合检测对直肠癌术后患者肛周感染的预测价值。结果与对照组相比,研究组红细胞平均体积、血红蛋白含量、平均血红蛋白量、血清VEGF水平降低,血清sTREM-1、PGE2水平升高(P<0.05);VEGF、sTREM-1、PGE2联合检测对直肠癌术后患者肛周感染诊断的曲线下面积(AUC)值高于单独检测的AUC值(P<0.05),且联合检测的敏感度为85.00%,特异度为93.90%。结论直肠癌术后患者肛周感染血常规部分指标发生下降,血清中VEGF水平降低,sTREM-1、PGE2水平升高,VEGF、sTREM-1、PGE2三者联合检测对直肠癌术后患者肛周感染具有较高的预测价值。

关键词：直肠癌术后肛周感染病原菌血管内皮生长因子可溶性髓系细胞触发受体1 前列腺素E2 受试者工作特征曲线

A series of dithienobenzodithiophene based small molecules for highly efficient organic solar cells

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Science China Chemistry 2017年第4期60卷 552-560页

作者： Huanran Feng Miaomiao Li wang ni Bin Kan Yunchuang wang Yamin Zhang Hongtao Zhang Xiangjian Wan Yongsheng Chen Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials State Key Laboratory and Institute of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) College of Chemistry Nankai University Tianjin 300071 China School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin 300071 China

Three acceptor-donor-acceptor （A-D-A） small molecules DCAODTBDT, DRDTBDT and DTBDTBDT using dithieno[2,3-d：2＇,3＇-d＇]benzo[1,2-b：4,5-b＇]dithiophene as the central building block, octyl cyanoacetate, 3-octylrhodanine and thiobarbituric acid as the end groups were designed and synthesized as donor materials in solution-processed photovoltaic cells （OPVs）. The impacts of these different electron withdrawing end groups on the photophysical properties, energy levels, charge carrier mobility, morphologies of blend films, and their photovoltaic properties have been systematically investigated. OPVs device based on DRDTBDT gave the best power conversion efficiency （PCE） of 8.34%, which was significantly higher than that based on DCAODTBDT （4.83%） or DTBDTBDT （3.39%）. These results indicate that rather dedicated and balanced consideration of absorption, energy levels, morphology, mobility, etc. for the design of small-molecule-based OPVs （SM-OPVs） and systematic investigations are highly needed to achieve high performance for SM-OPVs.

关键词： acceptor-donor-acceptor dithieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene solution-processed photovoltaic cells endacceptor moieties

2例围生期型常染色体隐性多囊肾病家系的PKHD1基因变异分析

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临床肾脏病杂志 2024年第10期24卷 803-807页

作者：曾兰王齐艳邓艺王丹妮朱书瑶王锦四川省妇幼保健院医学遗传与产前诊断科成都610031 四川省妇幼保健院放射科成都610031 四川省妇幼保健院儿科成都610031

目的对2例常染色体隐性多囊肾病(autosomal recessive polycystic kidney disease,ARPKD)家系进行基因变异分析,明确致病原因,为ARPKD的早期诊断、治疗、遗传咨询及产前诊断提供理论依据。方法收集2例胎儿引产组织及父母外周血进行全外... 详细信息

目的对2例常染色体隐性多囊肾病(autosomal recessive polycystic kidney disease,ARPKD)家系进行基因变异分析,明确致病原因,为ARPKD的早期诊断、治疗、遗传咨询及产前诊断提供理论依据。方法收集2例胎儿引产组织及父母外周血进行全外显子测序分析,结合Sanger测序进行家系分析及位点验证。结果全外显子组测序及Sanger测序提示家系1胎儿PKHD1基因存在c.3436C>T(p.Q1146X)和c.1981A>C(p.T661P)复合杂合变异;家系2曾生育1例ARPKD患儿,1岁时死于心力衰竭,本例胎儿PKHD1基因存在c.9719G>A(p.R3240Q),c.10057C>T(p.L3353F)和c.7237C>T(p.R2413C)复合杂合变异。结论两个家系均为PKHD1基因变异导致的围生期型ARPKD,共发现5个基因变异位点,其中2个为新发变异位点,c.10057C>T和c.1981A>C均为错义变异。鉴于ARPKD基因型和表型的复杂性,及早进行家系的遗传咨询将有助于基因诊断和早期产前诊断。

关键词：常染色体隐性多囊肾病 PKHD1基因遗传咨询基因变异产前诊断

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妊娠合并血栓性血小板减少性紫癜一例

海南医学 2024年第17期35卷 2536-2539页

作者：武磊李亚萍王樱霓王聪李冰琳西安市中心医院妇产科陕西西安710061 西安市中心医院质控科陕西西安710061

妊娠合并血栓性血小板减少性紫癜在临床上罕见。1例以“停经32+4周,发热6 d,血小板减少2 d”就诊于我院急诊的患者,诊断为妊娠合并血栓性血小板减少性紫癜,未行血浆置换,最终抢救成功。本文对该患者的临床资料进行分析并复习相关文献,... 详细信息

妊娠合并血栓性血小板减少性紫癜在临床上罕见。1例以“停经32+4周,发热6 d,血小板减少2 d”就诊于我院急诊的患者,诊断为妊娠合并血栓性血小板减少性紫癜,未行血浆置换,最终抢救成功。本文对该患者的临床资料进行分析并复习相关文献,加强对妊娠期血栓性血小板减少性紫癜的认识。

关键词：血栓性血小板减少性紫癜妊娠实验室检查

Ruthenium (II)-catalyzed synthesis of phthalides via the cascade addition and cyclization of aromatic acids with aldehydes

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Science China Chemistry 2018年第2期61卷 153-158页

作者： Juan Fan Peng-Min wang Jia-ni wang Xue Zhao Zhong-Wen Liu Jun-Fa Wei Xian-Ying Shi Key Laboratory for Macromolecular Science of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal University

The ruthenium-catalyzed intermolecular cascade cyclization of aromatic acids with aromatic aldehydes, which involves the direct insertion of C–H bond into a polar C=O bond and the successive intramolecular nucleophilic substitution, was developed for the synthesis of 3-substituted phthalides in good to excellent yields. This one-pot procedure characterizes in a short reaction time, the cheaper Ru(II) as a catalyst, readily available acids and aldehydes as starting materials, and water as the only theoretical *** merits make the protocol an efficient and cost-effective route for the synthesis of 3-substituted phthalides.

关键词： nucleophilic addition cascade cyclization ruthenium 3-substituted phthalides C–H activation

Classification of aviation incident causes using LGBM with improved cross-validation

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Journal of Systems Engineering and Electronics 2024年第2期35卷 396-405页

作者： ni Xiaomei wang Huawei CHEN Lingzi LIN Ruiguan School of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Aeronautical Engineering Nanjing Vocational University of Industry TechnologyNanjing 210023China

Aviation accidents are currently one of the leading causes of significant injuries and deaths worldwide. This entices researchers to investigate aircraft safety using data analysis approaches based on an advanced machine learning *** assess aviation safety and identify the causes of incidents, a classification model with light gradient boosting machine (LGBM)based on the aviation safety reporting system (ASRS) has been developed. It is improved by k-fold cross-validation with hybrid sampling model (HSCV), which may boost classification performance and maintain data balance. The results show that employing the LGBM-HSCV model can significantly improve accuracy while alleviating data imbalance. Vertical comparison with other cross-validation (CV) methods and lateral comparison with different fold times comprise the comparative approach. Aside from the comparison, two further CV approaches based on the improved method in this study are discussed:one with a different sampling and folding order, and the other with more CV. According to the assessment indices with different methods, the LGBMHSCV model proposed here is effective at detecting incident causes. The improved model for imbalanced data categorization proposed may serve as a point of reference for similar data processing, and the model’s accurate identification of civil aviation incident causes can assist to improve civil aviation safety.

关键词： aviation safety imbalance data light gradient boosting machine(LGBM) cross-validation(CV)

Crystallization characteristics of iron-rich glass ceramics prepared from nickel slag and blast furnace slag

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 455-459页

作者： Zhong-jie wang Wen ni Ke-qing Li Xiao-yan Huang Li-ping Zhu School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

The crystallization process of iron-rich glass-ceramics prepared from the mixture of nickel slag（NS） and blast furnace slag（BFS） with a small amount of quartz sand was investigated.A modified melting method which was more energy-saving than the traditional methods was used to control the crystallization *** results show that the iron-rich system has much lower melting temperature,glass transition temperature（Tg）,and glass crystallization temperature（Tc）,which can result in a further energy-saving *** results also show that the system has a quick but controllable crystallization process with its peak crystallization temperature at 918°*** crystallization of augite crystals begins from the edge of the sample and invades into the whole *** crystallization process can be completed in a few minutes.A distinct boundary between the crystallized part and the non-crystallized part exists during the *** the non-crystallized part showing a black colour,some sphere-shaped augite crystals already exist in the glass matrix before samples are heated to *** the crystallized part showing a khaki colour,a compact structure is formed by augite crystals.

关键词： glass ceramics grain growth crystallization slag

镇静催眠药物联合睡眠卫生教育对成人2型糖尿病共病失眠症的临床疗效

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重庆医学 2024年第13期53卷 2005-2010页

作者：张琳邹菁华王妮龚丽陈建梅重庆市九龙坡区人民医院神内内分泌科重庆400050 重庆医科大学附属第一医院精神科重庆400016

目的探讨镇静催眠药物联合睡眠卫生教育对成人2型糖尿病共病失眠症的临床疗效。方法收集2023年1-12月重庆市九龙坡区人民医院神内内分泌科接受短期(2周)胰岛素强化治疗的2型糖尿病共病失眠症患者的一般情况、检查指标和失眠严重程度... 详细信息

目的探讨镇静催眠药物联合睡眠卫生教育对成人2型糖尿病共病失眠症的临床疗效。方法收集2023年1-12月重庆市九龙坡区人民医院神内内分泌科接受短期(2周)胰岛素强化治疗的2型糖尿病共病失眠症患者的一般情况、检查指标和失眠严重程度指数量表(ISI)、宗氏焦虑自评量表(SAS)、宗氏抑郁自评量表(SDS)评分等资料,将接受镇静催眠药物联合睡眠卫生教育治疗的患者65例作为观察组,其中39例伴有轻度焦虑(A1组),22例伴有轻度抑郁(A2组);未接受镇静催眠药物联合睡眠卫生教育治疗的患者54例作为对照组,其中33例伴有轻度焦虑(B1组),22例伴有轻度抑郁(B2组)。所有患者均接受常规糖尿病饮食及运动指导、胰岛素强化治疗。比较各组治疗1、2周血糖控制情况和失眠、焦虑、抑郁改善情况。结果治疗1周时观察组、对照组空腹血糖(FPG)、餐后2 h血糖(2 hPG)、葡萄糖目标范围内时间(TIR)达标率间差异无统计学意义(P>0.05);治疗2周时观察组的FPG、2 hPG明显低于对照组(P0.05);治疗2周时观察组的ISI、SAS评分明显低于对照组(P0.05);观察组治疗2周时失眠、焦虑症状的缓解率较治疗1周时明显提高(P0.05);对照组治疗2周时失眠、焦虑、抑郁症状的缓解率与治疗1周时比较差异均无统计学意义(P>0.05)。结论镇静催眠药物联合睡眠卫生教育治疗成人2型糖尿病共病失眠症不仅可有效提高血糖控制达标率,还改善失眠、焦虑症状。

关键词： 2型糖尿病胰岛素强化治疗失眠焦虑抑郁

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