检索结果-南通市图书馆

Journal of Traditional Chinese Medicine 2024年第5期44卷 1000-1005页

作者： wang ming ZHENG Yun Department of Thoracic Surgery Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College Thoracic Oncology Department Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College

OBJECTIVE: To assess clinical value of modified Shenling Baizhu powder( 加味参苓白术散, SBP) in intervening targeted therapy-induced diarrhea. METHODS: This study was a prospective randomized controlled study. Eighty-five non-small cell lung cancer(NSCLC) patients with diarrhea who took targeted drugs were randomly divided into two groups. The experimental group received modified SBP, while the control group received imodium. During 2 courses of treatment(1 week/course) and 2 weeks of follow-up, we observed remission and recurrence of diarrhea, as well as the improvement of Karnofsky score(KPS) in the two groups and drug safety. RESULTS: Eighty cases were completed, with 40 cases in the experimental group and 40 cases in the control group. The control group's diarrhea remission rate was significantly lower than the experimental group's(P 0.05). No unique adverse events occurred in experimental group or control group. CONCLUSION: The modified SBP could improve targeted therapy-induced diarrhea in NSCLC, and is superior to imodium in relieving diarrhea, improving related symptom scores and symptoms, with no obvious drug-related adverse events.

关键词： adverse events carcinoma, non-small-cell lung diarrhea remission rate modified Shenling Baizhu powder targeted therapy-induced diarrhea

Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： wang Lu-ming ZHANG Wen-lan LYU Nuan SUO Yan-rong YANG Lin YU Bin JIANG Xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human ***-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to ***-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque *** paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

Pricing Guaranteed Minimum Death Benefits with Dollar Cost Averaging Under Time-changed Le′vy Models

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年

作者： Jia-ming wang Mei-qiao AI Zhi-min ZHANG College of Mathematics and Statistics Chongqing University

In this paper, we propose an efficient and accurate method for pricing Guaranteed Minimum Death Benefit (GMDB) under time-changed Le′vy processes. Suppose that the GMDB payoff depends on a dollar cost averaging (DCA) style periodic investment, and the activity rate process in stochastic time change is modeled by a square-root process. We develop a recursive method to derive the closed form valuation formula by using the frame duality projection method. Numerical examples are reported for demonstrating the effectiveness of our approach and illustrating the interplay between contract parameters and the valuation.

关键词：

Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1804-1817页

作者： Fazhan wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng ming wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Translational Medical Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Department of Neuro-Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China

Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA *** expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA *** by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered *** the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA *** mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in *** with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma *** natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy.

关键词： mRNA vaccine lipid nanoparticles spleen long-chain saturated fatty acid cancer immunotherapy

Sandwich-like Heterochromophore Metallo-Supramolecules Based on Dense Chromophore Arrangements with Energy and Chirality Transfer Properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第5期6卷 1264-1277页

作者： Ningxu Han Jianjun Ma Hao Yu Junjuan Shi Qixia Bai Xin Jiang Zhe Zhang Pingshan wang Jing Yu ming wang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012 Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhouGuangdong 510006 School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798

Multichromophoric architectures with wellorganized chromophoric arrangements are of vital importance to gain insights into interchromophoric ***,we report a novel heteroleptic self-assembly strategy and construct three achiral and one chiral sandwich-like heterochromophore complexes(Zn_(4)L^(G)L^(A-C)_(2)and Zn_(4)L_(G)L^(D)_(2)).Possible dynamic products,including homoleptic oligomers and isomers,are eliminated,producing achiral complexes with exceptional *** are observed in chiral complexes due to the flexible geometry of *** aligned chromophore arrangements with precise spacing and orientations are evidenced by single-crystal X-ray *** distinct segments in the ligands lead to different interchromophoric ***,energy transfer and tunable emission,including white-light emission,are achieved for Zn_(4)L^(G)L^(A)_(2)and Zn_(4)L^(G)L^(B)_(2).In addition,chirality transfer is observed for Zn_(4)L_(G)L^(D)_(2),due to conformational restriction from chiral LD,leading to chiral rotational conformations of tetraphenylethylene moiety in LG.

关键词： heterochromophore complexes fluorescence single crystal dissymmetrical ligands chirality

Solvent-Free Manufacturing of Lithium-Ion Battery Electrodes via Cold Plasma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第1期7卷 28-33页

作者： Zhiming Liang Tianyi Li Holden Chi Joseph Ziegelbauer Kai Sun ming wang Wei Zhang Tuo Liu Yang-Tse Cheng Zonghai Chen Xiaohong Gayden Chunmei Ban Paul M.Rady Department of Mechanical Engineering University of Colorado BoulderBoulder CO 80309USA Advanced Photon Source Argonne National LaboratoryLemont IL 60439USA Intecells Inc. Southfield MI 48084USA Department of Materials Science and Engineering Michigan Center for Materials CharacterizationUniversity of MichiganAnn Arbor MI 48109USA Department of Chemical and Materials Engineering University of KentuckyLexington KY 40506USA Department of Chemistry University of KentuckyLexington KY 40506USA Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA

Slurry casting has been used to fabricate lithium-ion battery electrodes for decades,which involves toxic and expensive organic solvents followed by high-cost vacuum drying and electrode *** work presents a new manufacturing method using a nonthermal plasma to create inter-particle binding without using any polymeric binding materials,enabling solvent-free manufacturing electrodes with any electrochemistry of *** cold-plasma-coating technique enables fabricating electrodes with thickness(>200 pm),high mass loading(>30 mg cm^(-2)),high peel strength,and the ability to print lithium-ion batteries in an arbitrary *** crosscutting,chemistry agnostic,platform technology would increase energy density,eliminate the use of solvents,vacuum drying,and calendering processes during production,and reduce manufacturing cost for current and future cell ***,lithium iron phosphate and lithium cobalt oxide were used as examples to demonstrate the efficacy of the cold-plasma-coating *** is found that the mechanical peel strength of cold-plasma-coating-manufactured lithium iron phosphate is over an order of magnitude higher than that of slurry-casted lithium iron phosphate *** cells assembled with a graphite anode and the cold-plasma-coating-lithium iron phosphate cathode offer highly reversible cycling performance with a capacity retention of 81.6%over 500 *** the highly conductive cathode material lithium cobalt oxide,an areal capacity of 4.2 mAh cm^(-2)at 0.2 C is *** anticipate that this new,highly scalable manufacturing technique will redefine global lithium-ion battery manufacturing providing significantly reduced plant footprints and material costs.

关键词： cold plasma deposition lithium-ion battery solvent-free manufacturing

Geochemistry and Zircon U-Pb and Hf Isotopes of Early Devonian Hardawu Granites in the Eastern Segment of the Ultrahigh-Pressure Metamorphic Belt, Northern Qaidam Basin

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第3期35卷 866-877页

作者： Hua Li ming wang Jiqing Li Haikui Tong Jiaxiang Dong minggang Tian Xiaolin Chen Leguang Li Ting Xie Xiong Li Yuying Che Qinghai Geological Survey Xining 810000China Technology Innovation Center for Exploration and Exploitation of Strategic Mineral Resources in Plateau Desert Region Ministry of Natural ResourcesXining 810000China Qinghai Geological Survey Institute Xining 810000China Geological Exploration Institute of Shandong Zhengyuan Jinan 271000China School of Earth Science China University of GeosciencesWuhan 430074China

The Hardawu granites in the eastern segment of the ultrahigh-pressure metamorphic belt,the northern Qaidam Basin,were studied by whole-rock major and trace elements and in-situ zircon U-Pb geochronology and Hf isotopes to discuss the petrogenesis and tectonic *** results show that the granites have a crystallization age of 401±3 Ma,suggesting that they were formed in the Early *** granites have SiO2 contents of 75.32 wt.%-76.05 wt.%,total alkali contents of 8.23 wt.%-8.36 wt.%,and K2O/Na2O ratios of *** were rich in K2O,poor in TiO2,MnO,MgO,and P2O5,and have A/CNK values of 1.05-1.07,Rittmann indexδvalues of 2.05-2.14,and differentiation index(DI)values of *** are high potassium calc-alkaline,weakperaluminum,and highly differentiated I-type *** granites also show enrichment of large ion lithophile elements(LILE)such as Rb,Ba,and Th,and depletion of high field strength elements(HFSE)such as Nb,Ta,and *** total REE concentrations range from 169 ppm to 232 ppm,with enrichments of light rare earth elements and negative Eu anomalies(δEu=0.39-0.55).The zirconεHf(t)values range from-0.65 to-2.29,and the two-stage model ages(tDM2)changed within a small range of 1.44 to 1.54 Ga,indicating that the magma of the Hardawu granites was originated from the partial melting of Mesoproterozoic lower crustal *** with previous studies,we suggest that the Hardawu granites were formed in the extensional tectonic setting after the collision between the Qaidam Block and the central and southern Qilian Block in the Early Devonian.

关键词： granite Early Devonian petrogenesis tectonic implication Qaidam Basin geochemistry

Polyoxometalates-derived ternary metal oxides electrocatalyst for N_(2) reduction under ambient conditions

在线全文

学校读者我要写书评

暂无评论

Tungsten 2024年第2期6卷 428-437页

作者： Meng-Le Yang Zhong-Xin Jin Xi-Xian Cao Xin-ming wang Hui-Yuan Ma Hai-Jun Pang Gui-Xin Yang The School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China

Accelerating the breaking of the nitrogen nonpolar bond(N≡N)is an important factor to improve the effi ciency of the electro-catalytic nitrogen reduction reaction(e-NRR).In this work,polyoxometalates-derived FeMo-based ternary oxide materials MoO_(2)-Mo_(4)O_(11)-FeMoO_(4)@X(abbreviated as MoFeO@X,X represents the synthesis temperature of 650,750 and 850℃)were designed and synthesized for e-NRR under ambient *** scanning electron microscopy images of MoFeO@750 show an ellipsoidal-like structure(0.86×0.6μm).The relatively large specifi c surface area,formation of multiple interfaces,together with the synergistic eff ect of iron and molybdenum bimetals,would make MoFeO@X catalyst more easily absorb and activate N_(2)in the ***,the synthesized MoFeO@750 shows an optimal NH_(3)production rate of 16.57μg·h^(−1)·mg cat.^(−1)and Faradaic effi ciency of 12.33%at−0.3 V versus reversible hydrogen electrode(ν***),with outstanding electrochemical and structural stability.

关键词： Polyoxometalates Electrocatalytic nitrogen reduction reaction Ternary oxide Electrocatalyst

Dramatic Difference Between Cu_(20)H_(8)and Cu_(20)H_(9)Clusters in Catalysis

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第6期6卷 1581-1590页

作者： Chun-Yu Liu Tong-Yu Liu Zong-Jie Guan Song wang Yuan-Yuan Dong Feng Hu De-en Jiang Quan-ming wang Department of Chemistry Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education)Tsinghua UniversityBeijing 100084 Jiangsu Engineering Research Centre for Digital Textile Inkjet Printing Key Laboratory of Eco-Textile Jiangnan UniversityMinistry of EducationWuxiJiangsu 214122 Department of Chemical and Biomolecular Engineering Vanderbilt UniversityNashvilleTennessee 37235 Department of Chemistry Vanderbilt UniversityNashvilleTennessee 37235 College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082 Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026

Sensitivity to structure and composition is very challenging to establish in nanocatalysis due to inadequate definition of structures that are very close in *** synthesized a pair of atomically precise copper clusters that are very close in composition,[Cu_(20)H_(9)(Tf-dpf)_(10)]·BF4(Cu_(20)H_(9))and[Cu_(20)H_(8)(Tf-dpf)_(10)]·(BF_(4))_(2)(Cu_(20)H_(8)),by using a pyridyl-functionalized flexible amidinate ligand,N,N′-di(5-trifluoromethyl-2-pyridyl)*** one-hydride difference in their composition leads to significant variation in geometric and electronic structures and,consequently,distinctly different optical and catalytic ***_(20)H_(8)exhibits 25 times higher catalytic activity than Cu_(20)H_(9)(96.7%vs 3.7%in yield)in the selective hydrogenation of anα,β-unsaturated aldehyde(cinnamaldehyde)to saturated aldehyde(3-phenylpropanal).Electrospray ionization mass spectrometry combined with density functional theory calculations reveal that the greater ease of dissociation of one Tf-dpf ligand compared to Cu_(20)H_(8)is the key to its higher *** work demonstrates a clear case of structure and composition sensitivity in nanocatalysis and that one hydride,out of∼330 atoms in the nanoclusters,can make a huge difference in the catalytic *** insights will be useful in the design and synthesis of atomically precise nanocatalysts.

关键词： copper cluster hydride amidinate ligand structural transformation hydrogenation catalysis

Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-ming wang Yu-Tao Pan Chen-Song Yang ming-Chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention