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Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator

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Nano-Micro Letters 2024年第3期16卷 351-366页

作者： Ya’nan Yang Jiaqi wang Zhe wang Changxiang Shao Yuyang Han Ying wang Xiaoting Liu Xiaotong Sun liru wang Yuanyuan Li Qiang Guo Wenpeng Wu Nan Chen Liangti Qu Key Laboratory of Cluster Science Ministry of Education of ChinaKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019People’s Republic of China Department of Chemistry Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal ***,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information ***,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any *** research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.

关键词： Moist-electric generators Grotthuss proton hopping Fast response Durable electrical output Personal health monitoring

钙结合蛋白S100A8/A9阻滞剂对人子宫内膜异位症在位内膜间质细胞系hEM15A的作用效果

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中国妇产科临床杂志 2024年第4期25卷 340-344页

作者：张雯文王丽茹朱根海海南医学院海口570311 海南省肿瘤医院妇科海口570312 海南省人民医院妇科海口570311

目的探讨S100钙结合蛋白A8/A9(S100 calcium binding protein A8/A9,S100A8/A9)阻滞剂对异位子宫内膜细胞的作用效果。方法以不同浓度的S100A8/A9蛋白的特异性阻滞剂帕奎莫德(ABR-25757)作用异位子宫内膜细胞(hEM15A)24 h后,通过细胞计... 详细信息

目的探讨S100钙结合蛋白A8/A9(S100 calcium binding protein A8/A9,S100A8/A9)阻滞剂对异位子宫内膜细胞的作用效果。方法以不同浓度的S100A8/A9蛋白的特异性阻滞剂帕奎莫德(ABR-25757)作用异位子宫内膜细胞(hEM15A)24 h后,通过细胞计数试剂盒-8(CCK8)法检测ABR-25757作用后细胞形态及细胞增殖活力,从4个梯度浓度中筛选出ABR-25757作用的最佳浓度。分为实验组(hEM15A+ABR-25757)和对照组(hEM15A+同体积PBS)。最佳浓度的ABR-25757作用hEM15A细胞24 h后,采用Transwell实验检测细胞的迁移和侵袭能力,采用实时荧光定量聚合酶链反应(real-time PCR,qPCR)检测细胞血管内皮生长因子(VEGF)及转化生长因子β1(TGF-β1)表达水平,采用酶联免疫吸附试验(ELISA)方法检测细胞培养上清液VEGF及TGF-β1水平。结果(1)以100、200、400、800μg/mL等不同浓度梯度ABR-25757作用hEM15A细胞24 h后,与对照组相比,不同浓度ABR-25757组均可降低hEM15A细胞增殖活力(100μg/mL组:P<0.05;其余浓度组:P<0.01)。由于200μg/mL浓度作用效果明显,且细胞死亡少,故选择200μg/mL为最佳浓度;(2)ABR-25757作用细胞后与对照组相比,hEM15A细胞迁移和侵袭能力明显减弱(P<0.01);(3)ABR-25757作用hEM15A细胞后VEGF和TGF-β1的mRNA表达水平均低于对照组(VEGF:P<0.01,TGF-β1:P<0.05);(4)ABR-25757作用后细胞培养上清液VEGF和TGF-β1水平均低于对照组(VEGF:P<0.01,TGF-β1:P<0.05)。结论ABR-25757是S100A8/A9的一种特异性抑制剂,能有效抑制异位内膜细胞的增殖、降低异位内膜细胞迁移和侵袭能力,以及有效下调VEGF、TGF-β1的表达。

关键词：子宫内膜异位症 S100A8/A9蛋白阻滞剂血管内皮生成因子转化生长因子-β1

基于知识图谱的三线建设发展脉络与演进趋势研究

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成都工业学院学报 2024年第4期27卷 81-88页

作者：兰清王丽茹成都工业学院党委教师工作部/人事处成都611730 成都工业学院马克思主义学院成都611730

为系统研究我国三线建设研究的发展脉络和演进趋势,利用CiteSpace软件,对知网、维普和万方数据库收录的1518篇相关论文进行文献计量学分析,构建三线建设研究知识图谱,从共现分析、聚类分析和突现分析等方面开展可视化分析。研究结果表明... 详细信息

为系统研究我国三线建设研究的发展脉络和演进趋势,利用CiteSpace软件,对知网、维普和万方数据库收录的1518篇相关论文进行文献计量学分析,构建三线建设研究知识图谱,从共现分析、聚类分析和突现分析等方面开展可视化分析。研究结果表明:2003—2023年,我国三线建设研究在2021年达到顶峰,后出现了一定程度的下滑;研究的作者与研究机构间的合作网络比较密集,但部分研究团体之间并无交集,相关研究自成体系。三线精神、红色资源是该领域内较为关注的热点话题,但研究尚不够深入。未来可围绕这2个话题进一步开展跨机构、跨学科等的交流合作,促进三线建设研究的进一步深化发展。

关键词：三线建设知识图谱文献计量趋势演进

靶向BCMA CAR-T治疗RRMM的局限性及优化策略

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中国医学创新 2024年第15期21卷 183-188页

作者：刘汇洪王立茹首都医科大学第八临床医学院北京100038 首都医科大学附属复兴医院血液内科北京100038

嵌合抗原受体T细胞(CAR-T)免疫疗法快速发展,为多发性骨髓瘤(MM)治疗带来新的曙光,尤其B细胞成熟抗原(BCMA)作为迄今为止最成功的靶标,靶向BCMA CAR-T疗法可以使MM的症状获得持久且深度的缓解,在复发难治性多发性骨髓瘤(RRMM)治疗中取... 详细信息

嵌合抗原受体T细胞(CAR-T)免疫疗法快速发展,为多发性骨髓瘤(MM)治疗带来新的曙光,尤其B细胞成熟抗原(BCMA)作为迄今为止最成功的靶标,靶向BCMA CAR-T疗法可以使MM的症状获得持久且深度的缓解,在复发难治性多发性骨髓瘤(RRMM)治疗中取得突破性进展。但由于抗原逃逸、CAR-T衰竭等因素,多数患者仍会进展或复发,靶向BCMA CAR-T治疗后复发或难治患者的后续治疗缺乏标准方案。同时,复杂、昂贵且耗时的个性化CAR-T制造流程也限制其临床疗效的发挥。针对此现状,该综述总结了靶向BCMA CAR-T治疗的局限性及其机制,同时结合MM治疗领域新进展,提出改善进展或RRMM患者结局的潜在优化治疗策略。

关键词： B细胞成熟抗原 CAR-T疗法复发难治性多发性骨髓瘤耐药性

2021年河南省中小学生营养改善计划地区家庭饮食环境分析

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中国公共卫生 2024年第4期40卷 418-422页

作者：李凤娟王丽茹刘晶晶许凤鸣王旭王延鑫张书芳河南省疾病预防控制中心公共卫生研究所郑州450016

目的分析2021年河南省农村义务教育学生营养改善计划重点监测县学生家庭饮食环境情况,为进一步加强营养健康教育提供数据支撑。方法于2021年在河南省实施“农村义务教育学生营养改善计划”的5个重点监测县中采取分层随机整群抽样方法抽... 详细信息

目的分析2021年河南省农村义务教育学生营养改善计划重点监测县学生家庭饮食环境情况,为进一步加强营养健康教育提供数据支撑。方法于2021年在河南省实施“农村义务教育学生营养改善计划”的5个重点监测县中采取分层随机整群抽样方法抽取5673名中小学生对其身高体重进行测量,并对其家长进行问卷调查,分析家长营养健康知识、饮食行为、家长对子女体型的认知等情况。结果儿童家长营养健康知识知晓率为68.94%(3911/5673),健康饮食行为发生率为26.65%(1512/5673),儿童超重肥胖检出率为27.38%(1553/5673),55.37%(3141/5673)的家长能准确评估儿童营养状况,偏差主要为低估儿童营养状况,占41.62%(2361/5673),且认知偏差与家长知识知晓率及健康饮食行为无关。家长对儿童体型的认知和儿童实际营养状况的一致性较差(Kappa=0.203,P<0.001)。结论河南省农村义务教育学生营养改善计划重点监测县家庭饮食环境中家长营养健康知晓率较高,但健康饮食行为发生率和对儿童营养状况的认知正确率偏低,存在知行分离现象;家长普遍低估了儿童的营养状况,对儿童超重肥胖的控制不利。

关键词：家庭饮食环境营养健康知识健康饮食行为体型认知中小学生河南省

神经外科导尿管相关性尿路感染的高危因素及预防策略

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中国卫生标准管理 2024年第14期15卷 166-170页

作者：黎秀婵黄晓菲王丽如方建冰麦惠广西医科大学第一附属医院神经外科广西南宁530021

目的探讨神经外科导尿管相关性尿路感染(catheter-associated urinary tract infection,CAUTI)发生的高危因素及预防干预策略。方法选择2018年1月—2023年10月广西医科大学第一附属医院神经外科收治的218例留置导尿管患者作为研究对象... 详细信息

目的探讨神经外科导尿管相关性尿路感染(catheter-associated urinary tract infection,CAUTI)发生的高危因素及预防干预策略。方法选择2018年1月—2023年10月广西医科大学第一附属医院神经外科收治的218例留置导尿管患者作为研究对象。统计不同临床特征患者CAUTI的发生率,进行多因素logistic回归分析,并提出相应的预防干预策略。结果218例神经外科导尿管患者中,发生CAUTI的患者为35例,发生率为16.06%。其中35例CAUTI患者检出病原菌103株,大肠埃希菌82株(79.61%),肺炎克雷伯菌19株(18.45%),金黄葡萄球菌2株(1.94%)。不同性别、年龄、是否意识障碍、尿道口清洗频率、导尿管留置时间、导尿管更换时间、患者24 h尿量、是否有既往大型手术史、合并不同个数其他疾病的尿路感染率比较,差异有统计学意义(P65~75岁、患者意识障碍、尿道口清洗频率为1次/d、导尿管留置时间>10 d、导尿管更换时间>15d是尿路感染率高的危险因素(P65~75岁、存在意识障碍、尿道口清洗频率1次/d、导尿管留置时间>10 d、导尿管更换时间>15 d的患者,制定针对性的预防措施,降低CAUTI发生风险。

关键词：神经外科导尿管尿路感染病原菌高危因素干预策略

Treatment patterns and a prognostic scoring system for elderly acute myeloid leukemia patients:a retrospective multicenter cohort study in China

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Cancer Biology & Medicine 2022年第6期19卷 871-883页

作者： Chunli Zhang Wei Wan Shuai Zhang Jingwen wang Ru Feng Jiangtao Li Junyue Chai Hebing Zhou liru wang Yuping Zhong Xiaodong Mo Mengzhu Shen Hongmei Jing Hui Liu Department of Hematology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Hematology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Hematology Beijing No.6 HospitalBeijing 100007China Department of Hematology Beijing Luhe HospitalCapital Medical UniversityBeijing 101100China Department of Hematology Fuxing HospitalCapital Medical UniversityBeijing 100038China Department of Hematology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100043China Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the *** aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic ***:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,*** complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy *** median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity *** and intermediate risk patients benefited more from standard chemotherapies than from low intensity ***,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk ***:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML *** chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups.

关键词： Acute myeloid leukemia chemotherapy comorbidity elderly geriatric assessment

Genetic diversity and population structure of Gossypium arboreum L. collected in China

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Journal of Cotton Research 2018年第3期1卷 1-8页

作者： JIA Yinhua PAN Zhaoe HE Shoupu GONG Wenfang GENG Xiaoli PANG Baoyin wang liru DU Xiongming Institute of Cotton Research of Chinese Academy of Agricultural Sciences State Key Laboratory of Cotton Biology Key Laboratory of Biology andGenetic Improvement of Cotton Ministry of Agriculture

Background: Gossypium arboreum is a diploid species cultivated in the Old World. It possesses favorable characters that are valuable for developing superior cotton ***: A set of 197 Gossypium arboreum accessions were genotyped using 80 genome-wide SSR markers to establish patterns of the genetic diversity and population structure. These accessions were collected from three major G. arboreum growing areas in China. A total of 255 alleles across 80 markers were identified in the genetic diversity ***: Three subgroups were found using the population structure analysis, corresponding to the Yangtze River Valley, North China, and Southwest China zones of *** growing areas in China. Average genetic distance and Polymorphic information content value of G. arboreum population were 0.34 and 0.47, respectively, indicating high genetic diversity in the G. arboreum germplasm pool. The Phylogenetic analysis results concurred with the subgroups identified by Structure analysis with a few exceptions. Variations among and within three groups were observed to be 13.61% and 86.39%, ***: The information regarding genetic diversity and population structure from this study is useful for genetic and genomic analysis and systematic utilization of economically important traits in G. arboreum.

关键词： Gossypium arboreum L. Population structure Genetic diversity Genetic differentiation Simple sequence repeat(SSR) markers

Visible light promoted aerobic selective photo-oxidation of cyclohexene on LaCo_(x)Cu_(1−x)O_(3) catalyst

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Nano Research 2024年第8期17卷 6940-6950页

作者： Xu Guo liru Song Wenyu wang Fengfeng Li Minh Ngoc Ha Jun Tang Qiang Ling Ping Cui Qingping Ke College of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243000China VNU Key Laboratory of Advanced Material for Green Growth Faculty of ChemistryUniversity of ScienceVietnam National UniversityHanoi 100000Vietnam

Heterogeneously catalyzed liquid oxidation of olefins with O_(2) provides an alternative way for synthesizing high-value added ***,we report a straightforward urea-redox and sol-gel process for synthesizing LaCo_(x)Cu_(1−x)O_(3) for aerobic photooxidation of *** research highlights a marked increase in the proportions of Co^(2+) and Cu+species in a low chemical state,as well as enhanced visible light absorption through this *** investigations suggest that the catalytic process,particularly with LaCo_(0.7)Cu_(0.3)O_(3),involves a radical pathway mediated by reactive oxygen *** presence of Cu+/Co^(2+) species and surface oxygen vacancies is proposed to boost O_(2) adsorption and activation on the catalyst,facilitating the formation of ***,Cu^(2+)/Co^(3+) species are thought to aid in generating cyclohexenederived radical *** efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_(3) catalyst relies on the formation of reactive oxygen species and carbon radicals,facilitated by its strong visible light *** achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%,along with stable recyclability after six *** creation of nano-structured LaCo_(x)Cu_(1−x)O_(3) through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.

关键词： perovskite oxide photocatalysis oxidation cyclohexene LaCoCuO_(3) cyclohex-2-ene-1-one