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Synthesis, Crystal Structure and Insecticidal Activities of Novel Neonicotinoid Derivatives

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Chemical Research in Chinese Universities 2010年第3期26卷 380-383页

作者： ZHAO Yu wang Gang li Yong-qiang wang Su-hua li Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry National Pesticide Engineering Research Center（Tianjin） Nankai University Tianjin 300071 P. R. China

Ten new N-oxalyl derivatives of neonicotinoid compound were designed and synthesized. Their structures were confirmed by ^1H NMR spectra, elemental analysis and X-ray diffraction. The preliminary insecticidal activities of the new compounds were evaluated. The results of bioassays indicate that the title Compounds exhibit moderate insecticidal activities. Surprisingly, the insecticidal activity of compound 7b against bean aphids at 200 mg/kg is 100%, which is comoarable to that of the commercialized imidacloprid.

关键词： Neonicotinoid N-Oxalyl derivative Insecticidal activity Bean aphid Imidacloprid

夏枯草开音合剂改善早期喉癌激光术后嗓音及生活质量随机对照研究

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中国中西医结合杂志 2024年第3期44卷 290-295页

作者：龚姝婧孙臻峰罗丹丁健董频王丽华郭裕上海交通大学医学院附属第一人民医院耳鼻咽喉科上海200080 上海市中医医院耳鼻咽喉科上海200071

目的观察夏枯草开音合剂对早期声门型喉癌CO_(2)激光术后患者嗓音及生活质量的疗效。方法选择2019年9月—2021年6月就诊于上海市第一人民医院的52例T1a期声门型喉癌患者,按随机数字法分为治疗组(26例)和对照组(26例),行Ⅲ-Ⅴa型CO_(2)... 详细信息

目的观察夏枯草开音合剂对早期声门型喉癌CO_(2)激光术后患者嗓音及生活质量的疗效。方法选择2019年9月—2021年6月就诊于上海市第一人民医院的52例T1a期声门型喉癌患者,按随机数字法分为治疗组(26例)和对照组(26例),行Ⅲ-Ⅴa型CO_(2)激光术,治疗组服用夏枯草开音合剂,对照组服用安慰剂,各服用1个疗程(3个月),同时辅以嗓音训练,随访6个月。通过两组患者术后1、3、6个月的嗓音声学分析和嗓音障碍指数及生活质量量表观察,评价夏枯草开音合剂的治疗效果。结果两组患者术后1个月各项指标比较,差异无统计学意义(P>0.05)。术后3个月时,治疗组标准化噪声能量(NNE)、谐噪比(HNR)及嗓音障碍指数(VHI)中的“生理”范畴评分优于对照组(P<0.05)。术后6个月,治疗组基频微扰(Jitter)、振幅微扰(Shimmer)、NNE、HNR、VHI和生活质量评分均优于对照组(P<0.05)。结论夏枯草开音合剂有助于改善T1a期声门型喉癌CO_(2)激光术后患者的嗓音及生活质量。

关键词： T1a期声门型喉癌夏枯草开音合剂嗓音生活质量中药中西医结合

Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing 1,2,4-Triazolinone Moiety

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Chemical Research in Chinese Universities 2013年第3期29卷 466-472页

作者： liU Zhuo PAN li liYong-hong wang Su-hua li Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China

A series of new sulfonylureas incorporating 1,2,4-triazolinone moiety was synthesized, which were further bio-assayed for the herbicidal activity against four herbs, representative of monocotyledons and dicotyledons. Some of them exhibited high potency to inhibit the growth of dicotyledons（Bassica napus and Arnaranthus retroflexus） in the pot experiment. Compounds 9a and 9b also displayed an excellent herbicidal activity against Bassica napus at a concentration of 15 g/hectare, which were comparable with commercial triasulfuron.

关键词： Sulfonylurea herbicide Acetohydroxyacid synthetase(AHAS) 1,2,4-Triazolinone derivative Protox Herbicidal activity

血清25(OH)D、MCP-1与甲状腺功能正常桥本甲状腺炎患者轻度认知功能障碍的关系研究

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现代生物医学进展 2024年第7期24卷 1296-1300页

作者：王怡向娟徐伟何艳王莉华重庆大学附属三峡医院内分泌科重庆404100

目的:探讨血清25羟维生素D[25(OH)D]、巨噬细胞炎症蛋白-1(MCP-1)与甲状腺功能正常桥本甲状腺炎(HT)患者轻度认知功能障碍(MCI)的关系,以期为甲状腺功能正常的HT患者发生MCI提供辅助预测指标。方法:选取2021年1月~2023年5月重庆大学附... 详细信息

目的:探讨血清25羟维生素D[25(OH)D]、巨噬细胞炎症蛋白-1(MCP-1)与甲状腺功能正常桥本甲状腺炎(HT)患者轻度认知功能障碍(MCI)的关系,以期为甲状腺功能正常的HT患者发生MCI提供辅助预测指标。方法:选取2021年1月~2023年5月重庆大学附属三峡医院收治的甲状腺功能正常HT患者167例为HT组,另选取同期体检健康志愿者87例为对照组,根据是否发生MCI将甲状腺功能正常HT患者分为MCI组(n=71)和非MCI组(n=96)。采用酶联免疫吸附法检测血清25(OH)D、MCP-1水平。建立多因素Logistic回归模型分析甲状腺功能正常HT患者MCI的影响因素,绘制受试者工作特征(ROC)曲线分析血清25(OH)D、MCP-1水平对甲状腺功能正常HT患者MCI的预测价值。结果:与对照组比较,HT组血清25(OH)D水平降低,MCP-1水平升高(P<0.05)。167例甲状腺功能正常HT患者MCI发生率为42.51%(71/167)。多因素Logistic回归分析显示,甲状腺过氧化物酶抗体(TPOAb)升高、MCP-1升高为影响甲状腺功能正常HT患者MCI的独立危险因素,25(OH)D升高为独立保护因素(P<0.05)。ROC曲线分析显示,血清25(OH)D联合MCP-1预测甲状腺功能正常HT患者MCI的曲线下面积为0.892,大于血清25(OH)D、MCP-1单独预测的0.785、0.770。结论:甲状腺功能正常HT患者血清25(OH)D水平降低和MCP-1水平升高与MCI发生密切相关,血清25(OH)D、MCP-1联合预测甲状腺功能正常HT患者MCI的价值较高。

关键词：桥本甲状腺炎甲状腺功能 25羟维生素D 巨噬细胞炎症蛋白-1 轻度认知功能障碍

Influence of HLA-DRB1 alleles and HBV genotypes on interferon-α therapy for chronic hepatitis B

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World Journal of Gastroenterology 2005年第30期11卷 4753-4757页

作者： Rui-Hai Chu li-Xian Ma Gang wang li-hua Shao Department of Infectious Diseases Qilu Hospital of Shandong University Jinan 250012 Shandong Province China

AIM. To investigate the influence of HLA-DRB1 alleles and HBV genotypes on inberferon-α therapy for chronic hepatitis B. METHODS： HLA-DRBI＊03, ＊07, ＊09,＊12, ＊15 alleles were determined using polymerase chain reaction/sequence specific primer （PCR/SSP） technique in 126 patients with chronic hepatitis B and 76 normal control subjects in Shandong Province, and HBV genotypes were determined by nested-PCR analysis using type-specific primers in 126 patients. RESULTS： The positivity of HLA-DRB1＊07 allele in chronic hepatitis B group was significantly higher than that in normal control group （X^2 = 6.33, P〈0.025, RR = 2.37）. Among the 126 patients, genotype B was found in 38 （30.2%）, genotype C in 69 （54.8%）, and mixed genotype （B＋C） in 19 （15.0%）, genotypes D-F were not found. Among the 46 DRB1＊07（＋） patients, 7 were responders and 39 were non-responders among them （X^2 = 6.71, P〈0.05）. The positivity of HLADRB1＊07 and prevalence of HBV genotype C were significantly higher in non-responders than in responders. CONCLUSION： High positivities of HLA-DRB1 ＊07 allele and HBV genotype C are closely associated with the lower response to interferon-α therapy for chronic hepatitis B.

关键词： HLA-DRB1 alleles HBV genotypes Interferon-α therapy Chronic hepatitis B

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PTA用钛合金蝶阀蝶板设计与分析

阀门 2024年第7期 790-795页

作者：李光辉龙昭君罗林华王利华陈红方海南逸盛石化有限公司海南僧州578101 东辰智能科技有限公司浙江杭州311107

蝶阀是目前PTA(Purified terephthalic acid)行业管路系统中常用的阀门之一。前期研制表明采用不锈钢材料制作的28寸蝶阀的蝶板在进行试验时无可见泄漏,而采用钛合金材料制作蝶板时密封面处存在介质渗漏问题。因此本文以28寸蝶阀为研究... 详细信息

蝶阀是目前PTA(Purified terephthalic acid)行业管路系统中常用的阀门之一。前期研制表明采用不锈钢材料制作的28寸蝶阀的蝶板在进行试验时无可见泄漏,而采用钛合金材料制作蝶板时密封面处存在介质渗漏问题。因此本文以28寸蝶阀为研究对象,首先分析不同材料和结构形式对蝶板整体刚度以及密封性能的影响,并采用数值模拟得到相同工况下不同材料和结构下蝶板的位移变形情况;其次通过试验验证阀门的密封可靠性;最后通过对结构进行优化以补充材料变形量产生的影响,给出合理的蝶板设计方案,为PTA行业蝶阀的蝶板材料选择及结构设计提供参考。

关键词：大口径钛合金蝶阀蝶板变形

单纯性肥胖儿童血清Leptin、25-(OH)D3与糖脂代谢、生长发育和肾素-血管紧张素-醛固酮系统的相关性分析

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现代生物医学进展 2024年第13期24卷 2511-2515页

作者：王丽花苏艳花陈晓娟王蕾杨舒扬山西省儿童医院内分泌科山西太原030013

目的:研究单纯性肥胖儿童血清瘦素(Leptin)、25羟基维生素D3[25-(OH)D3]与糖脂代谢、生长发育和肾素-血管紧张素-醛固酮系统(RAS)的相关性。方法:选取2021年9月~2023年9月山西省儿童医院收治的132例单纯性肥胖儿童纳入观察组,另选同期... 详细信息

目的:研究单纯性肥胖儿童血清瘦素(Leptin)、25羟基维生素D3[25-(OH)D3]与糖脂代谢、生长发育和肾素-血管紧张素-醛固酮系统(RAS)的相关性。方法:选取2021年9月~2023年9月山西省儿童医院收治的132例单纯性肥胖儿童纳入观察组,另选同期健康体检的健康儿童100例纳入对照组。检测血清Leptin、25-(OH)D3、糖脂代谢指标[空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)]及RAS系统指标[肾素(PRA)、血管紧张素-II(Ang-II)、醛固酮(ALD)],并测量生长发育指标[体质指数(BMI)、腰围(WC)、腰臀比(WHR)]。采用Pearson检验对单纯性肥胖儿童血清Leptin、25-(OH)D3与糖脂代谢、生长发育和RAS指标的相关性进行分析。结果:观察组血清Leptin高于对照组,25-(OH)D3低于对照组(P<0.05)。观察组FBG、TG、TC、LDL-C高于对照组,而HDL-C低于对照组(P<0.05)。观察组BMI、WC、WHR高于对照组(P<0.05)。观察组PRA、Ang-II、ALD高于对照组(P<0.05)。经Pearson检验分析,血清Leptin与FBG、TG、TC、LDL-C、BMI、WC、WHR、PRA、Ang-II、ALD呈正相关性,与HDL-C呈负相关性,25-(OH)D3与FBG、TG、TC、LDL-C、BMI、WC、WHR、PRA、Ang-II、ALD呈负相关性,与HDL-C呈正相关性(均P<0.05)。结论:单纯性肥胖儿童中,血清Leptin呈高表达,25-(OH)D3为低表达,并且与患儿的糖脂代谢、生长发育及RAS系统密切相关。血清Leptin、25-(OH)D3可能通过对机体糖脂代谢、生长发育及RAS系统的影响而参与到儿童单纯性肥胖的发病过程。

关键词：单纯性肥胖儿童 Leptin 25-(OH)D3 糖脂代谢生长发育肾素-血管紧张素-醛固酮系统相关性

Nonvolatile WORM memory devices based on polymethacrylate with azoanthraquinone group

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Science China Chemistry 2010年第3期53卷 587-592页

作者： li, hua Lu, Jian Mei li, Na Jun Xu, Qing Feng Ge, Jian Feng wang, li hua Luan, Zhao Chang Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Suzhou University Suzhou 215123 China

A novel polymethacrylate containing azoanthraquinone chromophore in the side chain(PMAzoaq6) was synthesized and *** electronic memory device having the indium-tin oxide(ITO)/PMAzoaq6/Al sandwich structure was fabricated and its electrical bistability was *** as-fabricated device was initially found to be at the OFF state and the switching threshold voltage was 1.5 *** undergoing the OFF-to-ON transition,the device maintains the high conducting state(ON state) even after turning off the electrical power and applying a reverse *** device exhibits a write-once-read-many-times(WORM) memory effect with a high ON/OFF current ratio of up to 105 and a long retention time in both ON and OFF states,which demonstrated that the synthetic azoanthraquinone-containing polymer possesses a high potential to become polymeric memory devices.

关键词： WORM polymer memory azo anthraquinone

Serum Metabolomic Indicates Potential Biomarkers and Metabolic Pathways of Pediatric Kashin-Beck Disease

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Biomedical and Environmental Sciences 2020年第10期33卷 750-759页

作者： wang Yu Meng wang Wei Yi SUN li Yan li Qiang ZHAO Zhi Jun HU Jian ZHANG Rong Yu wang li hua Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical University/Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang Province&Ministry of HealthHarbin 150081Heilongjiang China Qinghai Institute for Endemic Disease prevention and Control Xining 811602QinghaiChina

Objective To explore potential serum biomarkers of children with Kashin-Beck Disease(KBD)and the metabolic pathways to which the biomarkers *** A two-stage metabolomic study was *** discovery cohort included 56 patients,51 internal controls,and 50 external *** metabolites were determined by HPLC-(Q-TOF)-MS and confirmed by Human Metabolome Databases(HMDB)and Metlin *** 3.0 and the Kyoto Encyclopedia of Genes and Genomes(KEGG)database were used to analyze the metabolic pathways of the candidate *** use of HPLC-(Q-TRAP)-MS enabled quantitative detection of the target metabolites which were chosen using the discovery study and verified in another independent verification cohort of 31 patients,41 internal controls,and 50 external *** Eight candidate metabolites were identified out in the discovery study,namely kynurenic acid,N-α-acetylarginine,6-hydroxymelatonin,sphinganine,ceramide,sphingosine-1 P,spermidine,and *** metabolites exist in sphingolipid,glutathione,and tryptophan metabolic *** the second-stage study,five candidate metabolites were validated,including kynurenic acid,N-α-acetylarginine,sphinganine,spermidine,and sphingosine-1 *** for spermidine,all substances exhibited low expression in the case group compared with the external control group,and the difference in levels of sphinganine,spermidine,and sphingosine-1 P was statistically *** The direction of change of levels of sphinganine,spermidine,and sphingosine-1 P in the two-stage study cohorts was completely consistent,and the differences were statistically ***,these substances can be used as potential biomarkers of ***,these results raise the possibility that sphingolipid metabolic pathways may be closely related to KBD.

关键词： Kashin-Beck disease Potential biomarkers Metabolism pathways Serum