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STIL enhances the development of lung adenocarcinoma by regulating the glycolysis pathway

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Oncology Research 2025年第1期33卷 123-132页

作者： LEI wang XIANJIN xie Department of Respiratory Medicine Jen Ching Memorial HospitalSuzhou215300China Department of Respiratory Medicine Shandong Provincial Third HospitalJinan250010China

Background:To investigate SCL/TAL 1 interrupting locus(STIL)’s role and prognostic significance in lung adenocarcinoma(LUAD)progression,we examined STIL and E2 promoter binding factor 1(E2F1)expression and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis(GEPIA).Methods:Functional assays including CCK-8,wound-healing,5-ethynyl-2-deoxyuridine(EdU),Transwell assays,and flow cytometry,elucidated STIL and E2F1’s effects on cell viability,proliferation,apoptosis,and *** set enrichment analysis(GSEA)identified potential pathways,while metabolic assays assessed glucose ***:Our findings reveal that STIL and E2F1 are overexpressed in LUAD,correlating with adverse *** enhances cell proliferation,migration,and invasion,and suppresses apoptosis,activating downstream of *** E2F1 reversed the promotion effect of the STIL overexpression on cell viability and ***,STIL modulates glycolysis,influencing glucose consumption,lactate production,and energy balance in LUAD ***:Our model,incorporating STIL,age,and disease stage,robustly predicts patient prognosis,underscored STIL’s pivotal role in LUAD pathogenesis through metabolic *** comprehensive approach not only confirms STIL’s prognostic value but also highlights its potential as a therapeutic target in LUAD.

关键词： SCL/TAL1 interrupting locus(STIL) Lung adenocarcinoma E2 promoter binding factor 1 Glycolysis

Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder(加味丁桂散)in Patients with Chronic Nonbacterial Prostatitis:A Randomized,Double-Blind,Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2021年第3期27卷 170-176页

作者： HUANG Hai ZHOU Min-jie wang ke-xie YU Chao wang Yu-hang JI Jun PAN Wen YING Jian ZHAO Ling Department of Joint Surgery Guanghua HospitalShanghai University of Traditional Chinese MedicineShanghai200052China Department of Vasoular Surgery Shanghai Tradtional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200082China Department of Urology and An drology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Shanghai Qigong Research Institute Shanghai University of Traditional Chinese MedicineShanghai200030China School of Acupuncture-Moxbustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China

Objective:To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder(加味丁桂散,MDGP)in patients with chronic nonbacterial prostatitis(CNP).Methods:A randomized,double-blind,placebo-controlled clinical trial was conducted among 72 patients with *** were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio,and received either MDGP external umbilicus treatment(MDGP group,36 cases)or placebo(control group,36 cases)at acupoints Shenque(CV 8),twice a week for 4 *** addtion,patients all received herbal medicine treatment twice a day for 4 *** primary outcome was the US National Institutes of Health Chronic Prostatitis Symptom Scores Index(NIH-CPSI)with a questionnaire at weeks 2 and *** secondary outcomes including prostatic fluid examination(white blood cells and lecithin bodies),the clinical efficacy evaluation,and the adverse events were also assessed during the entire ***:The NIH-CPSI scores regarding pain or discomfort scores showed greater improvement in the MDGP group than placebo control group at weeks 2(P=0.001)and week 4(P=0.004),***-CPSI scores of symptom severity,total scores and leukocytes number in the prostatic fluid in the MDGP group were significantly improved(P0.05).The clinical effective rate was 73.53%(25/34)in the MDGP group,which was significally higher than the placebo control group with 48.39%(25/31,P<0.05).Patients were blinded successfully,and no serious adverse effects were found during the ***:A 4-week course of umbilicus treatment with modified Dinggui Powder seems to relieve pain and symptom severity effectively and increase the amount of leukocytes number in patients with CNP(Trial registration *** 800014687).

关键词： Modified Dinggui Powder umbilicus treatment chronic nonbacterial prostatitis randomized placebo-controlled trial

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Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan xie Yuchen wang Haiping Huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

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各向异性双相介质中多极源声波测井理论研究

地球物理学报 2000年第5期43卷 707-718页

作者：张碧星王克协中国科学院声学研究所北京100080 吉林大学物理系长春130023

将各向异性地层模拟为横向各向同性双相介质 ,使其对称主轴与井孔中心轴线相垂直 .本文针对井孔模型下的多极源声波测井问题提出了一种解析的摄动方法 .将各向异性双相介质看作是由对应的各向同性双相介质加上摄动部分而组成 ,并引入 5... 详细信息

将各向异性地层模拟为横向各向同性双相介质 ,使其对称主轴与井孔中心轴线相垂直 .本文针对井孔模型下的多极源声波测井问题提出了一种解析的摄动方法 .将各向异性双相介质看作是由对应的各向同性双相介质加上摄动部分而组成 ,并引入 5个关于弹性模量偏离各向同性时的摄动量 ,对对称主轴与井轴垂直的各向异性双相介质的多极源声波测井问题进行了系统的理论研究和分析 ,严格求解了井孔内外的零级和一级近似声波场 .发现在n级多极源激发下 ,井孔中不仅出现n级多极声场。

关键词：各向同性双相介质摄动方法多极源声波测井

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Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： wang Shuang MU Lin LI Xue xie Jun DONG Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期100卷 369-376页

作者： Shiyao Shang Fuzhou wang Zeyi Sun Chaofan Qiang ke Chu School of Materials Science and Engineering Lanzhou Jiaotong University

Electrochemical reduction of NO2-to NH3（NO2-RR） is recognized as an appealing approach for achieving renewable NH3synthesis and waste ***,we report isolated Bi alloyed Ru （Bi1Ru） as an efficient NO2-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO2-activation and suppress proton adsorption,while accelerating the NO2-RR protonation energetics to render a high NO2--to-NH3conversion ***,Bi1Ru assembled in a flow cell delivers an NH3yield rate of 1901.4μmol h-1cm-2and an NH3-Faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA *** study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO2-RR catalysts toward the ammonia electrosynthesis.

关键词： Ammonia

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含少量气泡流体饱和孔隙介质中的弹性波

物理学报 2018年第11期67卷 142-148页

作者：王婷崔志文刘金霞王克协吉林大学物理学院长春130012

考虑孔隙流体中含有少量气泡,且气泡在声波作用下线性振动,研究声波在这种孔隙介质中的传播特性.本文先由流体质量守恒方程和孔隙度微分与流体压力微分的关系推导出了含有气泡形式的渗流连续性方程;在处理渗流连续性方程中的气体体积分... 详细信息

考虑孔隙流体中含有少量气泡,且气泡在声波作用下线性振动,研究声波在这种孔隙介质中的传播特性.本文先由流体质量守恒方程和孔隙度微分与流体压力微分的关系推导出了含有气泡形式的渗流连续性方程;在处理渗流连续性方程中的气体体积分数时间导数时,应用Commander气泡线性振动理论导出气体体积分数时间导数与流体压强时间导数的关系,进而得到了修正的Biot形式的渗流连续性方程;最后结合Biot动力学方程求得了含气泡形式的位移场方程,便可得到两类纵波及一类横波的声学特性.通过对快、慢纵波的频散、衰减及两类波引起的流体位移与固体位移关系的考察,发现少量气泡的存在对快纵波和慢纵波的传播特性影响较大.

关键词：孔隙介质含气泡液体 Biot理论弹性波

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin wang Qijiao XIAO Huahua CHEN Xiaoxiao xie Fan ZENG Wen Liaoning key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

Hook Benefit Evaluation on the Increase of Urban Construction Land and the Decrease of Rural Construction Land in the Suburbs of Chongqing City,China

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Asian Agricultural Research 2011年第3期3卷 86-88页

作者： wang ke,xie De-ti,HUANG Chun-fang,wang San College of Resource and Environment,Southwest University,Chongqing 400715,China

According to the socio-economic statistical data and the land use data of Jingguan Town in the year 2008,hook benefit evaluation index system suitable for the actual situation of research region is determined,based on the systematic analyses of the basic data of current status and the related information of hook in research *** Comprehensive Evaluation Method is adopted to evaluate the increase of construction land of Jingguan Town before and after the *** shows that the economic,social and ecological benefits of research region have significantly improved after the *** the fuzzy comprehensive evaluation index system and evaluation methods established in this research can provide references for the hook benefit evaluation in the suburbs of Chongqing City,China.

关键词： Construction land Benefit Hook Jingguan Town China