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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing ling Yong Chen nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun xiaojin Sun xiaofeng wang Lei yang Bing Zhang Chen Zhang Shuang-nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu Yuan liu zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal nandra Jeremy Sanders Roberto Soria lian Tao Junfeng wang Song wang Tinggui wang Zhongxiang wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao wang juan wang Lei wang Wenxin wang Yilong wang Yusa wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan yang Xiongtao yang Yanji yang juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao xiaofan Zhao Zijian Zhao hongyan Zhou Yilin Zhou Yuxuan zhu Zhencai zhu national Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences department of Physics University of hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory department of Astronomy University of Cape Town department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC department of Astronomy School of Physics Huazhong University of Science and Technology InaF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of deep Space Sciences deep Space Exploration Laboratory department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Silicon-erbium ytterbium silicate nanowire waveguides with optimized optical gain

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Frontiers of physics 2017年第1期12卷 57-63页

作者： xiao-Xia wang Wei-Hao Zheng Qing-lin Zhang xiao-li zhu hong Zhou Xiu-juan zhuang An-lian Pan Xiang-Feng Duan Key Laboratory for Micro-nano Physics and Technology of Hunan Province School of Physics and Electronic Science and State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082 China department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA

Single-crystal erbium silicate nanowires have attracted considerable attention because of their high optical gain. In this work, we report the controlled synthesis of silicon-erbium ytterbium silicate core- shell nanowires and fine-tuning the erbium mole fraction in the shell from x = 0.3 to x = 1.0, which corresponds to changing the erbium concentration from 4.8 ×10^21 to 1.6 ×10^22 cm^-3. By controlling and properly optimizing the composition of erbium and ytterbium in the nanowires, we can effectively suppress upeonversion photoluminescence while simultaneously enhancing near-infrared emission. The composition-optimized nanowires have very long photoluminescence lifetimes and large emission cross- sections, which contribute to the high optical gain that we observed. We suspended these concentration- optimized nanowires in the air to measure and analyze their propagation loss and optical gain in the near-infrared communication band. Through systematic measurements using wires with different core sizes, we obtained a maximum net gain of 20 ± 8 dB·mm^-1, which occurs at a wavelength of 1534 nm, for a nanowire with a diameter of 600 nm and a silicon core diameter of 300 nm.

关键词： erbium ytterbium silicate nanowire erbium concentration gain

Hypertension Exacerbates Severity and Outcomes of COVID-19 in Elderly Patients:A Retrospective Observational Study

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Current Medical Science 2022年第3期42卷 561-568页

作者： li-song DAI meng-pei zhu Yu-min li hong-mei ZHOU hong-li liAO Pan-pan cheng Xin-yue XIA Xue-yun YAO Hui-juan ZHANG xiao-qi liU Wei HUANG Lei WAN Xiang-yang XU Fu-rong wang cheng-qi XU department of Radiology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China department of Respiratory Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China department of Radiology Wuhan Eighth HospitalWuhan 430014China department of Cardiology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China department of Ultrasound Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Key Laboratory of Molecular Biophysics of the Ministry of Education Cardio-X InstituteCollege of Life Science and Technology and Center for Human Genome ResearchHuazhong University of Science and TechnologyWuhan 430070China

Objective To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and *** This single-center retrospective cohort study enrolled consecutive COVID-19 patients aged 60 years old and older,who were admitted to liyuan Hospital from January 1,2020 to April 25,*** included patients were divided into two groups:hypertension and nonhypertension *** baseline demographic characteristics,laboratory test results,chest computed tomography(CT)images and clinical outcomes were collected and *** prognostic value of hypertension was determined using binary logistic *** Among the 232 patients included in the analysis,105(45.3%)patients had comorbid *** to the nonhypertension group,patients in the hypertension group had higher neutrophil-to-lymphocyte ratios,red cell distribution widths,lactate dehydrogenase,high-sensitivity C-reactive protein,D-dimer and severity of lung lesion,and lower lymphocyte counts(all Pdeaths[16(15.2%)vs.3(2.4%),Plity of survival(Pdependently correlated with all-cause in-hospital death in elderly patients with *** The elderly COVID-19 patients with hypertension tend to have worse conditions at baseline than those without *** may be an independent prognostic factor of poor clinical outcome in elderly COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 hypertension prognosis mortality risk factor

No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19

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World Journal of Clinical Cases 2020年第22期8卷 5576-5588页

作者： Jiang-Hua Zhou Bin Wu Wen-Xin wang Fang Lei Xu cheng juan-juan Qin Jing-Jing Cai xiao-Jing Zhang Feng Zhou Ye-Mao liu Hao-Miao li li-Hua zhu Zhi-Gang She Xin Zhang juan yang hong-liang li department of Cardiology Renmin Hospital of Wuhan UniversityBasic Medical SchoolWuhan UniversityWuhan 430071Hubei ProvinceChina Basic Medical School Institute of Model AnimalWuhan UniversityWuhan 430071Hubei ProvinceChina department of Cardiology the 3rd Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Medical Science Research Center Zhongnan Hospital of Wuhan UniversityInstitute of Model AnimalWuhan UniversityWuhan 430072Hubei ProvinceChina department of Cardiology Renmin Hospital of Wuhan UniversityInstitute of Model Animal of Wuhan UniversityWuhan 430071Hubei ProvinceChina Institute of Model Animal Wuhan UniversityDepartment of GastroenterologyWuhan Third HospitalTongren Hospital of Wuhan UniversityWuhan 430072Hubei ProvinceChina

BACKGROUND Dipeptidyl peptidase-4(DPP4)is commonly targeted to achieve glycemic control and has potent anti-inflammatory and immunoregulatory *** structural analyses indicated a potential tight interaction between DPP4 and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),raising a promising hypothesis that DPP4 inhibitor(DPP4i)drugs might be an optimal strategy for treating coronavirus disease 2019(COVID-19)among patients with ***,there has been no direct clinical evidence illuminating the associations between DPP4i use and COVID-19 *** To illuminate the associations between DPP4i usage and the adverse outcomes of *** We conducted a multicenter,retrospective analysis including 2563 patients with type 2 diabetes who were hospitalized due to COVID-19 at 16 hospitals in Hubei Province,*** excluding ineligible individuals,142 patients who received DPP4i drugs and 1115 patients who received non-DPP4i oral anti-diabetic drugs were included in the subsequent *** performed a strict propensity score matching(PSM)analysis where age,sex,comorbidities,number of oral hypoglycemic agents,heart rate,blood pressure,pulse oxygen saturation(SpO2)lin usage were ***,111 participants treated with DPP4i drugs were successfully matched to 333 non-DPP4i ***,a linear logistic model and mixed-effect Cox model were applied to analyze the associations between inhospital DPP4i use and adverse outcomes of *** After rigorous matching and further adjustments for imbalanced variables in the linear logistic model and Cox adjusted model,we found that there was no significant association between in-hospital DPP4i use(DPP4i group)and 28-d allcause mortality(adjusted hazard ratio=0.44,95%CI:0.09-2.11,P=0.31).likewise,the incidences and risks of secondary outcomes,including septic shock,acute respiratory distress synd

关键词： COVID-19 SARS-CoV-2 DPP4 inhibitors Diabetes Glucose control Adverse effects

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen wang Fan-lian Zeng Ya-wen Hu xiao-yan wang Fu-lei Zhao Pei Zhou Jing Hu Yuan-yuan xiao Zhong-lan Hu Ming-feng Guo xiao-qiong Wei xiao liu Nong-yu Huang Jun Zhang Shu-wen Chen juan cheng Hua-ping Zheng hong Zhou Qi-xiang Zhao Chen Zhang Yan Hao Song Zou Yi-yue Gui Jia-dong Yu lin-na Gu cheng-cheng Yue Hao-zhou Zhang Wen-ling Wu Yi-fan Zhou Xi-kun Zhou Guo-bo Shen Xiu Teng Jiong li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China department of liver Surgery&liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu Zhang Yue Huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-yang li Yan-Bing Xu xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng yang xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma xiao-Bo li Ping wang Xin-Ying Song li-Ming Song Shi-Jie Zheng Bing li hong-Mei Zhang Yue zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu hong Lu Bin meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei yang Xue-juan yang Shuang-nan Zhang Chao-Yue Zhang cheng-Mo Zhang Zhi-cheng Tang cheng cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 december *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi lian Wen-Zhen Kang Chun-Qiu Hao Jing wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-lin Miao Wen Kang Guoquan li Di Zhang Mingru Zhang Xiu-Xuan Sun likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin li Yanyan Jia lin-na liu Zhe Zhang Zhao-Wei Gao hong Du na Yao Qing wang Ke wang Jie-Jie Geng Bin wang Ting Guo Ruo Chen Yu-meng zhu li-juan wang Qian He Rui-Rui Yao Ying Shi Xiang-Min yang Jian-Sheng Zhou Yi-nan Ma Ya-Tao wang Xue liang Fei Huo Zhe wang yang Zhang Xu yang Ye Zhang Lu-Hua Gao ling wang xiao-Chun Chen Hao Tang Shuang-Shuang liu Qing-Yi wang Zhi-nan Chen Ping zhu national Translational Science Center for Molecular Medicine and department of Cell Biology Fourth Military Medical UniversityXi'anChina department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina department of Pathology Fourth Military Medical UniversityXi'anChina Jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

development of MRPC technology for STAR-TOF

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Nuclear Science and Techniques 2005年第4期16卷 231-237页

作者： SUN Yong-Jie li cheng SHAO Ming CHEN hong-Fang G. EPPLEY F.GEURTS H. HUANG HUANG Sheng-li W.J. liOPE T. NUSSBAUM RUAN li-juan J. SCHAMBACH wang xiao-lian WU Jian Z. XU department of Modern Physics University of Science and Technology of China Hefei 230026 China Rice University Bonner Nuclear Lab Houston TX 77005 USA University of California- Los Angeles Los Angeles CA90095 USA Brookhaven national Laboratory Upton New York 11973 USA University of Texas Austin TX 78712 USA）

A prototype of multi-gap resistive plate chamber (MRPC) modules with 6 gas gaps of 220 μm used for the time-of-flight (TOF) detectors has been developed by STAR TOF group. A tray (TOFr) composed of 28 MRPC modules was constructed and operated in STAR for the d+Au collisions and Au+Au collisions during 2003 RHIC and 2004 RHIC run. Results show its time resolution is 85 ps with the average efficiency of 95% and clear identification of K/π up to 1.6 GeV and proton/ K up to 3.0 GeV.

关键词： MRPC技术 STAR-TOF RHIC PID 气体电力探测技术

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan hong-Wei Fan Ming-Ming Zhang Yu Qiao xiao-Die liu Bao-juan li Ming-Hui wang Hai-Long Dong Hao-hong li Peng-cheng Huang Yun-Qing li Wu-Gang Hou Jin-lian li Tao Chen department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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