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生态砖护坡工程的应用—新县苏河镇黄坡佬填方边坡治理

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化工矿产地质 2024年第2期46卷 147-153页

作者：王凤波中化地质河南局集团有限公司河南郑州450003

由松散堆积物填方形成的边坡易发生边坡垮塌灾害,裸露堆积物与周边绿化环境的对比,亦凸显其对视觉景观的影响。结合新县苏河镇黄坡佬茶厂水泥路南侧填方边坡特征,通过多种护坡工程的对比选用铺设生态砖进行护坡工程。生态砖在护坡工程... 详细信息

由松散堆积物填方形成的边坡易发生边坡垮塌灾害,裸露堆积物与周边绿化环境的对比,亦凸显其对视觉景观的影响。结合新县苏河镇黄坡佬茶厂水泥路南侧填方边坡特征,通过多种护坡工程的对比选用铺设生态砖进行护坡工程。生态砖在护坡工程中兼有土壤固定、绿化美化的双重效果,通过工程实施可以有效地固土支撑边坡、增强边坡稳定性,同时也提供了良好的绿化效果。

关键词：生态砖填方边坡护坡绿化稳定性分析

沉默信息调节因子2相关酶1及相关信号网络在糖尿病中的作用

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包头医学院学报 2024年第5期40卷 90-96页

作者：蔡星王风波成都医学院第一附属医院康复医学科四川成都610500

糖尿病(diabetes mellitus,DM)是目前临床医学中最普遍的代谢性疾病之一,并且已经成为全球关注的公共卫生问题。沉默信息调节因子2相关酶1(silencing information regulator 2 related enzyme 1,SIRT1)是一种腺嘌呤二核苷酸依赖性去乙... 详细信息

糖尿病(diabetes mellitus,DM)是目前临床医学中最普遍的代谢性疾病之一,并且已经成为全球关注的公共卫生问题。沉默信息调节因子2相关酶1(silencing information regulator 2 related enzyme 1,SIRT1)是一种腺嘌呤二核苷酸依赖性去乙酰化酶,参与糖代谢和胰岛素的分泌过程,在DM的发病机制中扮演了重要角色。糖尿病主要是由于胰岛素分泌缺乏或者胰岛素抵抗导致的代谢紊乱综合征。SIRT1不仅在β细胞中通过p53、叉头盒转录因子O(forkhead box transcription factor class O,FoxO)、烟酰胺磷酸核糖转移酶(nicotinamide phosphoribose transferase,NAMPT)等相关靶点影响胰岛素分泌;还可以通过胰岛素受体、脂联素影响胰岛素敏感性从而干扰胰岛素抵抗。此外,SIRT1还可以通过抑制NF-κB信号通路,保护胰岛β细胞免受氧化应激和炎症细胞因子的刺激。同时,SIRT1通过促进线粒体的生物发生保证机体内所有细胞活动的供能,并避免脂质的积累。白色脂肪组织(white adipose tissue,WAT)、糖异生功能异常导致的糖尿病也受到SIRT1诸多影响。本文旨在探讨SIRT1与DM的关系及其中涉及的相关信号网络。

关键词：糖尿病沉默信息调节因子2相关酶1 信号网络

基于AHP与ArcGIS的某地区地质灾害易发性评价研究

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化工矿产地质 2024年第3期46卷 230-235页

作者：卓志荣王凤波中化地质河南局集团有限公司河南郑州450001

地质灾害易发性评价是针对区域地质灾害的易发程度进行的量化评价,根据评价结果因地制宜,指导区域地质灾害防治。本文以某地区为例,在地质环境现状基础上,采用AHP方法为评价因子赋予权重;采集评价区与地质灾害相关数据,为评价因子赋予权... 详细信息

地质灾害易发性评价是针对区域地质灾害的易发程度进行的量化评价,根据评价结果因地制宜,指导区域地质灾害防治。本文以某地区为例,在地质环境现状基础上,采用AHP方法为评价因子赋予权重;采集评价区与地质灾害相关数据,为评价因子赋予权值;运用ArcGIS系统构建地质灾害易发性评价数学模型,进行地质灾害易发性分区。评价结果表明与区域现状基本吻合,为当地规划建设和地质灾害防治提供科学依据和合理建议。

关键词：地质灾害评价因子易发性评价

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糖尿病脑病认知功能障碍机制研究进展

包头医学院学报 2024年第9期40卷 92-96页

作者：李昱升王风波成都医学院第一附属医院康复医学科四川成都610500

糖尿病脑病(diabetic encephalopathy, DE)是糖尿病常见的严重慢性并发症,可导致认知功能障碍和大脑神经结构改变,其发病机制可能与神经炎症、氧化应激、胰岛素抵抗等有关。目前,关于糖尿病脑病及认知功能障碍的治疗仍处于探索阶段。本... 详细信息

糖尿病脑病(diabetic encephalopathy, DE)是糖尿病常见的严重慢性并发症,可导致认知功能障碍和大脑神经结构改变,其发病机制可能与神经炎症、氧化应激、胰岛素抵抗等有关。目前,关于糖尿病脑病及认知功能障碍的治疗仍处于探索阶段。本文旨在对糖尿病脑病认知功能障碍的影像学表现、发病机制、治疗等方面进行综述。

关键词：糖尿病脑病认知障碍发病机制治疗

Steering and braking game control architecture based minimax robust stability control for emergency avoidance of autonomous vehicles

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Science China(Technological Sciences) 2022年第4期65卷 943-955页

作者： WU Jian WU DeXi YAN Yang ZHANG Ning BAO ChunJiang wang fengbo School of Mechanical and Automotive Engineering Liaocheng UniversityLiaocheng 252000China School of Mechanical Engineering Southeast UniversityNanjing 211189China

The existing electronic stability control(ESC)system does not consider the steering intention of an autonomous driving system(ADS)during autonomous driving emergency *** distributed control scheme between ESC and ADS does not involve any information interaction,and the balance between path tracking and lateral stability is not optimal.A Nash game control scheme of steering and braking system is proposed to ensure that both path tracking and stability are simultaneously in the loop and solve the conflict by simulating the interaction between the two agents considering the impact on the interaction between a path following and lateral *** agent considers its interests and the opponent’s interest,resulting in a global optimal control solution of steering control and ***,using minimax optimization theory,a lateral stability strategy is proposed to make the game control architecture under emergency avoidance more robust to uncertain lateral ***,simulation and hardware in the loop experiments show that the proposed scheme can consider both vehicle’s path following performance and lateral stability in the event of an emergency.

关键词： game framework emergency avoidance steering intention stability minimax theory

Vehicle Active Steering Control Research Based on Two-DOF Robust Internal Model Control

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Chinese Journal of Mechanical Engineering 2016年第4期29卷 739-746页

作者： WU Jian LIU Yahui wang fengbo BAO Chunjiang SUN Qun ZHAO Youqun School of Mechanical and Automotive Engineering Liaocheng University State Key Laboratory of Automotive Safety and Energy Tsinghua University College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics

Because of vehicle＇s external disturbances and model uncertainties,robust control algorithms have obtained popularity in vehicle stability *** robust control usually gives up performance in order to guarantee the robustness of the control algorithm,therefore an improved robust internal model control（IMC） algorithm blending model tracking and internal model control is put forward for active steering system in order to reach high performance of yaw rate tracking with certain *** proposed algorithm inherits the good model tracking ability of the IMC control and guarantees robustness to model *** order to separate the design process of model tracking from the robustness design process,the improved 2 degree of freedom（DOF） robust internal model controller structure is given from the standard Youla *** of double lane change maneuver and those of crosswind disturbances are conducted for evaluating the robust control algorithm,on the basis of a nonlinear vehicle simulation model with a magic tyre *** show that the established 2-DOF robust IMC method has better model tracking ability and a guaranteed level of robustness and robust performance,which can enhance the vehicle stability and handling,regardless of variations of the vehicle model parameters and the external crosswind *** between performance and robustness of active steering control algorithm is solved and higher control performance with certain robustness to model uncertainties is obtained.

关键词： active steering internal model control model tracking robust performance crosswind disturbances

长三角黏土地层轨道交通渣土资源化再利用关键技术研究

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科技资讯 2024年第18期22卷 124-126页

作者：袁丹娜张棚沈芳王凤波金肯职业技术学院江苏南京211156

结合目前国内轨道交通渣土资源化再利用的应用现状,对长三角黏土地层渣土资源化再利用关键技术及应用研究提出了解决思路,预计将优化长三角地区地铁渣土处理方式,为节约项目建设投资成本带来可观的经济效益。这一研究不仅对当前的轨道... 详细信息

结合目前国内轨道交通渣土资源化再利用的应用现状,对长三角黏土地层渣土资源化再利用关键技术及应用研究提出了解决思路,预计将优化长三角地区地铁渣土处理方式,为节约项目建设投资成本带来可观的经济效益。这一研究不仅对当前的轨道交通建设具有指导意义,对未来的城市发展和资源利用也具有重要的参考价值,同时可以为国内其他相关工程提供借鉴。

关键词：轨道交通黏土地层渣土资源化再利用高效脱水固化

维普期刊数据库博看期刊

Interconnected microstructure and flexural behavior of Ti_(2)C-Ti composites with superior Young’s modulus

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2088-2101页

作者： fengbo Sun Rui Zhang Fanchao Meng Shuai wang Lujun Huang Lin Geng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Waikato Centre for Advanced Materials and Manufacturing School of EngineeringUniversity of WaikatoHamilton 3240New Zealand State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001China

To enhance the Young’s modulus(E)and strength of titanium alloys,we designed titanium matrix composites with intercon-nected microstructure based on the Hashin-Shtrikman *** to the results,the in-situ reaction yielded an interconnected microstructure composed of Ti_(2)C particles when the Ti_(2)C content reached 50vol%.With widths of 10 and 230 nm,the intraparticle Ti lamellae in the prepared composite exhibited a bimodal size distribution due to precipitation and the unreacted Ti phase within the grown Ti_(2)C *** composites with interconnected microstructure attained superior properties,including E of 174.3 GPa and ultimate flexural strength of 1014 *** with that of pure Ti,the E of the composite was increased by 55% due to the high Ti_(2)C content and interconnected *** outstanding strength resulted from the strong interfacial bonding,load-bearing capacity of interconnected Ti_(2)C particles,and bimodal intraparticle Ti lamellae,which minimized the average crack driving *** flexural tests revealed preferential crack initiation along the{001}cleavage plane and grain boundary of Ti_(2)C in the region with the highest tensile *** addition,the propagation can be efficiently inhibited by interparticle Ti grains,which prevented the brittle fracture of the composites.

关键词： titanium matrix composites titanium carbide interface Young’s modulus flexural behavior

Expanding the horizons of targeted protein degradation:A non-small molecule perspective

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2402-2427页

作者： Xiaowei Huang fengbo Wu Jing Ye Lian wang Xiaoyun wang Xiang Li Gu He Department of Pharmacy and Department of Dermatology&Venerology West China HospitalSichuan UniversityChengdu 610041China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Dermatology Clinical Institute of Inflammation and ImmunologyFrontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond ***-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing *** we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.

关键词： Targeted protein degradation Proteolysis targeting chimera Endocytosis Autophagy Proximity-inducing modality Post-translational modification