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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi wang Huiling Deng Yuan Chen Yikai wang Yufeng Zhang Chenrui Liu Meng Zhang Ting Li Shuangsuo Dang Yaping Li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

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Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： Lina Deng Weiye Zhang Hanxuan Lin Lifen Xiang Ying Xu Yadi wang Qiang Li Yinyan Zhu Xiaodong Zhou Wenbin wang Lifeng Yin Hangwen Guo Chuanshan Tian Jian Shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum *** view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly *** far,the polarization state of light has rarely been reported as a control parameter for this ***,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static ***,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization *** transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic *** results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

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Hard-carbon hybrid Li-ion/metal anode enabled by preferred mesoporous uniform lithium growth mechanism

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Journal of Energy Chemistry 2024年第1期88卷 252-259,I0006页

作者： Fang Yan Yan Liu Yuan Li Yan wang Zicen Deng Meng Li Zhenwei Zhu Aohan Zhou Ting Li Jingyi Qiu Gaoping Cao Shaobo Huang Biyan wang Hao Zhang School of Chemistry and Biological Engineering University of Science and TechnologyBeijing 100083China Research Institute of Chemical Defense Beijing 100191China College of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023HenanChina National Base for International Science&Technology Cooperation School of ChemistryXiangtan UniversityXiangtan 411105HunanChina Materials and Manufacturing Department Beijing University of TechnologyBeijing 100124China

To achieve high energy density in lithium batteries,the construction of lithium-ion/metal hybrid anodes is a promising *** particular,because of the anisotropy of graphite,hybrid anode formed by graphite/Li metal has low transport kinetics and is easy to causes the growth of lithium dendrites and accumulation of dead Li,which seriously affects the cycle life of batteries and even causes safety ***,by comparing graphite with two types of hard carbon,it was found that hybrid anode formed by hard carbon and lithium metal,possessing more disordered mesoporous structure and lithophilic groups,presents better *** indicate that the mesoporous structure provides abundant active site and storage space for dead *** the synergistic effect of this structure and lithophilic functional groups(–COOH),the reversibility of hard carbon/lithium metal hybrid anode is maintained,promoting uniform deposition of lithium metal and alleviating formation of lithium *** hybrid anode maintains a 99.5%Coulombic efficiency(CE)after 260 cycles at a specific capacity of 500 m Ah/*** work provides new insights into the hybrid anodes formed by carbon-based materials and lithium metal with high specific energy and fast charging ability.

关键词： Hard carbon/Li metal hybrid anode Mesoporous structure Surface oxygen functional group Fast charging Lithium batteries

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Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong Wei Yibo wang Wen Ma Xiaoyu Zheng Jun wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully *** research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress *** In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental *** were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal *** Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ***,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and ***,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS *** was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the ***,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented *** analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling ***,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with ***

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin wang Qian Liu Hai-tao Yu Jia-zhao Xie Jun-ning Zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-Zhi wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

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Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue Xu Shurui Song Huiying wang Xilong Cao Xinran Zhao Wenli wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan Shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and ***,the industrial development of pear fruit is significantly limited by its short shelf *** acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf ***,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly *** this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide *** COL genes were divided into three subgroups according to the structural domains of the COL *** COL8,with two B-box motifs and one CCT domain,belonged to the first *** contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third *** four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit ***,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp ***,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its *** the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit *** contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit *** co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit *** re

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS

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A MOF/poly(thioctic acid)composite for enhanced gold extraction from water matrices

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Nano Research 2024年第1期17卷 382-389页

作者： Ruiqing Li Sen Yan Tianwei Xue rongxing Qiu Yin Li Wenli Hao Guangkuo Xu Yanliang wang Yanzhen Hong Yuzhong Su Hongtao wang Shuliang Yang Li Peng Jun Li College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China College of Energy Xiamen UniversityXiamen 361005China National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and EstersXiamen UniversityXiamen 361005China Collaborative Innovation Center of Chemistry for Energy Materials Xiamen UniversityXiamen 361005China

With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great *** of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains ***,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing ***-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the *** material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites.

关键词： metal-organic frameworks(MOFs) poly(thioctic acid)(pTA) polymer composites gold recovery urban mining

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RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium

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Journal of Genetics and Genomics 2024年第5期51卷 543-553页

作者： Ting Hu Lan Liu He wang Mei Yang Bocheng Xu Hanbing Xie Ziyuan Lin Xiaolei Jin Ping wang Yanyan Liu Huaqin Sun Shanling Liu Department of Medical Genetics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengduSichuan 610041China Medical College Tibet UniversityLhasaTibet 850000China SCU-CUHK Joint Laboratory for Reproductive Medicine West China Second University HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China

Noncompaction of the ventricular myocardium(NVM),the third most diagnosed cardiomyopathy,is characterized by prominent trabeculae and intratrabecular ***,the genetic etiology of 40%–60%of NVM cases remains ***,we identify two infants with NVM,in a nonconsanguineous family,with a typical clinical presentation of persistent bradycardia since the prenatal period.A homozygous missense variant(R223L)of RCAN family member 3(RCAN3)is detected in both infants using whole-exome *** the zebrafish model,marked cardiac dysfunction is detected in rcan3 deficiency(MO-rcan3^(ATG)-injected)and rcan^(−/−) *** dysplasia of both endocardial and myocardial layers is also detected in rcan3-deficient ***3 R223L variant mRNAs can not rescue heart defects caused by rcan3 knockdown or knockout;however,hRCAN3 mRNAs rescue these ***-seq experiments show that several genes involved in cardiomyopathies are significantly regulated through multiple signaling pathways in the rcan3-knockdown zebrafish *** human cardiomyocytes,RCAN3 deficiency results in reduced proliferation and increased apoptosis,together with an abnormal mitochondrial ***,we suggest that RCAN3 is a susceptibility gene for cardiomyopathies,especially NVM and that the R223L mutation is a potential loss-of-function variant.

关键词： Cardiomyopathy NVM RCAN3 Mitochondrial structure Heartdefects

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Comparative assessment of liver tissue:from microstructural and mesoscale vascular architecture to macroscopic mechanics

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Acta Mechanica Sinica 2024年第7期40卷 195-205页

作者： Wei Kang Kaixin Sun Lizhen wang Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of Engineering Medicine Beihang UniversityBeijing 100083China

Accurately characterizing the liver's mechanical properties is of paramount importance for disease diagnosis,treatment,surgical prosthetic modeling,and impact injury ***,due to its inherent biological soft tissue nature,the characterization of mechanical behavior varies across testing methods and sample *** this study,we employed transmission electron microscope and Micro CT to observe the morphology of the marginal and center of rat livers and conducted macroscopic mechanical tests to characterize their elasticity and *** results revealed that the central region displayed higher metabolic levels,elongated mitochondria,and an abundance of rough endoplasmic reticulum at the *** the mesoscale,larger diameter portal veins were mainly distributed in the central region,while smaller diameter arteries were predominantly located at the *** the macroscale,under a strain rate of 0.0167 s^(-1),no significant differences were observed in the elastic properties between the two ***,as the strain rate increased up to 0.167 s^(-1),the central region displayed higher porosity,resulting in reduced liquid loss,increased hardness,and higher viscosity compared to the ***,the liver demonstrated overall heterogeneity,with isotropic models suitable for the peripheral region,while more intricate models may be required to capture the complexity of the central region with its intricate vasculature.

关键词： Liver Mechanical properties Micro and macro tests

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PN/A工艺在热水解污泥消化液处理工程中的应用研究

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中国环境科学 2024年第7期44卷 3698-3706页

作者：王晓聪韩晓宇张树军李伟黄京焦佳童王倩王之敏曲之明北京排水集团有限责任公司北京市资源化工程技术研究中心北京100044

利用短程硝化厌氧氨氧化(PN/A)工艺在北京某污水处理厂成功启动了处理热水解污泥消化液的工程,调试运行结果表明:在接种生物膜填料数占总填料数18%和生物膜上厌氧氨氧化菌(AnAOB)占比为6.8%的情况下可快速启动PN/A系统,并在3个月内可以... 详细信息

利用短程硝化厌氧氨氧化(PN/A)工艺在北京某污水处理厂成功启动了处理热水解污泥消化液的工程,调试运行结果表明:在接种生物膜填料数占总填料数18%和生物膜上厌氧氨氧化菌(AnAOB)占比为6.8%的情况下可快速启动PN/A系统,并在3个月内可以达到设计处理水量,总氮去除负荷为0.26kg/(m^(3)·d),总氮去除率达到80%以上.通过定量PCR检测和高通量数据发现AOB和AnAOB丰度不同的空间分布特点,项目调试过程中氨氧化菌(ammonia oxidizing bacteria,AOB)和AnAOB均呈稳定增长的趋势,经过3个月启动培养后絮体中AOB丰度达到1011数量级,生物膜中的AnAOB达到1012数量级.实际运行数据证明该旁侧处理系统对水厂主流区产生积极影响,可降低日处理量为40×10^(4) t的污水厂2.9mg/L的进水总氮.另外,在该项目后期运行过程中出现反应池缺氧段和末端游离氨(free ammonia,FA)浓度不足的情况,导致短程硝化过程不稳定,通过控制反应池首端与末端FA浓度及剩余氨氮浓度,可实现对短程硝化过程的快速恢复.

关键词：污水处理厌氧氨氧化脱氮污泥消化液

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