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Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids:A case report

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4274-4280页

作者： Yong-Gang He Ling-Yu Zhang Jing Li Zheng wang chong-Yu Zhao Lu Zheng Xiao-Bing Huang Department of Hepatobiliary The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China School of Clinical Oncology Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Fujian Key Laboratory of Translational Cancer Medicine Fuzhou 350014Fujian ProvinceChina

BACKGROUND Patient-derived organoids(PDOs)have been demonstrated to predict the response to drugs in multiple cancer ***,it remains unclear about its application in *** SUMMARY A 59-year-old woman was admitted to the hospital due to upper abdominal pain for over 8 *** to relevant examinations,she was diagnosed as perihilar cholangiocarcinoma(pCCA)with intrahepatic metastasis and perihilar lymphatic *** multidisciplinary team discussion,percutaneous transhepatic cholangiodrainage was performed to relieve biliary obstruction,and puncture biopsy was conducted to confirm the pathological *** chemoembolization with nab-paclitaxel was used in combination with toripalimab and lenvatinib,but the levels of tumor markers including alpha fetal protein,carcinoembryonic antigen,carbohydrate antigen 15-3 and cancer antigen 125 were still *** PDO for drug screening showed sensitive to gemcitabine and ***,the chemotherapy regimen was adjusted to gemcitabine and cisplatin in combination with toripalimab and *** 4 cycles of treatment,the tumor was assessed resectable,and radical surgical resection was performed *** year after surgery,the patient was still alive,and no recurrence or *** PDOs for drug sensitivity contribute to screening effective chemotherapy drugs for advanced pCCA,promoting conversion therapy and improving the prognosis.

关键词： Patient-derived organoids Perihilar cholangiocarcinoma Conversion therapy Drug screening Intrahepatic metastasis Case report

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Wearable and interactive multicolored photochromic fiber display

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Light(Science & Applications) 2024年第3期13卷 454-465页

作者： Pan Li Yuwei wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu wang Xiaoling Lu Qian Ji Xinyuan Cai Li Liu chong Hou Ning Zhou Shaowu Pan Xiangru wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and Engineering and Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging(HUST) Ministry of EducationWuhan 430030China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Performing Arts Wuhan Conservatory of MusicWuhan 430060China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhan 430074China School of Fashion Beijing Institute of Fashion TechnologyBeijing 100029China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive ***,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight ***,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light *** designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the *** impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission *** addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single *** prepared fibers on mass-produced kilometer-long using the thermal drawing *** fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as *** work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration.

关键词： fiber interactive colored

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多点位监控视频分析在火灾过程重构中的应用

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消防科学与技术 2024年第2期43卷 231-236,243页

作者：王晓军苗新勇韩冲王鑫应急管理部天津消防研究所天津300381 工业与公共建筑火灾防控技术应急管理部重点实验室天津300381 天津市消防安全技术重点实验室天津300381 天津大学电气自动化与信息工程学院天津300072 北京市顺义区消防救援支队北京101399 天津大学微电子学院天津300072

以一起大型仓库火灾事故调查为例,介绍了多点位监控视频分析在火灾过程重构中的应用。通过点位初筛筛选出包含有效信息的视频,通过相对时间校准消除了各点位的时间误差,然后根据各点位视频画面综合分析确定了起火时间,根据各点位光影交... 详细信息

以一起大型仓库火灾事故调查为例,介绍了多点位监控视频分析在火灾过程重构中的应用。通过点位初筛筛选出包含有效信息的视频,通过相对时间校准消除了各点位的时间误差,然后根据各点位视频画面综合分析确定了起火时间,根据各点位光影交叉定位和相互印证,确定了起火部位和火势发展情况,从而重构了该起火灾的起火过程。在此基础上,分析了火灾调查工作中提取多点位监控视频的注意事项,总结了多点位监控视频分析中的一些原则和方法。

关键词：多点位视频分析起火时间起火部位火灾过程重构

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Super P and MoO_(2)/MoS_(2)co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin Liang Dong-Qing Zhao Qian-Qian Huang Sheng Liang Li-Li wang Lei Hu Ling-Li Liu Kun-Hong Hu chong-Hai Deng Sheng Cheng Er-Tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei UniversityHefei 230601China Instrumental Analysis Centre Hefei University of TechnologyHefei 230009China Hefei Youngy Energy Materials Co. Ltd.Hefei 230000China Department of Modern Mechanics University of Science and Technology of ChinaHefei 230026China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the"shuttle effect"has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO_(2)/MoS_(2)-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO_(2)/MoS_(2)-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·g^(-1).When used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： MoO_(2)/MoS_(2) Nanofiber Membrane Li-S battery

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Healthy life expectancy with cardiovascular disease among Chinese rural population based on the prospective cohort study

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Journal of Geriatric Cardiology 2024年第8期21卷 799-806页

作者： Feng JIANG Xiao-Tian LIU Ze HU Wei LIAO Shuo-Yi LI Rui-Fang ZHU Zhen-Xing MAO Jian HOU Sohail Akhtar Fayaz Ahmad Tahir Mehmood chong-Jian wang Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Mathematics and Statistics The University of HaripurHaripurPakistan School of Natural Sciences National University of Sciences and TechnologyIslamabadPakistan

BACKGROUND Limited research has explored the impact of cardiovascular disease(CVD)on healthy life expectancy(HLE)especially in resource-limited *** study aimed to investigate the association between CVD and HLE in Chinese rural *** This study included 11,994 participants aged 45 years and older from the baseline and follow-up surveys of the Henan rural cohort *** status was measured via a Visual Analogue *** multistate Markov model was applied to estimate the association between CVD and transitions in health,unhealthiness and ***-specific total life expectancy,HLE and unhealthy life expectancy were calculated by the multistate life table *** During a mean follow-up time of 3.85(3.84–3.86)years,there were 588 deaths *** individuals with CVD,the risk of switching from health to unhealthiness status was increased by 71%[hazard ratio(HR)=1.71,95%CI:1.42–2.07],the chance of recovery was reduced by 30%(HR=0.70,95%CI:0.60–0.82).Men aged 45 years without CVD could gain an extra 7.08(4.15–10.01)years of HLE and lose 4.00(1.60–6.40)years of unhealthy life expectancy compared to their peers with CVD,*** corresponding estimates among women were 8.62(5.55–11.68)years and 5.82(2.59–9.04)years,*** This study indicated that CVD was significantly associated with poorer health status and lower HLE among Chinese rural *** is an important public health policy to adopt targeted measures to reduce the CVD burden and enhance the quality of life and HLE in resource-limited areas.

关键词： Healthy cardiovascular life

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PSO-DF:基于高光谱的水稻叶片氮含量估测方法

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遥感技术与应用 2024年第2期39卷 280-289页

作者：车淼王海荣徐玺孙崇北方民族大学计算机科学与工程学院宁夏银川750021 国家民委图像图形智能处理重点实验室宁夏银川750021

水稻叶片氮含量的估测对实现田间施肥高效、水稻高产的目标具有重要意义。提出了一种基于粒子群深度森林的水稻叶片氮素估测方法(Particle Swarm Optimization-Deep Forest,PSODF),通过粒子群优化算法筛选深度森林模型(Deep Forest,DF)... 详细信息

水稻叶片氮含量的估测对实现田间施肥高效、水稻高产的目标具有重要意义。提出了一种基于粒子群深度森林的水稻叶片氮素估测方法(Particle Swarm Optimization-Deep Forest,PSODF),通过粒子群优化算法筛选深度森林模型(Deep Forest,DF)参数中最优的级联层估计器数量和估计器中的树数,从而提高深度森林模型在水稻氮素数据集上的回归精度。为验证PSO-DF的有效性,研究采用无人机搭载高光谱图像采集器获取宁夏粳稻高光谱图像,并对同期水稻叶片进行取样、测量、分析,并提取与水稻叶片氮含量相关系数最高的3个特征波段,将其作为光谱特征与水稻氮含量数据进行反演,对PSO-DF、原模型DF以及其他6种常见机器学习算法构建的水稻氮含量估测模型进行了对比。结果表明:PSO-DF算法构建的模型效果优于其他模型,其R2和RMSE指标均明显优于其他模型。

关键词：水稻氮素估测高光谱遥感粒子群优化的深度森林机器学习

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AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung chong Carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang Ruoyu Zhou Xiaoshu Zhou Fengling wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

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Electrical stress and acid orange 7 synergistically clear the blockage of electron flow in the methanogenesis of low-strength wastewater

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Environmental Science and Ecotechnology 2024年第4期20卷 291-299页

作者： Ze-chong Guo Min-Hua Cui Chun-Xue Yang Hong-Liang Dai Tong-Yi Yang Lin-Zhi Zhai Yong Chen Wen-Zong Liu Ai-Jie wang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Jiangsu Key Laboratory of Anaerobic Biotechnology Jiangnan UniversityWuxi214122China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen518055China School of Geography and Tourism Harbin UniversityHarbin150001China School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Energy recovery from low-strength wastewater through anaerobic methanogenesis is constrained by limited substrate *** development of efficient methanogenic communities is critical but *** we develop a strategy to acclimate methanogenic communities using conductive carrier(CC),electrical stress(ES),and Acid Orange 7(AO7)in a modified *** synergistic integration of CC,ES,and AO7 precipitated a remarkable 72-fold surge in methane production rate compared to the *** increase was attributed to an altered methanogenic community function,independent of the continuous presence of AO7 and ***7 acted as an external electron acceptor,accelerating acetogenesis from fermentation intermediates,restructuring the bacterial community,and enriching electroactive bacteria(EAB).Meanwhile,CC and ES orchestrated the assembly of the archaeal community and promoted electrotrophic methanogens,enhancing acetotrophic methanogenesis electron flow via a mechanism distinct from direct electrochemical *** collective application of CC,ES,and AO7 effectively mitigated electron flow impediments in low-strength wastewater methanogenesis,achieving an additional 34%electron recovery from the *** study proposes a new method of amending anaerobic digestion systems with conductive materials to advance wastewater treatment,sustainability,and energy self-sufficiency.

关键词： Methanogenesis Conductive carrier Electrical stress Acid orange 7 Electron transfer

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畜禽疾病防控的机体“三道”健康管理策略

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家畜生态学报 2024年第2期45卷 87-90页

作者：王冲陕西省白水县动物疫病预防控制中心陕西白水715600

现代养殖是基于现代装备工艺等生产要素构建的现代生产系统。疾病防控的核心是畜禽机体“消化道、呼吸道、生殖道”的“三道”系统健康管理。作为畜禽机体最大免疫器官的肠道健康管理,其重点是关注肠道营养免疫、霉菌毒素损害和肠道菌... 详细信息

现代养殖是基于现代装备工艺等生产要素构建的现代生产系统。疾病防控的核心是畜禽机体“消化道、呼吸道、生殖道”的“三道”系统健康管理。作为畜禽机体最大免疫器官的肠道健康管理,其重点是关注肠道营养免疫、霉菌毒素损害和肠道菌群平衡三方面;作为畜禽“防御门户”的呼吸道健康管理,必须在养殖大环境、小环境的安全风险管理和强化呼吸道粘膜免疫系统功能两方面获得突破;而生产中被称之为畜禽病毒菌感染“潜伏和传播之库”的生殖道健康管理,重心是基于精细化的保护性举措,须在消除病毒病菌“混感平台”的负效应和特定病毒的优化免疫上下功夫。实施全方位、全链条、多视角的畜禽“三道”健康精准管理,既是现实养殖生产管理的倒逼机制,更是现代养殖高质量健康发展的前提条件。

关键词：畜禽养殖消化道呼吸道生殖道健康管理

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Clinical Study of Tuina for Stiff Neck

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Journal of Acupuncture and Tuina Science 2009年第4期7卷 225-227页

作者：吴耀持张峻峰汪崇淼王健雄张沈煜 No.6 People’s Hospital Affiliated to Shanghai Jiaotong University

Objective： To observe the chmcal ettect ot luma tor stag necK. Methods： au oi 216 cases with stiff neck were randomly allocated into a tuina group （110 cases） and a control group （106 cases）. The patients in the tuina group were treated with ＂Three Parts, Four Points, Five Manipulation＂ tuina therapy, while those in the control group were treated with pucturing Wailaogong （Ex-UE 8）, Houxi （SI 3）, Jianjing （GB 21） and Ashi points in the affected side, Once a day, and 3 times constitute one treatment course. The effect was observed after 2-course treatments. Result： The effective rate in the tuina group and the control group was 93.64% and 83.02%, respectively, and there was statistical difference between the two groups （P 〈 0.05）. Conclusion： The tuina therapy of ＂Three Parts, Four Points, Five Manipulations＂ is better than simple acupuncture therapy in treating stiff neck.

关键词： Stiff Neck Neck Pain Tuina Massage Acupuncture Therapy

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