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经腹壁人工网片无张力双侧顶端悬吊盆底重建术的疗效分析

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实用医学杂志 2024年第12期40卷 1683-1689,1695页

作者：李娜王朕华牛倩倩陈贵芹罗穗豫董黎河南省人民医院妇科郑州大学人民医院河南大学人民医院郑州450003

目的观察经腹壁人工网片无张力双侧顶端悬吊盆底重建术的临床疗效。方法选取2021年3月1日至2023年10月31日在河南省人民医院因盆腔脏器脱垂行经腹壁人工网片无张力双侧顶端悬吊盆底重建术的患者作为观察组,共85例,同期行腹腔镜下骶骨固... 详细信息

目的观察经腹壁人工网片无张力双侧顶端悬吊盆底重建术的临床疗效。方法选取2021年3月1日至2023年10月31日在河南省人民医院因盆腔脏器脱垂行经腹壁人工网片无张力双侧顶端悬吊盆底重建术的患者作为观察组,共85例,同期行腹腔镜下骶骨固定术后的患者40例作为对照组,并分为保留子宫组、切除子宫组两个亚组。随访至2024年4月30日,分析其手术情况和术后并发症,并采用盆腔器官脱垂定量分期法(POP-Q)、盆底功能障碍性疾病症状问卷及其分量表(PFDI-20)、排尿困扰量表(UDI-6)、结直肠肛门困扰量表(CRADI-8)和盆腔器官脱垂困扰量表(POPDI-6)、盆底疾病生活质量影响问卷短表(PFIQ-7),盆腔器官脱垂/尿失禁性生活问卷(PISQ-12)对患者术前、术后治疗效果和生活质量进行组内及组间比较。结果观察组患者中位随访时间13.13个月,客观治愈率96.47%,再次手术率1.18%,围手术期并发症发生率为6.45%(切除子宫)、4.35%(保留子宫),网片暴露率1.61%(切除子宫)。对照组患者中位随访时间13.76个月,客观治愈率92.5%,再次手术率2.5%,围手术期并发症发生率为14.71%(切除子宫)、33.33%(保留子宫),网片暴露率8.82%(切除子宫)。观察组与对照组相比,客观治愈率、再次手术率无差异,观察组的手术时间短、出血少、术后排气快、住院时间短、围手术期并发症发生率低、网片暴露率低,尤其是保留子宫的患者,优势更明显。观察组和对照组患者组内比较时,术后1年与术前POP-Q的各指示点均明显改善(P0.05)。结论经腹壁人工网片无张力双侧顶端悬吊盆底重建术是治疗前、中盆腔脱垂的一种有效手术方案,可明显改善患者脱垂症状,提高患者生活质量,与骶骨固定术有相似的临床效果,尤其适用于保留子宫的患者。

关键词：前、中盆腔器官脱垂经腹壁人工网片无张力双侧顶端悬吊盆底重建术腹腔镜下骶骨固定术临床疗效

Glycerol monolaurate attenuated immunological stress and intestinal mucosal injury by regulating the gut microbiota and activating AMPK/ Nrf2 signaling pathway in lipopolysaccharide-challenged broilers

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Animal Nutrition 2022年第3期10卷 347-359页

作者： Linglian Kong zhenhua wang Chuanpi Xiao Qidong Zhu Zhigang Song Department of Animal Science and Technology Shandong Agricultural UniversityTai'anShandong 271018China Center for Mitochondria and Healthy Ageing College of Life SciencesYantai UniversityYantaiShandong 264005China Precision Livestock and Nutrition Unit Gembloux Agro-Bio TechUniversity of LiegeGembloux 5030Belgium

This study was conducted to investigate the effects of glycerol monolaurate(GML)on lipopolysaccharide(LPS)-induced immunological stress and intestinal mucosal injury in broilers and its underlying mechanisms.A total of 144 one-d-old Arbor Acres broilers were allocated to a 22 factorial arrangement involving dietary treatment(0 or 1,200 mg/kg dietary GML)and LPS challenge(injected with saline or Escherichia coli LPS on d 16,18,and 20).Samples were collected on d *** results revealed that dietary GML augmented serum immunoglobulin A(P=0.009)and immunoglobulin G(P<0.001)levels in challenged *** GML normalized LPS-induced variations in serum interleukin-6,interferongamma,and LPS levels(P<0.05),jejunal villus height(P=0.030),and gene expression of interleukin-6,macrophage inflammatory protein-3 alpha,Toll-like receptor 4,nuclear factor kappa-B,caspase-1,tight junction proteins,adenosine monophosphate-activated protein kinase alpha 1(AMPKa1),nuclear factorerythroid 2-related factor 2(Nrf2),and superoxide dismutase-1(P<0.05).GML supplementation ameliorated LPS-induced peroxidation by reducing malondialdehyde content and increasing antioxidant enzyme activity(P<0.05).Dietary GML enhanced the abundances of Anaerostipes,Pseudoflavonifractor,and Gordonibacter and reduced the proportion of Phascolarctobacterium in challenged *** GML was positively correlated with alterations in antioxidant enzyme activities and AMPKa1,Nrf2,and zonula occludens-1 *** genera Anaerostipes,Lachnospira,Gordonibacter,Lachnospira,Marvinbryantia,Peptococcus,and Pseudoflavonifractor were linked to attenuated inflammation and improved antioxidant capacity of challenged *** conclusion,dietary GML alleviated LPS-induced immunological stress and intestinal injury of broilers by suppressing inflammation and oxidative *** GML regulated cecal microbiota and activated the AMPK/Nrf2 pathway in LPS-challenged broilers.

关键词： Glycerol monolaurate Lipopolysaccharide challenge Inflammation Antioxidation Gut microbiota Adenosine monophosphate-activated protein kinase

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利用健康因子的卫星电池容量估计方法

飞控与探测 2024年第1期7卷 85-92页

作者：赵振雯王振华任家栋哈尔滨工业大学航天学院哈尔滨150001 银河航天(北京)通信技术有限公司北京100192

卫星在轨工作期间,准确估计电池容量对提高电源系统的安全性与可靠性有重要意义。为此,针对电池在工作过程中实际容量难以直接测量的问题,提出一种利用间接健康因子估计电池容量的方法。首先,从锂电池恒压充电模式下的电流数据中提取平... 详细信息

卫星在轨工作期间,准确估计电池容量对提高电源系统的安全性与可靠性有重要意义。为此,针对电池在工作过程中实际容量难以直接测量的问题,提出一种利用间接健康因子估计电池容量的方法。首先,从锂电池恒压充电模式下的电流数据中提取平均充电电流,将其作为反映电池容量变化的特征参数。在实现了锂电池健康状态表征的基础上,对比分析容量和平均充电电流随着充放电循环周期的变化曲线。然后,讨论了容量和平均充电电流之间的相关性,进而建立了容量估计模型。最后,通过从NASA锂电池数据集中提取容量和平均充电电流,划分训练集和测试集,验证了用该方法估计容量的有效性和准确性。

关键词：卫星锂电池容量估计间接健康因子平均充电电流相关性分析

基于主动防御的网络安全风险隐患监控预警系统设计

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铁路计算机应用 2024年第5期33卷 63-67页

作者：郝利荣王红伟王震华徐亮中国铁道科学研究院集团有限公司电子计算技术研究所北京100081 中国铁路西安局集团有限公司科技和信息化部西安710054

针对网络安全管理及监测手段整体协调的工作机制研究还处于起步阶段,网络安全管理的工作梳理、监测手段、检测工具等方面缺少体系化、标准化、流程化的管理措施和主动防御的能力。为此,开发全方位立体闭环的网络安全风险隐患监控预警系... 详细信息

针对网络安全管理及监测手段整体协调的工作机制研究还处于起步阶段,网络安全管理的工作梳理、监测手段、检测工具等方面缺少体系化、标准化、流程化的管理措施和主动防御的能力。为此,开发全方位立体闭环的网络安全风险隐患监控预警系统。该系统已在多个铁路局集团公司试点运行,能够通过上下协调联动机制,及时发现并解决铁路网络安全存在的问题,从而有效保障铁路基础设施安全平稳运行。

关键词：网络安全漏洞隐患动态预警基线核查主动防御

基于下丘脑-垂体-肾上腺轴构建首发精神分裂症患者真性高泌乳素血症的预测模型

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现代实用医学 2024年第4期36卷 443-446页

作者：王斓王振华费小聪雷礼磊湖州市第三人民医院浙江省湖州313000

目的探讨下丘脑-垂体-肾上腺(HPA)轴对首发精神分裂症患者真性高泌乳素血症(THPRL)的影响,并构建预测模型。方法本研究为前瞻性研究。选取2021年6月至2023年6月湖州市第三人民医院收治的首发精神分裂症伴HPRL患者102例,抽取空腹外周血检... 详细信息

目的探讨下丘脑-垂体-肾上腺(HPA)轴对首发精神分裂症患者真性高泌乳素血症(THPRL)的影响,并构建预测模型。方法本研究为前瞻性研究。选取2021年6月至2023年6月湖州市第三人民医院收治的首发精神分裂症伴HPRL患者102例,抽取空腹外周血检测HPA轴激素水平[泌乳素(PRL)、肾上腺皮质激素(ACTH)、皮质醇(Cor)]。采用聚乙二醇沉淀法进行巨泌乳素(MPRL)筛查,以回收率>60%作为THPRL的判断标准,将患者分为THPRL组和非THPRL组,比较两组的HPA轴激素水平及一般资料,Logistic回归分析影响THPRL的危险因素,并构建THPRL列线图预测模型,进行模型评价。结果THPRL组的女性患者闭经比例、使用典型抗精神疾病药物比例、溢乳比例及血清ACTH、Cor水平高于非THPRL组,辅助应用维生素B6比例低于非THPRL组(均P0.05)。结论溢乳,使用典型抗精神疾病药物,女性患者闭经及血清ACTH、Cor水平升高为首发精神分裂症患者THPRL的独立危险因素,基于此构建的列线图预测模型对THPRL的发生具有较高的预测效能。

关键词：精神分裂症高泌乳素血症下丘脑-垂体-肾上腺轴列线图

Nanoscale transition metal catalysts anchored on perovskite oxide enabling enhanced kinetics of lithium polysulfide redox in lithium-sulfur batteries

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能源化学:英文版 2023年第6期81卷 432-442,I0010页

作者： Wenshuo Hou Ruilong Li zhenhua wang Li Fang Zhe Bai Tan wang Yu Bai Kening Sun Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

To obtain high-performance lithium-sulfur(Li-S)batteries,it is necessary to rationally design electrocatalytic materials that can promote efficient sulfur electrochemical ***,the robust heterostructured material of nanoscale transition metal anchored on perovskite oxide was designed for efficient catalytic kinetics of the oxidation and reduction reactions of lithium polysulphide(Li PSs),and verified by density functional theory(DFT)calculations and experimental *** to the strong interaction of nanoscale transition metals with Li PSs through chemical coupling,heterostructured materials(STO@M)(M=Fe,Ni,Cu)exhibit excellent catalytic activity for redox reactions of Li *** bifunctional heterostructure material STO@Fe exhibits good rate performance and cycling stability as the cathode host,realizing a high-performance Li-S battery that can maintain stable cycling under rapid charge-discharge *** study presents a novel approach to designing electrocatalytic materials for redox reactions of Li PSs,which promotes the development of fast charge-discharge Li-S batteries.

关键词： Nanoscale transition metal Lithium polysulfide Catalytic activity Redox reaction Lithium-sulfur battery

Multimaterial Embedded 3D Printing of Composite Reinforced Soft Actuators

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Research 2023年第4期2023卷 727-737页

作者： zhenhua wang Boyu Zhang Qu He Hao Chen Jizhe wang Yuan Yao Nanjia Zhou Weicheng Cui Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhouZhejiang ProvinceChina Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhouZhejiang ProvinceChina Research Center for Industries of the Future and Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang ProvinceSchool of EngineeringWestlake UniversityHangzhouZhejiang ProvinceChina

Soft pneumatic actuators(SPAs)have attracted enormous attention in the growing field of *** different SPAs,composite reinforced actuators(CRAs)are widely used because of their simple structure and high ***,multistep molding,a time-consuming method,is still the predominant fabrication ***,we propose a multimaterial embedded printing method(ME3P)to fabricate *** comparison with other 3-dimensional printing methods,our method improves fabrication flexibility *** the design and fabrication of the reinforced composites’patterns and different geometries of the soft body,we demonstrate actuators with programmable responses(elongation,contraction,twisting,bending,and helical and omnidirectional bending).Finite element analysis is employed for the prediction of pneumatic responses and the inverse design of actuators based on specific actuation ***,we use tube-crawling robots as a model system to demonstrate our ability to fabricate complex soft robots for practical *** work demonstrates the versatility of ME3P for the future manufacturing of CRA-based soft robots.

关键词： composites composite printing

Enhancing anchoring and catalytic conversion of polysulfides by nitrogen deficient cobalt nitride for advanced lithium-sulfur batteries

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Journal of Energy Chemistry 2022年第10期31卷 407-415,I0010页

作者： Min Luo Yu Bai Rui Sun Meixiu Qu Mengyuan wang Zhanfeng Yang zhenhua wang wang Sun Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory for Chemical Power Source and Green Catalysis School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

While lithium-sulfur(Li-S)battery has attracted remarkable attention owing to the high theoretical capacity,its practical application is still hindered by the shuttle and sluggish conversion kinetics of intermediate lithium polysulfides(Li PSs).Defect engineering,which can regulate the electronic structure and in turn influence the surface adsorption and catalytic capability,has been regarded as a feasible strategy to deal with the above ***,few studies on nitrogen vacancies and their mechanisms are ***,cobalt nitride with nitrogen vacancies grown on multi-walled carbon nanotube(CNTCo N-VN)is designed and applied as the separator modification material to investigate the enhancing mechanism of nitrogen vacancies on Li-S *** experimental evidence and theoretical calculation indicate that the introduction of nitrogen vacancies into cobalt nitride can enhance the chemical affinity to Li PSs and effectively hamper the shuttle *** the reduced band gap of the d-band center of Co and p-band center of N for CNT-Co N-VNand the promoted diffusion of Li^(+) can expedite the solid-liquid and liquid-liquid conversions of sulfur *** to these superiorities,the cell with CNT-Co NVNmodified separator delivers a favorable initial capacity of 901 m Ah g^(-1)and a capacity of 660 m Ah g^(-1)can be achieved after 250 cycles at 2 *** work explores the application of metal nitride with nitrogen vacancies and sheds light on the development of functional separators for high-efficient Li-S batteries.

关键词： Cobalt nitride Nitrogen vacancy Redox kinetics Separators Li-S batteries

立体脑电图电极置入在药物难治性局灶性癫痫术前评估中的应用价值

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中华神经外科杂志 2024年第2期40卷 137-142页

作者：郭效东路小奇刘明辉王振华许鹏杨新超郝文明娄云霄李经纶王本瀚解放军联勤保障部队第988医院全军神经外科中心郑州450042

目的探讨立体脑电图(SEEG)电极置入在药物难治性局灶性癫痫术前评估中的应用价值.方法回顾性分析2018年1月至2022年12月解放军联勤保障部队第988医院全军神经外科中心应用少量SEEG电极置入技术评估24例药物难治性局灶性癫痫患者的临... 详细信息

目的探讨立体脑电图(SEEG)电极置入在药物难治性局灶性癫痫术前评估中的应用价值.方法回顾性分析2018年1月至2022年12月解放军联勤保障部队第988医院全军神经外科中心应用少量SEEG电极置入技术评估24例药物难治性局灶性癫痫患者的临床资料,通过发作症状,发作期及发作间期视频脑电图,头颅CT、MRI、正电子发射断层显像(PET)-CT等影像学资料,依据解剖-电生理-临床表现,提出癫痫发作起源和扩散路径的核心及备用假设;将电极置入癫痫网络的相关靶点,SEEG监测判断癫痫起源区;通过皮质电刺激(ECS)诱发惯常发作验证致痫区、定位功能区后行射频热凝(RFTC)毁损治疗,仍有癫痫发作者行二期开颅手术切除致痫灶;采用Engel分级评估癫痫的控制效果.结果 24例患者共置入126根电极,每例置入(5.3±1.1)根(3~8根).单侧电极置入6例,双侧电极置入18例.24例患者的实际靶点与计划靶点误差为(1.61±0.88)mm.无一例患者补充置入电极.SEEG监测时间为(10.1±2.6)d,均捕捉到3~20次惯常发作.ECS诱发出惯常发作15例,非惯常发作5例,未诱发出发作4例.明确致痫区23例,其中颞叶、额叶各10例,枕叶3例;未能定位1例.行RFTC治疗22例,毁损后出现头痛9例、严重脑水肿致对侧上肢无力1例,无症状硬膜下血肿1例,均无颅内感染、脑脊液漏、电极折断移位等并发症发生.未行RFTC治疗2例,其中1例未能验证假设,1例致痫区与运动语言区重叠,调整抗癫痫发作药物后均好转.24例患者均获得临床随访,随访时间[M(Q1,Q3)]为12.5(10.2,26.8)个月,末次随访显示,22例行RFTC治疗的患者中,Engel分级Ⅰ级1例;Engel分级Ⅱ级21例,其中16例行二期手术切除致痫区,切除术后癫痫发作消失13例(Engel分级Ⅰ级),无改善3例(Engel分级Ⅱ级),5例拟行二次电极置入RFTC治疗.结论合理掌握适应证,采用少量SEEG电极置入可帮助判断致痫区部位,指导手术切除致痫区,且术后效果好,在药物难治性局灶性癫痫术前评估中有一定的应用价值.

关键词：耐药性癫痫致痫区立体脑电图射频热凝毁损皮质电刺激