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肥胖相关肾病的发病机制及营养治疗进展

临床和实验医学杂志 2024年第14期23卷 1567-1568,F0003页

作者：王雨王宇霞李程洪忠新首都医科大学附属北京友谊医院临床营养科北京100050

我国成年居民肥胖患病率呈上升趋势,肥胖与肾脏病的发生、发展密切相关。其发病机制可能与肥胖引起肾小球高滤过、肾素-血管紧张素-醛固酮系统过度激活、机体慢性炎症、高胰岛素血症和胰岛素抵抗、异位脂质积累和脂毒性等相关。营养治疗... 详细信息

我国成年居民肥胖患病率呈上升趋势,肥胖与肾脏病的发生、发展密切相关。其发病机制可能与肥胖引起肾小球高滤过、肾素-血管紧张素-醛固酮系统过度激活、机体慢性炎症、高胰岛素血症和胰岛素抵抗、异位脂质积累和脂毒性等相关。营养治疗,包括营养素摄入、食物的选择以及膳食方案的制定,是肥胖相关肾病治疗的基石及重要组成部分,除此之外还有药物及减重手术等治疗方式。

关键词：肥胖相关肾病减重营养治疗

Self-Trapped Exciton Photoluminescence from Polycrystalline K2AgI3 Obtained by Solid-State Reaction Method

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Chinese Physics Letters 2011年第1期28卷 201-204页

作者： DAI Peng XU Zou-Ming wang yu-xia Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 School of Physics and Material Science Anhui University Hefei 230039

Polycrystalline K2AgI3 is synthesized by solid-state reaction at 403K using AgI and KI as starting materials. X-ray diffraction, photoluminescence （PL） spectra, photoluminescenee excitation （PLE,） spectra, electron para- magnetic resonance （EPR） and absorption spectra are employed to investigate the structure and photo-physical properties of such material. A broad luminescence band centered at about 608nm at 180K with large Stokes shift is found. When the temperature rises to about 300K, an obvious PL blue-shift, PL intersity weakening, and an emission band broadening are observed. It is suggested that the emission at about 608 nm may originate from the recombination of self-trapped exeitons.

关键词： Condensed matter: electrical magnetic and optical Surfaces interfaces and thin films

Effects of Vegetation Cover and Rainfall Intensity on Sediment-Bound Nutrient Loss,Size Composition and Volume Fractal Dimension of Sediment Particles

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Pedosphere 2011年第5期21卷 676-684页

作者： ZHANG Guan-Hua LIU Guo-Bin wang Guo-Liang wang yu-xia College of Resource and Environment Northwest A&F University Yangling 712100 (China) Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water Resources Yangling 712100 (China)

Vegetation and rainfall are two important factors affecting soil erosion and thus resulting in nutrient loss in the Chinese Loess Plateau.A field experiment was conducted to investigate the effects of rainfall intensities(60,100 and 140 mm h-1) and vegetation(Caragana korshinskii) coverages(0%,30% and 80%) on soil loss,nutrient loss,and the composition and volume fractal dimension of eroded sediment particles under simulated rainfall *** results showed that vegetation cover,rainfall intensity and their interaction all had significant effects on sediment transport and the sedimentbound nutrient *** rainfall intensity and lower coverage led to higher sediment and nutrient *** linear relationships were observed between soil loss and nutrient *** treatments showed more significant effects on the enrichment ratio(ER) of nitrogen(ERN) than organic matter(EROM) and phosphorus(ERP).Compared with the original surface soil,the eroded sediment contained more fine *** the same coverage,the clay content significantly decreased with increasing rainfall *** ER of sediment-bound nutrients was positively correlated with that of clay,suggesting that the clay fraction was preferentially eroded and soil nutrients were mainly adsorbed onto or contained within this *** were increments in the fractal dimension of the sediment particles compared to that of the original surface ***,the fractal dimension was positively correlated with clay,silt,and sediment-bound OM,N,and P contents,whereas it was negatively correlated with sand *** study demonstrated that fractal dimension analysis can be used to characterize differences in particle-size distribution and nutrient loss associated with soil erosion.

关键词： fractal features Loess Plateau particle-size distribution runoff nutrients simulated rainfall

种肥混播对夏玉米产量、酶活性和土壤微生物的影响

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中国土壤与肥料 2024年第6期 149-156页

作者：李子双高玮李洪杰周晓琳王学霞杜梦扬陈延华王玉霞倪小会王薇邹国元曹兵德州市农业科学研究院山东德州253015 北京市农林科学院植物营养与资源环境研究所北京100097 河北农业大学资源与环境科学学院河北保定071001 北京市缓控释肥料工程技术研究中心北京100097

探索夏玉米种子与控释肥混播对夏玉米产量、氮磷钾养分吸收、施肥经济效益、酶活性及土壤微生物的影响,为夏玉米轻简化生产和化肥减施增效提供技术支撑。以夏玉米品种‘郑单958’为材料进行了大田试验,试验设不施氮对照、常规施肥、种... 详细信息

探索夏玉米种子与控释肥混播对夏玉米产量、氮磷钾养分吸收、施肥经济效益、酶活性及土壤微生物的影响,为夏玉米轻简化生产和化肥减施增效提供技术支撑。以夏玉米品种‘郑单958’为材料进行了大田试验,试验设不施氮对照、常规施肥、种子控释肥混播和氮磷钾减量50%控释肥种子混播共4个处理,分析调查了夏玉米产量、氮磷钾吸收、叶片酶活性及根际土壤微生物功能基因。与常规施肥相比,2个控释肥处理的夏玉米产量增加7.7%~22.1%,夏玉米氮、磷、钾吸收量分别增加0.75%~33.3%、16.3%~27.1%、4.78%~36.5%,氮肥吸收利用率提高20.7%~24.6%,氮肥偏生产力提高14~74.1 kg/kg,氮肥农学利用率提高14.1~20.2 kg/kg,夏玉米每公顷净收益(扣除肥料投入)比常规施肥增加9.67%~19.6%。吐丝期根际土壤硝化和反硝化微生物基因数、叶片硝酸还原酶、谷氨酰胺合成酶、谷氨酸合成酶和谷氨酸脱氢酶与常规施肥没有显著差异。种肥混播在夏玉米上实现了增产增收,提高了氮磷钾养分吸收量和氮肥利用效率,降低了环境污染风险。

关键词：夏玉米控释肥氮肥利用效率酶活性微生物功能基因

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Highly Selective Preparation of 3-and 6-Modified Mannose/Altrose Derivatives

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Chemical Research in Chinese Universities 2006年第3期22卷 339-342页

作者： LIU xiao-hong XIE Dang CHENG Chang-mei wang xia-yu GUO xiao-qiang ZHAO yu-fen Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology of Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P.R. China Institute of Polymer Science and Engineering Xiangtan University Xiangtan 411105 P.R. China

A highly efficient method to get 3-and 6-modified mannose/ahrose derivatives for oligosaccharide synthesis is described. All the compounds were obtained exclusively with the combinations of 3-and/or 6-hydroxyl protect... 详细信息

关键词： Mannose Altrose Selective protection Selective deprotection

A hybrid physics-informed data-driven neural network for CO_(2) storage in depleted shale reservoirs

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Petroleum Science 2024年第1期21卷 286-301页

作者： Yan-Wei wang Zhen-Xue Dai Gui-Sheng wang Li Chen yu-Zhou xia yu-Hao Zhou College of Construction Engineering Jilin UniversityChangchun130026JilinChina Institute of Intelligent Simulation and Early Warning for Subsurface Environment Jilin UniversityChangchun130026JilinChina School of Energy Resources China University of GeosciencesBeijing100083China Department of Safety Environmental Protection and Quality ManagementShengli OilfieldSinopecDongying257000ShandongChina Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiChina College of Computer Science and Technology China University of Petroleum(East China)Qingdao266580ShandongChina Department of Physics University of FribourgFribourg1700Switzerland

To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport ***,most current CO_(2) sequestration models do not adequately consider multiple transport ***,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and *** this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training *** this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and *** incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion ***,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated *** validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise *** study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.

关键词： Deep learning Physics-informed data-driven neural network Depleted shale reservoirs CO_(2)storage Transport mechanisms

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西藏胡黄连乙酸乙酯部位的化学成分的研究

广州化工 2024年第4期52卷 70-72页

作者：朱仝飞闫志慧王玉霞李萍重庆医药高等专科学校重庆401331 重庆市药物制剂工程技术研究中心重庆401331

对西藏胡黄连Picrorhiza scrophulariiflora干燥根茎进行化学成分研究。采用反复硅胶柱色谱、制备薄层色谱及羟丙基葡聚糖凝胶柱色谱等方法进行分离纯化,运用有机谱学方法鉴定化合物的结构。从西藏胡黄连的95%乙醇回流提取物的乙酸乙酯... 详细信息

对西藏胡黄连Picrorhiza scrophulariiflora干燥根茎进行化学成分研究。采用反复硅胶柱色谱、制备薄层色谱及羟丙基葡聚糖凝胶柱色谱等方法进行分离纯化,运用有机谱学方法鉴定化合物的结构。从西藏胡黄连的95%乙醇回流提取物的乙酸乙酯萃取部位中分离得到6个化合物,分别为儿茶素(1)、木犀草素(2)、山奈酚(3)、槲皮素(4)、芸香苷(5)、金丝桃苷(6)。其中化合物3~6为首次从胡黄连属植物中分离得到。

关键词：西藏胡黄连黄酮化学成分

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie wang yu xia Qing-lei GAO Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor *** intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor *** evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse *** cytokines possess multifaced functions in the anti-tumor immune ***,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor *** manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these *** also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

Reliability analysis of carbon fiber rod-reinforced umbilical cable under tension using an improved sampling method

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Petroleum Science 2024年第4期21卷 2769-2778页

作者： yu Zhang Hong-yu Zhang Ran xia Si-Ao Jiang Fang wang College of Safety and Ocean Engineering China University of Petroleum China Academy of Aerospace Aerodynamics China Aerospace Science and Technology Group College of Engineering Science and Technology Shanghai Ocean University

The umbilical cable is a vital component of subsea production systems that provide power, chemical agents, control signals et al., and its requirement for reliability is exceedingly high. However, as the umbilical cable is a composite structure comprising multiple functional units, the reliability analysis of such cables involves numerous parameters that can impact calculation efficiency. In this paper, the reliability analysis of a new kind of umbilical cable with carbon fiber rod under tension is analyzed. The global dynamic analytical model is first established to determine the maximum tension load, then the local analytical model of umbilical cable including each unit are constructed by finite element method(FEM). Based on the mechanical analytical model, the reliability of umbilical cable under tension load is studied using response surface method(RSM) and Monte Carlo method. During the calculation process, a new tangent plane sampling method to calculate the response surface function(RSF) is proposed in this paper, which could make sampling points faster come close to the RSF curve, and it is proved that the calculation efficiency increases about 33% comparing with traditional method.

关键词： Umbilical cable Carbon fiber rod Failure analysis Response surface method Reliability