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Effect of dietary supplementation on improvement of growth and immune function of broilers

Engineering Sciences 2014年第1期12卷 10-16页

作者： Chen Liancheng Zeng Wei Li Yu wang yongqiang Mirigen Biotechnology Co. Ltd. Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi Jilin Agricultural University

The purpose of this investigation was to evaluate the effect of a dietary supplement （Mirigen TM）, a fungal cell wall derivative product, as a new generation alternative to antibiotics, on the growth and the innate and adaptive immune functions in broilers from birth to 45 d of age. Newborn chicken were randomly assigned to one of three groups： G 1 （n=150） controls no supplement fed; G2 （n=150） is fed with dietary supplement at a designed regular dose （0.5 %, weight of additive to food）; G3 （n= 150） is fed with dietary supplement at double doses （1%）. All three groups were housed in the same conditions. Body weight and blood were taken on day 1, 14, 28 and 45. Medications used and costs/treatment were recorded for each group. The whole blood was used to purify heterophils for reactive oxygen species （ROS） generation and E coli killing abilities examination assays, and the serum samples were preserved in freezer for enzyme linked immunosorbent assays （ELISAs） to determine concentration of macrophage inflammatory protein-1β （MIP-1β）, CD4/CD8, interferon-y （IFN-y）, and titers of antibody against Newcastle disease virus （NDV）. Group differences were analyzed using analysis of variance （ANOVA） algorithm （S-Plus）. There was no significant birth weight difference in three groups. After 45 d growth, the dietary supplement treated groups had significantly higher body weight gain （BWG） with lower mortality rate if compared to the untreated control group （P〈0.05）. Their BWG and mortality rate were 2.23 kg and 10 % in GI （control group）, 2.89 kg and 2 % in G2 （experimental group, 0.5 % dose）, and 2.77 kg and 1% in G3 （experimental group, 1% dose）, respectively. Heterophil ROS generation in treated groups were markedly improved through the addition of dietary supplement in both regular and double doses to the diet （P〈 0.05）. The ability of heterophil to kill E coli was also significantly improved in dietary supplement treated groups （P〈0.01）. Comparing to control group, there w

关键词： broilers growth health immunity dietary supplement

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Meta-Analysis on Efficacy of Vaccination against Staphylococcus aureus and Escherichia coli

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Veterinary Science Research 2020年第1期2卷 35-41页

作者： Ziyang Fu Haikun Liu Hong Cao yongqiang wang Key Laboratory of Animal Epidemiology of the Ministry of Agriculture China College of Veterinary Medicine China Agricultural UniversityBeijing100193China

Mastitis is a common disease responsible for the biggest economic loss in the dairy *** therapy does not provide long-term *** residue is a major concern in food *** is an alternative control method with great potential for bovine *** study focus on evaluating vaccine efficacy regarding reducing the incidence of clinical and subclinical ***-analysis was used to pool data extracted from previous studies.26 records from 13 studies were examined.A fixed effect model was constructed assigning incidence as the measurement of the *** ratio(RR)was the parameter that measured the incidence differences between treated group and control *** and records were categorised based on vaccine *** vaccine against Staphylococcus aureus,RR was 0.76;95%CI(0.65,0.89),while in vaccine against Escherichia coli RR was 0.96;95%CI(0.86,1.08).

关键词： Bovine mastitis Vaccination Meta-analysis

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“戏剧·表演·城市化”——2019年世界戏剧研究联盟大会综述

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戏剧艺术 2019年第5期 153-160页

作者：王咏蔷上海戏剧学院研究生部

2019届世界戏剧研究联盟大会在上海举行,由上海戏剧学院主办。这是世界戏剧研究联盟自成立以来首次与中国的艺术院校合作,在中国举行年会;这也是该大会在亚洲举办的第二次会议。这次大会的主题是"戏剧、表演与城市化"。这次大会共收到稿... 详细信息

2019届世界戏剧研究联盟大会在上海举行,由上海戏剧学院主办。这是世界戏剧研究联盟自成立以来首次与中国的艺术院校合作,在中国举行年会;这也是该大会在亚洲举办的第二次会议。这次大会的主题是"戏剧、表演与城市化"。这次大会共收到稿件600余篇,注册参会564人。会议围绕"戏剧、表演和城市化"这一主题分为主题演讲、小组活动、常规座谈、新学者论坛和新学者工作坊几个部分。

关键词：世界戏剧研究联盟大会戏剧与都市化跨文化戏剧

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Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains

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Engineering 2022年第8期8卷 24-33页

作者： Yingbo Shen Fupin Hu yongqiang wang Dandan Yin Lu Yang Yiqiang Chen Chunyan Xu Jiyun Li Junyao Jiang Xueyang wang Yulin Fu Dongyan Shao Dejun Liu Tengfei Ma Chang Cai Zhangqi Shen Shaolin wang Juan Li Rong Zhang Yuebin Ke Congming Wu Jianzhong Shen Timothy R.Walsh Yang wang Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Antibiotics&Key Laboratory of Clinical Pharmacology of Antibiotics(MoH) Huashan HospitalFudan UniversityShanghai 200040China Department of Preventive Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology College of Veterinary MedicineZhejiang A and F UniversityHangzhou 311300China State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention(CDC)Beijing 102206China The Second Affiliated Hospital of Zhejiang University Zhejiang UniversityHangzhou 310009China Key Laboratory of Genetics&Molecular Medicine of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055China Department of Zoology University of OxfordOxford OX13SZUK

Although carbapenem use is prohibited in animals in China,carbapenem-resistant Escherichia coli(CREC),especially New Delhi metallo-β-lactamase(NDM)-producing strains,are widely prevalent in foodproducing *** present,the impact of livestock-associated CREC strains on human populations at the national level is ***,we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 22 Chinese provinces or municipalities and analyze anthropogenic factors associated with their *** also ascertain the blaNDMand blaKPCabundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human ***,631/29799(2.1%)clinical Escherichia coli(***)isolates were identified as *** analysis revealed that being male,an age below 1,an age between 13 and 18,provinces with greater chicken production,and provinces with higher pig production were associated with higher odds of CREC *** general,73.8%(n=45/61)of pig farms and 62.2%(n=28/45)of chicken farms had a blaNDMabundance of 1×10^(-5)to 1×10^(-3)and 1×10^(-3)to 1×10^(-2),*** all the Chinese NDM-positive ***(n=463)available at the National Center for Biotechnology Information(NCBI),the genomic analysis revealed that blaNDM-5and Inc X3 were the predominant carbapenemase gene-plasmid combination,while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome *** the findings suggest frequent CREC transmission between humans and animals,indicating that further discussions on the use of antibiotics in animals and humans are needed,both in China and across the globe.

关键词： Carbapenem resistance Escherichia coli blaNDM-5 One Health Antimicrobial resistance transmission

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Research on Influence of Exterior Components of Truck on the Rainproof

Research on Influence of Exterior Components of Truck on the...

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2020中国汽车工程学会年会暨展览会

作者： Chen Ying wang yongqiang Yuan Weiping FAW Jiefang Automotive Co.Ltd. College of Automotive Engineering Jilin University

This research focuses on solving the outer rear-view mirror rain problem and soiling problem of *** the road test and the CFD for truck external flow field,the rain and soiling distribution and mechanism is *** structure optimization and road test on rainy days,the improvement project of exterior components is *** results show that the road test and CFD for truck external flow field can simulate rain and soiling and provide optimization advice to designers;and the number,length increase of the front decorative plate spoiler blade,the inlet area and outlet area size and proportion increase of the front decorative plate spoiler and the headlamp spoiler,clearance reduction between wheel well and tyre can decrease the rain attached to the outer rear-view mirror and greatly improve cleanliness on body of the *** results of this paper have important reference value for the research and development and modelling design of exterior components of truck body.

关键词： truck layout point CFD and road test exterior components rain and muddy water

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社会化服务、技术认知与农户节水灌溉技术采纳行为——基于河北省775份小麦—玉米种植户调查数据的实证分析

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干旱区资源与环境 2023年第5期37卷 76-83页

作者：王永强王哲河北农业大学经济管理学院保定071000

社会化服务组织具有农业技术信息渠道和农业技术供给主体的双重身份。文中分析社会化服务对农户节水灌溉技术采纳行为的影响,探究农户节水灌溉技术认知在二者之间是否发挥中介作用,进一步揭示不同灌溉井深区农户之间的差异,并利用河北省... 详细信息

社会化服务组织具有农业技术信息渠道和农业技术供给主体的双重身份。文中分析社会化服务对农户节水灌溉技术采纳行为的影响,探究农户节水灌溉技术认知在二者之间是否发挥中介作用,进一步揭示不同灌溉井深区农户之间的差异,并利用河北省775份小麦-玉米种植户调查数据进行实证检验。研究结果表明:社会化服务组织作为一种新型农业技术信息获取渠道和可靠的技术供给主体可以提高农户技术认知,显著促进了农户采纳节水灌溉技术,并对深井区农户的节水灌溉技术采纳行为促进作用更为明显。因此,建议将社会化服务组织作为推广大田作物节水灌溉技术的重要载体,提高农户节水灌溉技术认知,促进农户采纳节水灌溉技术。

关键词：社会化服务技术认知节水灌溉技术采纳

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Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng Yanyi Jiang Hengxing Chen yongqiang wang Qiusheng Lan Shuiqin Chen Zhanwang Huang Jingyuan Zhang Duanqing Tian Yuntan Qiu Diankui Cai Jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AJUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AJUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AJUBA through the KRAS *** of both EHF and its coactivator AJUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

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包容审慎监管视角下平台经济竞争失序的法治应对

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法学评论 2024年第2期42卷 77-87页

作者：王永强中南财经政法大学法学院

平台经济的竞争失序主要表现为初级程度的滥用平台内优势地位、中级程度的妨碍平台间互联互通、高级程度的超级平台扼杀式并购三种典型样态。包容审慎监管在促进我国平台经济快速发展方面功不可没。以产业主管机构为主导的监管存在重产... 详细信息

平台经济的竞争失序主要表现为初级程度的滥用平台内优势地位、中级程度的妨碍平台间互联互通、高级程度的超级平台扼杀式并购三种典型样态。包容审慎监管在促进我国平台经济快速发展方面功不可没。以产业主管机构为主导的监管存在重产业规制、轻竞争法治的遗缺,导致我国监管应对平台竞争失序不力的窘境。针对平台经济的监管亟待改革,应当回归竞争法治路径,对包容性监管与审慎性监管予以平衡,促进反垄断与反不正当竞争监管的良好衔接与兼容。在具体法治对策上,一要协调《反不正当竞争法》修订与《反垄断法》规则的衔接关系,精准规制滥用平台内优势地位的行为;二要引入平台竞争秩序监管的“位阶规则”,审慎规制妨碍平台间互联互通的行为;三要健全经营者集中分类分级审查制度,有效规制超级平台扼杀式并购。

关键词：平台经济包容审慎监管竞争失序反垄断法反不正当竞争法

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2022-2023年中昆仑山北坡不同海拔气象要素梯度对比分析

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高原气象 2025年第1期44卷 224-239页

作者：徐月月何清毛东雷付光祥李晶晶王永强张乾新疆师范大学地理科学与旅游学院/新疆干旱区湖泊环境与资源重点实验室新疆乌鲁木齐830054 中国气象局乌鲁木齐沙漠气象研究所新疆塔克拉玛干沙漠气象国家野外科学观测研究站中国气象局塔克拉玛干沙漠气象野外科学试验基地新疆沙漠气象与沙尘暴重点实验室新疆乌鲁木齐830002 新疆维吾尔自治区和田地区民丰县气象局新疆民丰848599

中昆仑山北坡既包含绿洲、荒漠及其过渡带等不同下垫面,又囊括沙漠和高原气候,由北向南生态环境差异大,气候变化多端,然而由于山地地区自然环境恶劣,气象台站较少且分布不均,给该地区气象要素的研究带来了一定挑战,致使对该区域气象要... 详细信息

中昆仑山北坡既包含绿洲、荒漠及其过渡带等不同下垫面,又囊括沙漠和高原气候,由北向南生态环境差异大,气候变化多端,然而由于山地地区自然环境恶劣,气象台站较少且分布不均,给该地区气象要素的研究带来了一定挑战,致使对该区域气象要素的掌握尚不全面,因此开展关于中昆仑山北坡气象要素的研究十分有必要。本文利用中昆仑山北坡9个不同海拔气象台站连续一年(2022年8月至2023年7月)的气象要素数据,探究该山区1.5 m高度处近地面气象要素随海拔梯度的时空变化特征。结果表明:(1)不同海拔风向变化显著,风速随海拔升高而增大,海拔1738~3044 m的站点受山谷风影响,存在两个主导风向且风速日变化呈“双峰型”;(2)中昆仑山北坡的气温垂直递减率(Temperature lapse rate,以下简称TLR)均低于标准大气气温直减率,平均气温垂直递减率TLR_(mean)、最高气温垂直递减率TLR_(max)和最低气温垂直递减率TLRmin分别为-0.56℃·(100m)^(-1)、-0.60℃·(100m)^(-1)和-0.47℃·(100m)^(-1),季节性特征表现为夏季陡,冬季浅;(3)不同海拔存在多个逆温层和逆湿层,逆温和逆湿强度的季节差异较大,表现为夏季逆温强度最小,逆湿强度较大,冬季逆温强度最大,逆湿强度最小,最强逆温和逆湿均出现在海拔1256~1409 m;(4)夏季典型天气下晴天的逆温逆湿均大于阴雨天,晴天最大逆温强度是阴雨天的4.32倍,晴天比湿变化范围大于阴雨天,逆湿强度是阴雨天的1.11倍;(5)中昆仑山北坡4-9月占全年总降水的86%以上,随海拔升高降水梯度变化明显,表现为“增多-减少-增多”的趋势,在2800~3200 m存在一个明显降水带。

关键词：气温垂直递减率温湿廓线降水梯度海拔梯度中昆仑山北坡

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基于Friis的GIS局放信号与放电量定量计算研究

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高压电器 2019年第3期55卷 21-28页

作者：王永强张斌华北电力大学河北省输变电设备安全防御重点实验室河北保定071003 国网山西省电力公司检修分公司太原030032

迄今为止由于国内外学者对于特高频法监测GIS局部放电的放电信号与放电量的关联关系没有达成一致,导致特高频法监测GIS局部放电视在放电量的标定缺乏统一标准,进而难以判断GIS局部放电的严重程度,严重制约了特高频监测GIS局部放电的发... 详细信息

迄今为止由于国内外学者对于特高频法监测GIS局部放电的放电信号与放电量的关联关系没有达成一致,导致特高频法监测GIS局部放电视在放电量的标定缺乏统一标准,进而难以判断GIS局部放电的严重程度,严重制约了特高频监测GIS局部放电的发展。鉴于此,文中提出一种利用Friis传输方程对GIS局部放电定量计算的方法,该方法将局部放电源作为发射天线模型化处理,并引入Friis传输方程,将计算等效为天线传输过程,应用HFSS仿真得到的四阶Moore分形天线作为接收天线模型,并结合天线收发相关理论,得出GIS局部放电的视在放电量与特高频信号能量与信号电压峰值之间存在关联关系。通过GIS局部放电试验拟合验证,实测结果表明局部放电视在放电量与天线接收特高频信号的能量呈二次曲线关系和信号峰值电压呈一次函数关系。

关键词：局部放电 Moore分形天线 Friis传输方程放电信号能量峰值电压

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