检索结果-南通市图书馆

Direct Synthesis and Realization of Symmetric Waveguide Filters

在线全文

学校读者我要写书评

暂无评论

Direct Synthesis and Realization of Symmetric Waveguide Filt...

2005'全国微波毫米波会议

作者： Shihu Han,xiliang wang,Yong Fan School of Electronic,University pf Electronic Science and Technology of China.

＜正＞Direct synthesis of waveguide filters of symmetric generalized chebyshev for fast realization is *** function of generalized chebyshev filters is constructed by recursive *** matrix（even-or odd-mode） of symmetric circuits is accurately computed according to formulas for given topology.A four-cavity waveguide filter is presented to demonstrate the feasibility of the design approach.

关键词： Symmetric Generalized Chebyshev waveguide filters Filter Synthesis

在线全文

cnki会议

学校读者我要写书评

暂无评论

相依结构、动态系统性风险测度与后验分析

统计研究 2018年第3期35卷 3-13页

作者：王锦阳刘锡良杜在超西南财经大学中国金融研究中心西南财经大学经济与管理研究院

本文利用Copula相依结构理论扩展和求解了现有的系统性风险测度Co VaR,以得到适用于不同类型常参数和时变参数Copula函数及不同分布假设的动态系统性风险测度。为了验证和评估模型设定的准确性与应用价值,本文构建了适用于该动态系统性... 详细信息

本文利用Copula相依结构理论扩展和求解了现有的系统性风险测度Co VaR,以得到适用于不同类型常参数和时变参数Copula函数及不同分布假设的动态系统性风险测度。为了验证和评估模型设定的准确性与应用价值,本文构建了适用于该动态系统性风险测度Co VaR的严谨后验分析工具。除"无条件覆盖性"、"独立性"和"条件覆盖性"外,本文首次提出了"混合独立性"检验。基于我国14家上市商业银行的实证分析表明:我国上市商业银行与我国银行业之间的相依结构呈现多样化特征;无论是样本内还是样本外预测区间,本文的动态Copula-Co VaR模型能够有效地捕捉典型系统性风险事件;严谨的后验分析不仅需要检验系统性风险测度Co VaR,也需要检验条件事件的临界值VaR。

关键词：相依结构条件在险价值CoVaR 系统性风险后验分析

Long non-coding RNA RP11J20.1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis

在线全文

学校读者我要写书评

暂无评论

Long non-coding RNA RP11J20.1 predicts a poor prognosis and ...

第十一届全国免疫学学术大会

作者： Penghui Yang Sijie Cheng Chengcai Lai Jin Yan Peirui Zhang Shaogeng Zhang xiliang wang Beijing 302 Hospital Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and Biosecurity

Hepatocellular carcinoma(HCC) is a leading cause of cancer mortality worldwide. Despite progress in the diagnosis and treatment of HCC, its prognosis still remains unfavorable. In accumulating studies, long non-coding RNAs(lncRNAs) are emerging as vital players in tumorigenesis and cancer progression. However, the molecular mechanisms and clinical significance of lncRNAs in HCC remain largely elusive. In this study, we analyzed lncRNA microarray expressionprofiles of tumor samples and its matched adjacent tissue samples from 10 HCC patients and found that the expression of RP11J20.1 in HCC tissues is makedly lower than adjacent tissues. Expression of RP11J20.1 was also remarkably downregulated in 112 HCC tissues and cell lines by qRT-PCR. Low RP11J20.1 expression was correlated with alphafetoprotein(AFP) level, tumor size and microvascular invasion. Kaplan-Meier survival analysis demonstrated that low RP11J20.1 expression predicts poor prognosis of HCC patients. Gain-of-function and loss-of-function experiments showed that RP11J20.1 promotes HCC cells proliferation, cell cycle progression, and inhibits HCC cells apoptosis. Further experiments revealed that RP11J20.1 promotes HCC cells proliferation through inhibiting STAT1 genes expression. Collectively, our results demonstrated the clinical prognostic significance and roles of RP11J20.1 in HCC, and suggested that RP11J20.1 may be considered as a prognostic biomarker and therapeutic target for HCC.

关键词： lncRNA hepatocellular carcinoma RP11J20 1 qRT-PCR

从染指渗透到聚积强势——以九一八事变前中国东北的日本人流为中心

在线全文

cnki会议

学校读者我要写书评

暂无评论

史学月刊 2015年第6期 77-86页

作者：李淑娟王希亮哈尔滨师范大学社会与历史学院黑龙江省社会科学院历史所研究员黑龙江哈尔滨150003

日俄战争后,日本攫取了满铁经营权及关东州租借权,伴随着日本资本殖民经营东北,大批日本人流相率涌进东北,在日本当局统一组织的商业会议所及居留民会的指挥下,凭借不平等条约赋予的各种特权,在经济、政治、文化等领域践行日本的大陆扩... 详细信息

日俄战争后,日本攫取了满铁经营权及关东州租借权,伴随着日本资本殖民经营东北,大批日本人流相率涌进东北,在日本当局统一组织的商业会议所及居留民会的指挥下,凭借不平等条约赋予的各种特权,在经济、政治、文化等领域践行日本的大陆扩张政策,成为构建日本人强势社会的基础因子。

关键词：中国东北日本人流日本商业会议所日本人居留民团

A live attenuated influenza virus carrying human adenovirus hexon epitopes elicits protective immunity in mice

在线全文

学校读者我要写书评

暂无评论

A live attenuated influenza virus carrying human adenovirus ...

第十一届全国免疫学学术大会

作者： Gu Hongjing Duan Yueqiang Zhao Zhongpeng Xing Li Lai Chengcai wang Keyu Yang Xiaolan Yang Penghui wang xiliang Beijing Institute of Microbiology and epidemiology Beijing 302 Hospitial

Objective: Human adenovirus(HAdVs) are known to cause a broad spectrum of disease in pediatric and adults patients. To date, there is no specific therapy for HAdv infection. Vaccination is one of the most effective methods of preventing infection by adenovirus and the server outcomes thereof. We focus on novel HAd V vaccine ***: We designed a cold-adapted(ca), live attenuated HAdv termed r FLU/HAdv ca containing neuraminidase(NA) genes with two nineteen congenerous hexon protein epitopes, hemagglutinin(HA) from a 2009 pandemic A H1N1 isolate, A/Beijing/501/2009 virus(BJ501), and the remaining six internal gene segments from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus(AA virus). Next, the r FLU/HAdv ca virus were rescued by reverse genetic technology, identified by western blot and electron microscopy, and evaluated using Balb/c ***: r FLU/HAdv ca virus were observed that spherical structure and diameter size in 80–120 nm. And r FLU/HAdv ca exhibited phenotypes of temperature sensitivity(ts),ca,and attenuation(att). The candidate r FLU/HAdv ca was immunogenic in mice and induced strong mucosal secretory IgA(s IgA) in the respiratory tract. Thress dosages of intranasal immunization induced robust HI antibodies and offered efficient protection against challenge by HAd V BJ809 and HAd V BJ1026 in Balb/c ***: recombinant r FLU/HAd V ca warrants further investigation as a promising HAd V candidate vaccine and underscored that the immuno-protection should be confirmed in primate models.

关键词： Human adenovirus Live attenuated influenza virus Reverse Genetic technology

在线全文

cnki会议

学校读者我要写书评

暂无评论

公共气象服务文档自动化研究与应用

中低纬山地气象 2018年第3期42卷 95-98页

作者：王锡良四川省阿坝州气象局四川马尔康624000

为了提高公共气象服务工作效率,减轻工作人员的劳动强度,比较了几种Office文档自动化技术的优劣。利用*** ***、*** ***不依赖于Microsoft Office软件就能生成、修改、转换和打印Word和Excel文档的特性,采用C#语言,结合公共气象服务工... 详细信息

为了提高公共气象服务工作效率,减轻工作人员的劳动强度,比较了几种Office文档自动化技术的优劣。利用*** ***、*** ***不依赖于Microsoft Office软件就能生成、修改、转换和打印Word和Excel文档的特性,采用C#语言,结合公共气象服务工作中的实际需求,自动、快速地处理和生成具有Microsoft Office软件格式的文档服务产品。

关键词：公共气象服务文档自动化 Aspose.Words Aspose.Cells

在线全文

学校读者我要写书评

暂无评论

男性不育的分子和遗传诊断的现状与挑战

中华检验医学杂志 2015年第8期38卷 511-513页

作者：刘政王喜良邱广斌解放军第二〇二医院检验科沈阳110003

遗传因素是引起男性不育的重要原因之一，约占病例总数的30％，开展分子和遗传检测对男性不育的诊断和治疗具有重要意义。目前临床开展的男性不育分子和遗传检测技术主要包括染色体分析、Y染色体微缺失检测、基因突变筛查以及精子质量... 详细信息

遗传因素是引起男性不育的重要原因之一，约占病例总数的30％，开展分子和遗传检测对男性不育的诊断和治疗具有重要意义。目前临床开展的男性不育分子和遗传检测技术主要包括染色体分析、Y染色体微缺失检测、基因突变筛查以及精子质量和功能的相关检查，本文就目前相关技术的临床应用及面临的挑战作一评析。

关键词：不育男(雄)性分子诊断技术染色体缺失遗传学技术

Basic fibroblast growth factor(FGF2) plays a crucial role in influenza A virus-induced acute lung injury through neutrophil recruitment

在线全文

学校读者我要写书评

暂无评论

Basic fibroblast growth factor(FGF2) plays a crucial role in...

中国生物工程学会第二届青年科技论坛暨首届青年工作委员会学术年会

作者：杨鹏辉 Keyu wang Chengcai Lai Shaogeng Zhang Hongjing Gu Yueqiang Duan Xiaolan Yang Li Xing xiliang wang State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and Epidemiology 中国人民解放军第三〇二医院

Influenza virus(IFV) infection is a major cause of severe respiratory illness that affects almost every country in the world. IFV infections result in respiratory illness and even acute lung injury and death, but the underlying mechanisms responsible for IFV pathogenesis remain to be fully elucidated. In this study, we found that the basic fibroblast growth factor2(FGF2) level was markedly increased in H1N1 virus-infected humans and mice. FGF2, which is predominately derived from epithelial cells, recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFκB signaling pathway. FGF2 depletion or knockout exacerbated influenza-associated disease by impairing neutrophil recruitment and activation. More importantly, administration of recombinant FGF2 protein significantly alleviated the severity of IFV-induced lung injury and promoted the survival of IFV-infected animals that was mediated by the recruited neutrophils. These findings demonstrate that FGF2 plays a critical role in preventing IFV-induced lung injury and suggest FGF2 as a promising potential therapeutic target during IFV infection.

关键词： H1N1 FGF2 neutrophils NFκB signaling therapy

应用AnnexinV-FITC/PI-FCM定量分析对5-FU诱导卵巢癌细胞系凋亡的研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国实用妇科与产科杂志 2000年第6期16卷 357-358页

作者：胡煜李巨王喜良中国人民解放军沈阳军区202医院妇产科沈阳110003

目的　应用AnnexinV -FITC/PI -FCM定量分析 5 -氟尿嘧啶 (5 -FU)诱导卵巢癌细胞系OVCAR发生的凋亡。方法　将 5 -FU以 0、2 0mg/L、10 0mg/L、2 0 0mg/L的浓度 ,分别处理OVCAR细胞 12、2 4、48小时 ,然后用形态学观察、DNA琼脂糖电泳和... 详细信息

目的　应用AnnexinV -FITC/PI -FCM定量分析 5 -氟尿嘧啶 (5 -FU)诱导卵巢癌细胞系OVCAR发生的凋亡。方法　将 5 -FU以 0、2 0mg/L、10 0mg/L、2 0 0mg/L的浓度 ,分别处理OVCAR细胞 12、2 4、48小时 ,然后用形态学观察、DNA琼脂糖电泳和AnnexinV -FITC/PI流式细胞技术 (flowcytometric,FCM)检测其诱发凋亡的情况。结果　AnnexinV -FITC -FCM分析见 ,随 5 -FU作用浓度增加、时间延长 ,凋亡细胞比例明显升高 ,差异显著 (P <0 .0 1) ,继发性坏死细胞比例增加 ,差异明显 (P <0 .0 5 )。结论　 5 -FU可以诱发OVCAR细胞发生凋亡 ,应用AnnexinV -FITC/PI -FCM能对细胞凋亡定性的同时测出活细胞、凋亡细胞、继发性坏死细胞和培养操作过程中出现机械损伤细胞的比例 ,与传统方法相比 ,更能直观。

关键词：卵巢癌 5-氟尿嘧啶 AnnexinV 细胞凋亡