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低温对铁皮石斛活性成分合成影响机制的转录组学研究

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贵州农业科学 2025年第1期53卷 97-105页

作者：王小仲马艳任得强关岭自治县农业农村局贵州关岭561300 贵州中医药大学贵州贵阳550025

【目的】挖掘低温条件下铁皮石斛多糖、生物碱、黄酮合成路径上的差异表达基因,为低温胁迫对铁皮石斛活性成分合成的影响机制提供理论依据。【方法】用Illumina Novaseq^(TM)6000测序技术对低温胁迫下铁皮石斛叶片进行转录组测序;使用Cu... 详细信息

【目的】挖掘低温条件下铁皮石斛多糖、生物碱、黄酮合成路径上的差异表达基因,为低温胁迫对铁皮石斛活性成分合成的影响机制提供理论依据。【方法】用Illumina Novaseq^(TM)6000测序技术对低温胁迫下铁皮石斛叶片进行转录组测序;使用Cutadapt对获得的序列进行过滤组装,获得有效序列(Clean data),选择log_(2)Fold Change(处理组/对照组)≥1,且FDR≤0.001作为参数筛选差异表达基因;通过参考基因组、Swissprot数据库、Uniprot数据库对差异表达基因进行注释,运用GO、KEGG数据库对差异表达基因进行富集分析。【结果】测序得到46.85 Gb数据,有1815个差异表达基因参与铁皮石斛低温胁迫响应,其中,1281个基因上调表达,534个基因下调表达;有12个多糖、6个生物碱、53个黄酮类化合物合成路径上的差异表达基因被检测到。qRT-PCR验证与转录组分析结果一致。【结论】铁皮石斛的多糖、生物碱、黄酮合成路径上的71个差异表达基因参与了低温胁迫的响应,从而对铁皮石斛药材品质产生影响,其中,黄酮类物质可能在铁皮石斛低温耐受过程中发挥重要作用。

关键词：铁皮石斛低温胁迫药材品质差异表达基因黄酮转录组学

Discovery of Paleogene Sporopollen from the Matrix Strata of the Naij Tal Group-Complex in the Eastern Kunlun Orogenic Belt

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Acta Geologica Sinica(English Edition) 2006年第4期80卷 490-497页

作者： GUO Xianpu wang Naiwen DING xiaozhong ZHAO Min wang Daning Institute of Geology Chinese Academy of Geological Sciences Beijing 100037

The Naij Tai Group-complex is a suite of tectonic-sedimentary méiange aggregation of the Eastern Kunlun orogenic belt, which is composed of two parts, i.e. the exotic blocks of various ages and the matrix strata. On the basis of coral, brachiopod and gastropod fossils found in the exotic blocks, the age of this group-complex was once defined to the Late Ordovician or the Paleozoic. This paper reports for the first time 44 genera and 31 species of Mid-Late Oiigocene sporopoilen in samples from the matrix strata in this group-complex and the Paleogene Quercoidites-Persicarioipollis assemblage is named. The paper aims to provide some detailed evidence for determining the age of the matrix strata in this group-complex based upon a study at the Caiyuanzigou section, which would be of great geological significance for further understanding this group-complex as a suite of tectonic-sedimentary méiange aggregation. The new finding will certainly benefit from now on the investigation of formation and evolution mechanism for the Eastern Kunlun orogenic belt.

关键词： Naij Tai Group-complex Paleogene sporopoilen méiange aggregation Eastern KunlunIt Orogenic Belt

Overcoming the limitations of anthracene alkylation using SZ-DeAl-DFNS acid catalyst

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Chinese Chemical Letters 2021年第12期32卷 3976-3979页

作者： Yangyang Fang xiaozhong wang Qianyan Pan Yingqi Chen Liyan Dai College of Chemical and Biological Engineering Zhejiang UniversityZhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture TechnologyHangzhou 310027China Institute of Zhejiang University-Quzhou Quzhou 324000China

In situ formation of composite micro-mesoporous dendritic fibrous nano-silica(DFNS) and Al-DFNS was prepared using a cetylpyridinium bromide(CPB) template synthetic system. Dealumination is induced by impregnation of zirconium with flux followed by a sulfuric acid treatment. This procedure results in a series of highly uniform nano-spheres, which exhibit stronger acid property than that of Al-MCM-41. In the selective alkylation of anthracene with tert–amyl alcohol, SO_(4)^(2-)modified Zr-contained dealuminated Al-DFNS(SZ-De Al-DFNS) shows great catalytic activity and higher conversion(60.8%). The DFNS samples were characterized with XRD, SEM, TEM, NH_(3)-TPD and other techniques. The results reveal that DFNSs consist of center-radial micro-mesopores and that the acid contribution of SZ-De Al-DFNS is much broader,as compared with amorphous aluminosilicate.

关键词： Dendritic fibrous nano-silica Hierarchical structure Anthracene alkylation Shape-selective catalysis

Synthesis and Enhanced Acetone-sensing Properties of Ordered Large-pore Mesoporous Nickel Oxides with Ultrathin Crystalline Frameworks

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Chemical Research in Chinese Universities 2024年第3期40卷 521-528页

作者： SHAO Chen GUO Ru LI Hui wang xiaozhong YANG Qingfeng LAI Xiaoyong State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021P.R.China

Acetone is a tracer for monitoring air quality and a potential breath maker for diabetes. It remains a great challenge for current portable sensors to sensitively and selectively detect acetone at low-ppb (part per billion) level. Herein, we present an ordered mesoporous nickel oxide (NiO) with both large mesopores and ultrathin crystalline frameworks for the detection of low-ppb acetone. The ordered mesoporous NiO replicas with predominant large mesopores of 11 nm, high specific surface areas of 121–128 m2/g and ultrathin crystalline frameworks of 5 nm were synthesized by the nanocasting method and the crystalline properties of NiO frameworks were adjusted by changing the annealing temperature from 300℃ to 750℃, which resulted in different contents of oxygen deficient on the surface of ultrathin frameworks. The gas-sensing properties for all the NiO samples were investigated and the ordered large-pore mesoporous NiO (NiO-600) with maximum oxygen deficient obtained at 600℃ exhibited the highest response (R_(gas)/R_(air)−1=2.9) toward acetone (1 ppm, ppm: part per million), which is 3.4 and 30 times larger than those for common mesoporous NiO obtained at 300℃ and bulk NiO. Notably, a low detection limit (2 ppb), good selectivity and cycling stability were also observed in NiO-600.

关键词： Mesoporous semiconductor NiO Gas sensing Acetone

Ordered mesoporous NiFe_2O_4 with ultrathin framework for low-ppb toluene sensing

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Science Bulletin 2018年第3期63卷 187-193页

作者： Xiaoyong Lai Kun Cao Guoxin Shen Ping Xue Dan wang Fang Hu Jianli Zhang Qingfeng Yang xiaozhong wang State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical Engineering Ningxia University Yinchuan750021 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China School of Materials Science and Engineering Shenyang University of Technology Shenyang 110870 China

Highly sensitive and selective detection against specific target gases, especially at low-ppb （part per bil- lion） level, remain a great number of challenges in gas sensor applications. In this paper, we first present an ordered mesoporous NiFe204 for highly sensitive and selective detection against low-ppb toluene. A series of mesoporous NiFe204 materials were synthesized by templating from mesoporous silica KIT-6 and its framework thickness was reduced from 8.5 to 5 nm by varying the pore size of KIT-6 from 9.4 to 5.6 nm, accompanied with the increase of the specific surface area from 134 to 216 m^2 g^-1. The ordered mesoporous NiFe2O4 with both ultrathin framework of 5 nm and large specific surface area of up to 216 m^2 g^-1 exhibits a highest response （Rgas/Ralr-1 = 77.3） toward 1,000 ppb toluene at 230℃ and is nearly 7.3 and 76.7 times higher than those for the NiFe204 replica with thick framework and its bulk counter- part respectively, which also possesses a quite low limit of detection （〈2 ppb）, and good selectivity.

关键词： Mesoporous material NiFe2O4 Gas sensing Low-ppb toluene

HIGH-Tc SUPERCONDUCTING PROPERTIES OF YBa_(2)Cu_(3-x)Sn_(x)O_(7-y) SYSTEM

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Chinese Physics Letters 1990年第7期7卷 326-329页

作者： wang Yuxia RUAN Yaozhong TAN Yudong wang xiaozhong ZHOU Guien FAN Chenggao ZHANG Yuheng Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026 Structure and Components Alalysu Center University of Science and Technology of ChinaHeifei 230026

The effect of Sn concentration on the superconducting properties and structure of YBa_(2)Cu_(3-x)Sn_(x)O_(7-y) system were systematically *** zero resistance temperature was found to be above 90K as z ranges from 0 to *** x>1.3,the system exhibited no superconducting properties at liquid nitrogen *** results of X-ray diffraction showed a regular pattern of mixed structures of 123 phase and a new phase in the system with the increase of Sn *** analysis suggested that the new phase might be BaSnO3 with deformed perovskite structure and about 6% of Cu were substituted by Sn in the 123 phase at x=*** is therefore likely that the new phase modulates the structure of 123 phase and stabilize the 123 *** the Sn atoms enter 123 phase and occupy the Cu sites in the Cu-O chain and break the chain,the system remains with Tc>***,the Cu-O chain plays a less important role in the high-Tc superconductivity.

关键词： temperature. resistance system

Identification of inflammatory factor-related genes associated with the prognosis and immune cell infiltration in colorectal cancer patients

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Genes & Diseases 2023年第5期10卷 2109-2124页

作者： Jialing Hu Yingcheng He Kaili Liao Qijun Yang Yuhan Xu Gaoquan Cao xiaozhong wang Department of Anesthesiology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Anesthesiology Ganzhou People's HospitalGanzhouJiangxi 341000China Queen Mary College of Nanchang University NanchangJiangxi 330001China Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China The Forth Clinical School of Nanchang University NanchangJiangxi 330002China

This study aims to identify the inflammatory factor-related genes which help to predict the prognosis of patients with colorectal ***(Gene Set Enrichment Analysis)was used to acquire inflammation-related genes and the corresponding expression information was collected from TCGA database to determine the DEGs(differentially-expressed genes)in CRC *** conducted enrichment analysis and PPI(protein–protein interaction)of these ***,key genes that are both differentially-expressed and prognosis-related were screened out,which were used to establish the prognostic *** obtained 79 DEGs and 19 prognostic genes,10 prognostic-related differential genes were eventually *** genes were used to construct the prognostic *** also identified that the immune infiltration score of macrophages between different risk groups was significantly different and similar distinction was witnessed in immune function score of APC(antigen-presenting cell)co-stimulation and type I IFN(interferon)response.

关键词： Biomarker Colorectal cancer(CRC) Immune infiltration Inflammatory factors Predicting model

Transcriptomic analysis identifies a pan-cancer association of IL27 expression with cancer prognosis and immune microenvironment

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Genes & Diseases 2023年第2期10卷 393-395页

作者： Kaili Liao Jingyi wang Zimeng Li Yuqiu Li Yunqi Cheng Yingcheng He Hongping Wan xiaozhong wang Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China School of Public Health Nanchang UniversityNanchangJiangxi 330006China Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Nowadays great progress has been made in targeted therapy and comprehensive therapy for a few cancers. But the prognosis of the vast majority of cancer patients is still weakness. It has been proven that inflammation can affect the development and treatment of cancer. Some previous studies have suggested that inflammation-related interleukins (ILs) play a significant role in the development of some cancers.1,2 ILs act as a considerable role in immunity,3 and inflammation affects the development of cancer. Therefore, the expression profile of IL gene may also be one of the vital markers of early pathological changes, occurrence and progression of cancer.4,5 Currently, studies on the expression of IL27 in cancer are still extremely limited. Our work comprehensively and systematically studied the IL27 gene expression in the generic cancer when compared with the existing IL27 gene related research experiment. We screened out cancer species linked with poor prognosis, and explored the correlation between IL27 gene expression and immune cell infiltration and immune microenvironment in these cancers further, providing an increasing number of the direct basis for subsequent studies. Our findings showed that IL27 can be used to assess prognosis and immune infiltration in patients with colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), skin cutaneous melanoma (SKCM) and testicular germ cell tumors (TGCT) as a biomarker.

关键词： IL27 inflammation prognosis

基于数据挖掘探究曾斌芳治疗代偿期乙型肝炎肝硬化用药规律

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中国中医药信息杂志 2025年第1期32卷 49-54页

作者：孙婉卿郭峰王晓忠曾斌芳(指导) 新疆医科大学中医学院新疆乌鲁木齐830017 昌吉回族自治州中医医院新疆昌吉831100 新疆维吾尔自治区中医医院新疆乌鲁木齐830000

目的应用数据挖掘技术探究曾斌芳教授治疗代偿期乙型肝炎肝硬化用药规律。方法收集2018年10月-2023年11月曾斌芳教授于门诊及病区诊治的代偿期乙型肝炎肝硬化患者病例资料。应用Excel2021录入患者基本信息及诊疗内容,建立医案标准化诊... 详细信息

目的应用数据挖掘技术探究曾斌芳教授治疗代偿期乙型肝炎肝硬化用药规律。方法收集2018年10月-2023年11月曾斌芳教授于门诊及病区诊治的代偿期乙型肝炎肝硬化患者病例资料。应用Excel2021录入患者基本信息及诊疗内容,建立医案标准化诊疗数据库。采用古今医案云平台2.3.9统计药物频次、性味归经、药物功效,并进行关联规则、层次聚类、复杂网络分析。结果共纳入处方555首,涉及中药303味,药物总频次为8276。筛选出高频药物38味。药性以平、温、寒为主,药味以甘、苦、辛为主,归经以脾经、肝经居多,功效以补虚药、利水渗湿药、清热药、活血化瘀药为主。关联规则、层次聚类分别得到15组药对和5组聚类方。复杂网络构建的中药核心组合为当归、醋鳖甲、炙甘草、柴胡、茯苓、猪苓、川芎、黄芩、白术。结论曾斌芳教授根据代偿期乙型肝炎肝硬化湿热毒邪稽留血分,日久正虚瘀滞的病机特点,主张于邪实正虚阶段从肝脾同调、乙癸同源论治,并将消法、清法运用于补法中,以此攻补兼施,寒热平调,可为临证治疗提供一定参考。

关键词：代偿期乙型肝炎肝硬化数据挖掘中药名医经验曾斌芳