检索结果-南通市图书馆

Expression and role of Tie-2 in rectal carcinoma

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2010年第1期22卷 66-68页

作者： Zhen-hua Ma,Kang wang,Mao Zhang,wei-hua Shang Department of General Surgery,the First Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710061,China Department of General Surgery First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China

Objective To investigate the expression of Tie-2 in rectal carcinoma and its relationship with invasion and metastasis in rectal *** S-P immunohistochemical assay was used to detect the expression of Tie-2 in 40 cases of rectal carcinoma and 10 cases of normal rectal *** Tie-2 was mainly localized in the cytoplasm and nucleus of vascular endothelial cells in cancerous tissues and partly in the cytoplasm of some cancerous *** expression of Tie-2 in rectal carcinoma was significantly higher than that in normal rectal tissues(P0.05),but with lymphatic metastasis(P<0.05).Conclusion Tie-2 plays a key role in carcinogenesis and lymph node metastasis of rectal carcinoma.

关键词： Tie-2 rectal carcinoma immunohistochemistry

A preliminary study of imaging paclitaxel-induced tumor apoptosis with 99Tcm-His10-Annexin V

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第15期126卷 2928-2933页

作者： ZHENG Yu-min wang Feng FANG wei hua Zi-chun wang Zi-zheng MENG Qing-le YAN Jue Department of Nuclear Medicine China-Japan Friendship HospitalBeijing 100029 China Department of Nuclear Medicine Nanjing First Hospital affiliated to Nanjing Medical University Nanjing Jiangsu 210006 China Department of Nuclear Medicine Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037China The State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing Jiangsu 210093 China

Backgroud in tumors the process of apoptosis occurs over an interval of time after chemotherapy, it is important to determine the best time for detecting apoptosis by in vivo imaging. In this study, we evaluated the dynamics and feasibility of imaging non-small cell lung cancer （NSCLC） apoptosis induced by paclitaxel treatment using a 99Tcm-labeled Annexin V recombinant with ten consecutive histidines （Hislo-Annexin V） in a mouse model. Methods 99Tcm-His10-Annexin V was prepared by one step direct labeling; radio-chemical purity （RCP） and radio-stability was tested. The binding of 99Tcm-His10-Annexin V to apoptotic cells was validated in vitro using camptothecin-induced Jurkat cells. In vivo bio-distribution was determined in mice by dissection. The human H460 NSCLC tumor cell line （H460） tumor-bearing mice were treated with intravenous paclitaxel 24, 48 and 72 hours later. 99Tcm-His10-Annexin V was injected intravenously, and planar images were acquired at 2, 4 and 6 hours post-injection on a dual-head gamma camera fitted with a pinhole collimator. Tumor-to-normal tissue ratios （T/NT） were calculated by ROI analysis and they reflected specific binding of 99Tcm-His10-Annexin V. Mice were sacrificed after imaging. Caspase-3, as the apoptosis detector, was determined by flow cytometry, and DNA fragmentation was analyzed by the terminal deoxynucleotidytransferase mediated dUTP nick-end labeling （TUNEL） assay. Nonspecific accumulation of protein was estimated using bovine serum albumin （BSA）. The imaging data were correlated with TUNEL-positive nuclei and caspase-3 activity. Results 99Tcm-His10-Annexin V had a RCP 〉98% and high stability 2 hours after radio-labeling, and it could bind to apoptotic cells with high affinity. Bio-distribution of 99Tcm-His10-Annexin V showed predominant uptake in kidney, relatively low uptake in myocardium, liver and gastrointestinal tract, and rapid clearance from blood and kidney was observed. The TINT was significantly increased after pa

关键词： His10-Annexin V apoptosis non-small cell lung cancer

Liquid Chromatography-mass Spectrometry Analysis on Effect of Roughage Types on Liver Metabolic in Dairy Cows

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Northeast Agricultural University(English Edition) 2020年第2期27卷 59-66页

作者： wang wei-hua Zhang Yan-ying huang Guan Zhang Na College of Life Sciences Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Dairy Science of Education Ministry Northeast Agricultural UniversityHarbin 150030China

The major objective of this study was to determine the effect of corn straw or mixed diet on the small molecule metabolites of liver and milk production of healthy Chinese Holstein cows during *** this study,metabolomic methods based on ultra performance liquid chromatography-mass spectrometry(LC-MS)were used to study the liver metabolites of dairy cows fed on corn straw diet or mixed *** healthy Chinese Holstein cows were randomly assigned to two groups,under the same management condition,fed different diets respectively,corn straw group(CS)or a mixture of alfalfa hay and Chinese wild rye hay mixed forage group(MF).All the cows were fed for 8 weeks and recorded body weight,dry matter intake,body condition score,fat,protein,lactose,milk yield and the total *** were sampled from each cow through a liver puncture needle for analysis of a significant difference in small molecule metabolites in cow liver samples from the two different *** results suggested that different diet types had significant effects on liver metabolism and milk components in dairy *** contents of milk fat,the total solids,milk protein,lactose,dry matter intake(DMI),milk yield,milk protein(%),lactose(%)and milk fat(%)of the corn straw group were significantly lower than those of the mixed forage group(p<0.05);the contents of phosphatidylcholine(PC),histidine,hypoxanthine and mridine in liver tissues of the corn straw group were significantly lower than those in the mixed forage group(p<0.05);acetylcarnitine,uric acid,triacylglycerol(TG),acetal phosphatidylcholine(plasmenyl-PC),acetalphosphatidylethanolamine(plasmenyl-PE)and sphingomyelin(SM)of the corn straw group were significantly higher than those in the mixed forage group(p<0.05).In summary,cows fed on mixed forage diet significantly improved milk yield and lactation performance clearly.

关键词： dairy cow liver liquid chromatography-mass spectrometry(LC-MS) lactation metabolomics

Particle size distribution of the organic matters in the treated leachate using aged-refuse-bioreactor

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering 2009年第7期3卷 18-22页

作者： SUN Ying-jie wang hua-wei ZHAO You-cai School of Environmental ＆ Municipal Engineering Qingdao Technological University Qingdao 266033 China The State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

Micro-filtration membrane （1.2 μm）, hyper-filtration membrane （0.45 μm） and nano-filtration membrane （1000 Dalton） were used to characterize the particle size distribution of the organic matters in effluent leachate treated by the aged-refuse-bioreactor（ARB） installed at Laogang Refuse Landfill, Shanghai. The results showed that the particle size distribution of the treated fresh and aged leachate using the ARB were quite consistent. The organic matter with particle size below 1000 Dalton accounted for about 90%, balanced with the suspended （〉1.2 μm） and colloidal （1000 Dalton-l.2μm） matters. Hence, it is proposed that coagulation, nano-filtration and electrically chemical oxidation may be not applicable for the advanced treatment for the effluents to reach the discharge standard limit value defined in Chinese national Standard for Pollution Control on the Landfill Site of Municipal Solid Wastes （GB16889-2008）, CODCr〈100 mg/L. Aged refuse bioreactor combined reverse osmosis was suggested as an economically and technically feasible technology to treat sanitary landfill leachate.

关键词： landfill leachate particle size distribution nano-filtration aged refuse bioreactor: reverse osmosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混合动力汽车能耗最优数学建模与仿真

系统仿真学报 2007年第18期19卷 4309-4311,4325页

作者：曾小华王庆年王伟华汽车动态模拟国家重点实验室吉林长春130025 吉林大学汽车工程学院吉林长春130025

提出了传统汽车燃油消耗的数学计算公式,对比地建立了混合动力汽车(HEV)的能量消耗计算模型,并对HEV控制策略提出了基于最小化能量消耗的优化目标。根据该优化目标,基于某一车型,寻找混合动力汽车的两动力源(发动机与电动机)之间的最佳... 详细信息

提出了传统汽车燃油消耗的数学计算公式,对比地建立了混合动力汽车(HEV)的能量消耗计算模型,并对HEV控制策略提出了基于最小化能量消耗的优化目标。根据该优化目标,基于某一车型,寻找混合动力汽车的两动力源(发动机与电动机)之间的最佳分配,使系统的能量消耗最少。利用这种方式建立了规律控制模型,并对混合动力汽车进行整车性能仿真,仿真结果表明:相比原缺省的控制方式,该控制方式使得HEV更省油,对于某一工况,燃油消耗率降低了20%左右。

关键词：混合动力汽车燃油经济性优化规律控制仿真

永磁同步电机电流增量预测算法参数设计及性能分析

在线全文

学校读者我要写书评

暂无评论

电机与控制学报 2013年第12期17卷 98-105页

作者：王伟华肖曦清华大学电机系北京100084

针对永磁同步电机电流环带宽的拓展受到数字控制一拍滞后延时限制的问题,提出一种电流增量预测算法及相应的PI调节器参数设计规则。该算法通过两个相邻周期的离散电压方程相减的方式预测出下一周期电流值,用预测值取代检测值改进PI调节... 详细信息

针对永磁同步电机电流环带宽的拓展受到数字控制一拍滞后延时限制的问题,提出一种电流增量预测算法及相应的PI调节器参数设计规则。该算法通过两个相邻周期的离散电压方程相减的方式预测出下一周期电流值,用预测值取代检测值改进PI调节器。对算法稳定性及参数敏感性进行研究,给出一套PI参数设计规则,并与传统PI调节器的动态性能进行比较。研究结果表明,增量预测算法可以有效消除一拍滞后延时的影响,同时拓宽PI参数稳定域,计算量少,且对电机参数依赖度低,配合提出的参数设计规则可显著拓展电流环带宽。仿真和实验结果验证了所提方案的有效性。

关键词：伺服系统永磁同步电机增量预测算法带宽

基于电感辨识的PMSM电流自适应增量预测控制

在线全文

学校读者我要写书评

暂无评论

电机与控制学报 2014年第2期18卷 75-82页

作者：王伟华肖曦清华大学电机系北京100084

为了提高永磁同步电机电流增量预测控制策略的参数自适应性,提出一种基于增量式模型参考自适应的电感在线辨识算法。该算法使用永磁同步电机的增量模式的电压方程作为可调模型,以实际电机作为参考模型,建立基于模型参考自适应的参数辨... 详细信息

为了提高永磁同步电机电流增量预测控制策略的参数自适应性,提出一种基于增量式模型参考自适应的电感在线辨识算法。该算法使用永磁同步电机的增量模式的电压方程作为可调模型,以实际电机作为参考模型,建立基于模型参考自适应的参数辨识机制,在线辨识交直轴电感;通过判断激励信号的有效性去除噪声等非理想因素的影响,消除辨识结果的稳态波动。研究结果表明,所提出的增量式模型参考自适应算法可以辨识出准确的电感参数,避免辨识结果的频繁波动,显著提高增量预测控制策略对模型参数的自适应性,同时计算量少,对电机参数依赖度低。仿真和实验结果验证了所提方案的有效性。

关键词：模型参考自适应增量预测控制永磁同步电机带宽

Socioeconomic and Environmental Determinants to Preterm Birth in Tibetan Women： An Analysis Based on the Hierarchically Conceptual Frame

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第19期130卷 2307-2315页

作者： Xiao-Jing Fan Jian-Min Gao Yi-Jun Kang Shao-Nong Dang wei-hua wang Hong Yan Duo-Lao wang Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center Xi'an Shaanxi 710061 China Department of Health Management and Policy School of Public Policy and Administration Xi'an Jiaotong University Xi'an Shaanxi 710049 China Shaanxi Provincial Centre for Disease Control and Prevention Xi'an Shaanxi 710054 China Department of Clinical Sciences Liverpool School of Tropical Medicine Liverpool L3 5QA UK

Background： Preterm birth is a common cause of death in newborns and may result from many determinants, but evidence for the socioeconomic and environmental determinants of preterm birth in Tibetan women of childbearing age is limited. The aim of this study was to understand the current status of preterm birth in native Tibetan women and investigate the socioeconomic and environmental determinants. Methods： Data were drawn from a cohort study which was conducted from August 2006 to August 2012 in rural Lhasa, Tibet, China. A total of 1419 Tibetan pregnant women were followed from 20 weeks＆#39; gestation until delivery; the loss to follow-up rate was 4.69%. The incidence of preterm birth was estimated to show the status of preterm births in Tibet. Logistic regression models for longitudinal data were established, and odds ratios （ORs） together with 95% confidence intervals （CIs） were used to evaluate the association between the occurrence of preterm birth and 16 selected potential determinants based on the hierarchical conceptual frame. Results： The incidence of preterm birth was 4.58% （95% CI = 3.55–5.80%）. After adjusting for health-related variables of the mothers and newborns, socioeconomic and environmental determinants associated with preterm birth included season （spring： OR = 0.28, 95%CI = 0.09–0.84; autumn： OR = 0.21, 95% CI = 0.06–0.69; and winter： OR = 0.31, 95% CI = 0.12–0.82） and calendar year of delivery （2010： OR = 5.03, 95% CI = 1.24–20.35; 2009： OR = 6.62, 95% CI = 1.75–25.10; and 2007–2008： OR = 5.93, 95% CI = 1.47–23.90）. Conclusions： The incidence of preterm birth among native Tibetan women was low and there was a decreasing trend in recent years;however, it is still essential to strengthen seasonal maternal care, extend the spacing between pregnancies, and reinforce adequate maternal nutrition.

关键词： Determinants Preterm Birth Tibet

Synchronization Control of Planar 2-DOF Robot with Redundant Actuation

在线全文

学校读者我要写书评

暂无评论

International Journal of Plant Engineering and Management 2011年第1期16卷 35-40页

作者： MI Jian-wei wang hua-dong BAO Hong DU Jing-li Key Laboratory of Electronic Equipment Structures Design of Ministry of Education Xidian University Xi'an 710071 P. R. China

Considering the special characteristics of the redundant parallel manipulator, with emphasis on the variable of structure, the relatively small workspace and the strong coupling relationship among arms, a synchronization control strategy is presented in this paper. Since in the feedforward, the inertial and the coriolis matrix are designed constant according to the relatively small workspace, position measurement of the endeffector in plane is ignored. Synchronization error and coupling error are introduced to reject the model errors of inertial and coriolis matrix as stated above. Using the method, the errors of driving arms can be reduced, and the synchronization performance among axes can be improved. The stability of the controllers was proved by Lyapunov method. Finally, experimental results show the feasibility of the method.

关键词： redundant parallel manipulator coupling error synchronization control