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Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit

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Science China Life Sciences 2025年

作者： Ruyu wang Tianxiao wang Ziyu Chen Jiandong Jiang Yifei Du Hua Yuan Yongchu Pan Yuli wang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University Department of Stomatology Chongzhou People's Hospital Medical Basic Research Innovation Centre for Cardiovascular and Cerebrovascular Diseases Ministry of Education International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Department of Orthodontic The Affiliated Stomatological Hospital of Nanjing Medical University State Key Laboratory Cultivation Base of Research Prevention and Treatment for Oral Diseases Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine Nanjing Medical University

Delayed tooth extraction socket(TES) healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients. Excessive amounts of M1 macrophages, apoptotic neutrophils(ANs), and neutrophil extracellular traps(NETs) impair alveolar bone regeneration during TES healing. In the present study, we first discovered that conditioned medium(CM) collected from berberine-treated human bone marrow mesenchymal stem cells(BBR-HB-CM) accelerated TES healing. BBR-HB-CM contained bioactive materials that promoted the polarization of macrophages from M1 to M2, impeded the formation of ANs and NETs, and modulated M2 macrophage efferocytosis in vivo and in vitro. Mechanistically, BBR-HB-CM promoted bone formation by inhibiting macrophage-myofibroblast transition and reprogrammed macrophage polarization through p85/AKT/mTOR pathway-dependent autophagy. The 3-methyladenine abolished the therapeutic effects of BBR-HB-CM. Further studies revealed that BBR-HB-CM accelerated TES healing in rats with type 2 diabetes mellitus. Overall, our results demonstrated that BBR-HB-CM had high potential to promote rapid TES healing.

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Orbits of Jacobi forms and theta relations

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Science China Mathematics 2025年

作者： Valery Gritsenko Haowu wang Laboratoire Paul Painlevé Université de Lille International Laboratory for Mirror Symmetry and Automorphic Forms National Research University Higher School of Economics School of Mathematics and Statistics Wuhan University

Jacobi theta functions with rational characteristics can be viewed as vector-valued Jacobi *** relations usually correspond to different constructions of certain Jacobi forms. From this observation, we extract a new approach, which is called orbits of Jacobi forms, to produce identities on Jacobi theta *** approach not only provides simple proofs of many known theta relations but also produces a large number of new identities, which can be considered as generalizations of Riemann’s theta relations.

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Waveguide-integrated ultra-stable perovskite single-crystal photodetector

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Science China Technological Sciences 2025年

作者： Zhenyu ZHANG Guoping wang State Key Laboratory of Radio Frequency Heterogeneous Integration Shenzhen University

Notwithstanding the exceptional photodetection capabilities of the laterally-structured perovskite single-crystal sheet(SCS), attributed to its notably lengthy carrier diffusion length and reduced defect density, operating the device within free space and exposing the SCS to the environment present obstacles in attaining on-chip integration and long-term *** overcome these challenges, this study proposes the introduction of a waveguide(WG) structure methodology, and selects the silicon WG(SWG) core and the polymer polymethyl methacrylate(PMMA) WG(PWG) fiber as materials. Furthermore, it integrates these two WG structures with the laterally-structured SCS photodetector into WG-SCS devices, enabling photodetection under near-field excitation of the WG. Significantly, the WG-SCS device encapsulated with silicone sealant demonstrates exceedingly high stability, with no degradation in performance after being exposed to light and water stimuli for1000 h. This study demonstrates the viability of on-chip integration of lateral-structured SCS photodetectors by means of introducing WG structures and investigates the technical facets of the device's long-term environmental stability. The results are expected to exert a crucial role in device integration in future applications such as optical communication, quantum photonics, and biochemical sensing.

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Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： LIU Jian CHEN Meiting JI Xiaoli XU Chao wang Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology research 2025年第1期33卷 225-234页

作者： Wei Zhang Weicheng wang Rui wang Xiao Han Lijun Zhu Wenjie Guo Yanhong Gu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China. Department of Oncology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou 225300 China. State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China.

Background:As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC.Methods and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax's efficacy against tumors. Then we employed various techniques to evaluate different aspects of the experimental outcomes. Immunohistochemistry was used to detect cell proliferation and angiogenesis in tumor tissues. Western blot analysis was utilized to examine the occurrence of cell apoptosis, and flow cytometry to quantitate immune cells within the tumor tissues. Moreover, immunofluorescence was employed to measure cytokine levels.Results:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax, as opposed to individual drug use. Venetoclax was found to amplify the impact of fruquintinib, leading to decreased cancer cell proliferation, increased cancer cell apoptosis, lowered angiogenesis, better vascular structure normalization, and improved immune cell infiltration.Conclusion:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune microenvironment. Our study presents the justification for utilizing the fruquintinib and venetoclax combination in treating CRC. Venetoclax holds promise in being assimilated into anticancer medications for CRC.

关键词： Anti-angiogenesis B-cell lymphoma protein 2 (BCL2) Colorectal cancer (CRC) Fruquintinib Immunotherapy Vascular endothelial growth factor receptor (VEGFR) Venetoclax

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Pattern analysis of a linear dune field on the northern margin of Qarhan Salt Lake,northwestern China

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Journal of Arid Land 2016年第5期8卷 670-680页

作者： LI Jiyan DONG Zhibao QIAN Guangqiang ZHANG Zhengcai LUO wanyin LU Junfeng wang Meng Taiyuan Normal University Jinzhong 030619 China Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China

In terms of formation mechanisms of linear dunes,there are open arguments for their widespread distribution and multi-morphological *** order to clarify the formation mechanism of linear dunes of Qarhan Salt Lake,we used pattern analysis method to analyze the statistical characteristics and spatial variation of their pattern *** at the west-northwest margin,the pattern parameters showed regular spatial variation from the up-middle part towards the downwind end of the dune *** on the cumulative probability plots for inter-crest spacing and crest length,we divided the linear dunes into three groups,which corresponding to the three evolution stages of these *** first group comprises erosional relics,with shorter crests,smaller inter-crest spacing and more random dune *** second group comprises dunes whose sand supply is just sufficient to maintain stability and these dunes are approaching the net erosion *** crest length and inter-crest spacing of these dunes are much larger than those of the first group,and dune orientation is closer to the resultant drift direction （RDD） .The last group comprises linear dunes that are still undergoing vertical accretion and longitudinal elongation,which follows the RDD of the modern wind *** presence of regular spatial variation of pattern parameters and a similar geometry with the vegetated linear dunes suggest that deposition and erosion coexist in the development and evolution of linear dunes of Qarhan Salt Lake,*** predominates at the downwind end of linear dunes in the vertical accretion and longitudinal elongation stage,whereas erosion mainly occurs at the upwind end of linear dunes in the degradation ***,the formation mechanism of linear dunes in Qarhan Salt Lake can be reasonably explained by the combination of depositional and erosional theories.

关键词： pattern analysis self-organization linear dunes dune field Qarhan Salt Lake Qaidam Basin

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi Lai Hua-Ping wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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流式细胞仪在航海医学实验教学中的设计与应用

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中国现代教育装备 2015年第17期 19-21页

作者：章海荣韩玲王万银刘玉龙张倩家常亮第二军医大学海医系上海200433

流式细胞仪作为一种先进的细胞定量分析检测仪器,广泛应用于航海医学专业教育与科研研究领域,并起到了关键作用。流式细胞仪实验课程通过流式细胞术原理讲解、仪器演示以及实验操作环节,帮助学员渐进学习和掌握相应内容。根据航海医学... 详细信息

流式细胞仪作为一种先进的细胞定量分析检测仪器,广泛应用于航海医学专业教育与科研研究领域,并起到了关键作用。流式细胞仪实验课程通过流式细胞术原理讲解、仪器演示以及实验操作环节,帮助学员渐进学习和掌握相应内容。根据航海医学专业的教学需求,开设流式细胞仪实验课程,按照流式细胞仪的构造及原理讲解、细胞样本制备、细胞DNA含量和凋亡检测、操作演示等四方面进行教学。通过流式细胞仪实验课程教学的实施,学员整体加深了对流式细胞仪基础知识的理解和掌握,提升了动手操作能力、科研分析及解决问题的能力,为学员在日后的科研实验中利用该项技术奠定了良好的基础。

关键词：流式细胞仪实验教学

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Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu wang Chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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