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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge wang Ke-Ning Qi Yu-Chong wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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基于网络药理学研究藏药五味甘露药浴颗粒治疗RA的分子作用机制

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中药材 2019年第11期42卷 2639-2650页

作者：丁荣王静喻莲慧陈虹望王天虹成都中医药大学药学院四川成都611137 成都中医药大学民族医药学院四川成都611137

目的:基于网络药理学预测藏药五味甘露药浴颗粒治疗类风湿性关节炎(RA)的有效成分、潜在靶点及相关通路。方法:首先查阅、整理文献,及数据库筛选出五味甘露药浴颗粒中的有效化学成分,构建化合物-靶点网络。用MAS 3.0服务器获取潜在靶点... 详细信息

目的:基于网络药理学预测藏药五味甘露药浴颗粒治疗类风湿性关节炎(RA)的有效成分、潜在靶点及相关通路。方法:首先查阅、整理文献,及数据库筛选出五味甘露药浴颗粒中的有效化学成分,构建化合物-靶点网络。用MAS 3.0服务器获取潜在靶点和通路的相关信息,构建出靶点-通路网络。结果:通过文献查询及筛选获取了五味甘露药浴颗粒中的化学成分共99种,涉及到1 424个作用靶标,筛选后得到152个潜在靶点和71条信号通路。结论:五味甘露药浴颗粒通过参与调节免疫、炎症反应、细胞凋亡等过程来发挥抗类风湿性关节炎作用,在治疗RA中起到多成分、多靶点、多途径的协同调控作用。

关键词：网络药理学藏药五味甘露药浴颗粒 RA 作用机制

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Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes:A Meta-Regression of Acupuncture Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2024年第3期30卷 260-266页

作者： XIU Wen-cui GANG Wei-juan ZHOU Qi SHI Lan-jun HU Xiang-yu MING tian-yu LUO Zhen ZHANG Yu-qing JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing100700China China Center for Evidence-Based Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonOntarioL8S 4L8Canada Center for Evidence-Based Integrative Medicine-Clarity Collaboration Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China

Background:The effects of acupuncture have varied in different randomized controlled trials(RCTs),and there are many factors that influence treatment effect of acupuncture in different outcomes,with conflicting ***:To identify factors and their impact on the treatment effect of acupuncture in different ***:Acupuncture RCTs were searched from 7 databases including Medline(Pub Med),Embase,Cochrane Central Register of Controlled Trials,China National Knowledge Infrastructure,Wanfang Database,VIP Database,and China Biology Medicine disc between January 1st,2015 and December 31st,*** studies must compare acupuncture to no acupuncture,sham acupuncture,or waiting lists,and report at least 1patient-important outcome.A multi-level meta-regression was conducted using a 3-level robust mixed model and univariate analyses were performed for all independent variables,even those excluded from the multivariable model due to *** used thresholds of 0.2 and 0.4 for the difference of standardized mean differences(SMDs),categorising them as small(0.4) ***:The pain construct analysis involved 211 effect estimates from 153 studies and 14 independent ***-frequency acupuncture treatment sessions produced larger effects compared to low-frequency sessions [large magnitude,the difference of adjusted SMDs 0.46,95% confidence interval(CI) 0.07 to 0.84;P=0.02].The non-pain symptoms construct analysis comprised 323 effect estimates from 231 studies and 15 independent *** acupuncture showed moderately larger effects when compared to non-penetrating acupuncture(0.30,95% CI 0.06 to 0.53;P=0.01).The function construct analysis included 495 effect estimates from 274 studies and 14 independent *** acupuncture and the flexible acupuncture regimen showed moderately larger effects,compared to non-penetrating acupuncture and fixed regimen,respectively(0.40,95% CI 0

关键词： acupuncture randomized controlled trial patient-important outcome meta-regression

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基因工程技术与我国的海水鱼类养殖

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海洋科学 2000年第1期24卷 18-21页

作者：王宏田张培军中国科学院海洋研究所实验海洋生物学开放研究实验室青岛266071

基因工程技术应用于海水鱼类的养殖,其主要的目的在于:(1)增加海水鱼的产量,缩短其商品化的周期;(2)增强海水鱼抵抗不利环境的能力,尤其要提高海水鱼的抗病性;(3)鱼类新品种的培育.本文拟就这一技术在鱼类养殖中的应用现状给予概述,并... 详细信息

基因工程技术应用于海水鱼类的养殖,其主要的目的在于:(1)增加海水鱼的产量,缩短其商品化的周期;(2)增强海水鱼抵抗不利环境的能力,尤其要提高海水鱼的抗病性;(3)鱼类新品种的培育.本文拟就这一技术在鱼类养殖中的应用现状给予概述,并着重介绍对于我国海水鱼类养殖具有潜在应用价值的新技术.

关键词：基因工程养殖海水鱼类中国

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天津高校图书馆CALIS分布式联合虚拟参考咨询服务实践与问题研究

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图书馆论坛 2013年第4期33卷 157-161页

作者：王天虹钱蔚蔚天津师范大学图书馆天津300387

基于CVRS系统的天津高校图书馆CALIS分布式联合虚拟参考咨询服务发挥了各馆馆藏资源优势,实现了各高校专家团队的联合咨询,但在服务过程中仍然存在问题。文章重点分析CVRS系统存在的功能缺陷,以及服务过程中存在的低知晓率和缺乏有效控... 详细信息

基于CVRS系统的天津高校图书馆CALIS分布式联合虚拟参考咨询服务发挥了各馆馆藏资源优势,实现了各高校专家团队的联合咨询,但在服务过程中仍然存在问题。文章重点分析CVRS系统存在的功能缺陷,以及服务过程中存在的低知晓率和缺乏有效控制服务质量手段等问题,并提出对策,为更好地发挥CVRS的优势,提高天津高校图书馆CALIS分布式联合虚拟参考咨询的服务水平提供参考。

关键词：天津高校图书馆联合虚拟参考咨询服务 CVRS

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环境因子对硬骨鱼精子运动的影响及其分子机制

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海洋科学 1999年第4期23卷 21-23页

作者：王宏田张培军中国科学院海洋研究所青岛266071

虽然在有些情况下,精子能够游动却已失去使卵细胞受精的能力,但通常而言,运动能力强的精子会有更多的机会使卵子受精.因此,对于精子运动能力的研究将有助于提高受精率.

关键词：环境因子硬骨鱼精子运动分子机制鲑鱼

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Pars plana vitrectomy with internal limiting membrane plugging assisted by autologous blood for optic disc pit associated with vitreomacular traction

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1957-1959页

作者： Bin Chen Yan-Ting Li tian-hong Wu Ya-Ping Yuan Yun-Feng Lu Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

Dear Editor,We report a case of optic disc pit(ODP)associated with vitreomacular traction which has been successfully treated by a combined *** have obtained the written informed consent from the patient,and this case... 详细信息

关键词： technique. traction macular

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Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： Yu-Zhe Cao Guang-Lei Zheng tian-Qi Zhang hong-Yan Shao Jia-Yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

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Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-hong Zhou Min-Bo Yan Ming Xiao Biao Liu Ying-Hao Yin Xiao-Li Tan Yong-Quan Huang Yu-hong Lin Ting Xie Jia-Li tian Qi wang Jian-Ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue ***,inconvenience and high costs limit the wide application of such ***,we describe a simple,fast,and economical method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts

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搜索路径给定时的搜索对策问题及其应用

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火力与指挥控制 2017年第9期42卷 98-102页

作者：王天虹宋业新薛洪展海军工程大学理学院武汉430033

搜索路径给定时的最优搜索方案问题,也可以理解为是关于搜索者和目标的二人对策问题,主要讨论了当搜索路径给定时的单个搜索者和单个目标的搜索对策问题。首先根据问题的特点,利用动态规划和迭代的方法,确定关于目标逃逸路径混合策略的... 详细信息

搜索路径给定时的最优搜索方案问题,也可以理解为是关于搜索者和目标的二人对策问题,主要讨论了当搜索路径给定时的单个搜索者和单个目标的搜索对策问题。首先根据问题的特点,利用动态规划和迭代的方法,确定关于目标逃逸路径混合策略的最优分区,证明该分区是多面体凸集;针对目标不同逃逸路径的分区,求出搜索者的最大期望收益,再将问题转化为二人有限零和对策,计算出搜索者的支付矩阵,确定最优搜索策略。最后结合海军护航行动,对我舰载直升机搜索小型海盗船进行分析和计算,说明搜索路径给定时的最优搜索对策对于双方的资源分配和提高搜索效率具有一定的应用价值。

关键词：搜索对策动态规划迭代最优搜索策略

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