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真三轴单面卸荷条件下中间主应力对深埋洞室岩爆影响特征

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煤炭学报 2024年第S1期49卷 220-235页

作者：孙飞跃郭佳奇刘希亮郝宪杰王树仁河南理工大学土木工程学院河南省地下工程与灾变防控重点实验室中国矿业大学(北京)能源与矿业学院

岩爆灾害已成为国内外深埋洞室建设的重大安全隐患。利用新型真三轴岩爆试验系统，开展了不同中间主应力下“单面侧向卸荷-三向五面受力-竖向持续加载”的室内物理模拟试验，对比分析了不同中间主应力下岩样的弹射破坏过程、破坏形态特... 详细信息

岩爆灾害已成为国内外深埋洞室建设的重大安全隐患。利用新型真三轴岩爆试验系统，开展了不同中间主应力下“单面侧向卸荷-三向五面受力-竖向持续加载”的室内物理模拟试验，对比分析了不同中间主应力下岩样的弹射破坏过程、破坏形态特征、声发射特性、碎块特征以及弹射动能等变化规律；基于三维离散元理论和多晶建模技术(随机生成Voronoi矿物晶粒)，研究了真三轴单面卸荷条件下岩爆“孕育—发生—发展—破坏”全过程及能量演化特征。研究结果表明：不同中间主应力下岩爆弹射破坏过程可概括为颗粒局部弹射、岩石劈裂成板、板折断裂成块及块片全面弹射；其中，岩石劈裂成板是岩爆孕育过程中必然经历的破坏现象。岩样临空面破坏形态具有相似的多元分区破坏特征，即邻近临空面区域产生以张拉破坏为主的劈裂裂缝，远离临空面区域产生以剪切破坏为主的贯穿性斜裂缝。声发射撞击数演化过程可分为相对平稳阶段、快速上升阶段、整体破坏阶段及平静期阶段。随着中间主应力的不断增大，碎块的弹射动能呈增大的变化趋势。岩爆碎块多以粗粒、中粒与细粒碎块为主，且随中间主应力的增加，微粒碎块质量基本不变，细粒、中粒与粗粒碎块质量则呈平稳增加的趋势。利用考虑颗粒矿物成分的晶体尺度精细仿真模型(CSFM)模拟了岩爆“孕育—发生—发展—破坏”全过程，获得了岩样的应力-应变曲线，其变化趋势与室内试验测试结果基本一致且曲线吻合度较好。弹性应变能的演化曲线大致可分为早期增长速率递增阶段、近似线性增长阶段、屈服平台期间增长速率递减阶段及峰后急剧下降阶段。

关键词：深埋洞室岩爆中间主应力真三轴试验离散元方法

临床病理技术在胸腔积液细胞块诊断过程中的应用效果观察

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首都食品与医药 2024年第14期31卷 89-91页

作者：刘水王树人江苏省盐城市第一人民医院江苏盐城224000

目的探讨临床病理技术在胸腔积液细胞块诊断过程中的应用效果。方法选取2021年2月-2023年12月100例胸腔积液患者,随机分为两组,对照组50例采用常规细胞涂片法检查,治疗组50例采用细胞块免疫组化法检查,比较两组诊断结果、不同癌细胞不... 详细信息

目的探讨临床病理技术在胸腔积液细胞块诊断过程中的应用效果。方法选取2021年2月-2023年12月100例胸腔积液患者,随机分为两组,对照组50例采用常规细胞涂片法检查,治疗组50例采用细胞块免疫组化法检查,比较两组诊断结果、不同癌细胞不同抗体表达。结果对照组诊断结果阳性、阴性分别有44例(88.00%)、6例(12.00%),治疗组分别有50例(100.00%)、0例(0.00%),治疗组阳性检出率高于对照组(P<0.05);细胞块免疫组化法显示,间皮细胞在CK5/6、WT-1、Calretinin抗体、CEA、TTF-1抗体、CK7的表达分别为30.95%、28.57%、26.19%、14.29%、0.00%、0.00%,腺癌分别为12.07%、10.34%、0.00%、32.76%、24.14%、20.69%,两组比较,差异显著(P<0.05)。结论在诊断胸腔积液细胞块时,与传统的细胞涂片方法相比,细胞块免疫组化法的阳性率更高,可通过不同抗体的表达水平将腺癌与间皮癌区分,具有重要的临床应用价值。

关键词：临床病理技术胸腔积液细胞块诊断应用效果

US-CNB免疫组化检测用于乳腺癌淋巴结转移诊断中的临床价值

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首都食品与医药 2024年第7期31卷 54-57页

作者：王树人刘水江苏省盐城市第一人民医院江苏盐城224000

目的探究乳腺癌淋巴结转移患者采用超声引导下粗针穿刺(US-CNB)免疫组化诊断的价值。方法选取盐城市第一人民医院收治的86例乳腺癌淋巴结转移患者(2020年2月-2023年8月)深入分析,依据随机数字表法分成两组,每组43例,对照组:超声引导下... 详细信息

目的探究乳腺癌淋巴结转移患者采用超声引导下粗针穿刺(US-CNB)免疫组化诊断的价值。方法选取盐城市第一人民医院收治的86例乳腺癌淋巴结转移患者(2020年2月-2023年8月)深入分析,依据随机数字表法分成两组,每组43例,对照组:超声引导下细针穿刺(US-FNAC)细胞学检测,观察组:采用US-CNB免疫组化检测,以病理学诊断为金标准,分析诊断效能。结果US-FNAC细胞学检测可对淋巴结相关区域进行检测,显示该区域中细胞核染色情况,快速确定癌细胞;US-CNB病理组织学检测能发现细胞核深度染色的癌细胞。两组灵敏度、特异度、准确度分别相差28.00%、44.44%、18.60%,观察组更高(P<0.05)。结论在对乳腺癌疾病患者诊断时,US-CNB免疫组化诊断准确度较高,可清晰显示是否向淋巴结转移,对临床鉴别诊断具有较高价值,能为选择正确治疗方案提供可靠数据支持。

关键词：乳腺癌淋巴结转移超声引导下粗针穿刺灵敏度准确度

Imaging-Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles

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Chinese Journal of Chemistry 2023年第19期41卷 2557-2573页

作者： Ran Ma Yanglong Hou shuren wang Beijing Key Laboratory of Magnetoelectric Materials and Devices School of Materials Science and EngineeringBeijing Innovation Centre for Engineering Science and Advanced TechnologyPeking UniversityBeijing100871 China

In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer *** is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic ***,by virtue of various modification strategies,the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic,which is worthy of further *** this review,we summarize the recent developments in imaging-guided strategies and synergistic cancer therapy based on multifunctional ***,we discuss the challenge and perspective of the next generation of MNPs-based imaging-guided cancer therapy,hoping to provide guidance in potential applications.

关键词： Cancer Cancer therapy Modal imaging Magnetic nanoparticles Synergistic action Nanotechnology Synthesis design Drugdelivery Imagingagents

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消化内镜手术术后疼痛分析:回顾性队列研究

山东大学学报（医学版） 2024年第2期62卷 42-50页

作者：武姗姗汪树仁赵同航张宗旺聊城市人民医院麻醉科山东聊城252000 聊城市东昌府区妇幼保健院麻醉科山东聊城252000

目的微创消化内镜手术术后疼痛易被忽视,为优化患者个体化镇痛方案,提高患者的舒适性,回顾分析了不同消化内镜手术术后疼痛程度,为临床工作提供参考。方法回顾性收集1 657例患者资料。采用中文版简明疼痛量表(Chinese Version of the ... 详细信息

目的微创消化内镜手术术后疼痛易被忽视,为优化患者个体化镇痛方案,提高患者的舒适性,回顾分析了不同消化内镜手术术后疼痛程度,为临床工作提供参考。方法回顾性收集1 657例患者资料。采用中文版简明疼痛量表(Chinese Version of the Brief Pain Inventory, BPI-C)进行术后疼痛评估,BPI-C评分大于或等于4表示疼痛控制不佳。采用Logistic回归分析探讨影响术后疼痛的因素。采用广义估计方程(generalized estimating equation, GEE)比较不同手术类型在不同时间点的术后疼痛程度。结果该研究纳入了7种常见的消化内镜手术,大约19.2%的患者BPI-C疼痛评分大于或等于4。GEE分析显示7类手术间术后疼痛存在差异,而且不同时间点术后疼痛强度不同,各类手术患者术后疼痛高峰在术后6 h左右(P<0.001)。12.19%的患者接受了术后镇痛治疗,而仍有31.14%的患者术后渴望使用镇痛药物。结论微创消化内镜手术术后会发生中至重度疼痛,患者对术后镇痛的需求较高,临床医生需提高镇痛意识,优化镇痛方案。

关键词：消化内镜手术术后疼痛疼痛评估不良反应

Self-assembled magnetic nanomaterials:Versatile theranostics nanoplatforms for cancer

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Aggregate 2021年第2期2卷 88-99页

作者： shuren wang Zhiyi wang Yanglong Hou Beijing Key Laboratory of Magnetoelectric Materials and Devices Department of Materials Science and Engineering College of EngineeringBeijing Innovation Centre for Engineering Science and Advanced TechnologyPeking UniversityBeijingChina

Self-assembled magnetic nanomaterials(MNMs)are a class of promising biomaterials possessing excellent physiochemical and biological characteristics,making them highly attractive in biomedical applications.A myriad of magnetic nanosystems can be created by using self-assembly as a synthetic *** nano-bio interfacial properties are shown in these promising self-assembled magnetic nanosystems,while still retaining their physical/chemical *** review aims to provide a systematical overview of the self-assembled *** addition,this review highlights their implementations in cancer theranostics in ***,this review points out the direction for the application of self-assembled MNMs in biomedicine,and presents how clinical oncology could benefit from the self-assembled nanotechnology.

关键词： biomedicine cancer theranostics self-assembled magnetic nanomaterials self-assembled nanotechnology

Height of fractured zone inside overlying strata under high-intensity mining in China

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International Journal of Mining Science and Technology 2019年第1期29卷 45-49页

作者： Wenbing Guo Gaobo Zhao Gaozhong Lou shuren wang School of Energy Science and Engineering Henan Polytechnic University Coal Production Safety Collaborative Innovation Center in Henan Province Henan Polytechnic University International Joint Research Laboratory for Underground Space Development and Disaster Prevention of Henan Province Henan Polytechnic University

The height of fractured zone(HFZ) at the high-intensity longwall mining panel plays a vital role in the safety analysis of coal mining under bodies of water. This paper described definitions of the highintensity mining. The processes of overburden failure transfer(OFT) were analyzed, which were divided into the development stage and the termination stage. Through theoretical analysis, the limited suspension-distance and the limited overhanging distance were proposed to judge the damage of each stratum. Mechanical models of strata suspended integrity and overhanging stability were established.A theoretical method to predict the HFZ at the high-intensity longwall mining panel was put forward based on the processes of OFT. Taking a high-intensity longwall mining panel(No. 11915 panel) as an example, the theoretical method proposed, the engineering analogy and the empirical formulas in the Regulation were used to predict the HFZ. The results show that the theoretical result is consistent with the engineering analogies' result and empirical formulas' result. The rationality and reliability of the theoretical method proposed is verified.

关键词： High-intensity mining Overburden failure Height of fractured zone Overlying strata movement

Instability characteristics of the cracked roof rock beam under shallow mining conditions

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International Journal of Mining Science and Technology 2018年第3期28卷 437-444页

作者： Zhao Yanhai wang shuren Zou Zhengsheng Ge Linlin Cui Fang School of Civil Engineering Henan Polytechnic University School of Mining Engineering University of New South Wales

To establish the movement relationship for the roof breaking under shallow mining conditions, the mechanical model of the roof rock beam was built, then the structure instability process of the roof rock beam was analyzed. The changing criterion of the vertical displacement was established and the relationship between the deflection and the rotary motion of roof block was determined. Regarding a mining face in Shangwan Mine, the responsing laws of the deflection and horizontal thrust of the roof rock beam were obtained through FLAC3D numerical analysis. The results show that the structure instability of the cracked roof rock beam depends on the interaction between the vertical load and the horizontal *** the roof rock beam, when the vertical load keeps constant, the horizontal thrust fluctuating rises with increasing deflection. The horizontal thrust increases constantly with the deeper buried depth and the smaller span.

关键词： Shallow mining Working face Roof rock beam Structure stability Horizontal thrust

Method of accurate grinding for single enveloping TI worm

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Science China(Technological Sciences) 2005年第4期48卷 430-440页

作者： SUN Yuehai ZHENG Huijiang BI Qingzhen wang shuren School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China

TI worm drive consists of involute helical gear and its enveloping Hourglass worm. Accurate grinding for TI worm is the key manufacture technology for TI worm gearing being popularized and *** to the theory of gear mesh, the equations of tooth surface of worm drive are gained, and the equation of the axial section profile of grinding wheel that can accurately grind TI worm is extracted. Simultaneously, the relation of position and motion between TI worm and grinding wheel are expounded. The method for precisely grinding single enveloping TI worm is obtained.

关键词： worm gears, helical gear, hourglass worm, grinding, grinding wheel.