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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang ronghao wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Leader-following consensus control for linear multi-agent systems with quantized communication 36

Leader-following consensus control for linear multi-agent sy...

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第36届中国控制会议

作者： Qianyu Shen ronghao wang School of Automation Nanjing University of Science and Technology College of Defense Engineering PLA University of Science and Technology

ISBN: (纸本)9781538629185

In this paper,we consider consensus problems for linear multi-agent systems with quantized communication among *** order to achieve consensus,distributed consensus protocols which only based on the quantized relative states of neighboring agents is *** sufficient conditions are presented to reach the consensus of linear multi-agent systems by using algebraic graph theory,Lyapunov stability analysis and Krasovskii ***,it is also pointed out that when the agents obtain time delayed information,the given system can also reach consensus under some ***,numerical simulations are presented to verify the effectiveness of the theoretical analysis.

关键词： Quantized consensus Linear multi-agent systems Krasovskii solution Time delay

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A High-Throughput Phenotyping Pipeline for Image Processing and Functional Growth Curve Analysis

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Plant Phenomics 2020年第1期2卷 188-195页

作者： ronghao wang Yumou Qiu Yuzhen Zhou Zhikai Liang James C.Schnable Department of Statistics University of Nebraska-LincolnLincoln 68503USA Department of Statistics Iowa State UniversityAmes 50011USA Department of Plant and Microbial Biology University of MinnesotaSaint PaulMN 55108USA Center for Plant Science Innovation Department of Agronomy and HorticultureUniversity of Nebraska-LincolnLincoln 68503USA

High-throughput phenotyping system has become more and more popular in plant science *** data analysis for such a system typically involves two steps:plant feature extraction through image processing and statistical analysis for the extracted *** current approach is to perform those two steps on different *** develop the package“implant”in R for both robust feature extraction and functional data *** image processing,the“implant”package provides methods including thresholding,hidden Markov random field model,and morphological *** statistical analysis,this package can produce nonparametric curve fitting with its confidence region for plant growth.A functional ANOVA model to test for the treatment and genotype effects on the plant growth dynamics is also provided.

关键词： steps image operations

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Finite-time Reliable Stabilization for Switched Stochastic Systems Under Asynchronous Switching

Finite-time Reliable Stabilization for Switched Stochastic S...

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第25届中国控制与决策会议

作者： wang ronghao Qian Zhigen Xing Jianchun wang Ping Yang Qiliang College of Defense Engineering PLA University of Science and Technology PLA Academy of National Defense Information

ISBN: (纸本)9781467355339

In this paper, the finite-time stabilization problems for switched stochastic systems are addressed. Firstly, when there exists asynchronous switching between the controller and the system, a sufficient condition for the existence of stabilizing switching law for switched stochastic systems is derived. It is proved that the switched stochastic systems are finite-time stabilizable under asynchronous switching satisfying the average dwell-time condition. Furthermore, the problem of reliable control for switched stochastic systems under asynchronous switching is also investigated. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.

关键词： Asynchronous Switching Switched Stochastic Systems Average Dwell-time Finite-time Reliable Control

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An Improved MAC Protocol for Underwater Acoustic Networks

An Improved MAC Protocol for Underwater Acoustic Networks

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第25届中国控制与决策会议

作者： wang Ping Fu Donghao Xing Jianchun Yang Qiliang wang ronghao Wu Wenhao The PLA University of Science and Technology Urumuqi Urban construction Archives

ISBN: (纸本)9781467355339

Considering the particularity of underwater acoustic channel and the performance of underwater acoustic sensor networks, this paper presents a MAC layer protocol based on CDMA with throughput adaptive regulation and energy-efficient （TAEE-CDMA） protocol. On the premise that the MAI problem was suppressed, the protocol firstly used Lagrange multiplier method to make the node run with minimum energy consumption, then adjusted the transmit power of node to change the throughput size according to the dynamic changes of the node cache queue, which can ensure the monitoring task of network be completed and make the network run with optimal performance. The analysis and simulation results showed that the protocol had advantages of energy-efficient, real-time and high reliability.

关键词： Underwater Acoustic Network Throughput Energy-efficient Adaptive Regulation MAC

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考虑计算延迟的Boost变换器异步切换控制方法

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东南大学学报（自然科学版） 2021年第1期51卷 92-100页

作者：王荣浩中国人民解放军陆军工程大学国防工程学院南京210007

为应对Boost变换器电路中控制律的计算延迟及高频切换,提出一种基于时间切换的有限时间异步控制方法实现变换器的稳定控制.首先利用切换系统方法建立Boost变换器在开关动作和电路拓扑切换间发生延迟的异步控制模型;然后结合平均驻留时... 详细信息

为应对Boost变换器电路中控制律的计算延迟及高频切换,提出一种基于时间切换的有限时间异步控制方法实现变换器的稳定控制.首先利用切换系统方法建立Boost变换器在开关动作和电路拓扑切换间发生延迟的异步控制模型;然后结合平均驻留时间方法与多Lyapunov函数,利用占空比实现变换器的混杂切换控制;最后基于有限时间控制原理,得到控制律的计算时间、切换信号驻留时间与系统稳定运行时间之间的定量关系.结果表明,在0.9 ms运行时间内,当电路系统的切换信号与实际控制律切换信号间存在0.05 ms的延迟时,异步切换控制总切换次数为5,少于同步切换控制总切换次数11,未出现高频振动现象.异步切换控制方法能够有效抑制电路输出响应在平衡点附近的高频振动,控制性能更优.

关键词： Boost变换器切换系统计算延迟平均驻留时间多Lyapunov函数有限时间异步控制

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Fixed-time consensus of second-order leader-following multi-agent systems with inherent nonlinear dynamics

Fixed-time consensus of second-order leader-following multi-...

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第37届中国控制会议

作者： Kewei Qian ronghao wang School of Automation Nanjing University of Science and Technology National Defense Engineering College Army Engineering University

This paper studies fixed-time consensus of second-order leader-following multi-agent systems with inherent nonlinear dynamics. Firstly, a new fixed-time consensus protocol is designed to solve the tracking problem of the second-order nonlinear systems. By using Lyapunov theory and graph theory, we choose a different Lyapunov function candidate to verify the theoretical results. Then we consider the second-order multi-agent systems with multiple leaders and propose a new protocol to solve the fixed-time containment control problem. Finally, two numerical examples are proposed to demonstrate the effectiveness of the proposed fixed-time protocols.

关键词： Fixed-time consensus Second-order multi-agent systems Leader-following consensus Containment control Nonlinear systems

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Sampled-data leader-following consensus of second-order nonlinear multi-agent systems with disturbance and missing data

Sampled-data leader-following consensus of second-order nonl...

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第30届中国控制与决策会议

作者： Huang Yueying wang ronghao School of Automation Nanjing University of Science and Technology College of Defense Engineering Army Engineering University of PLA

In this paper,the leader-following consensus problem of second-order nonlinear multi-agent systems with disturbances and random missing input data is *** stochastic variables with a Bernoulli distributed sequence are used to model missing input data.A novel protocol with missing data is *** more,the sufficient condition is obtained to ensure the leader-following ***,a numerical example is provided to verify the effectiveness of the proposed protocol.

关键词： Multi-agent Systems Sampled-data Protocol Missing Data and Leader-following Consensus

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H-Infinity Quantized Feedback Control for Networked Control Systems with Periodic Scheduling Protocol

H-Infinity Quantized Feedback Control for Networked Control ...

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2015年中国智能自动化学术会议

作者： Chuan Zhou Hui Lu ronghao wang School of Automation Nanjing University of Science and Technology College of Defense Engineering PLA University of Science and Technology

A novel simultaneous design scheme of H-infinity quantized feedback controller and periodic scheduling protocol for a class of networked control systems(NCSs) with bit rate constraints and time delay is proposed in this paper.A mid-tread uniform quantizers is used and the quantization error is treated as a model uncertainty by utilizing sector-bounded *** NCSs is modeled as a discrete-time switched system with parameter *** procedures for H-infinity controller design under the static periodic scheduling protocol are given to maintain the asymptotic stability and robust performance of the closed-loop *** a simulation example is given to illustrate effectiveness of the proposed method.

关键词： Networked control systems Periodic scheduling

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A New Structural Damage Evaluation Method Based on Modified Extreme Learning Machine

A New Structural Damage Evaluation Method Based on Modified ...

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第40届中国控制会议

作者： He Can Wu Xiaochen wang ronghao National Defense Engineering College Army Engineering University

Structural damage assessment is an important part of structural health ***,there is the defect of low accuracy in the existed evaluation *** order to solve this problem,a new model for structural damage assessment using particle swarm optimization（PSO） and extreme learning machine（ELM） named PELM is proposed in this ***,PSO is used to calculate the best parameters of ELM,and then the optimized ELM model is adopted to evaluate the structural *** model and other two different models are used to assess the structural damages of a pile structure as an experiment,the results show that PELM model has a higher prediction accuracy than SVM model and ELM model.

关键词： Structural health monitoring damage evaluation particle swarm optimization extreme learning machine

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