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Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression

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Genes & Diseases 2024年第1期11卷 176-188页

作者： Zhuang Chen qiming wang Jinbo Liu Wenkang wang Weitang Yuan Yang Liu Zhenqiang Sun Chengzeng wang Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan 450001China Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450008China Department of Breast Surgery The First Affliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Radiotherapy Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450008China The First Affiliated Hospital of Zhengzhou University ZhengzhouHenan 450052China

A pre-metastatic niche(PMN)is a protective microenvironment that facilitates the colonization of disseminating tumor cells in future metastatic *** vesicles(EVs)play a role in intercellular communication by delivering cargoes,such as noncoding RNAs(ncRNAs).The pivotal role of extracellular vesicle-derived noncoding RNAs(EV-ncRNAs)in the PMN has attracted increasing *** this review,we summarized the effects of EV-ncRNAs on the PMN in terms of immunosuppression,vascular permeability and angiogenesis,inflammation,metabolic reprogramming,and fibroblast *** particular,we provided a comprehensive overview of the effects of EV-ncRNAs on the PMN in different ***,we discussed the promising clinical applications of EV-ncRNAs,including their potential as diagnostic and prognostic markers and therapeutic targets.

关键词： Biomarker Extracellular vesicles Noncoding RNAs

Legume green manure can intensify the function of chemical nitrogen fertilizer substitution via increasing nitrogen supply and uptake of wheat

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The Crop Journal 2024年第4期12卷 1222-1232页

作者： Jingui Wei Zhilong Fan Falong Hu Shoufa Mao Fang Yin qiming wang Qiang Chai Wen Yin State Key Laboratory of Arid Land Crop Science Lanzhou 730070GansuChina College of Agronomy Gansu Agricultural UniversityLanzhou 730070GansuChina

Achieving the green development of agriculture requires the reduction of chemical nitrogen(N)fertilizer *** studies have confirmed that returning green manure to the field is an effective measure to improve crop yields while substituting partial chemical N ***,it remains unclear how to further intensify the substituting function of green manure and elucidate its underlying agronomic *** a split-plot field experiment in spring wheat,different green manures returned to the field under reduced chemical N supply was established in an oasis area since 2018,in order to investigate the effect of green manure and reduced N on grain yield,N uptake,N use efficiency(NUE),N nutrition index,soil organic matter,and soil N of wheat in *** results showed that mixed sown common vetch and hairy vetch can substitute 40%of chemical N fertilizer without reducing grain yield or N ***,mixed sown common vetch and hairy vetch under reduced N by 20%showed the highest N agronomy efficiency and recovery efficiency,which were 92.0%and 46.0%higher than fallow after wheat harvest and conventional N application rate,*** increase in NUE of wheat was mainly attributed to mixed sown common vetch and hairy vetch,which increased N transportation quantity and transportation rate at pre-anthesis,enhanced N harvest index,optimized N nutrition index,and increased activities of nitrate reductase and glutamine synthetase of leaf,***,mixed sown common vetch and hairy vetch under reduced N by 20%improved soil organic matter and N ***,mixed sown common vetch and hairy vetch can substitute 40%of chemical N fertilizer while maintaining grain yield and N accumulation,and it combined with reduced chemical N by 20%or 40%improved NUE of wheat via enhancing N supply and uptake.

关键词： Legume green manure Reduced N input Wheat N uptake and supply Agronomic mechanism

Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial

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Cancer Biology & Medicine 2024年第10期 951-962页

作者： Cuicui Zhang Tianqing Chu qiming wang Ying Cheng Yongxiang Zhang Ruili wang Leilei Ma Chaonan Qian Baohui Han Kai Li Department of Thoracic Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Department of Respiratory Medicine Shanghai Chest Hospital Shanghai Jiaotong University Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Department of Thoracic Medical Oncology Jilin Cancer Hospital Department of Respiratory & Critical Care Medicine Tianjin Chest Hospital Panovue Biotechnology (Beijing) Co. Ltd Medical Affairs Department Chia-Tai Tian Qing Pharmaceutical Co.Ltd. Department of Radiation Oncology Guangzhou Concord Cancer Center

Objective: The possible enhancing effect of anlotinib on programmed death receptor ligand（PD-L1） antibody and the efficacypredicting power of PD-L1 in micro-conduit endothelium, including lymphatic endothelial cells（LECs） and blood endothelial cells（BECs）, were determined to identify patients who would benefit from this ***: PD-L1 positivity in LECs, BECs, and tumor cells（TCs） was assessed using paraffin sections with multicolor immunofluorescence in an investigator's brochure clinical trial of TQB2450（PD-L1 antibody） alone or in combination with anlotinib in patients with non-small cell lung cancer. Progression-free survival（PFS） with different levels of PD-L1 expression was compared between the two ***: Among 75 patients, the median PFS（m PFS） was longer in patients who received TQB2450 with anlotinib [10 and 12 mg（161 and 194 days, respectively）] than patients receiving TQB2450 alone（61 days） [hazard ratio（HR）10 mg= 0.390（95% confidence interval {CI}, 0.201±0.756）, P = 0.005; HR12 mg= 0.397（0.208±0.756）, P = 0.005]. The results were similar among 58 patients with high PD-L1 expression in LECs and TCs [159 and 209 vs. 82 days, HR10 mg= 0.445（0.210±0.939）, P = 0.034; HR12 mg= 0.369（0.174±0.784）, P = 0.009], and 53 patients with high PD-L1 expression in BECs and TCs [161 and 209 vs. 41 days, HR10 mg= 0.340（0.156±0.742）, P = 0.007; HR12 mg= 0.340（0.159±0.727）, P = 0.005]. No differences were detected in the m PFS between the TQB2450 and combination therapy groups in 13 low/no LEC-expressing and 18 low/no BEC-expressing PD-L1 ***: Mono-immunotherapy is not effective in patients with high PD-L1 expression in LECs and/or BECs. Anlotinib may increase efficacy by downregulating PD-L1 expression in LECs and/or BECs, which is presumed to be a feasible marker for screening the optimal immune patient population undergoing anti-angiogenic therapy.

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双凝胶在食品领域:从组成到应用

食品科学 2024年第6期45卷 277-284页

作者：张倩蒋玲王启明雷小娟明建西南大学食品科学学院重庆400715 川渝共建特色食品重庆市重点实验室重庆400715

双凝胶是油凝胶和水凝胶在一定温度下剪切混合制成的双相体系。作为一种两亲性半固体制剂,双凝胶具有良好的稳定性、包埋特性、加工特性等,引起了人们的广泛关注。双凝胶在替代传统固体脂肪,提高复合食品的营养价值以及递送生物活性物... 详细信息

双凝胶是油凝胶和水凝胶在一定温度下剪切混合制成的双相体系。作为一种两亲性半固体制剂,双凝胶具有良好的稳定性、包埋特性、加工特性等,引起了人们的广泛关注。双凝胶在替代传统固体脂肪,提高复合食品的营养价值以及递送生物活性物质方面有巨大的潜力。本文综述了双凝胶的组成及合成方法,并梳理了双凝胶的种类,总结了双凝胶在食品领域的主要应用进展,并展望其发展前景,以期为双凝胶在食品领域的进一步研究和应用提供一定的指导。

关键词：双凝胶油凝胶剂水凝胶剂生物活性物质递送 3D打印食品

基于响应复合能量因子的波浪激励下高桩码头桩基损伤识别

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振动与冲击 2024年第5期43卷 31-40,93页

作者：李成明王启明朱瑞虎胡艳王泊淳河海大学数学学院南京211100 河海大学港口海岸与近海工程学院南京210098 河海大学海岸灾害及防护教育部重点实验室南京210098

波浪是高桩码头桩基长期、重要外部激励,探索波浪激励下桩基损伤识别对构建码头健康监测体系具有重要意义。由于波浪激励下桩基动力响应呈现多类型信号混叠、窄带、非平稳的特性,使得现有损伤识别方法难以实现准确判定。为解决上述问题... 详细信息

波浪是高桩码头桩基长期、重要外部激励,探索波浪激励下桩基损伤识别对构建码头健康监测体系具有重要意义。由于波浪激励下桩基动力响应呈现多类型信号混叠、窄带、非平稳的特性,使得现有损伤识别方法难以实现准确判定。为解决上述问题,首先构建基于自适应噪声的完备集成经验模态分解与K-means++的信号自动重构方法,以提取损伤特征子信号;然后,通过融合能量、相位等信息,构建新型复合能量损伤识别指标,以提高微小波浪激励下损伤识别的敏感性和鲁棒性。进一步,在高桩码头桩基多种损伤工况下开展波浪激励试验,验证新方法在损伤识别方面的有效性。结果表明,新构建的复合能量因子兼顾能量、相位的优点,能准确识别出损伤存在、损伤位置和损伤程度。

关键词：损伤识别复合能量因子高桩码头波浪激励信号重构

Grain yield and N uptake of maize in response to increased plant density under reduced water and nitrogen supply conditions

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Journal of Integrative Agriculture 2024年第1期23卷 122-140页

作者： Jingui Wei Qiang Chai Wen Yin Hong Fan Yao Guo Falong Hu Zhilong Fan qimingwang State Key Laboratory of Aridland Crop Science Lanzhou 730070China College of Agronomy Gansu Agricultural UniversityLanzhou 730070China College of Life Sciences Northwest Normal UniversityLanzhou 730070China

The development of modern agriculture requires the reduction of water and chemical N fertilizer *** the planting density can maintain higher yields,but also consumes more of these restrictive ***,whether an increased maize density can compensate for the negative effects of reduced water and N supply on grain yield and N uptake in the arid irrigated areas remains *** study is part of a long-term positioning trial that started in 2016.A split-split plot field experiment of maize was implemented in the arid irrigated area of northwestern China in 2020 to *** treatments included two irrigation levels:local conventional irrigation reduced by 20%(W1,3,240 m^(3)ha^(-1))and local conventional irrigation(W2,4,050 m^(3)ha^(-1));two N application rates:local conventional N reduced by 25%(N1,270 kg ha^(-1))and local conventional N(360 kg ha^(-1));and three planting densities:local conventional density(D1,75,000 plants ha^(-1)),density increased by 30%(D2,97,500 plants ha-1),and density increased by 60%(D3,120,000 plants ha^(-1)).Our results showed that the grain yield and aboveground N accumulation of maize were lower under the reduced water and N inputs,but increasing the maize density by 30% can compensate for the reductions of grain yield and aboveground N accumulation caused by the reduced water and N *** water was reduced while the N application rate remained unchanged,increasing the planting density by 30% enhanced grain yield by 13.9% and aboveground N accumulation by 15.3%.Under reduced water and N inputs,increasing the maize density by 30% enhanced N uptake efficiency and N partial factor productivity,and it also compensated for the N harvest index and N metabolic related enzyme *** with W2N2D1,the N uptake efficiency and N partial factor productivity increased by 28.6 and 17.6%under W1N1D2.W1N2D2 had 8.4% higher N uptake efficiency and 13.9% higher N partial factor productivity than W2N2D1.W1N2D2 improv

关键词： water and N reduction plant density maize grain yield N uptake compensation effect

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汉语方言分区的八个基本问题

中国语言学研究

中国语言学研究 2024年第1期 184-213页

作者：汪启明西南交通大学

汉语方言分区是方言研究的起点,也是归宿,是整个汉语方言研究的核心任务。论文就学术界在方言分区方面的八个基本问题做了学术追溯和讨论。包括:分区的主观性与客观性,方言分区的有意识与无意识,方言分区的历时与共时,方言地理分布与现... 详细信息

汉语方言分区是方言研究的起点,也是归宿,是整个汉语方言研究的核心任务。论文就学术界在方言分区方面的八个基本问题做了学术追溯和讨论。包括:分区的主观性与客观性,方言分区的有意识与无意识,方言分区的历时与共时,方言地理分布与现象位移,方言分区的标准之争及演变,方言分区的材料问题,方言的教学分区与研究分区,方言分布、分类和分区,并就这些问题提出了自己的意见。主张“分区可以多标准、多类型、多层次”,先分类,再划区,方言区都是人为的,现有的方言材料具有不完备性,较大的方言区都是混合方言区,方言之间的过渡带值得深入研究。

关键词：汉语方言分类分区基本问题

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柚皮素及其纳米递送体系研究进展

食品与发酵工业 2024年第7期50卷 338-345页

作者：夏莎莎王启明饶哲楠明建西南大学食品科学学院重庆400715 西南大学食品贮藏与物流研究中心重庆400715

柚皮素是广泛存在于柑橘类水果中一种黄酮类化合物,具有多种生理功效,如抗肿瘤、抗氧化和抗炎活性等。然而,由于柚皮素的疏水性,导致其生物利用度较差,应用潜力受到阻碍。为了提高柚皮素的生物利用度,研究人员开发了包括聚合物纳米颗粒... 详细信息

柚皮素是广泛存在于柑橘类水果中一种黄酮类化合物,具有多种生理功效,如抗肿瘤、抗氧化和抗炎活性等。然而,由于柚皮素的疏水性,导致其生物利用度较差,应用潜力受到阻碍。为了提高柚皮素的生物利用度,研究人员开发了包括聚合物纳米颗粒、脂质体、纳米乳液、纳米混悬液在内的纳米递送系统。在此,该文对柚皮素的生理功能、体内代谢及其纳米递送体系进行了介绍,针对目前研究中存在的问题对未来柚皮素纳米递送体系的研究方向和应用前景进行了展望。

关键词：柚皮素生理功效纳米递送体系稳定性生物利用度

我国院前急救可视化技术的应用和运行管理研究

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中国医疗管理科学 2024年第3期14卷 9-12页

作者：王启铭深圳市天维尔智慧应急技术研究院广东省深圳市518057

随着光纤通信、数字通信、云计算和5G移动通信等技术的快速发展,全程可视化技术在院前医疗急救领域得到了具体应用和有益实践。通过发挥信息系统支撑作用,院前医疗急救行为相关记录完整率不断提升,既有效缩短了急救反应时间,又使得院前... 详细信息

随着光纤通信、数字通信、云计算和5G移动通信等技术的快速发展,全程可视化技术在院前医疗急救领域得到了具体应用和有益实践。通过发挥信息系统支撑作用,院前医疗急救行为相关记录完整率不断提升,既有效缩短了急救反应时间,又使得院前医疗急救服务能力、抢救水平、医疗质量及规避风险等方面得到了明显提高和改善。伴随技术进步,与之相关的运行管理问题也随之而来,这势必涉及对接主体、权限管理、信息安全、干预处理、知情调阅以及法律风险等一系列相关问题,对此就上述问题从需求牵引的角度进行了探讨。

关键词：院前急救可视化技术医疗管理