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Breast cancer radiotherapy： controversies and prospectives

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Chinese Medical Journal 2008年第20期121卷 1957-1959页

作者： YU Jin-ming wang yong-sheng Breast Cancer Center Shandong Cancer Hospital Jinan Shandong 250117 China

Despite consensus on breast cancer radiotherapy, there are still some controversies over post-mastectomy radiotherapy （PMRT） in patients with 1-3 positive lympn nodes, accelerated partial breast irradiation （APBI）, appropriate sequence of radiotherapy, chemotherapy and hormonal treatment, and radiotherapy after preoperative systemic therapy.

关键词：多数赞同乳房乳房切除术乳腺肿瘤

Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation

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Chinese Journal of Natural Medicines 2021年第10期19卷 732-740页

作者： ZHANG Wei BAI Shan-Shan ZHANG Qi SHI Ru-Ling wang He-Cheng LIU You-Cai NI Tian-Jun WU Ying YAO Zhao-Yang SUN Yi wang ming-yong School of Basic Medical Sciences Xinxiang Medical UniversityXinxiang 453003China Grade 2019 School of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453003China School of Public Health Xinxiang Medical UniversityXinxiang 453003China School of Life and Pharmaceutical Sciences Dalian University of TechnologyPanjin 124221China School of Basic Medical Sciences Sanquan College of Xinxiang Medical UniversityXinxiang 453003China School of Nursing Care Xinxiang Medical UniversityXinxiang 453003China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China School of Laboratory Medicine Xinxiang Medical UniversityXinxiang 453003China Xinxiang Key Laboratory of Immunoregulation and Molecular Diagnostics Xinxiang 453003China Central Laboratory the First Affiliated Hospital of Henan University of Science and TechnologyLuoyang 471003China

Physalin B(PB),one of the major active steroidal constituents of Solanaceae Physalis plants,has a wide variety of biological *** found that PB significantly down-regulatedβ-amyloid(Aβ)secretion in N2a/APPsw ***,the underlying mechanisms are not well *** the current study,we investigated the changes in key enzymes involved inβ-amyloid precursor protein(APP)metabolism and other APP metabolites by treating N2a/APPsw cells with PB at different *** results indicated that PB reduced Aβ secretion,which was caused by down-regulation of β-secretase(BACE1)expression,as indicated at both the protein and mRNA *** research revealed that PB regulated BACE1 expression by inducing the activation of forkhead box O1(FoxO1)and inhibiting the phosphorylation of signal transducer and activator of transcription 3(STAT3).In addition,the effect of PB on BACE1 expression and Aβsecretion was reversed by treatment with FoxO1 siRNA and STAT3 antagonist *** conclusion,these data demonstrated that PB can effectively down-regulate the expression of BACE1 to reduce Aβsecretion by activating the expression of FoxO1 and inhibiting the phosphorylation of STAT3.

关键词： Physalin B β-amyloid BACE1 FoxO1 Alzheimer’s disease

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N帧连续景象匹配一致性决策算法

计算机学报 2005年第6期28卷 1032-1035页

作者：王永明北京信息高技术研究所北京100085

下视景象匹配是各类巡航飞行器实现精确导航的重要手段,它是通过事先装载在飞行器的地面基准图像与实时获取的地面景象图进行相关匹配,完成飞行器的飞行误差修正和精确定位.由于基准图和实时图在获取手段、时间上等方面的差异,在相关匹... 详细信息

下视景象匹配是各类巡航飞行器实现精确导航的重要手段,它是通过事先装载在飞行器的地面基准图像与实时获取的地面景象图进行相关匹配,完成飞行器的飞行误差修正和精确定位.由于基准图和实时图在获取手段、时间上等方面的差异,在相关匹配中,配准点往往落在相关阵的次峰上,导致匹配失败.该文提出了多帧连续景象匹配,利用单次匹配后形成的相关阵中的主次峰信息与导航信息进行一致性决策的图论算法.由于引入了相关阵中的次峰信息,并结合惯导位移进行一致性判断,使得匹配算法能有效剔除误匹配点,从而提高了算法的匹配概率和鲁棒性.

关键词：景象匹配相关峰一致性决策

Energy calculation of Fe(001) twist grain boundary

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商丘师范学院学报 2009年第3期25卷 63-68页

作者： wang yong-ming wang Peng-fei College of Physics and Information Technology Shaanxi Normal University Xi＇an 710062 China

With modified analytical embedded atom method(MAEAM),the energy of(001)twist grain boundary(GB)has been calculated for metal *** results show that the unrelaxed energy keeps almost constant with twist angle θ except several cusps at some special Σ *** GB energies drop significantly after expansion perpendicular to the ***-boundary translation results in periodic energy variation,but the energy variation is slight.

关键词：物理教学铁原子 MAEAM GB

基于一种快速归一化积相关算法的图像匹配研究

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兵工学报 2010年第2期31卷 160-165页

作者：韩冰王永明第二炮兵工程学院陕西西安710025 第二炮兵装备研究院北京100085

在灰度图像匹配中,归一化积相关算法具有鲁棒性强、精准度高和易于硬件实现等优点。但算法复杂、计算速度慢是制约其应用的主要原因。基于迭代的思想提出了一种快速归一化积相关算法。该方法在计算基准子图图像能量时,只通过几个像素值... 详细信息

在灰度图像匹配中,归一化积相关算法具有鲁棒性强、精准度高和易于硬件实现等优点。但算法复杂、计算速度慢是制约其应用的主要原因。基于迭代的思想提出了一种快速归一化积相关算法。该方法在计算基准子图图像能量时,只通过几个像素值的加减运算,便可快速实现基准子图像素求和,大大降低了计算的复杂度。实验证明,本算法与原算法具有相同的匹配精度,但计算时间仅为原算法的1/9.

关键词：飞行器控制、导航技术归一化积相关图像能量迭代法图像匹配

Theoretical Analyses of 4f^11→4f^105d Excitation Spectra of Er^3＋ Doped in LiYF4

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Chinese Journal of Structural Chemistry 2005年第1期24卷 1-1页

作者： LI Cai-Yun wang yong-ming (Department of Basic Course, Chinese People’s Armed Police Force Academy, Langfang 065000, China) DepartmentofBasicCourse ChinesePeople＇sArmedPoliceForceAcademyLangfang065000China

Spectral terms and J-spectral multiplet of low-spin 4f105d configuration of Er3+ were obtained with the method of ligand field theory. According to the selection rules for dipole transitions, the excitation spectra of Er3+ doped in LiYF4 in vacuum ultraviolet region (120～160 nm) of the spectrum were theoretically interpreted by applying the crystal field model, and the six bands were assigned to the spin-allowed transitions from the ground state (4I15/2) to J-spectral multiplet of low-spin 4f105d configuration of Er3+ion.

关键词： LiYF_4 crystal Er^(3+) ion fd excitation spectra theoretical analysis

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基于元胞自动机的道路交通堵塞仿真研究

系统仿真学报 2010年第9期22卷 2149-2154页

作者：王永明中国安全生产科学研究院北京100012 北京科技大学土木与环境工程学院北京100083

意外交通事件的发生会干扰正常的交通流秩序,甚至引起交通堵塞。建立交通意外事件影响下的交通流仿真模型,将能有效地对拥堵传播控制进行研究。对堵塞车流中车辆个体的行为特征进行了详尽分析后,通过设置"挤车变道"规则对现有的元胞自... 详细信息

意外交通事件的发生会干扰正常的交通流秩序,甚至引起交通堵塞。建立交通意外事件影响下的交通流仿真模型,将能有效地对拥堵传播控制进行研究。对堵塞车流中车辆个体的行为特征进行了详尽分析后,通过设置"挤车变道"规则对现有的元胞自动机模型进行了改进,建立起一种适合描述交通堵塞传播的元胞自动机模型。该模型能够较为准确地模拟出堵塞交通流的时空传播过程。最后,利用本模型探索了主要交通流参数对堵塞传播的影响规律。

关键词：交通堵塞堵塞传播规律元胞自动机交通流

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高温熔盐体系惰性阳极与月壤电解制氧技术

工程科学学报 2021年第12期43卷 1618-1629页

作者：寇明银王明涌焦树强北京科技大学钢铁冶金新技术国家重点实验室北京100083 北京科技大学冶金与生态工程学院北京100083 北京科技大学稀贵金属绿色回收与提取北京市重点实验室北京100083

目前,熔盐电化学冶金普遍采用炭素阳极,阳极CO_(2)产物是重要的碳排放源.若在高温熔盐体系中使用惰性析氧阳极,则可实现熔盐电解过程低碳排放.因此,开发适用于熔盐电解体系的惰性阳极至关重要,也是近年来国内外研究热点.本文首先综述了... 详细信息

目前,熔盐电化学冶金普遍采用炭素阳极,阳极CO_(2)产物是重要的碳排放源.若在高温熔盐体系中使用惰性析氧阳极,则可实现熔盐电解过程低碳排放.因此,开发适用于熔盐电解体系的惰性阳极至关重要,也是近年来国内外研究热点.本文首先综述了各种高温熔盐体系惰性阳极的研究进展,所涉及熔盐体系包括:铝电解氟化物盐、CaCl_(2)熔盐、碳酸盐和熔融氧化物等.另外,近年来月球开发利用受到广泛关注,太阳能驱动的月壤原位熔盐电化学制氧,将是支撑人类未来月面生存氧气需求的重要方法之一,故惰性析氧阳极不可或缺.因此,本文也简要综述了基于惰性阳极的月壤电解制氧技术.

关键词：碳减排高温熔盐惰性阳极熔盐电解月壤制氧

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SOLID STATE PHOTOCHEMICAL SYNTHESIS OF A NOVEL HOST COMPOUND METHYL 4-(DI-3-INDOLYL) METHYLBENZOATE AND X-RAY CRYSTAL STRUCTURE OF ITS 1:1 INCLUSION COM-PLEX WITH ACETONE

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Chinese Journal of Structural Chemistry 1992年第5期 358-361页

作者： Meng Ji-Ben Du Da-ming wang yong-Mei wang Hong-Gen wang Ru-JiDepartment of Chemistry and Central Laboratory, Nankai University , Tianjin, 300071

A novel host compound methyl 4-(di-3-indolyl) methylbenzoate p-CH3OCOC6H4CH (C8H6N)2(3) was prepared by irradiation of the mixed crystals of methyl p-formylbenzoate (1) and indole (2.). The crystal structure of 1:1 inclusion complex (3’ ) formed by compound (3) and acetone has been examined by X-ray diffraction analysis. The crystal belongs to triclinic system, space group P1, with cell parameters: a = 9.902(3), b = 10. 626(2), c=12. 945(2) A , α=70. 69(2),β = 72.56(2), γ = 69. 53(2)°, V = 1177. 82(?)3, Mr = 438. 53, Z = 2, Dx = 1. 236g/ cm3, μ = 0. 75cm-1, F (000) = 464. The final R is 0. 041 for 2006 observed unique reflections. There are three main planes in one molecule of this compound, the dihedral angles between them are 62. 37°, 89. 12° and 83. 308, respectively.

关键词： COM METHYLBENZOATE AND X-RAY CRYSTAL STRUCTURE OF ITS 1 SOLID STATE PHOTOCHEMICAL SYNTHESIS OF A NOVEL HOST COMPOUND METHYL 4 DI-3-INDOLYL ITS