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Food Science and Human Wellness 2023年

作者： jiaqi wang Sen Mei Chi Jin Muhammad Aamer Mehmood Qing Zhang Weili Li Tao Wu Food Microbiology Key Laboratory of Sichuan Province， Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing， Xihua University Department of Bioinformatics and Biotechnology， Government College University Faisalabad

The utilization of Lactobacillus plantarum (LP) in chili sauce production is well-known for its capacity to enhance product quality and sensory attributes. However， there is still limited knowledge regarding the taste-active metabolites in the sauce. To bridge this gap， our study employed metabolomics and web-based computational tools to investigate the dynamic changes of taste-active metabolites during chili sauce fermentation. By leveraging the advantages of the feature-based molecular network (FBMN)， we conducted a rapid annotation of metabolites， successfully identifying 205 metabolites， a considerable portion of which were previously unreported. Through the utilization of the VirtualTaste tool， we identified dihydrosphingosine， lactic acid， isoleucine， phytosphingosine， and gluconic acid as potential taste indicators for quality control. Pathway enrichment analysis further supported their primary involvement in key biochemical pathways， including amino acid tRNA biosynthesis， phenylalanine， tyrosine， tryptophan biosynthesis， and sphingolipid metabolism. This investigation provides valuable insights into the underlying mechanisms contributing to the distinctive flavor profile of chili sauce.

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DISTRIBUTIONS AND HYDROLOGICAL CHARACTERISTICS OF TROPICAL CYCLONE RAINSTORMS AND FLOODS IN CHINA

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Journal of Geographical Sciences 1996年第3期6卷 39-45页

作者： wang jiaqi Shen Guochang Geng Leihua Gu Wenyan Yao Huiming(Nanjiang Institute of Hydrology and Water Resources, Nanjing 210244People’s Republic of China)

Regional distribution of the rainstorms and floods caused and affected by tropical cyclones are described and the geographicla divisions of China are also given in this paper. The hydrological characteristics of tropi... 详细信息

关键词： tropical cyclones rainstorm flood hydrological characteristics

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3013-3028页

作者： Ziruoyu wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang jiaqi wang Jiying Zhu Jianbo Pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang Key Laboratory of Metabolism and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical CollegeFudan University200032ShanghaiChina CAS Key Lab of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences116023DalianChina The Chemical Proteomics Center and State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences201203ShanghaiChina University of Chinese Academy of Sciences 100049BeijingChina Department of Urology Zhongshan HospitalFudan University200032ShanghaiChina Department of Urology Zhongshan Hospital Wusong BranchFudan University200032ShanghaiChina Center for Novel Target and Therapeutic Intervention Chongqing Medical University400016ChongqingChina Department of Urology Huashan HospitalFudan University200040ShanghaiChina

Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for ***,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical *** multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in *** the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary *** further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug ***,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft *** integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies.

关键词： drug PC3 diagnosis operative

Smart Contract Fuzzing Based on Taint Analysis and Genetic Algorithms

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Journal of Quantum Computing 2020年第1期2卷 11-24页

作者： Zaoyu Wei jiaqi wang Xueqi Shen Qun Luo School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing100876China College of New Media Beijing Institute of Graphic CommunicationBeijing102600China

Smart contract has greatly improved the services and capabilities of blockchain,but it has become the weakest link of blockchain security because of its code ***,efficient vulnerability detection of smart contract is the key to ensure the security of blockchain *** to Ethereum smart contract,the study solves the problems of redundant input and low coverage in the smart contract *** this paper,a taint analysis method based on EVM is proposed to reduce the invalid input,a dangerous operation database is designed to identify the dangerous input,and genetic algorithm is used to optimize the code coverage of the input,which construct the fuzzing framework for smart contract ***,by comparing Oyente and ContractFuzzer,the performance and efficiency of the framework are proved.

关键词： Smart contract fuzzing taint analysis genetic algorithms

Changes in Local Immune Functions in Mooren's Ulcer

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Eye Science 1996年第1期16卷 33-35页

作者： Zheng wang, jiaqi Chen, Huling ZhengZhongshan Ophthalmic Center, Sun Yat-sen Unicersity of Medical Sciences, Guangzhou 510060,China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren’s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, GD1 and ***: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4 + /CD8+ ratio is significantly higher than normal control. Conclusion: The aberrant expression of MHC- II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/ Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren’s ulcer. Eye Science 1996; 12: 33-35.

关键词： Mooren’s ulcer cornea antibody

Mn-doped SiGe thin films grown by UHV/CVD with room-temperature ferromagnetism and high hole mobility

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Science China Materials 2022年第10期65卷 2826-2832页

作者： Limeng Shen Xi Zhang jiaqi wang Jianyuan wang Cheng Li Gang Xiang College of Physics Sichuan UniversityChengdu 610064China Key Laboratory of Radiation Physics and Technology Ministry of EducationInstitute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China College of Physics Xiamen UniversityXiamen 361005China

In this work,silicon-germanium(SiGe)thin films are epitaxially grown on Ge substrates by ultra-high vacuum chemical vapor deposition and then doped with Mn element by ion-implantation and subsequent rapid thermal annealing(RTA).The characterizations show that the epitaxial SiGe thin films are single-crystalline with uniform tensile strain and then become polycrystalline after the ion implantation and following *** magnetization measurements indicate that the annealed thin films exhibit Mn concentration-dependent ferromagnetism up to 309 K and the X-ray magnetic circular dichroism characterizations reveal the spin and orbital magnetic moments from the substitutional Mn *** minimize the influence of anomalous Hall effect,magneto-transport measurements at a high magnetic field up to 31 T at 300 K are performed to obtain the hole mobility,which reaches a record-high value of~1230 cm^(2)V^(-1)s^(-1),owing to the crystalline quality and tensile strain-induced energy band modulation of the *** first demonstration of Mn-doped SiGe thin films with roomtemperature ferromagnetism and high carrier mobility may pave the way for practical semiconductor spintronic applications.

关键词： diluted magnetic semiconductor Mn-doped SiGe ferromagnetism hole mobility UHV/CVD

Smart Contract Fuzzing Based on Taint Analysis and Genetic Algorithms

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Journal of Information Hiding and Privacy Protection 2020年第1期2卷 35-45页

关键词： Smart contract fuzzing taint analysis genetic algorithms

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“翻转的野蛮人”——亨利·米肖的东方游历

国外文学 2019年第4期 19-26,152,153页

作者：王佳玘中国人民大学外国语学院

法国诗人亨利·米肖于1933年出版了他的东方游记《一个野蛮人在亚洲》。全书从题目到内容都一反传统,极具个人特色,成为批评家们谈论不绝的经典之作。本文着眼于游记的创作背景,追溯米肖与东方文明的渊源,侧重围绕“野蛮人”这一核心称... 详细信息

法国诗人亨利·米肖于1933年出版了他的东方游记《一个野蛮人在亚洲》。全书从题目到内容都一反传统,极具个人特色,成为批评家们谈论不绝的经典之作。本文着眼于游记的创作背景,追溯米肖与东方文明的渊源,侧重围绕“野蛮人”这一核心称谓,梳理它在欧洲历史上的概念演变,进而探讨米肖是出于何种深意以“野蛮人”自比,最终得出与国内学者普遍解读不同的结论:米肖此举不止出于对东方文化的认同与崇拜,更是为了赋予“自我”一种绝对自由的视角,超越东西之间、文明与野蛮之间的二元对立,以此勾勒一幅崭新的世界文明图景。

关键词：亨利·米肖野蛮人《一个野蛮人在亚洲》

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国内外饮料标准及法规指标对比分析

中国食品卫生杂志 2020年第4期32卷 449-455页

作者：王家祺王君国家食品安全风险评估中心北京100022

目的研究国际组织和其他国家对饮料法规和标准管理情况,为我国饮料质量和安全标准完善提出建议,为我国饮料安全标准修订提供参考。方法梳理我国与国际食品法典委员会(CAC)、欧盟、美国、澳新、加拿大、韩国等国际组织和国家与饮料相关... 详细信息

目的研究国际组织和其他国家对饮料法规和标准管理情况,为我国饮料质量和安全标准完善提出建议,为我国饮料安全标准修订提供参考。方法梳理我国与国际食品法典委员会(CAC)、欧盟、美国、澳新、加拿大、韩国等国际组织和国家与饮料相关的标准法规,对饮料类别、重金属、真菌毒素、微生物、其他指标和规定进行对比分析,对我国现行饮料标准中存在的问题进行研究,提出关注和重点考虑的问题。结果国际上其他国家的饮料标准管理与我国有所不同,我国饮料安全标准的指标基本与国际接轨,今后修订时应重点考虑菌落总数指标、现制现售饮料等问题,同时完善饮料行业术语分类标准,做好安全标准和质量标准的有效衔接。结论我国饮料标准管理体系符合我国国情,安全标准制定相对合理和完善,但应适时做好饮料的安全标准和质量标准修订工作,促进行业健康和谐发展。

关键词：饮料标准法规指标对比

Skin Retention Determination and Clinical Efficacy Evaluation of a Novel High Oil-Contained Hpr Transfersome Permeable Formulation

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China Detergent & Cosmetics 2022年第4期7卷 73-78页

作者： wang jiaqi Ma Chaolong Tian Meixiang Sun Changlei Gong Jinkang Shanghai World Leader Pharmaceutical Co. Ltd.China

In order to increase the skin retention of HPR(Hydroxypinacone Retinoate),a novel high oil-contained HPR transfersome WL-HPR1130 was *** essence containing HPR was used as the control group,WL-HPR1130 essence was used as the experimental group,the skin retention of HPR were determined *** anti-wrinkle efficacy of WL-HPR1130 essence was evaluated at the same *** retention of HPR was 11.40μg/cm2 in the experimental group and 1.41μg/cm2 in the control group,which was 8.08 times higher than the control *** wrinkles and fine lines were significantly reduced and smoothed after 2 and 4 weeks by experimental group *** average length,width and depth of wrinkles were decreased by 14.26%,18.31%,7.17%after 2 weeks,and were decreased by 29.39%,38.25%,8.60%after 4 *** average length,width and depth of fine lines were decreased by 22.35%,12.60%,8.00%after 2 weeks,and were decreased by 27.10%,20.24%and 15.90%after 4 weeks,which has a significant visual ***1130,a novel high oil-contained HPR transfersome formulation,can significantly increase the retention of HPR in the *** the WL-HPR1130 essence have remarkable anti-wrinkle and smooth fine lines effects.

关键词： hydroxypinacone retinoate retention transdermal absorption transfersome anti-wrinkle