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Prediction of large vessel occlusion for ischaemic stroke by using the machine learning model random forests

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Stroke & Vascular Neurology 2022年第2期7卷 94-100页

作者： jianan wang Jungen Zhang Xiaoxian Gong Wenhua Zhang Ying Zhou Min Lou Department of Neurology Zhejiang University School of Medicine Second Affiliated Hospital Department of NeurologyHangzhouZhejiangChina

Backgrounds The timely identification of large vessel occlusion(LVO)in the prehospital stage is extremely important given the disease morbidity and narrow time window for *** current evaluation strategies still remain *** goal of this study was to develop a machine learning(ML)model to predict LVO using prehospital accessible *** Consecutive acute ischaemic stroke patients who underwent CT or MR angiography and received reperfusion therapy within 8 hours from symptom onset in the Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation-II dataset from January 2016 to August 2021 were *** developed eight ML models to integrate National Institutes of Health Stroke Scale(NIHSS)items with demographics,medical history and vascular risk factors to identify LVO and validate its *** Finally,15365 patients were included in the training set and 4215 patients were included in the test *** the test set,random forests(RF),gradient boosting machine and extreme gradient boosting presented area under the curve(AUC)of 0.831(95%CI 0.819 to 0.843),which were higher than other models,and RF presented the highest specificity(0.827).In addition,the AUC of RF was higher than other scales,and the accuracy of the model was improved by 6.4%compared with *** also found the top five items of identifying LVO were total NIHSS score,gaze deviation,level of consciousness(LOC),LOC commands and motor left *** Our proposed model could be a useful screening tool to predict LVO based on the prehospital accessible medical data.

关键词： boosting random narrow

Effects of a nitric oxide donor and nitric oxide scavengers on Sorbus pohuashanensis embryo germination

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Journal of Forestry Research 2018年第3期29卷 628-635页

作者： Ling Yang Dongyan Zhang Hongnan Liu Cheng Wei jianan wang Hailong Shen State Key Laboratory of Forest Genetics and Breeding School of Forestry Northeast Forestry University

The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination of Sorbus pohuashanensis were studied in a petri dish test. SNP at 0.5–5 mmol L-1 increased germination percentage, mean time to germination, germination index and germination energy compared with the control to different degrees. Treatment with 2 mmol L-1 SNP improved germination most significantly; embryo germination percentage for mother tree 1(91.11%) and mother tree 2(64.44%) were much higher than the control. In addition,excessive SNP levels did not enhance embryo *** treatment with SNP and an NO scavenger delayed embryo germination. Treatment with c PTIO inhibited embryo germination; germination percentage was 42.22% and was lower than that of the control. These results show that low concentrations of exogenous NO can enhance the embryo germination of S. pohuashanensis,providing a simple, effective way for promoting germination of S. pohuashanensis.

关键词： Mountain ash Embryo germination Nitric oxide Sodium nitroprusside Nitric oxide scavenger

Solving diversified top-k weight clique search problem

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Science China(Information Sciences) 2021年第5期64卷 47-48页

作者： Junping ZHOU Chumin LI Yupeng ZHOU Mingyang LI Lili LIANG jianan wang School of Information Science and Technology Northeast Normal University Modélisation Information & Systèmes Université de Picardie Jules Verne

Dear editor,Diversified top-k weight clique search （DTKWCS） is a problem that computes k cliques to maximize the sum of weights of all vertices contained in the cliques;that is,∑;∈{c;∪c;∪…∪c;}w（v） is maximiz... 详细信息

关键词： encoding independent set maximal clique partial MaxSAT top-k

Different physiopsychological changes between AMS-susceptible and AMS-resistant pre-selected Antarctic expeditioners in Tibet

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Advances in Polar Science 2021年第3期32卷 239-247页

作者： WU Xiaopei LIU Shiying wang Xi wang jianan QIN Pengrui XU Chengli Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijing 100005China Center of Environmental and Health Sciences Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China

Through dynamically monitoring changes of acute mountain sickness(AMS)occurrences,cardiopulmonary function and mood states from Shanghai(4 m)to Lhasa(3650 m)and Yambajan(4300 m),Tibet,we obtained physiopsychological data of the 37th Chinese Antarctic pre-selected expeditioners for Kunlun *** analyzing different physiopsychological changes between AMS-susceptible(AMS-S)and AMS-resistant(AMS-R)expeditioners,we would explore indicators to screen hypoxia-susceptible *** to AMS occurrences evaluated by Lake Louise Score(LLS)in Yambajan,we divided the expeditioners(n=24,31.92±5.76 a)into AMS-S and AMS-R *** a series of medical instrumentsand questionnaires,we monitored their cardiopulmonary function and mood states,and analyzed the differences of physiopsychological parameters between AMS-S and AMS-R *** with Shanghai,when expeditioners arrived in Yambajan,in both AMS-S and AMS-R groups,oxygen saturation(SpO2)significantly decreased,and blood pressure significantly increased(P<0.05).As for electrocardiogram(ECG),interval from the beginning to the end of QRS complex wave(QRS),interval from the beginning of QRS complex wave to the end of T wave(QT),interval between 2 adjacent P waves(PP)and interval between 2 adjacent R waves(RR)significantly decreased,heart rate(HR)and HR-corrected QT interval(QTc)significantly increased(P<0.05).Cardiac contractility and pumping function significantly decreased,systemic vascular resistance significantly increased(P<0.05).Pulmonary airway patency significantly increased(P<0.05).Compared with AMS-R group,AMS-S group showed significantly lower SpO2 and higher stroke volume variation(SVV)in Shanghai,however,significantly lower maximal expiratory flow at 75%of forced vital capacity(MEF75),higher levels of anxiety,fatigue and confusion in Yambajan(P<0.05).In conclusion,when expeditioners arrived at 4300 m,their cardiopulmonary function and mood states changed ***2,SVV,MEF75,anxie

关键词： Antarctic preselected expeditioner hypoxia Tibet acute mountain sickness cardiovascular function pulmonary function mood

The construction of pseudo-Janus silica/surfactant assembly and their application to stabilize Pickering emulsions and enhance oil recovery

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Frontiers of Chemical Science and Engineering 2022年第7期16卷 1101-1113页

作者： Han Jia Jiajun Dai Tingyi wang Yingbiao Xu Lingyu Zhang jianan wang Lin Song Kaihe Lv Dexin Liu Pan Huang Shandong Key Laboratory of Oilfield Chemistry School of Petroleum EngineeringChina University of Petroleum(East China)Qingdao 266580China Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao 266580China Technology Inspection Center Shengli Oilfield CompanySINOPECDongying 257000China Department of Chemical and Materials Engineering University of Alberta EdmontonAB T6G 1H9Canada

Nanoparticles with high surface energy and chemical activity have drawn substantial attention in petroleum industry. Recently, Janus nanoparticles exhibited tremendous potential in enhanced oil recovery (EOR) due to their asymmetric structures and properties. In this study, a series of amphiphilic pseudo-Janus@OTAB (PJ@C18) nanoparticles with different concentrations of stearyltrimethylammoium bromide (OTAB) were successfully fabricated. The structures and properties of PJ@C18 were characterized by Fourier transform infrared spectroscopy and ζ-potential measurements. Based on the emulsification experimental results, the interaction models and the self-assembly behavior between hydrophilic nanoparticles (SiO_(2)@NH_(2)) and OTAB molecules at the oil/water interface were proposed, which was further confirmed via the measurements of the contact angle and dynamic interfacial tension. Interestingly, it was found that the change of pH value from 7.5 to 4.0 caused the type reversal of the PJ@C18-1000 stabilized Pickering emulsions. Furthermore, the PJ@C18-1000 stabilized Pickering emulsion system with excellent salt and temperature tolerances (10000 mg∙L^(–1), 90℃) significantly improved the oil recovery in the single-tube (more than 17%) and double-tube (more than 25%) sand pack model flooding tests. The findings of this study could help to better understand the construction mechanism of pseudo-Janus silica/surfactant assembly and the potential application of PJ@C18-1000 stabilized Pickering emulsions for EOR.

关键词： Janus nanoparticles surfactant double phase inversion self-assembly enhanced oil recovery

Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis

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Science China(Life Sciences) 2014年第2期57卷 171-180页

作者： wang LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan wang jianan Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University

Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular *** has been proven that autophagy could be utilized for cell survival under ***-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ***,it has never been fully understood how leptin was involved in the protective effects conferred by *** the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome ***,similar effects were also observed when BMSCs were pretreated with *** beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/***,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin *** data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway.

关键词： BMSCs autophagy hypoxic-preconditioning leptin apoptosis

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医护人员信息安全行为评估工具的研究进展

中国护理管理 2024年第7期24卷 1047-1052页

作者：徐亦虹徐虹霞吴文瑾王佳楠丁珊妮吴觅之潘红英浙江大学医学院附属邵逸夫医院护理部杭州市310016

文章对医疗信息安全行为的表现形式及其评价工具进行综述,比较现有国内外信息安全行为评估工具,为医疗信息安全行为工具的本土化发展提供思路。建议在国内信息安全政策的基础上,结合信息安全专家和临床专家的建议,参考国内外信息安全行... 详细信息

文章对医疗信息安全行为的表现形式及其评价工具进行综述,比较现有国内外信息安全行为评估工具,为医疗信息安全行为工具的本土化发展提供思路。建议在国内信息安全政策的基础上,结合信息安全专家和临床专家的建议,参考国内外信息安全行为评估工具,构建适合用于我国医护人员医疗信息安全行为的评估工具。

关键词：信息安全医疗信息安全行为评估工具综述

基于响应面法的UHPC复合胶凝材料体系优化研究

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混凝土与水泥制品 2024年第5期 17-22,28页

作者：李响王佳男胡江海付文翔徐方湖北武麻高速公路有限公司湖北武汉430010 中国地质大学(武汉)工程学院湖北武汉430074

采用基于响应面法(RSM)的D-optimal最优化设计方法设计了超高性能混凝土(UHPC)净浆配合比,研究了复合胶凝材料组分对UHPC净浆湿堆积密实度、力学性能、干燥收缩性能的影响,结合XRD、SEM等微观测试结果分析了复合胶凝材料组分间的相互作... 详细信息

采用基于响应面法(RSM)的D-optimal最优化设计方法设计了超高性能混凝土(UHPC)净浆配合比,研究了复合胶凝材料组分对UHPC净浆湿堆积密实度、力学性能、干燥收缩性能的影响,结合XRD、SEM等微观测试结果分析了复合胶凝材料组分间的相互作用机理。结果表明:粉煤灰和硅灰可有效提高UHPC净浆的湿堆积密实度,优化基体内部颗粒堆积状态;硫铝酸盐水泥和粉煤灰对UHPC净浆的早期强度影响显著,掺入硫铝酸盐水泥可大幅提高UHPC净浆的早期力学性能。

关键词：超高性能混凝土胶凝材料体系响应面法净浆硫铝酸盐水泥干缩

川东北五宝场地区沙溪庙组二段沉积相特征及演化

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石油地质与工程 2024年第3期38卷 70-76页

作者：王佳楠林可光王海霞徐艳霞孙海涛中国石油大学(北京)地球科学学院北京102249 中国石油西南油气田公司川东北气矿四川达州635099 中国石油西南油气田公司勘探开发研究院四川成都610041

针对川东北五宝场地区沙溪庙组二段沉积相特征不清晰的问题,基于岩心、钻井、测井和地震资料,厘定了五宝场地区沙溪庙组主力储层沙二段沉积相类型及分布,明确了亚相之间的沉积界限,分析了沉积演化过程。结果表明:五宝场地区沙二段主体... 详细信息

针对川东北五宝场地区沙溪庙组二段沉积相特征不清晰的问题,基于岩心、钻井、测井和地震资料,厘定了五宝场地区沙溪庙组主力储层沙二段沉积相类型及分布,明确了亚相之间的沉积界限,分析了沉积演化过程。结果表明:五宝场地区沙二段主体发育曲流河三角洲沉积。沙二1亚段沉积时期,主要发育三角洲前缘沉积,南部黄龙场井区可见前三角洲沉积;沙二2亚段沉积时期,北部出现三角洲平原沉积,南部以三角洲前缘沉积为主,黄龙场井区局部可见前三角洲沉积;沙二3亚段沉积时期,广泛发育三角洲平原沉积,南部黄龙场井区以三角洲前缘沉积为主。其中,古气候、构造运动和古地貌等共同控制了川东北五宝场地区中侏罗统沙二段沉积相平面展布和沉积演化,古地形起主导作用,进而影响砂体分布。

关键词：五宝场地区沙溪庙组沉积演化沉积相曲流河三角洲