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煤矿巷道支护方案智能设计研究

工矿自动化 2024年第8期50卷 76-83,90页

作者：陈万辉郭瑞韩伟宋永明梁燕翔刘耀王佳明许娜孟波中国华电集团有限公司北京100031 内蒙古蒙泰不连沟煤业有限责任公司不连沟煤矿内蒙古鄂尔多斯010300 中国矿业大学力学与土木工程学院江苏徐州221116

目前煤矿巷道支护方案设计仍以人工设计、工程类比、FLAC模型模拟为主,存在主观性强、普适性低、未充分利用煤矿支护大数据等问题,而基于专家系统的设计方法规则设定程序繁琐,工程量大,智能化程度较低。将案例推理(CBR)和深度学习技术... 详细信息

目前煤矿巷道支护方案设计仍以人工设计、工程类比、FLAC模型模拟为主,存在主观性强、普适性低、未充分利用煤矿支护大数据等问题,而基于专家系统的设计方法规则设定程序繁琐,工程量大,智能化程度较低。将案例推理(CBR)和深度学习技术引入巷道支护方案设计领域,基于煤矿支护规程、支护规范及煤矿巷道地质报告等文本大数据,提出了一种煤矿巷道支护方案智能设计方法。获取346份不同煤矿的巷道支护资料,抽取结构化数据并划分为输入、输出参数,通过常属性变量滤波和高相关性滤波方法对输入、输出参数进行优化。建立CBR模型,并将抽取的结构化数据导入CBR模型,形成支护方案比选案例库,计算新的巷道支护方案与历史方案的相似度,输出相似度最高的3条历史方案进行对比,实现相似案例比选。分别采用BP神经网络和基于长短期记忆(LSTM)网络建立煤矿巷道支护方案自动生成模型,通过对比预测指标,确定采用基于LSTM模型与CBR模型结合,建立煤矿巷道支护方案智能设计系统。将该系统用于不连沟煤矿掘进F6226工作面辅运巷支护方案设计,通过试验验证了系统生成方案下巷道两帮变形量和顶板最大位移均小于人工设计方案,巷道顶板及两帮完整性较好,围岩承载能力增强,支护效果明显。

关键词：煤矿巷道支护支护方案设计案例推理案例比选深度学习长短期记忆网络

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云南省农田表土重金属分布特征与污染评价

化工矿物与加工 2024年第2期53卷 54-60页

作者：张子豪李海侠王家明胡静远王美辰叶俊民王杨昆明理工大学国土资源工程学院中化地质矿山总局山东地质勘查院

为了解云南省农田表土中重金属含量的分布特征和污染情况，在全省范围内农田设立了113个具有代表性的表土采样点，测定了样品中Cu、Pb、Cr、Zn含量。采用单因子指数法、内梅罗综合污染指数法、地统计学分析及Pearson相关性分析对表土重... 详细信息

为了解云南省农田表土中重金属含量的分布特征和污染情况，在全省范围内农田设立了113个具有代表性的表土采样点，测定了样品中Cu、Pb、Cr、Zn含量。采用单因子指数法、内梅罗综合污染指数法、地统计学分析及Pearson相关性分析对表土重金属污染进行了评价，结果表明：Cu、Pb、Cr、Zn四种重金属含量均值分别是云南省背景值的1.87、1.52、1.92、1.39倍；Cu、Cr、Zn含量的空间分布大体呈东高西低，Pb含量呈从西南到东北逐渐降低的趋势，综合污染指数分布与重金属含量分布较为一致；相关性分析中Pb、Zn与有机质呈显著正相关，Cu、Cr与砂粒呈正相关。Cu、Cr、Zn在空间分布和相关性分析中均显示其有相似的来源，推测为有机肥料。整体上，云南省农田污染属于轻微污染。

关键词：农田表土重金属污染有机质地统计分析单因子指数法内梅罗综合污染指数法

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基于生物信息学建立室管膜瘤TGF-β通路相关基因预后风险模型及其应用

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现代肿瘤医学 2024年第6期32卷 1032-1037页

作者：范雁东朱曼丽邓国棋王佳明罗坤新疆医科大学第二附属医院神经外科新疆乌鲁木齐830054 新疆医科大学中心实验室新疆乌鲁木齐830054 新疆医科大学第一附属医院神经外科新疆乌鲁木齐830054

目的:基于生物信息学方法建立室管膜瘤中TGF-β信号通路相关基因的预后预测模型。方法:利用无监督聚类算法区分室管膜瘤的不同分子亚型;利用基因集变异分析(gene set variation analysis,GSVA)计算不同室管膜瘤分子亚型中TGF-β信号通... 详细信息

目的:基于生物信息学方法建立室管膜瘤中TGF-β信号通路相关基因的预后预测模型。方法:利用无监督聚类算法区分室管膜瘤的不同分子亚型;利用基因集变异分析(gene set variation analysis,GSVA)计算不同室管膜瘤分子亚型中TGF-β信号通路相关评分;利用乘积极限法(Kaplan-Meier analysis,KM)计算不同室管膜瘤分子亚型中患者的生存率;利用线性模型算法(linear models for microarray data,limma)分析不同室管膜瘤分子亚型间的差异基因;利用最小绝对收缩和选择算子算法(least absolute shrinkage and selection operator,LASSO)和COX比例风险模型(COX proportional-hazards model)构建室管膜瘤中TGF-β信号通路相关基因的预后预测模型;利用受试者工作特征曲线(receiver operating characteristic curve,ROC)评估预后预测模型的性能;利用皮尔逊相关性分析考察关键基因的相关性;利用qRT-PCR技术和免疫印迹技术考察室管膜瘤组织中关键基因的表达水平。结果:无监督聚类算法显示,室管膜瘤中存在两种不同的分子亚型;GSVA和KM分析显示,不同亚型的室管膜瘤中TGF-β信号通路评分和预后存在显著差异;基因差异表达分析结果显示,不同亚型的室管膜瘤中TGF-β通路相关基因表达存在显著差异;LASSO显示,BMP4、FBN1、CDC20、TGFB1是预后预测模型的关键基因;ROC分析结果显示,TGF-β信号通路相关基因模型具有较高的预测性能;皮尔逊相关性分析结果显示,BMP4、FBN1、CDC20、TGFB1与TGF-β信号通路下游基因具有显著的表达相关性;qRT-PCR和免疫印迹技术结果显示,BMP4、FBN1、CDC20、TGFB1在室管膜瘤组织中的表达显著上调。结论:基于TGF-β通路相关基因BMP4、FBN1、CDC20、TGFB1构建的预后预测模型能够有效预测患者的生存情况。

关键词： TGF-β信号通路室管膜瘤生物信息学预测模型

An artificial intelligence model for embryo selection in preimplantation DNA methylation screening in assisted reproductive technology

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Biophysics Reports 2023年第6期9卷 352-361页

作者： Jianhong Zhan Chuangqi Chen Na Zhang Shuhuai Zhong jiaming wang Jinzhou Hu Jiang Liu Institute of Biophysics Chinese Academy of Science Guangdong Women's and Children's Hospital Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital Dongguan People's Hospital University of the Chinese Academy of Science School of Future Technology University of the Chinese Academy of Science

Embryo quality is a critical determinant of clinical outcomes in assisted reproductive technology(ART).A recent clinical trial investigating preimplantation DNA methylation screening(PIMS) revealed that whole genome DNA methylation level is a novel biomarker for assessing ART embryo quality. Here, we reinforced and estimated the clinical efficacy of PIMS. We introduce PIMS-AI, an innovative artificial intelligence(AI) based model, to predict the probability of an embryo producing live birth and subsequently assist ART embryo selection. Our model demonstrated robust performance, achieving an area under the curve(AUC) of 0.90 in cross-validation and 0.80 in independent testing. In simulated embryo selection, PIMS-AI attained an accuracy of 81% in identifying viable embryos for patients. Notably,PIMS-AI offers significant advantages over conventional preimplantation genetic testing for aneuploidy(PGT-A), including enhanced embryo discriminability and the potential to benefit a broader patient population. In conclusion, our approach holds substantial promise for clinical application and has the potential to significantly improve the ART success rate.

关键词： Assisted reproductive technology DNA methylation Artificial intelligence Embryo selection

整合mRNA转录本与基因组信息的基因组选择方法研究

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遗传 2024年第7期46卷 560-569页

作者：胡玉龙杨芳陈彦潼谌烁楷闫煜博张跃博吴晓林汪加明何俊高宁湖南农业大学动物科学技术学院长沙410128 美国奶牛育种委员会马里兰州鲍伊市207163 威斯康星大学动物与奶业科学系威斯康星州麦迪逊市537064 湖南新五丰股份有限公司长沙410005

基因组预测已成为畜禽、作物遗传评估和人类疾病风险预测的主要技术,但经典的基因组预测方法在性状遗传调控机制等生物学先验信息的整合方面有一定的不足。本研究提出一种将mRNA转录本信息整合应用于复杂性状表型预测的方法。基于国际... 详细信息

基因组预测已成为畜禽、作物遗传评估和人类疾病风险预测的主要技术,但经典的基因组预测方法在性状遗传调控机制等生物学先验信息的整合方面有一定的不足。本研究提出一种将mRNA转录本信息整合应用于复杂性状表型预测的方法。基于国际上广泛应用于数量遗传学研究的果蝇群体,对本研究提出的新方法进行准确性评估。结果显示,整合mRNA转录本,可有效提高部分性状基因组预测准确性,但对部分性状的表型预测准确性没有改善。与GBLUP相比,雄性果蝇D-香芹酮嗅觉反应(dCarvone)准确性由0.256提高到0.274,提高幅度7%。雄性果蝇咖啡因耐受反应(cafe)准确性由0.355提高到0.401,提高幅度13%。雄性果蝇百草枯耐受反应(survival_paraquat)准确性由0.101提高到0.138,提高幅度36%。雌性果蝇1-已醇嗅觉反应(1hexanol)准确性由0.147提高到0.210,提高幅度43%。综上所述,对于部分性状,通过整合mRNA转录本可有效提高基因组预测准确性(提高幅度为7%~43%)。对于部分性状,整合mRNA转录本并考虑互作效应可进一步提高预测准确性。

关键词：基因组选择基因组预测 mRNA转录本整合组学

Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties

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Particuology 2024年第4期87卷 194-204页

作者： Qiaoqiao Lan Xuying Zhang jiaming Liang Wei wang Leili Lv Jiamin He Zefeng wang Chunsheng Qu The People's Hospital of Lishui Lishui323000China College of Ecology Lishui UniversityLishui32300China R&D Center of Green Manufacturing New Materials and Technology of Synthetic Leather Sichuan University-Lishui University Lishui323000China

Over the past few decades,extensive scientific has been dedicated to polymer synthesis employing renewable *** this study,we devised and synthesized multifunctional polyeugenol-based nanoparticles,exhibiting remarkable antioxidant and antibacterial *** grafting of eugenol onto the nanoparticle surface was achieved via a thiol-ene chemical reaction with a grafting rate of 3.5%.To comprehend the properties of the synthesized nanoparticles,we employed Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and pyrolysis-gas chromatography mass *** scanning electron microscopic and transmission electron microscopic analyses revealed the presence of a crosslinked structure within the polyeugenol-based nanoparticles,as well as a heteroge-neous microsphere structure on the *** to the inherent crosslinking structure,the polyeugenol-based nanoparticles demonstrated robust the resistance to solvents,as ascertained through thermog-ravimetric analysis and solvent resistance ***,nitrogen adsorption/desorption studies confirmed the adsorption capacity of the polyeugenol-based nanoparticles,rendering them potentially suitable for drug transport ***,the assays for assessing cytocompatibility and reactive oxygen species scavenging activities demonstrated better performance of the eugenol-based nano-particles compared to ***,the polyeugenol-based nanoparticles exhibited certain bactericidal activities against Escherichia coli,Staphylococcus aureus,and Fusobacterium ***,these observations indicated the nontoxic nature and expansive application prospects of the polyeugenol-based nanoparticles in the domains of medicine and food *** work presented a pioneering concept for the development of antioxidant and antibacterial multifunctional polymer materials derived from eugenol.

关键词： Polyeugenol-based nanoparticles Bactericidal activities Cytocompatibility

SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

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药学学报:英文版 2023年第7期13卷 3043-3053页

作者： Yiqun Li Mingrui Yang Yanan Nan jiaming wang Sanjiao wang Dongxiao Cui Jiajian Guo Pengfei He Wenxin Dai Shuqi Zhou Yue Zhang Wenfu Ma School of Life Science Beijing University of Chinese MedicineBeijing 102488China

Via an insufficient coat protein complex I(COPI)retrieval signal,the majority of SARSCo V-2 spike(S)is resident in host early secretory organelles and a tiny amount is leaked out in cell *** surface-exposed S can be recognized by B cell receptor(BCR)or anti-S therapeutic monoclonal antibodies(m Abs)that is the trigger step for B cell activation after S m RNA vaccination or infected cell clearance by S m ***,a drug strategy to promote S host surface exposure is ***,we first combined structural and biochemical analysis to characterize S COPI sorting signals.A potent S COPI sorting inhibitor was then invented,evidently capable of promoting S surface exposure and facilitating infected cell clearance by S antibody-dependent cellular cytotoxicity(ADCC).Importantly,with the inhibitor as a probe,we revealed Omicron BA.1 S is less cell surface exposed than prototypes because of a constellation of S folding mutations,possibly corresponding to its ER chaperone *** findings not only suggest COPI is a druggable target against COVID-19,but also highlight SARS-Co V-2 evolution mechanism driven by S folding and trafficking mutations.

关键词： COPI inhibitor SARS-CoV-2 spike Spike sorting motifs Protein folding Protein trafficking Anti-COVID-19 Omicron variants and drug discovery

Vacancy defect MoSeTe embedded in N and F co-doped carbon skeleton for high performance sodium ion batteries and hybrid capacitors

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Journal of Energy Chemistry 2024年第3期90卷 652-664,I0014页

作者： Dehui Yang Wentao Guo Fei Guo jiaming Zhu Gang wang Hui wang Guanghui Yuan Shenghua Ma Beibei wang State Key Laboratory of Photon-Technology in Western China Energy International Collaborative Center on Photoelectric Technology and Nano Functional MaterialsInstitute of Photonics&Photon-TechnologyNorthwest UniversityXi’an 710127ShannxiChina Key Laboratory of Synthetic and Natural Functional Molecule Chemistry(Ministry of Education) College of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127ShannxiChina School of Chemistry and Chemical Engineering Ankang Research Centre of New Nano-materials Science and TechnologyShaanxi University Innovation Research Institute of Advanced Energy Storage Materials and Battery Technology for Future IndustrializationAnkang UniversityAnkang 725000ShannxiChina

Sodium-ion batteries(SIBs) and hybrid capacitors(SIHCs) have garnered significant attention in energy storage due to their inherent advantages,including high energy density,cost-effectiveness,and enhanced ***,developing high-performance anode materials to improve sodium storage performa nce still remains a major ***,a facile one-pot method has been developed to fabricate a hybrid of MoSeTe nanosheets implanted within the N,F co-doped honeycomb carbon skeleton(MoSeTe/N,F@C).Experimental results demonstrate that the incorporation of large-sized Te atoms into MoSeTe nanosheets enlarges the layer spacing and creates abundant anion vacancies,which effectively facilitate the insertion/extraction of Na^(+) and provide numerous ion adsorption sites for rapid surface capacitive ***,the heteroatoms N,F co-doped honeycomb carbon skeleton with a highly conductive network can restrain the volume expansion and boost reaction kinetics within the *** anticipated,the MoSeTe/N,F@C anode exhibits high reversible capacities along with exceptional cycle *** coupled with Na_(3)V_(2)(PO_(4))_(3)@C(NVPF@C) to form SIB full cells,the anode delivers a reversible specific capacity of 126 mA h g^(-1) after 100 cycles at 0.1 A g^(-1).Furthermore,when combined with AC to form SIHC full cells,the anode demonstrates excellent cycling stability with a reversible specific capacity of50 mA h g^(-1) keeping over 3700 cycles at 1.0 A g^(-1).In situ XRD,ex situ TEM characterization,and theoretical calculations(DFT) further confirm the reversibility of sodium storage in MoSeTe/N,F@C anode materials during electrochemical reactions,highlighting their potential for widespread practical *** work provides new insights into the promising utilization of advanced transition metal dichalcogenides as anode materials for Na^(+)-based energy storage devices.

关键词： MoSeTe N F co-doped honeycomb carbon skeleton Sodium-ion batteries Sodium-ion hybrid capacitor

胡黄连苷Ⅱ调节cAMP/PKA信号轴对脊髓损伤大鼠神经功能恢复的影响

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河北医药 2024年第9期46卷 1285-1290页

作者：范雁东王佳明马木提江·木尔提扎罗坤新疆医科大学第一附属医院神经外科乌鲁木齐市830054 新疆医科大学第二附属医院神经外科

目的探讨胡黄连苷Ⅱ(PicrosideⅡ,PⅡ)对脊髓损伤(spinal cord injury,SCI)大鼠神经功能恢复的影响及对环磷酸腺苷(cAMP)-蛋白激酶A(PKA)信号通路的调节作用。方法建立SCI大鼠模型,大鼠分为正常组(CT组)、SCI模型组(SCI组)、PⅡ低剂量... 详细信息

目的探讨胡黄连苷Ⅱ(PicrosideⅡ,PⅡ)对脊髓损伤(spinal cord injury,SCI)大鼠神经功能恢复的影响及对环磷酸腺苷(cAMP)-蛋白激酶A(PKA)信号通路的调节作用。方法建立SCI大鼠模型,大鼠分为正常组(CT组)、SCI模型组(SCI组)、PⅡ低剂量组(PⅡL组,5 mg·kg^(-1)·d^(-1))、PⅡ高剂量组(PⅡH组,20 mg·kg^(-1)·d^(-1))和PⅡ高剂量+PKA抑制剂组(PⅡH+H-89组,20 mg·kg^(-1)·d^(-1) PⅡ+5 mg·kg^(-1)·d^(-1)),每组18只。Basso-Beattie-Bresnahan(BBB)评分评价SCI大鼠运动功能,HE染色评价脊髓组织病理学特征,劳克坚牢蓝(LFB)染色观察脱髓鞘情况,免疫荧光检测胶质纤维酸性蛋白(GFAP)、离子钙结合适配器分子-1(IBA-1)表达,ELISA检测丙二醛(MDA)、超氧化物歧化酶(SOD)、环腺苷酸(cAMP)的含量,Western blot检测磷酸化(p)-PKA、PKA、p-环磷酸腺苷反应成分结合蛋白(CREB)、CREB蛋白表达。结果与CT组比较,SCI组大鼠脊髓组织缺损、空腔,大量炎性细胞浸润,脱髓鞘以及GFAP、IBA-1、MDA表达增加,BBB评分以及SOD、cAMP、p-PKA/PKA、p-CREB/CREB表达减少(P<0.05);与SCI组比较,PⅡL组、PⅡH组组织损伤改善,空腔及炎性细胞减少,脱髓鞘以及GFAP、IBA-1、MDA表达降低,BBB评分以及SOD、cAMP、p-PKA/PKA、p-CREB/CREB表达增加(P<0.05);与PⅡH组比较,PⅡH+H-89组组织损伤严重,脱髓鞘以及GFAP、IBA-1、MDA表达增加,BBB评分以及SOD、cAMP、p-PKA/PKA、p-CREB/CREB表达减少(P<0.05)。结论PⅡ可能通过激活cAMP/PKA信号轴促进SCI大鼠神经功能恢复。

关键词：胡黄连苷Ⅱ 脊髓损伤神经功能环磷酸腺苷-蛋白激酶A