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Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway

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Chinese Journal of Natural Medicines 2019年第5期17卷 346-354页

作者： wang han-qing wang Sha-Sha Chiufai Kuok wang Qi CHENG Xiao-Lan College of Pharmacy Ningxia Medical University School of Rehabilitation Medicine Binzhou Medical University School of Health Sciences Macao Polytechnic Institute Nanjing Dorra Pharmaceutical Co. Ltd. Laboratory of Cellular and Molecular Biology Jiangsu Province Academy of Traditional Chinese Medicine

Diabetic nephropathy(DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae(Umb) has been well characterized to exert protective effects in diabetes. However, the action and mechanism of Umb in DN remains unclear. In this work, we studied the effect of Umb in a streptozotocin(STZ)-induced DN rat model and explore its underlying mechanism. DN rats were treated with Umb(20, 40 mg·kg^(-1)) or irbesartan(15 mg·kg^(-1)) for 4 weeks. Levels of serum glucose, insulin, blood uric acid, creatinine, triglycerides(TG) and total cholesterol(TC) were measured by commercial assay kits,respectively. Histopathological changes and inflammatory cytokine levels including IL-6, IL-1β and TNF-α in the kidney were also evaluated. Alterations in the expression of podocin, CD2 AP and TLR/NF-κB were assessed by western blotting. Our results showed that Umb reduced renal injury in DN rat model, as evidenced by the decrease in blood glucose, 24 h urinary protein, serum creatinine,and blood uric acid. Umb also significantly ameliorated the renal histopathological alteration, and down-regulated the expression of epithelial-to-mesenchymal transition-related molecular markers podocin and CD2AP. Moreover, Umb inhibited TLR2, TLR4, MyD88 expressions, NF-κB activation and considerably reduced levels of other downstream inflammatory molecules(TNF-α, IL-6, IL-1β).These findings indicated that Umb improved renal function through regulating inflammation and TLR/NF-κB pathway, suggesting the potential efficacy of Umb in DN treatment.

关键词： Diabetic nephropathy Umbelliferone Streptozotocin Inflammation TLR/NF-κB pathway

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Quantum Chemistry Study on Dissociation of Oxalyl Bromide

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1334-1339页

作者： GENG Zhi-Yuan wang Dong-Mei wang Yong-Cheng DAI Guo-Liang LU Ling-Ling wang han-qing College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China Lanzhou Institute of Chemistry and Physics The Chinese Academy of Sciences Lanzhou 730000 China Department of Chemistry Baoji College of Arts ＆ Sci. Baoji 721007 China

The multi-bond dissociation dynamics of oxalyl bromide （（BrCO）2） has been investigated by DFT and CIS calculations. Upon the results, conclusion could be drawn that dissociation of C-Br bond of oxalyl bromide at the ground state （So） is of barfierless. After the absorption of a photon, （BrCO）2 is excited to the first excited state and one of its C-Br bonds is broken to yield Br ·＊ and BrCOCO· ＊ free radicals. In addition, BrCOCO · ＊ with high energy is apt to release energy, and ultimately, turns into BrCOCO ·of the ground state. The energy is adequate for BrCOCO· to break down into Br · and 2CO; at the same time the C-C and C-Br bonds of BrCOCO · free radicals dissociate.

关键词： oxalyl bromide multi-bond dissociation BrCOCO free radical DFT

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Continuous time-varying Q-factor estimation method in the time-frequency domain

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Applied Geophysics 2020年第5期17卷 844-856,904页

作者： wang qing-han Liu Yang Liu Cai Zheng Zhi-Sheng College of Geo-exploration Science and Technology Jilin UniversityChangchun130026China

The Q-factor is an important physical parameter for characterizing the absorption and attenuation of seismic waves propagating in underground media,which is of great signifi cance for improving the resolution of seismic data,oil and gas detection,and reservoir *** this paper,the local centroid frequency is defi ned using shaping regularization and used to estimate the Q values of the *** propose a continuous time-varying Q-estimation method in the time-frequency domain according to the local centroid frequency,namely,the local centroid frequency shift(LCFS)*** method can reasonably reduce the calculation error caused by the low accuracy of the time picking of the target formation in the traditional *** theoretical and real seismic data processing results show that the time-varying Q values can be accurately estimated using the LCFS *** with the traditional Q-estimation methods,this method does not need to extract the top and bottom interfaces of the target formation;it can also obtain relatively reasonable Q values when there is no eff ective frequency spectrum ***,a reasonable inverse Q fi ltering result can be obtained using the continuous time-varying Q values.

关键词： local centroid frequency local time-frequency transform Q-factor estimation shaping regularization

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An ESR study of photochemical reactions of Co2（CO）6（PBu3）2 with quinones and phenothiazine

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Chinese Journal of Chemistry 1985年第2期3卷 89-95页

作者： YAN Rong-Zhuang wang han-qing Lanzhou Institute of Chemical Physics,Academia Sinica,Lanzhou Lanzhou Institute of Chemical Physics Academia Sinica Lanzhou

The photochemical reactions of Co（CO）（PBu）with various quinones and phenothia-zine were studied by *** results indicate that the photolysis of Co（CO）（PBu）in the pre-sence of o-quinones led to the observation of an ESR spectrum,showing a broad 8 or 12 groups ofhyperfine lines due to interaction with cobalt （Co,I=7/2）.The results show that with o-quinonesthe cobalt radical adducts are formed via metal chelation to the carbonyl ***,whenCo（CO）（PBu）was irradiated in the presence of p-quinones,only the para-semiquinone radicalswere *** photolysis of Co（CO）（PBu）with phenothiazine in toluene yields pheno-thiazine *** sixteen and eighteen electrons rule have been used to account for these ob-servations.

关键词： Co ESR with quinones and phenothiazine CO

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CRYSTAL STRUCTURE OF 2-METHYL-3-PHENYLACRYLOYL-QUINOXALINE 1,4-DIOXIDE

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Chinese Journal of Structural Chemistry 1990年第3期 203-206页

作者： wang Yi wang Min wang han-qing Lanzhou Institute of Chemical Physics, Acaderma Sinica, Lanzhou

C18H14N2O3,Mr=306. 32,Monoclinic,P21/b,a = 5. 579(1),b = 8. 963 (2),c = 29. 405(7) A,γ= 92. 62(2)°,V= 1468. 8(7) A3.Z=4, Dx= 1.385 gcm-3, CuKa radiation, μ= 7. 45 cm-1,F(000) = 640,final R= 0. 039,Rw= 0. 045 for 1006 observed (I>3σ(I)) reflections. The quinoxaline part of the molecule is virtually planar. The dihedral angle between the benzene ring of the phenylacryloyl and quinoxaline ring is 99. 6°.

关键词： wang

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Antibacterial Activity of Plants in Cirsium:A Comprehensive Review

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Chinese Journal of Integrative Medicine 2024年第9期30卷 835-841页

作者： TANG Xiao-meng XIE Ming-xia GOU Jun-li CHEN Liang TIAN Jin-long ZhanG Xia LU You-yuan wang han-qing College of Pharmacy Ningxia Medical UniversityYinchuanNingxia750004China College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410007China General Hospital of Ningxia Medical University YinchuanNingxia750004China Ningxia Regional Characteristic Traditional Chinese Medicine Collaborative Innovation Center Co-constructed by the Province and Ministry Ningxia Engineering and Technology Research Center for Modernization of Regional Characteristic Traditional Chinese MedicineNingxia Medical UniversityYinchuan750004China Key Laboratory of Ningxia Minority Medicine Modernization Ministry of EducationYinchuan750004China

As ethnic medicine,the whole grass of plants in Cirsium was used as *** review focuses on the antimicrobial activity of plants in Cirsium,including antimicrobial components,against different types of microbes and bacteriostatic *** results showed that the main antimicrobial activity components in Cirsium plants were flavonoids,triterpenoids and phenolic acids,and the antimicrobial ability varied according to the species and the content of *** them,phenolic acids showed a strong antibacterial ability against Acinetobacter baumannii,Pseudomonas aeruginosa,and Enterococcus *** antibacterial mechanisms include:(1)damaging the cell membrane,cell walls,mitochondria and nucleus of bacteria;(2)inhibiting the synthesis of proteins and nucleic acids;(3)suppressing the synthesis of enzymes for tricarboxylic acid cycle pathways and glycolysis,and then killing the bacteria via inhibition of energy ***,most research results on antimicrobial activity of Cirsium plants are reported based on in vitro *** evidence from clinical data and comprehensive evaluation are needed.

关键词： Cirsium traditional use antibacterial active components bacteriostatic activity bacteriostatic mechanism Chinese medicine

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INTRA-ION PAIR ELECTRON TRANSFER OF PHOTOEXCITED METHYLENE BLUE BORATE

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Chinese Chemical Letters 1995年第7期6卷 597-600页

作者： Xiu Zhi wang han qing CHEN Er Jian wang (Institute of Photographic Chemistry, Academia Sinica, Beijing 100101National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou,730000) Acad Sinica Inst Photog Chem Beijing 100101 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

The photochemical reaction of methylene blue (n-butyltriphenyl) borate, MBRBPh3 was examined. The ultrafast quenching rate and large negative value of Delta G indicated that the intra-ion pair ET plays an important role in photoreaction of MBRBPh3. The sequent boron- carbon bond cleavage of butyltriphenylboranyl radical intermediate was found by GC-MS and photo-CIDNP studies.

关键词： ION INTRA-ION PAIR ELECTRON TRANSFER OF PHOTOEXCITED METHYLENE BLUE BORATE

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当代环境伦理脉络下主体核心价值抉择的反思——以程明道仁学为切入

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道德与文明 2019年第6期 127-133页

作者：王涵青黄冈师范学院文学院

当代丰富多元的环境伦理学理论,相应于现实生活中每个行为主体多以强烈的人类中心主义为基本价值而抉择与行动,有着明显落差。而要使主体能有意识地将行为与环境问题联结,做出有益于解决环境问题的抉择,需处理的便是"唤醒"主体的环境关... 详细信息

当代丰富多元的环境伦理学理论,相应于现实生活中每个行为主体多以强烈的人类中心主义为基本价值而抉择与行动,有着明显落差。而要使主体能有意识地将行为与环境问题联结,做出有益于解决环境问题的抉择,需处理的便是"唤醒"主体的环境关怀意识。在此层面,程明道以"仁"为整体存在界之万事万物共通/共同之处而言"天人无间、天人无二",回到人之主体透过"识仁"工夫体贴天理而能共通/共同,是为可发展的方向。在形上层面,程明道由天人合一与一体之仁充实了环境伦理的原则,其理论内涵同时关涉人类中心主义与生态中心主义理论面向的特质:就生态中心主义面向,人与天地万物同为一本,同具有内在价值;就人类中心主义面向,人又"能推"而不同且高于万物。程明道的体证/体仁之路在此双向特征中展开并贴切主体生命实感,正是我们借以唤醒主体环境关怀意识,建构主体核心价值的切入点。

关键词：环境伦理程明道仁学体证之路知行之路

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Entropy Assessment on Environmental Influence of Condense Heat in Recovery System in Air-Conditioning Refrigerating Machine

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湖南大学学报（自然科学版） 2009年第S1期36卷 96-101页

作者： TANG Wen-wu1,2,wang han-qing1,2(1.School of Energy Science and Engineering,Central South University,Changsha,Hunan 410083,China 2.School of Civil Engineering,Hunan University of Technology,Zhuzhou,Hunan 412008,China) School of Energy Science and Engineering Central South University Changsha 410083 China School of Civil Engineering Hunan University of Technology Zhuzhou 412008 China

This paper presented an entropy evaluation method for the influences of condense heat recovery system on the *** at the damage of the condense heat to the environment,an entropy of resource loss and an emission entropy from the condense heat recovery system in the air conditioning refrigerating machine were *** the evaluation of the entropies,we developed a new algorithm for the parameter identification,called the composite influence coefficient,based on the Least Squares Support Vector Machine *** simulation,the numerical experiments shows that the Least Squares Support Vector Machine method is one of the powerful methods for the parameter identification to compute the damage entropy of the condense heat,with the largest training error being-0.025(the relative error being-3.56%),and the biggest test error being 0.015(the relative error being 2.5%).

关键词： air-conditioning refrigerating machine condense heat entropy evaluation LS-SVM

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论“苏州片”失蜡铸造工艺的特色及其价值

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东南文化 2016年第5期 26-31,F0002页

作者：王汉卿苏州工艺美术职业技术学院江苏苏州215104

"苏州片"是我国传统失蜡铸造的代表性工艺,以其法制作的仿古铜器,以精绝、乱真闻名于世,研究者与苏州艺人经数年的密切合作,成功复原此工艺。"苏州片"仿古铜器工艺蜡料配方独特、制范技艺考究、制作过程精细缜密,不仅具有历史人文价值,... 详细信息

"苏州片"是我国传统失蜡铸造的代表性工艺,以其法制作的仿古铜器,以精绝、乱真闻名于世,研究者与苏州艺人经数年的密切合作,成功复原此工艺。"苏州片"仿古铜器工艺蜡料配方独特、制范技艺考究、制作过程精细缜密,不仅具有历史人文价值,而且具有一定的经济、科技价值。传统手工艺要揭示其科学内涵,保护传承的同时注重创新,紧跟时代特色,走向产业化,才能在现代社会赢得生存空间。

关键词： “苏州片” 失蜡法仿古铜器研究科学配方技艺特色价值

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