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Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape

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Cancer Communications 2024年第6期44卷 670-694页

作者： xin-Yu Zhang Jian-Bo Shi Shu-Fang Jin Rui-Jie wang Ming-Yu Li Zhi-Yuan Zhang xi Yang Hai-Long Ma Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiP.R.China National Clinical Research Center for Oral Diseases ShanghaiP.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research institute of Stomatology ShanghaiP.R.China Department of Second Dental Center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityShanghaiP.R.China

Background:Metabolic reprograming and immune escape are two hallmarksof ***,how metabolic disorders drive immune escape in head andneck squamous cell carcinoma(HNSCC)remains ***,the aim ofthe present study was to investigate the metabolic landscape of HNSCC and itsmechanism of driving immune ***:Analysis of paired tumor tissues and adjacent normal tissues from69 HNSCC patients was performed using liquid/gas chromatography-mass spectrometry and *** tumor-promoting function of kynurenine(Kyn)was explored in vitro and in *** downstream target of Kyn wasinvestigated in CD8^(+)T *** regulation of CD8+T cells was investigatedafter Siglec-15 overexpression in *** engineering nanoparticle was establishedto deliver Siglec-15 small interfering RNA(siS15),and its association withimmunotherapy response were *** association between Siglec-15and CD8^(+)programmed cell death 1(PD-1)^(+)T cells was analyzed in a HNSCCpatient ***:A total of 178 metabolites showed significant dysregulation in HNSCC,including carbohydrates,lipids and lipid-like molecules,and amino *** these,amino acid metabolism was the most significantly altered,especiallyKyn,which promoted tumor proliferation and *** addition,most immune checkpoint molecules were upregulated in Kyn-high patientsbased on ***,tumor-derived Kyn was transferredinto CD8^(+)T cells and induced T cell functional exhaustion,and blockingKyn transporters restored its killing *** to the results,mechanistically,Kyn transcriptionally regulated the expression of Siglec-15 via arylhydrocarbon receptor(AhR),and overexpression of Siglec-15 promoted immuneescape by suppressing T cell infiltration and *** AhR in vivoreduced Kyn-mediated Siglec-15 expression and promoted intratumoral CD8^(+)Tcell infiltration and killing ***,a NH_(2)-modified mesoporous silicananoparticle was des

关键词： head and neck squamous cell carcinoma kynurenine Siglec-15 T cell exhaustion untargeted metabolomics

Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： xiAO Tian Li YUAN Shu Qian GAO Jing Yu Julien SBaker YANG Yi De wang xi Jie ZHENG Chan Juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents china Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： Sheng-Feng Zhou Yu Long Yan-Liang Yi Cheng Deng Lian-xi Hu institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

西汉关中地区生态环境特征与都城长安相互影响之关系

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陕西师范大学学报（哲学社会科学版） 2000年第3期29卷 35-42页

作者：朱士光陕西师范大学历史地理研究所陕西西安710062

西汉初高祖刘邦建都长安，既看重关中地区当时便于控内御外的宏观地理优势，同时还看重关中地区生态环境的优越。西汉２００余年的史实也表明，关中地区优越的生态环境对都城长安的建设与物资供应以及经济的繁荣提供了物质保证；而西汉... 详细信息

西汉初高祖刘邦建都长安，既看重关中地区当时便于控内御外的宏观地理优势，同时还看重关中地区生态环境的优越。西汉２００余年的史实也表明，关中地区优越的生态环境对都城长安的建设与物资供应以及经济的繁荣提供了物质保证；而西汉王朝针对王畿所在的关中地区采取的一些政治、经济、文化措施，也对保护与改善这一地区的生态环境发挥了积极的作用。

关键词：西汉关中地区生态环境长安都城建设

1978～2008:历史地理学研究的学术评论

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史学月刊 2009年第4期 5-23页

作者：侯甬坚陕西师范大学西北历史环境与经济社会发展研究中心

1978～2008年,国内历史地理学研究的学术收获有目共睹,其中也包含了此前阶段学界科研工作的诸多成绩和经验。在取得历史地理学性质归属地理学共识后,作为学科两大基本骨架之一的历史自然地理研究在1970～1980年代呈现出一种兴盛局面。自... 详细信息

1978～2008年,国内历史地理学研究的学术收获有目共睹,其中也包含了此前阶段学界科研工作的诸多成绩和经验。在取得历史地理学性质归属地理学共识后,作为学科两大基本骨架之一的历史自然地理研究在1970～1980年代呈现出一种兴盛局面。自从1990年代初倡导历史人文地理的研究以来,其研究盛况一直延续至今,而历史自然地理研究反而呈式微之势,这在较大程度上应归因于研究对象固有的自然或人文性质的差别。就研究本身的动力因素而言,学者们自觉为现实社会服务的努力和对历史地理学学术价值的不懈追求,构成了两种相互交织而又风格别具的治学理念。环境考古学、文化人类学、社会学(社会史)、GIS技术、环境史等学科或研究思潮的接续浸润,推动着历史地理学科朝着多样化和纵深方向发展。借鉴国内外历史地理学的研究经验,我国历史地理学界面临着加强自然科学和社会科学汇合的高难度任务,还需要讨论历史环境影响评价的原则和范式。探讨学界最近30年的研究进展、特点及其可能的发展趋向,评论学科组织系统、学界动态反应、学术研究功能等重要内容,有助于我们把握历史地理学的学科方向,树立国际视野,将研究工作推向更高的学术层次。

关键词： 1978-2008年历史地理学历史自然地理历史人文地理历史环境影响评价学科组织系统

Multipartite oil-flower/oil-bee mutualisms involving male-bee-pollinated orchids in tropical Asia

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National Science Review 2024年第5期11卷 105-107页

作者： Meng Zhang Li-Bing Jia Susanne S.Renner Zhi-xi Tian xiao-An wang Jiang-Yun Gao Yi-Bo Luo Antonio J.C.Aguiar Huan-Li Xu Shuang-Quan Huang institute of Evolution and Ecology School of Life Sciences Central China Normal University Department of Biology Washington University State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan University State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Department of Zoology University of Brasília Department of Entomology College of Plant Protection China Agricultural University

Most animal-pollinated flowers offer nectar or pollen as a reward to their pollinators. A small fraction, however, have switched to other rewards, such as fatty oils offered in glandular hairs or just below the epidermis. This type of reward has evolved in some 150 genera in at least 11 families, including South American and African Orchidaceae [1,2]. Oiloffering flowers are exploited by a few hundred species of oil-collecting bees in temperate and tropical biomes on all continents except Antarctica [1,2]. Oil bees depend obligatorily on floral oil for cell lining and as larval food [3,4], which is why oil collecting usually is confined to female bees.

关键词： CTENOPLECTRINI HYMENOPTERA DENDROBIUM APIDAE

Responses of arbuscular mycorrhizal fungi to straw return and nitrogen fertilizer reduction in a rainfed maize field

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Pedosphere 2024年第2期34卷 351-360页

作者： Zhenling PENG Hao xi Lin MAO Huyuan FENG Jianjun ZHANG Yongjun LIU State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of EcologyLanzhou UniversityLanzhou 730000China College of Life Sciences Northwest Normal UniversityLanzhou 730070China School of Life Sciences Lanzhou UniversityLanzhou 730000China Dryland Agriculture institute Gansu Academy of Agricultural SciencesLanzhou 730070China

Straw return can be used to reduce fertilizer input and improve agricultural sustainability and soil ***,how straw return and reduced fertilizer application affect beneficial soil microbes,particularly arbuscular mycorrhizal fungi(AMF),remains poorly ***,we conducted a five-year field experiment in a rainfed maize field on the Loess Plateau of northwestern *** tested four treatments with straw return combined with four nitrogen(N)application rates,i.e.,100%,80%,60%,and 0%of the common N application rate(225 kg N ha^(-1)year^(-1))in this region,and two reference treatments(full or no N application),with three replicates for each *** colonization was quantified and AMF communities colonizing maize roots were characterized using Illumina *** virtual taxa(VTs)of AMF were identified in root samples,among which VT113(related to Rhizophagus fasciculatus)and VT156(related to Dominikia gansuensis)were the predominant *** root length colonization and AMF VT richness were sensitive to N fertilization,but not to straw return;furthermore,both gradually increased with decreasing N application *** VT composition of the AMF community was also affected by N fertilization,but not by straw return,and the community variation could be well explained by soil available N and phosphorus ***,60%,80%,and full N fertilization produced similar maize ***,our study revealed the response patterns of AMF to straw return and N fertilizer reduction and showed that straw return combined with N fertilizer reduction may be a promising practice to maintain mycorrhizal symbiosis concomitantly with crop productivity.

关键词： agricultural sustainability crop productivity mycorrhizal colonization mycorrhizal symbiosis root length colonization virtual taxon

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弯张换能器装配预应力及入水后的变化

物理学报 2004年第2期53卷 498-502页

作者：贺西平李斌陕西师范大学物理与信息技术学院西北工业大学航海工程学院西安710072

精确控制施加于驱动元件上的预应力 ,对换能器的设计及其工作过程都有重要意义 ,特别对于稀土磁致伸缩换能器来说 ,有助于发挥其最大潜能 .利用有限元方法 ,计算了VII型水声弯张换能器壳体给驱动元件施加一定预应力时 ,壳体所需的装配... 详细信息

精确控制施加于驱动元件上的预应力 ,对换能器的设计及其工作过程都有重要意义 ,特别对于稀土磁致伸缩换能器来说 ,有助于发挥其最大潜能 .利用有限元方法 ,计算了VII型水声弯张换能器壳体给驱动元件施加一定预应力时 ,壳体所需的装配位移的大小 ,并通过实验作了验证 ;弯张换能器随入水深度的不同 ,驱动元件两端所受到的总的预应力是不同的 .利用有限元方法 ,计算了换能器入水深度与预应力的关系 .

关键词：弯张换能器预应力入水深度装配位移稀土磁致伸缩换能器有限元分析

Involvement of hippocampal glucocorticoid receptor and BDNF in depression induced by chronic unpredictable mild stress

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Involvement of hippocampal glucocorticoid receptor and BDNF ...