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UltrahighQ Sr_(1+x)Y_(2.O_(4+x)(x=0-0.04)microwave dielectric ceramics for temperature-stable millimeter-wave dielectric resonator antennas

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Journal of Advanced Ceramics 2024年第2期13卷 155-165页

作者： Guoqiang He Yu Jiang kaixin Song Yanjun liu Yuan Nie Wenjie Zhang Ziqi Zhao Yinghan He Xinyue Ma Xiuli Chen Xu Li Huanfu Zhou Collaborative Innovation Centre for Exploration of Hidden Nonferrous Metal Deposits and Development of New Materials in Guangxi Key Laboratory of Nonferrous Materials and New Processing TechnologyMinistry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China college of Electronic Information Hangzhou Dianzi UniversityHangzhou 310018China

Microwave dielectric ceramics should be improved to advance mobile communication technologies *** this study,we prepared Sr_(1+x)Y_(2.O_(4+x)(x=0-0.04)ceramics with nonstoichiometric Sr^(2.)ratios based on our previously reported SrY_(2.O_(4) microwave dielectric ceramic,which has a low dielectric constant and an ultrahigh quality factor(Q value).The ceramic exhibited a 33.6% higher Q-by-frequency(Q×f)value(Q≈12.500)at x=0.02.than SrY_(2.O_(4).All Sr_(1+x)Y_(2.O_(4+x)(x=0-0.04)ceramics exhibited pure phase structures,although variations in crystal-plane spacings were *** ceramics are mainly composed of Sr-O,Y1-O,and Y_(2.-O octahedra,with the temperature coefficient of the resonant frequency(τ_(f))of the ceramic increasing with Y_(2.-O octahedral *** ceramic comprises uniform grains with a homogeneous elemental distribution,clear grain boundaries,and no obvious cavities at x=*** Sr_(1+x)Y_(2.O_(4+x)(x=0-0.04)ceramics exhibited good microwave dielectric properties,with optimal performance observed at x=0.02.dielectric constant(εr)=15.41,Q×f=112.375 GHz,and τ_(f)=-17.44 ppm/℃).The τ_(f) value was reduced to meet the temperaturestability requirements of 5G/6G communication systems by adding CaTiO_(3),with Sr_(1.02.Y_(2.O_(4.02.+2.t% CaTiO_(3) exhibiting ε_(r)=16.14,Q×f=51,004 GHz,andτf=0 ppm/℃.A dielectric resonator antenna prepared using Sr_(1.02.Y_(2.O_(4.02.+2.t%CaTiO_(3) exhibited a central frequency of 2..6 GHz,with a corresponding gain and efficiency of 3.66 dBi and 83.14%,***,Sr_(1.02.Y_(2.O_(4).02.based dielectric resonator antennas are suitable for use in 5G millimeter-wave band(2..5-2..5 GHz)applications.

关键词： millimeter wave microwave dielectric ceramics dielectric resonator antenna nonstoichiometric ratio

Inulin alleviates HFD-induced NAFLD by hepatic macrophage polarization and lipid metabolism via gut-liver axis

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Food Science and Human Wellness 2024年

作者： Wei Song Jinhong Hu Lina Zhu Bing Chen Lingling Li Xiaole Cui Ting Zhang Yaxing Miao kaixin Su Changchun liu Yane Luo Tianli Yue college of Food Science and Technology， Laboratory of Nutritional and Healthy Food-Individuation Manufacturing engineering， Research Center of Food Safety Risk Assessment and Control， Northwest {2.

Long-term intake of high-fat diet (HFD) leads to systemic hypo-inflammation， which is involved in the pathogenesis of many liver diseases. The aim of this study was to evaluate the interventional effect of inulin addition on HFD-induced non-alcoholic fatty liver disease (NAFLD). Here， we assessed liver inflammation and lipid metabolism by ELISA kits and real-time quantitative polymerase chain reaction (qPCR)， and explored its relationship with intestinal flora and metabolites by 16S rDNA gene sequencing and untargeted metabolomics. In addition， we determined the effect of the inositol-requiring enzyme-1α (IRE1α-XBP1) pathway on liver macrophage polarization by flow cytometry. In conclusion， our study has demonstrated that inulin ameliorates high levels of bile acids and colonic immune disorders induced by HFD， and improves hepatic macrophage polarization and hepatic lipid metabolism via the intestine-hepatic axis， thus providing a mechanistic basis for therapeutic approaches to modulate bile acids to improve colonic inflammation and nonalcoholic fatty liver disease.

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基于马尔可夫模型的多等级灾害下复杂系统可靠性和维修分析

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运筹与管理 2024年第1期33卷 83-89页

作者：兑红炎刘凯鑫陶俊勇郑州大学管理学院河南郑州450001 国防科技大学智能科学学院湖南长沙410073

近些年来,自然灾害发生的频率逐渐增加,复杂系统的规模越来越大,导致了巨大的经济损失。由于自然灾害的预测较难,且灾害极易对复杂系统造成巨大冲击,因此,对复杂系统的可靠性和维修分析显得尤为重要。本文研究多等级灾害下的复杂系统的... 详细信息

近些年来,自然灾害发生的频率逐渐增加,复杂系统的规模越来越大,导致了巨大的经济损失。由于自然灾害的预测较难,且灾害极易对复杂系统造成巨大冲击,因此,对复杂系统的可靠性和维修分析显得尤为重要。本文研究多等级灾害下的复杂系统的维修策略。首先基于马尔可夫模型对多态复杂系统性能进行分析,基于系统性能变化对复杂系统的损失进行分析,然后以系统总损失最小为目标来确定故障组件的维修集合。由于资源限制,假设每次只能修复一条故障线路,而且不同线路对系统损耗的影响不同,因此必须确定修复故障线路的顺序,本文利用综合重要度来确定维修集合中组件的维修顺序。最后以IEEE18节点标准配电系统为例,对其进行可靠性和维修分析,提出给定故障组件集合下的维修策略,从而验证了模型的可行性。

关键词：可靠性维修马尔可夫模型组件重要度

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基于激光雷达扫描的料仓原料储料量测量方法

华中农业大学学报 2024年第3期43卷 293-301页

作者：牛智有沈柏胜路开新徐志杰江善晨刘静刘梅英华中农业大学工学院/农业农村部智慧养殖技术重点实验室武汉430070

为提高仓内原料储料量测量自动化和智能化水平,设计了一种基于二维激光雷达扫描的储料量测量装置与系统。本系统采用RPLIDARS1型二维激光雷达扫描获取不同储料量物料的原始点云数据,通过坐标变换、重叠点提取、滤波、分割等方法对原始... 详细信息

为提高仓内原料储料量测量自动化和智能化水平,设计了一种基于二维激光雷达扫描的储料量测量装置与系统。本系统采用RPLIDARS1型二维激光雷达扫描获取不同储料量物料的原始点云数据,通过坐标变换、重叠点提取、滤波、分割等方法对原始点云进行预处理,采用贪婪投影三角化算法将预处理后的点云进行三维重建,获得仓内原料的三维模型,结合物料三维模型和物料的容重获得仓内原料的储料量,从而实现储料量的自动测量。以玉米为试验对象,测量小型储料塔内玉米储料量并对玉米不同储料量进行扫描测量,验证模型的准确性,结果显示:测量结果的平均绝对误差为8.05kg,平均相对误差为1.52.。研究结果表明,基于二维激光雷达扫描的储料量测量方法是可行的,具有较好的稳定性和测量精度,能够满足实际生产需求。

关键词：料仓储料量激光雷达点云处理三维重建

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淡水流域底栖动物eDNA宏条形码筛选研究

山西化工 2024年第9期44卷 198-200,233页

作者：张玉蕾刘占鑫刘凯鑫武宇鹏太原科技大学环境与资源学院山西太原030024

利用eDNA宏条形码对淡水生态系统进行研究的过程中,通用基因的筛选很重要。本研究计算并比较了cox1、cob、12.rDNA和18SrDNA基因的进化速率和基因差异位点,结果显示cox1基因具有适中的进化速率和较高的种间差异,适合作为eDNA宏条形码的... 详细信息

利用eDNA宏条形码对淡水生态系统进行研究的过程中,通用基因的筛选很重要。本研究计算并比较了cox1、cob、12.rDNA和18SrDNA基因的进化速率和基因差异位点,结果显示cox1基因具有适中的进化速率和较高的种间差异,适合作为eDNA宏条形码的通用基因。通过对比不同长度的cox1基因片段对结果的影响,发现300 bp左右的短片段在底栖动物物种多样性方面有较高的覆盖度。因此,本研究确定300 bp长度的cox1基因作为淡水底栖动物eDNA宏条形码的通用基因片段,以提高物种多样性评估的覆盖度,为淡水生态系统的生物多样性研究和生态修复提供技术服务。

关键词： eDNA宏条形码底栖动物线粒体cox1

Seasonal variations in gonad morphology and hypothalamic GnRH-I and GnIH in Eurasian Tree Sparrow,a multi-brooded passerine

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Avian Research 2022年第3期13卷 369-378页

作者： Limin wang Ghulam Nabi Li Zhang Dan liu Mo Li Juyong Li {2. Shi Ibrahim M.Ahmad Yuefeng Wu John C.Wingfield Dongming Li Ministry of Education Key Laboratory of Molecular and Cellular Biology Key Laboratory of Animal PhysiologyBiochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuang050024China Department of Neurobiology Physiology and BehaviorUniversity of Californi1DavisCAUSA

The hypothalamic-pituitary-gonadal(HPG)axis ubiquitously regulates seasonal reproduction,following the rhythmicity of a suite of environmental *** display prominent seasonal variations in gonad size regulated by two hypothalamic peptides,gonadotropin-releasing hormone-1(GnRH-I)and gonadotropin-inhibiting hormone(GnIH).How multi-brooded avian species adjust GnRH-I and GnIH to regulate gonadal morphology seasonally remains largely ***,we studied the variations in the hypothalamic immunoreactivity(ir)of GnRH-I and GnIH,gonadal proliferation,and apoptosis in a typical multi-brooded species,the Eurasian Tree Sparrow(Passer montanus),across the pre-breeding(PB),first breeding(FB),second breeding(SB),pre-basic molt(PM),and wintering stages(WS).Our results showed that both sexes had higher preoptic area(POA)-GnRH-I-ir but lower paraventricular nucleus(PVN)-GnIH-ir neurons during the breeding stages(FB and SB)relative to other life-history stages,with no significant differences between two *** testes and ovaries were significantly larger during the breeding *** volume increased during the two broods due to anincreased diameter of seminiferous ***,there were more testicular apoptotic cells in PB and WS stages than in breeding stages,and in PB stage than in PM *** had higher POA-GnRH-I expression than females during the breeding stages,but both sexes had comparable PVN-GnIH expression throughout the annual *** sexes of the sparrows may undergo a similar pattern of life-history stage-dependent variation in the hypothalamic GnRH-I,GnIH,and gonadal morphology,except that during breeding stages,males may display higher expression of POA-GnRH-I relative to *** higher expression of POA-GnRH-I-ir in breeding male sparrows may be critical for male-dependent parental care.

关键词： Eurasian Tree Sparrow Gonads Hypothalamus Reproduction Seasonality

猕猴脑网络组图谱:包含分区、连接和组织学的多层面全新大脑地图

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Science Bulletin 2024年第14期69卷 2241-2259页

作者：陆玉恒崔玥曹龙董振伟程禄祺吴雯王昌硕刘新异刘有通张宝贵李德莹赵舶凯王海艳李开心马亮时维阳李雯马亚伟杜宗昌张佳琪熊辉罗娜刘妍妍侯肖逍韩景路孙洪吉蔡涛彭强冯琳清王骄健 George Paxinos 杨正宜樊令仲蒋田仔 Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou 450001China Neuroscience Research Australia and The university of New South Wales Sydney NSW 2031Australia Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China School of Mechanical and Power engineering Harbin University of Science and TechnologyHarbin 150080China School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004China Sino-Danish college University of Chinese Academy of ScienceBeijing 100049China Research Center for Augmented Intelligence Zhejiang LabHangzhou 311100China Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital Yongzhou 425000China

The rhesus macaque(Macaca mulatta)is a crucial experimental animal that shares many genetic,brain organizational,and behavioral characteristics with humans.A macaque brain atlas is fundamental to biomedical and evolutionary ***,even though connectivity is vital for understanding brain functions,a connectivity-based whole-brain atlas of the macaque has not previously been *** this study,we created a new whole-brain map,the Macaque Brainnetome Atlas(MacBNA),based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI *** new atlas consists of 2.8 cortical and 56 subcortical regions as well as their structural and functional *** parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained *** a demonstrative application,the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain *** resulting resource includes:(1)the thoroughly delineated Macaque Brainnetome Atlas(MacBNA),(2.regional connectivity profiles,(3)the postmortem high-resolution macaque diffusion and T2.weighted MRI dataset(Brainnetome-8),and(4)multi-contrast MRI,neuronal-tracing,and histological images collected from a single *** can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and ***,it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

关键词： Macaca mulatta Brain atlas Connectivity-based parcellation Diffusion MRI Cytoarchitecture Cross-species comparison

基于UPLC-Q-TOF-MS和网络药理学探讨冬凌草复方增强免疫功能作用及机制

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中国医院药学杂志 2024年第1期44卷 47-58页

作者：刘福宇唐寅博单凯欣蒋鑫孔小莉黄敬旺张卫华方晓艳河南中医药大学药学院河南郑州450046 河南省冬凌草工程中心河南济源454600 北京中医药大学北京100029

目的:研究冬凌草复方的化学成分及其增强免疫功能的作用机制。方法:采用鸡红细胞吞噬、淋巴细胞转化、脾细胞抗体生成实验研究冬凌草复方增强小鼠免疫功能活性。运用UPLC-Q-TOF-MS对冬凌草复方化学成分进行分析鉴定。利用TCMSP、SEA和Sw... 详细信息

目的:研究冬凌草复方的化学成分及其增强免疫功能的作用机制。方法:采用鸡红细胞吞噬、淋巴细胞转化、脾细胞抗体生成实验研究冬凌草复方增强小鼠免疫功能活性。运用UPLC-Q-TOF-MS对冬凌草复方化学成分进行分析鉴定。利用TCMSP、SEA和Swiss Target Prediction数据库获得化学成分靶点,通过GeneCards、OMIM和TTD数据库收集免疫相关靶点,使用Venn在线网站获得药物和疾病的交集靶点,并结合String数据库和Cytoscape软件构建核心靶点网络图。采用David数据库对核心靶点进行GO和KEGG分析,使用Cytoscape软件绘制“活性成分-靶点-通路”网络图,通过Autodock vina软件对核心靶点和关键成分进行分子对接验证。结果:与空白组相比,冬凌草复方中剂量组可明显提高小鼠腹腔巨噬细胞吞噬百分率和吞噬指数(P1)、脾淋巴细胞增殖能力(P1)和溶血空斑个数(P1),表明冬凌草复方具有增强小鼠非特异性和特异性免疫功能的作用。从复方中共鉴定12.个化学成分,网络药理学获得药物关键成分为6-醛基异麦冬黄烷酮A、甲基异茜草素等,核心靶点包括AKT1、VEGFA、IL1B等,主要涉及PI3K-Akt、HIF-1、IL-17等信号通路,分子对接结果显示核心靶点与关键成分具有较好的结合活性。结论:冬凌草复方可能通过多成分、多靶点、多通路增强机体免疫功能。

关键词：冬凌草复方免疫功能 UPLC-Q-TOF-MS 网络药理学分子对接

mTORC2.RICTOR exerts differential levels of metabolic control in human embryonic,mesenchymal and neural stem cells

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Protein & Cell 2022年第9期13卷 676-682页

作者： Qun Chu Feifei liu Yifang He Xiaoyu Jiang Yusheng Cai Zeming Wu Kaowen Yan Lingling Geng Yichen Zhang Huyi Feng kaixin Zhou Si {2. Weiqi Zhang Guang-Hui liu Shuai Ma Jing Qu Moshi Song State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China china National Center for Bioinformation Beijing 100101China university of Chinese Academy of Sciences Beijing 100049China Aging Translational Medicine Center International Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Sino-Danish college University of Chinese Academy of SciencesBeijing 101408China Chongqing Renji Hospital University of Chinese Academy of SciencesChongqing 400062China college of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Dear Editor,Stem cells,including pluripotent stem cells and adult stem cells,possess the remarkable capability of being able to selfrenew while at the same time having potential to differentiate into different cell lineages and functionally distinct cell *** embryonic stem cells(hESCs)can differentiate into all adult stem cell types,including human mesenchymal stem cells(hMSCs)and human neural stem cells(hNSCs),but can also give rise to all terminally differentiated cell types(wang et al.,2.2.a).Through the continuous replenishment of differentiated cells,stem cells support tissue homeostasis and respond to tissue *** the promising applications of stem cells in cell therapy and regenerative medicine,insights into molecular events underlying stem cell maintenance,self-renewal ability and pluripotency,continue to garner strong interest(Shan et al.,2.2.).Although metabolic pathways have been implicated in the reciprocal regulations of stem cell self-renewal and differentiation as well as organ homeostatic maintenance(Garcia-Prat et al.,2.17),central aspects of how metabolic requirements differ and are regulated across the various types of human stem cells in our body remain enigmatic.

关键词： injuries homeostasis neural