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RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： Wei-Wei Liu Si-Qing Zheng Tian Li Yun-fei fei Chen wang Shuang Zhang fei wang Guan-Min Jiang Hao wang Department of Laboratory Medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical Medicine Shandong UniversityJinanChina Core Unit of National Clinical Research Center for Laboratory Medicine HefeiChina Neurosurgical Department The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of *** a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular *** be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological *** this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial *** we highlight the regulation of RNA modifications on immunometabolism,further influencing immune *** all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations

Commentary on "Simplifying the ShangRing technique for circumcision in boys and men: use of the no-flip technique with randomization to removal at 7 days versus spontaneous detachment"

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Asian Journal of Andrology 2019年第4期21卷 423-424页

作者： Yi-fei wang .

It has been 10 years since we published the first report describing use of the ShangRing for circumcision in boys and men. That report, by Peng et al.{ from China, showed that the device was safe and that ShangRing circumcision was quicker than with conventional surgical techniques commonly used. The ShangRing, pictured in Figure 1, isa novel collar clamp circumcision device that was invented by Mu Jian-Zhong Shang in China in the early 2000s to reduce potential surgical complications following male circumcision. Based on its successful use in 2006, Mr. Shang started SNNDA Medical Company to produce and distribute the ShangRing. The device has two parts consisting of an inner ring and an outer ring. The foreskin is sandwiched between the two rings, ensuring hemostasis without the need for suturing, which greatly simplifies the circumcision. The device is typically removed by a clinician 7-10 days later.

关键词： ShangRing technique no-flip technique Simplifying

Experimental study and cellular automaton simulation on solidification microstructure of Mg-Gd-Y-Zr alloy

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Rare Metals 2021年第1期40卷 128-136页

作者： Xu-Yang wang fei-Fan wang Ke-Yan Wu Xian-fei wang Lv Xiao Zhong-Quan Li Zhi-Qiang Han School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology(Ministry of Education) Tsinghua UniversityBeijing 100084China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The solidification microstructure of Mg-Gd-YZr alloy was investigated via an experimental study and cellular automaton(CA)*** this study,stepshaped castings were produced,and the temperature variation inside the casting was recorded using thermocouples during the solidification *** effects of the cooling rate and Zr content on the grain size of the Mg-Gd-Y-Zr alloy were *** results showed that the grain size decreased with an increase in the cooling rate and Zr *** on the experimental data,a quantitative model for calculating the heterogeneous nucleation rate was developed,and the model parameters were *** evolution of the solidification microstructure was simulated using the CA method,where the quantitative nucleation model was used and a solute partition ceoefficient was introduced to deal with the solute trapping in front of the solid-liquid(S/L)*** simulation results of the grain size were in good agreement with the experimental *** simulation also showed that the fraction of the eutectics decreased with an increasing cooling rate in the range of 2.6-11.0℃·s^(-1),which was verified indirectly by the experimental data.

关键词： Solidification microstructure Mg-Gd-Y-Zr alloy Cooling rate Zr content Nucleation Cellular automaton

基于Budyko理论的长江典型流域径流演变与归因分析

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水土保持研究 2025年第1期32卷 172-180页

作者：宋阁庆马晓燕王茂林袁春慧杨陈王飞邓悦甘肃省水文站兰州730030 兰州理工大学能源与动力工程学院兰州730050 扶风县水利工作站陕西宝鸡722999

[目的]探究变化环境下的长江典型流域径流演变和驱动因素,量化气候变化及下垫面变化对流域径流变化的贡献率,以期为白水江流域水资源优化配置和流域治理提供科学依据。[方法]采用Mann-Kendall趋势检验、交叉小波分析和Budyko理论等研究... 详细信息

[目的]探究变化环境下的长江典型流域径流演变和驱动因素,量化气候变化及下垫面变化对流域径流变化的贡献率,以期为白水江流域水资源优化配置和流域治理提供科学依据。[方法]采用Mann-Kendall趋势检验、交叉小波分析和Budyko理论等研究方法,分析了白水江流域1970-2016年的年径流量演变规律及其影响因素。[结果](1)白水江流域年径流量呈显著(p<0.05)下降趋势,径流和降水突变年份均在1994年。(2)白水江流域年径流量与年降水量呈正相关性关系,径流深在影响期(1995-2016年)相比基准期(1970-1994年)对年降水量最敏感,其次为潜在蒸散发量和下垫面参数。(3)量化解析了下垫面、年降水量和潜在蒸散发量对白水江流域径流的贡献率,其中,下垫面贡献率为46.14%,降水量贡献率为41.02%,潜在蒸散发量贡献率为12.84%。[结论]1970-2016年白水江流域年径流量和年降水量均呈下降趋势,白水江流域径流的驱动因素是由于气候和人类活动的综合影响。降水是导致白水江流域径流减少的主要气候因素,下垫面变化是白水江流域径流减少的一个关键因素。

关键词： Budyko理论径流归因分析白水江流域

Ti_(3)C_(2)T_(x)-TiSe_(2) analogous heterostructure for flexible zinc ion battery

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Journal of Materials Science & Technology 2023年第19期150卷 225-232页

作者： Li Wen Junjie Shi Qixiang Zhang fei wang Siliang wang Shaojun Zhang Qiang wang Ke Mao fei Long Yihua Gao Center for Nanoscale Characterization&Devices(CNCD) School of Physics and Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Information Materials and Intelligent Sensing Laboratory of Anhui Province School of Integrated CircuitsAnhui UniversityHefei 230601China College of Materials Science and Engineering Guangxi Key Laboratory of Optical and Electronic Materials and DevicesGuilin University of TechnologyGuilin 541004China

Exploring zinc-free anode materials is one of the effective strategies to get the zinc dendrites problem of flexible zinc ion battery(ZIB)*** this work,an analogous heterostructure(AHS)is constructed from the excellent MXene(Ti_(3)C_(2)T_(x))and TiSe_(2) *** AHS not only possesses numerous diffu-sion paths and Zn^(2+)storage sites but also possesses a stable conductive network to accelerate charge transfer in the *** a collaborative advantage,electrochemical measurement results show that MXene/TiSe_(2) electrodes display an excellent specific capacity of 177.9 mAh g^(-1) at 0.10 A g^(-1) and a long-term cycling stability of 77.4%capacity retention after 400 *** computations further demon-strate the excellent performance of MXene/TiSe_(2) electrodes including desirable electronic conductivity and low Zn^(2+)migration *** assembled flexible ZIB not only delivers a good specific capacity of 42.2μAh cm^(-2) at 0.20 mA cm^(-2) and a competitive energy density of 37.4μWh cm^(-2) but also exhibits excellent flexibility and ***,after 400 cycles at 0.60 A g^(-1),flexible ZIB shows a capacity retention of 73.8%.This work gives a successful attempt to design 2D layered materials as Zn metal-free anode for flexible ZIB.

关键词： Flexible zinc ion battery Analogous heterostructure Zinc dendrite Zinc free metal anode MXene flakes TiSe_(2)nanosheets

Altering the Hierarchical Morphology Distribution of Injection Molded Polyethylene by the Introduction of Crosslink Network and Periodical Shear

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Chinese Journal of Polymer Science 2016年第12期34卷 1479-1489页

作者： Zhi-hao Zhao fei-fei wang Man Zhou Kai-zhi Shen 张杰 College of Polymer Science and Engineer'ing State Key Laboratory of Polymer Materials En~neeringSichuan UniversityChengdu 610065China

High density polyethylene （HDPE） with moderate content of crosslink network （CPE） was successfully prepared through chemical method. Specimens for structural characterization have been molded by conventional injection molding （CIM） and pressure vibration injection molding （PVIM）. Influence of crosslink network on hierarchical morphology distribution and mechanical properties was systematically studied. Polarized light microscopy （PLM） revealed that both CIM and PVIM PE samples have a typical ＂skin-core＂ structure and the thickness of shear layer of CIM PE and PVIM CPE samples obviously increase. Scanning electron microscopy （SEM） showed that shish-kebab structures are clearly observed in shear layer of CIM CPE sample, indicating that the crosslink network can surely improve the formation of shish-kebab structures. Moreover, we suppose that shish-kebab structures emerged in shear and core layer of PVIM CPE sample. Wide- angle X-ray diffraction （WAXD） and small-angle X-ray scattering （SAXS） confirmed that more orientation and shish-kebab structures form even in core layer of PVIM CPE sample, which demonstrated that the hierarchical morphology was apparently altered by periodical shear and crosslink network. Finally, the mechanical properties revealed that this oriented structure increase the tensile strength from 31 MPa of CIM PE sample to 46 MPa of PVIM CPE sample. However, the tensile behavior tended to change from ductile fracture to brittle fracture.

关键词： Shish-kebab Morphology distribution Periodical shear Mechanical properties.

Mercury emissions in China:a general review

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Waste Disposal and Sustainable Energy 2019年第2期1卷 127-132页

作者： Xinyu Jiang fei wang State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

This paper provides a general review of the research status of mercury emissions in *** surveys rank Asia as the region with the largest share of global mercury emissions,accounting for almost *** contributes about one-third of the world’s mercury emissions,which is 600-800 t per *** thus,it plays a vital role in reducing global mercury *** since 2003 has been *** emissions in China have risen in the beginning and then *** are differences in the composition of mercury emissions sources between China and the world,in which coal combustion and non-ferrous metals smelting contribute more than 50%of the emissions in *** mercury emission standards in China are close to those of the European Union and the United States,annual mercury emissions in China are four times higher than those of the United *** emissions in China are concentrated in the central and eastern regions now,but the annual mercury emissions are increasing in the western regions,which may be related to the construction of industrial parks.

关键词： Mercury emissions inventory Mercury distribution Emission standard Mercury emission trend

抗战时期中共中央对陕甘宁边区回族情况的社会调查

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回族研究 2019年第4期 26-32页

作者：王飞陇东学院历史与地理学院

抗战时期,中共中央在陕甘宁边区实施的回族情况的社会调查,弄清了回族群众生产、生活状况,为制定切实的民族政策提供了决策依据。它丰富了党的民族工作方法,实现了党的民族工作创新,为解放战争期间解放回族同胞、开展回族群众工作提供... 详细信息

抗战时期,中共中央在陕甘宁边区实施的回族情况的社会调查,弄清了回族群众生产、生活状况,为制定切实的民族政策提供了决策依据。它丰富了党的民族工作方法,实现了党的民族工作创新,为解放战争期间解放回族同胞、开展回族群众工作提供了参考。边区回族情况的社会调查统计推动了党的民族理论发展和成熟,对党的民族政策形成、发展具有促进作用,尤其是回民自治乡的建立为后来的民族区域自治提供了蓝本,在党的民族政策的历史中具有重要地位。

关键词：社会调查抗战时期陕甘宁边区回族

Deep-reinforcement-learning-based UAV autonomous navigation and collision avoidance in unknown environments

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Chinese Journal of Aeronautics 2024年第3期37卷 237-257页

作者： fei wang Xiaoping ZHU Zhou ZHOU Yang TANG School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

In some military application scenarios,Unmanned Aerial Vehicles(UAVs)need to perform missions with the assistance of on-board cameras when radar is not available and communication is interrupted,which brings challenges for UAV autonomous navigation and collision *** this paper,an improved deep-reinforcement-learning algorithm,Deep Q-Network with a Faster R-CNN model and a Data Deposit Mechanism(FRDDM-DQN),is proposed.A Faster R-CNN model(FR)is introduced and optimized to obtain the ability to extract obstacle information from images,and a new replay memory Data Deposit Mechanism(DDM)is designed to train an agent with a better *** training,a two-part training approach is used to reduce the time spent on training as well as retraining when the scenario *** order to verify the performance of the proposed method,a series of experiments,including training experiments,test experiments,and typical episodes experiments,is conducted in a 3D simulation *** results show that the agent trained by the proposed FRDDM-DQN has the ability to navigate autonomously and avoid collisions,and performs better compared to the FRDQN,FR-DDQN,FR-Dueling DQN,YOLO-based YDDM-DQN,and original FR outputbased FR-ODQN.

关键词： Faster R-CNN model Replay memory Data Deposit Mechanism(DDM) Two-part training approach Image-based Autonomous Navigation and Collision Avoidance(ANCA) Unmanned Aerial Vehicle(UAV)