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Journal of Materials Science & Technology 2013年第11期29卷 1104-1110页

作者： Pengfei Li Aihua Yao Tian Zhou deping wang School of Materials Science and Engineering Tongji University Key Laboratory of Advanced Civil Engineering Materials Ministry of EducationTongji University

N-Acetyl-L-cysteine-capped CdSe-polyelectrolytes @ hydroxyapatite （NAC-CdSe-PEs@HA） composite microspheres were fabricated through a stepwise layer-by-layer method and used for fluorescence detection of Cu2＋ ions. The hollow HA microsphere was confirmed to be an ideal host to load CdSe quantum dots （QDs） due to their large surface area, well-defined porous structure, and large inner hollow size. Furthermore, the introduction of polyelectrolyte layers contributed to the increase of the loading amount and the electrostatic interaction between microsphere and QDs. Experiments results showed that among various metal ions investigated, Cu2＋ exhibited the highest quenching effect on the fluorescence of CdSe QDs loaded in the composite microspheres. Additionally, the composite exhibited improved sensibility in detecting Cu2＋ due to the presence of HA microspheres. Importantly, it is easy to separate and recycle the composite microspheres from the detection solution due to their relatively large size and high stability, thereby avoiding secondary contamination.

关键词： CdSe quantum dots Hydroxyapatite Fluorescence quenching Copper ions

Dual excitable upconversion nanoparticle@polydopamine nanocomposite with intense red emission and efficient photothermal generation

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Journal of Rare Earths 2023年第12期41卷 1860-1868,I0002页

作者： Huazhen Liao Song Ye Xinling Xu Peixuan Lin Ling Pan deping wang School of Materials Science and Engineering Tongji UniversityShanghai201804China

Integration of strong upconversion emission with deep tissue penetration and stable photothermal generation is of great significance for imaging-guided photothermal therapy under infrared ***,the NaYF_(4):Yb^(3+),Ho^(3+),Ce^(3+)@NaGdF_(4):Yb^(3+),Nd^(3+)@NaGdF_(4)core-shell-shell upconversion nanoparticles(UCNPs) with increasing Ce^(3+)doping concentration were firstly synthesized,in which the size manipulation,enhanced red to green emission intensity ratio(IR/IG),980 and 808 nm dual-modal excitations,as well as improved total upco nversion emission intensity can be *** the coating of polydopamine(PDA) through dopamine spontaneous polymerization on the UCNPs surface under alkaline condition,the obtained UCNP@PDA nanocomposites show efficient photothermal effect under 808 nm excitation,while the thickness variation of PDA can be indicated by the upconversion spectra under 980 nm ***,the photothermal effect of the UCNP@PDA nanocomposites with high IR/IGratio is mo re stable with PDA thickness variation,which bene fits from the structure design that allows PDA to simultaneously absorb the visible emission from inside UCNPs and the external 808 nm infrared *** in vitro cytotoxicity assay and photothermal therapy demonstrate that the UCNP@PDA nanocomposite has good biocompatibility and ability to kill tumor cells by photothermal effect under 808 nm *** research may provide a nanoplatform for integrating deep bioimaging with highly stable photothermal therapy without the sacrifice of radiative transitions of rare earth ions.

关键词： Upconversion nanoparticle Photothermal effect Polydopamine Enhanced red emission Ce^(3+)doping Rare earths

Synthesis of π-extended dibenzo[d,k]ullazines by a palladium-catalyzed double annulation using arynes

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Chinese Chemical Letters 2021年第4期32卷 1407-1410页

作者： deping wang Yan Liu Linhua wang Hu Cheng Yuming Zhang Ge Gao Key Laboratory of Green Chemistry and Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China

An efficient Pd-catalyzed double annulation reaction of 1-(2,6-dibro mophenyl)-1 H-pyrroles with arynes is developed to synthesizeπ-extended dibenzo[d,k]ullazines in good to excellent *** the first time,the parent di... 详细信息

关键词： Ullazine Dibenzo[d k]ullazine Palladium catalysis Annulation Aryne

The Sedimentation and Formation Mechanism of Lacustrine Endogenic Debris Flow

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Acta Geologica Sinica(English Edition) 1992年第2期66卷 119-140,220-221页

作者： wang deping Institute of Geology, Shengli Petroleum Administration, Dongying, Shandong Liu Linqun Institute of Geology Shengli Petroleum Administration Dongying Shandong

The debris flow formed by mass transportation of lacustrine deltaic sediments is quite unique comparedwith subaerial one, and is called 'endogenic debris flow' in this paper. The major diagnostic features ofendogenic debris flow sediments are muddy rip-ups, sandy lumps, randomly distributed carbonaceous plantleaves and rhyotaxitic structure. However, such debris flow can not be completely generalized by the conclu-sion that larger granules are supported by cohesive strength of the matrix. The fact that sediments can betransported in plastic state is considered to be related with two different functions of combined clay-water ma-terials: serving as a matrix in texture and as an adhesive between grains. This paper also discusses the originand sediment types of endogenic debris flow as well as the general concepts of matrix and debris flow. From the viewpoint of 'true debris flow', this paper attempts to generalize and illustrate the basic featuresand variation of endogenic debris flow sediments on the basis of the Bingham (Coulomb-viscosity) model.

关键词： debris lacustrine sedimentary Bingham adhesive texture granules viscosity bedding gentle

Investigation on Magnetorheological Effect of Novel Self-healing Magnetorheological Elastomers

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 88-97页

作者： wang deping wang Jing wang Xin Noman Tariq Yu Zhen Zheng Wenbo Wei Yintao General Research and Development Institute China FAW Corporation LimitedChangchun 130013 China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Magnetorheological elastomers(MREs)hold significant promise in various fields such as automotive engineering,and civil engineering,where they serve as intelligent *** on the application of an external magnetic field,these materials exhibit varying magnetorheological and viscoelastic properties,including shear stress,yield stress,dynamic moduli,and *** this work,a new type of MRE,termed self-healing MREs(SH-MREs),has been developed by adding a novel self-healing agent into existing *** dynamic modulus and loss factor of SH-MREs with different compositions have been characterized under various conditions of frequency,temperature,and *** results show that as the strain value increases,the loss factor also ***,the loss factor initially increases and then decreases with increasing magnetic field *** higher concentrations of ferromagnetic particles increase the loss factor,they enhance the operational range due to their better responsiveness to magnetic ***-MREs demonstrate improved damping capabilities,attributed to the formation of coordination bonds between ferromagnetic particles and the self-healing *** stable structure increases the viscosity of *** results of the regression model suggest a direct proportionality between sensitivity to the magnetic field and the ferromagnetic particle concentration.

关键词： magnetorheological elastomer magnetorheological effect storage modulus loss factor

Preparation of bioactive glasses with controllable degradation behavior and their bioactive characterization

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Chinese Science Bulletin 2007年第2期52卷 272-276页

作者： YAO AiHua wang deping FU Qiang HUANG WenHai Mohamed N. RAHAMAN School of Materials Science and Technology Tongji University Shanghai 200092 China University of Missouri-Rolla MO 65409 USA

Bioactive glasses and ceramics have been widely investigated for bone repair because of their excel-lent bioactive characteristics. However, these biomaterials undergo incomplete conversion into a bone-like material, which severely limits their biomedical application. In this paper, borosilicate bioac-tive glasses were prepared by traditional melting process. The results showed that borosilicate glasses possessed high biocompatibility and bioactivity. In addition, when immersed in a 0.02 mol/L K2HPO4 solution, particles of a borate glass were fully converted to HA. The desirable conversion rate to HA may be achieved through the adjustment of the B2O3/SiO2 ratio. The results of XRD and FTIR analysis indicated that the degradation product was carbonate-substituted hydroxyapatite, which was similar to the inorganic component of bone.

关键词：生物活性陶瓷玻璃降解行为生物材料骨组织

Recent progress in functional metal-organic frameworks for bio-medical application

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Regenerative Biomaterials 2024年第2期3卷 37-54页

作者： Wenwen Chai Xiaochen Chen Jing Liu Liyan Zhang Chunyu Liu Li Li John Robert Honiball Haobo Pan Xu Cui deping wang School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Orthopaedics&Traumatology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)have a high specific surface area,adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly,which has intrigued wide interest in a broad range of *** the arena of biomedical engineering,the functionalized modification of MOFs has produced drug carriers with excellent dispersion and functionalities such as target delivery and response release,with promising applications in bio-detection,disease therapy,tissue healing,and other *** review summa-rizes the present state of research on the functionalization of MOFs by physical binding or chemical cross-linking of small *** *** hvdrogels and evaluates the role and approach of MOFs functionalization in boosting the reactivity of *** this basis,research on the application of functionalized MOFs composites in biomedical engineering fields such as drug delivery,tissue repair,disease treatment,bio-detection and imaging is surveyed,and the development trend and application prospects of functionalized MOFs as an important new class of biomedical materials in the biomedical field are anticipated,which may provide some inspiration and reference for further development of MOF for bio-medical applications.

关键词： metal-organic frameworks porous functionalization tissue repair disease treatment

Formation and Characterization of Bone-like Nanoscale Hydroxyapatite in Glass Bone Cement

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Journal of Materials Science & Technology 2004年第6期20卷 772-774页

作者： Qiang FU, Nai ZHOU, Wenhai HUANG, deping wang and Liying ZHANGSchool of Materials Science and Engineering, Tongji University, Shanghai 200092, China Sch. of Mat. Sci. and Eng. Tongji Univ. Shanghai 200092 China

Glass based bone cement (GBC) was synthesized by mixing CaO-SiO2-P2O5 based glass powder with ammonium phosphate liquid medium. Bone-like hydroxyapatite (HAP, Ca10(PO4)6(OH)2) was found to form after GBC was immersed in simulated body fluid (SBF). HAP crystal grew with an increasing time along c axle and reached about 200 nm in length after 30 days, however, the end plane granularity remained 30-50 nm. The chemical composition, crystal structure and morphology of HAP formed from GBC were proved to have great resemblance with living HAP. It is believed that GBC was a desirabie biomedicai material with high bioactivity. Furthermore, the high compressive strength guaranteed the possibility of GBC in clinical application.

关键词： Bioactivity Bone cement Hydroxyapatite Microstructure

BaTiO_(3)@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism

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Nano Research 2023年第2期16卷 2775-2785页

作者： Yanlin Feng Jianlin wang Xin Ning Aiyun Li Qing You Wanzhen Su deping wang Jianyun Shi Lan Zhou Fangfang Cao Xiaoyuan Chen Jimin Cao Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuan 030001China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and Faculty of EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

Abnormal metabolism has become a potential target for highly malignant and invasive triple-negative breast cancer(TNBC)due to its relatively low response to traditional *** existing metabolic interventions demonstrated unsatisfactory therapeutic outcomes and potential systemic toxicity,resulting from the metabolic instability and limited targeting ability of inhibitors as well as complex tumor *** address these limitations,here we developed a robust pyroelectric BaTiO_(3)@Au core–shell nanostructure(BTO@Au)to selectively and persistently block energy generation of tumor *** by near-infrared(NIR)laser,the Au shell could generate heat to activate the BaTiO_(3)core to produce reactive oxygen species(ROS)regardless of the constrained microenvironment,thus prominently inhibits mitochondrial oxidative phosphorylation(OXPHOS)and reduces ATP production to induce TNBC cell *** therapeutic effects have been well demonstrated in vitro and in vivo,paving a new way for the development of metabolic interventions.

关键词： pyroelectric nanoheterostructure reactive oxidative species(ROS) metabolic interventions mitochondrial oxidative phosphorylation(OXPHOS) triple-negative breast cancer(TNBC)

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黄金大米及其安全性

中国生物工程杂志 2012年第9期32卷 138-139页

作者： wang deping 中国生物工程学会科普工作委员会

1 黄金大米的发明黄金大米（Golden Rice,简称金米）的发明者是瑞士联邦理工学院苏黎世分校（Swiss Federal Institute of Technology Zurich）植物科学研究所的名誉教授印戈·珀特里库斯（Ingo Potrykus）和德国弗莱堡大学应用生物科... 详细信息

1 黄金大米的发明黄金大米（Golden Rice,简称金米）的发明者是瑞士联邦理工学院苏黎世分校（Swiss Federal Institute of Technology Zurich）植物科学研究所的名誉教授印戈·珀特里库斯（Ingo Potrykus）和德国弗莱堡大学应用生物科学中心的教授彼得·拜尔（Peter Beyer）。

关键词：黄金大米安全性科学研究所瑞士联邦科学中心发明者苏黎世