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基于网络药理学探讨沙参麦冬汤治疗干眼的作用机制

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实用中医内科杂志 2022年第5期36卷 66-69,I0014-I0016页

作者：王冉张祝强左韬辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属第二医院辽宁沈阳110034

目的利用网络药理学的方法,建立沙参麦冬汤的活性成分作用靶点通路的网络图,对作用靶点的基因功能和通路进行富集分析,从而探讨沙参麦冬汤治疗干眼的可能作用机制。方法通过中药系统药理学数据库与分析平台(TCMSP)及中医药综合数据库(TC... 详细信息

目的利用网络药理学的方法,建立沙参麦冬汤的活性成分作用靶点通路的网络图,对作用靶点的基因功能和通路进行富集分析,从而探讨沙参麦冬汤治疗干眼的可能作用机制。方法通过中药系统药理学数据库与分析平台(TCMSP)及中医药综合数据库(TCMID)收集沙参麦冬汤药物有效成分,通过GeneCards数据库收集干眼靶点,将有效成分靶点与干眼靶点取交集,利用GeneCards数据库和OMIM数据库去重、合并,预测沙参麦冬汤的相关靶标,筛选沙参麦冬汤的活性成分治疗疾病的潜在作用靶标。利用String平台进行蛋白质的相互作用分析,构建并挖掘PPI网络中潜在的蛋白质功能模块。采用Metascape平台分析“药物-成分-疾病-靶点”及其参与的生物过程及通路,而后采用Cytoscape 3.8.2软件构建“沙参麦冬汤成分-干眼靶点-通路”网络。凭借蛋白质相互作用数据库(STRING)创建潜在靶标蛋白的相互作用网络,并找到沙参麦冬汤治疗干眼的关键基因蛋白。使用Metascape对沙参麦冬汤治疗干眼的潜在作用靶标进行生物学功能和代谢通路分析。结果沙参麦冬汤中共筛选出163种有效活性成分,核心靶点有白蛋白(ALB)、AKT1、白介素(IL-6)、VEGFA、MAPK8、CASP3、EGFR、PPAGR等,沙参麦冬汤治疗干眼的生物学通路主要作用于TNF signaling pathway信号通路、cAMP signaling pathway信号通路、Retinol metabolism信号通路等,其功能主要是对炎性反应信号通路关键蛋白的调控作用,促进眼表上皮细胞和杯状细胞分泌黏蛋白。结论研究初步揭示了沙参麦冬汤治疗干眼的多成分、多靶点、多通路的作用机制,为沙参麦冬汤的临床开发利用提供基础。

关键词：沙参麦冬汤网络药理学干眼靶点预测

中国建筑产业竞争力形成机理动态演进规律空间差异化研究

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管理评论 2017年第1期29卷 93-104页

作者：刘炳胜王然陈晓红孟俊娜薛斌天津大学管理与经济学部天津300072 中南大学商学院长沙410083

针对中国区域建筑产业在发展过程中存在着明显差异性的现状,在充分借鉴原有研究成果的基础上,将支持向量机模型、主成分模型与时序多指标模型结合,实证研究中国建筑产业竞争力形成机理动态演进规律的空间差异。研究发现,创新因素作为东... 详细信息

针对中国区域建筑产业在发展过程中存在着明显差异性的现状,在充分借鉴原有研究成果的基础上,将支持向量机模型、主成分模型与时序多指标模型结合,实证研究中国建筑产业竞争力形成机理动态演进规律的空间差异。研究发现,创新因素作为东部地区建筑产业竞争力重要的影响因素,其影响仍在持续增加;产业组织状况对中部地区建筑产业的发展有着逐步增强的积极作用;而对于西部地区建筑产业,作为产业竞争力重要的影响因素,生产要素投入的影响仍在逐步增加。这一研究发现揭示了未来中国各区域建筑产业发展的方向,实现了产业竞争力研究在空间维与时间维上的理论与方法创新,为后续面向中国建筑产业协同发展的产业规制研究奠定了研究基础。

关键词：建筑产业竞争力差异化形成机理

The Squeeze & Excitation Normalization Based nnU-Net for Segmenting Head & Neck Tumors

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Chinese Journal of Electronics 2024年第3期33卷 766-775页

作者： Juanying XIE Ying PENG Mingzhao wang School of Computer Science Shaanxi Normal University

Head and neck cancer is one of the most common malignancies in the *** propose SE-nnU-Net by adapting SE(squeeze and excitation) normalization into nnU-Net,so as to segment head and neck tumors in PET/CT images by combining advantages of SE capturing features of interest regions and nnU-Net configuring itself for a specific *** basic module referred to convolution-ReLU-SE is designed for *** the encoder it is combined with residual structure while in the decoder without residual *** loss function combines Dice loss and Focal *** specific data preprocessing and augmentation techniques are developed,and specific network architecture is ***,the deep supervised mechanism is introduced to calculate the loss function using the last four layers of the decoder of *** SE-nnU-net is applied to HECKTOR 2020 and HECKTOR 2021 challenges,respectively,using different experimental *** experimental results show that SE-nnU-Net for HECKTOR 2020 obtained 0.745,0.821,and 0.725 in terms of Dice,Precision,and Recall,respectively,while the SE-nnU-Net for HECKTOR 2021 obtains 0.778 and 3.088 in terms of Dice and median HD95,*** SE-nnU-Net for segmenting head and neck tumors can provide auxiliary opinions for doctors diagnoses.

关键词： Image segmentation Head Data preprocessing Artificial neural networks Network architecture Data models Neck

基于拉普拉斯变换的二阶系统传递函数的参数研究

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菏泽学院学报 2017年第5期39卷 7-10页

作者：江立辉牛欣汪冉汪成合肥学院数学与物理系安徽合肥230601 合肥学院机械工程系安徽合肥230601

为了研究二阶系统传递函数中固有频率和阻尼比这两个参数,运用牛顿第二定律构建微分方程数学模型,并利用拉普拉斯变换理论,说明了传递函数中的固有频率和阻尼比这两个重要参数表达式的正确性和合理性.从固有频率和阻尼比的实际含义出发... 详细信息

为了研究二阶系统传递函数中固有频率和阻尼比这两个参数,运用牛顿第二定律构建微分方程数学模型,并利用拉普拉斯变换理论,说明了传递函数中的固有频率和阻尼比这两个重要参数表达式的正确性和合理性.从固有频率和阻尼比的实际含义出发,对它们的计算公式进行详细证明,从而加深对二阶系统传递函数参数的理解,并将其更好地运用到实际问题中.

关键词：二阶系统传递函数固有频率阻尼比拉普拉斯变换

KeyEE:Enhancing Low-Resource Generative Event Extraction with Auxiliary Keyword Sub-Prompt

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Big Data Mining and Analytics 2024年第2期7卷 547-560页

作者： Junwen Duan Xincheng Liao Ying An Jianxin wang Hunan Key Laboratory of Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China Big Data Institute Central South UniversityChangsha 410083China

Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to *** classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained *** recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for *** tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language *** the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated ***,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this *** experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.

关键词： natural language processing Event Extraction(EE) Multi-Prompt Learning(MPL) low-resource

Situational Intertextuality:The Similar Styles and Same Structure of Han and Wei Fu and Novels

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2024年第2期18卷 230-247页

作者： wang Sihao Department of Chinese Language and Literature University of MacaoMacaoChina

Both the fu(narrative)writers and novelists in the Han and Wei periods excelled in observing and selecting“situations”and forming intertextuality in text *** common structure shared by Han and Wei fu and novels features a question-and-answer format that contributes to the“fictionality”and narrative development and a“particularly brilliant ending”that is instrumental in providing wise advice and expressing *** works,through their classic themes,story arrangements,and plot settings in telling the tales of individuals or the supernatural,inspired novel creation in the Wei and Jin ***,fu works may contain novelistic allusions,while novels may quote fu works and contain stories involving fu *** are“similar in style and same in structure,”contributing to the prosperity of early Chinese literature through fictionality and exaggeration,with paradigmatic significance in the construction of“situations”in Chinese narrative literature.

关键词： fu,novel situations similar in style

Severe Global Environmental Issues Caused by Canada’s Record-Breaking Wildfires in 2023

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Advances in Atmospheric Sciences 2024年第4期41卷 565-571页

作者： Zhe wang Zifa wang Zhiyin ZOU Xueshun CHEN Huangjian WU Wending wang Hang SU Fang LI Wenru XU Zhihua LIU Jiaojun ZHU State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China

Due to the record-breaking wildfires that occurred in Canada in 2023,unprecedented quantities of air pollutants and greenhouse gases were released into the *** wildfires had emitted more than 1.3 Pg CO_(2)and 0.14 Pg CO_(2)equivalent of other greenhouse gases(GHG)including CH4 and N_(2)O as of 31 *** wildfire-related GHG emissions constituted more than doubled Canada’s planned cumulative anthropogenic emissions reductions in 10 years,which represents a significant challenge to climate mitigation *** model simulations showed that the Canadian wildfires impacted not only the local air quality but also that of most areas in the northern hemisphere due to long-range transport,causing severe PM_(2.5)pollution in the northeastern United States and increasing daily mean PM_(2.5)concentration in northwestern China by up to 2μg *** observed maximum daily mean PM_(2.5)concentration in New York City reached 148.3μg m-3,which was their worst air quality in more than 50 years,nearly 10 times that of the air quality guideline(i.e.,15μg m-3)issued by the World Health Organization(WHO).Aside from the direct emissions from forest fires,the peat fires beneath the surface might smolder for several months or even longer and release substantial amounts of CO_(2).The substantial amounts of greenhouse gases from forest and peat fires might contribute to the positive feedback to the climate,potentially accelerating global *** better understand the comprehensive environmental effects of wildfires and their interactions with the climate system,more detailed research based on advanced observations and Earth System Models is essential.

关键词： Canada forest fire greenhouse gases PM_(2.5) transboundary air pollution

The Influence of Different Solar System Planetary Ephemerides on Pulsar Timing

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Research in Astronomy and Astrophysics 2024年第8期24卷 85-99页

作者： Jian-Peng Dai Wei Han Na wang School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

Pulsar timing offers a comprehensive avenue for exploring diverse topics in physics and *** solar system planetary ephemeris is crucial for pulsar timing as it provides the positions and velocities of solar system planets including the ***,it is inevitable that inherent inconsistencies exist in these *** between various ephemerides can significantly impact pulsar timing and parameter ***,pulsar timing highly depends on the JPL DE ephemeris,for instance,the Pulsar Timing Array data analysis predominantly utilizes *** this study,we examine inconsistencies across various ephemeris series,including JPL DE,EPM,and ***,discrepancies emerge particularly between the current ephemeris DE436 and the earliest released ephemeris DE200,as well as the most recent ephemerides,e.g.,DE440,INPOP21A,and *** detailed analysis of the effects of ephemeris on geometric correction procedures for the conversion of measured topocentric times of arrival is presented in this *** researches reveal that variations in the Roemer delays across different ephemerides lead to distinct *** timing residuals and the fact that these discrepancies can be readily incorporated into the subsequent pulsar parameters,leading to inconsistent fitting estimates,suggest that the influence of errors in the ephemeris on the timing process might currently be underappreciated.

关键词： (stars)pulsars general-Planetary Systems-time-ephemerides

A Fast Startup Crystal Oscillator with Digital SAR-AFC Based Two-Step Injection

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Chinese Journal of Electronics 2024年第5期33卷 1147-1153页

作者： Bo ZHOU Yifan LI Zuhang wang School of Integrated Circuits and Electronics Beijing Institute of Technology

Crystal oscillators（XOs） provide a high-precision reference frequency but have a long startup time,which severely increases the average power consumption in duty-cycled *** paper proposes a fully-digital low-cost two-step injection technique,by using a successive approximation register（SAR） based auto frequency control（AFC） loop,to speed up the startup behavior of XOs.A theoretical analysis is carried out to determine the optimum injection time and design low-power *** in a 65 nm CMOS process,the proposed 12 MHz fast startup XO occupies an active area of 0.02 mm2and achieves a startup time less than 35 μ*** XO power consumption in the steady state is 40 μW from a 1.0-V supply,with a startup energy of 17.2 nJ.

关键词： Time-frequency analysis Power demand Power measurement Crystals Time measurement Steady-state Registers Crystal oscillator Two-step injection Successive approximation register Auto frequency control Fully-digital Fast startup ENERGY

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