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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng qingguo wang Changxiang Li Xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

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RANDOM ANALYSIS OF HYDRODYNAMIC CHARACTERIS-TICS OF TRAJECTORY JET CAUSED BY DIFFERENT TYPES OF PIERS

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Journal of Hydrodynamics 2000年第3期12卷 34-40页

作者： Cui, Li wang, qingguo wang, Yongtao Dalian Univ of Technology Dalian China

This paper presents some results on different tail patterns of piers with an overflow dam, and discusses in particular the hydrodynamic characteristics, the distance of water jet scour and the range of erosion area fluctuating for different parameters of average flow field when river beds are under the pressure of water jet scour caused by some special broad-tail piers. The present paper also covers some preliminary research on the relationship of movable bed tests, and introduces the method of calculating the erosion depth and area, therefore provides the best pier pattern in the construction of river beds against erosion.

关键词： Dams Erosion Hydrodynamics Jets Piers Rivers

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Global Output-Feedback Tracking for Nonlinear Cascade Systems with Unknown Growth Rate and Control Coefficients

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Journal of Systems Science & Complexity 2015年第1期28卷 30-46页

作者： YAN Xuehua LIU Yungang wang qingguo School of Electrical Engineering University of Jinan School of Control Science and Engineering Shandong University Department of Electrical and Computer Engineering National University of Singapore

This paper deals with the global practical tracking problem by output-feedback for a class of uncertain cascade systems with zero-dynamics and unmeasured states dependent *** systems investigated are substantially different from the closely related works,and have zero-dynamics,unknown growth rate,and unknown time-varying control *** makes the problem much more difficult to *** by the authors' recent works,this paper proposes a new adaptive control scheme to achieve the global practical *** is shown that the designed controller guarantees that the state of the resulting closed-loop system is globally bounded and the tracking error converges to a prescribed arbitrarily small neighborhood of the origin after a finite *** is achieved by combining the methods of universal control and dead zone with backstepping technique,and using the framework of performance analysis in the closely related works.A numerical example demonstrates the effectiveness of the theoretical results.

关键词： Adaptive control dynamic high-gain global practical tracking output-feedback uncertain nonlinear systems.

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Locomotion Generation and Motion Library Design for an Anguilliform Robotic Fish

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Journal of Bionic Engineering 2013年第3期10卷 251-264页

作者： Xuelei Niu Jianxin Xu Qinyuan Ren qingguo wang Department of Electrical and Computer Engineering National University of Singapore Singapore 117576 Singapore

In this paper, modeling, locomotion generation, motion library design and path planning for a real prototype of an Anguilliform robotic fish are presented. The robotic fish consists of four links and three joints, and the driving forces are the torques applied to the joints. Considering kinematic constraints and hydrodynamic forces, Lagrangian formulation is used to obtain the dynamic model of the fish. Using this model, three major locomotion patterns of Anguilliform fish, including forward locomotion, backward locomotion and turning locomotion are investigated. It is found that the fish exhibits different locomotion patterns by giving different reference joint angles, such as adding reversed phase difference, or adding deflections to the original reference angles. The results are validated by both simulations and experiments. Furthermore, the relations among the speed of the fish, angular frequency, undulation amplitude, phase difference, as well as the relationship between the turning radius and deflection angle are investigated. These relations provide an elaborated motion library that can be used for motion planning of the robotic fish.

关键词： biomimetics robotic fish mathematical model locomotion generation motion library

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Exfoliated sodium-montmorillonite in nitrile butadiene rubber nanocomposites with good properties

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Chinese Science Bulletin 2009年第5期54卷 877-879页

作者： wang qingguo ZHANG XiaoHong QIAO JinLiang Key Laboratory of Rubber-plastics of Ministry of Education Qingdao University of Science and Technology Qingdao 266042 China SINOPEC Beijing Research Institute of Chemical Industry Beijing 100013 China

We prepared and utilized a novel ultrafine fully-vulcanized powder nitrile butadiene rubber (UFPNBR)/ sodium montmorillonite (Na-MMT) nanocompound powder, in which nanoscale UFPNBR particles and nanoscale platelets of Na-MMT were isolated and stuck each other. When the UFPNBR/Na-MMT nano-compoud powder was mixed with crude nitrile butadiene rubber (NBR), UFPNBR particles could be easily dispersed in NBR matrix because of good compatibility, and nanoscale Na-MMT was also dis-persed well in NBR matrix due to the carrier aidance of UFPNBR particle, thus the NBR/UFPNBR/Na- MMT ternary nanocomposites adapting to industry was fabricated. X-ray diffraction test and scanning electron microscopy (SEM) observation indicated that nanoscale Na-MMT was dispersed well in NBR matrix. Compared with NBR/Na-MMT binary composites, NBR/UFPNBR/Na-MMT ternary nanocompo-sites have shorter vulcanization time and higher flame retardancy due to the exfoliated Na-MMT in NBR matrix.

关键词：橡胶纳米复合材料 Na-蒙脱土阻滞性丁晴橡胶

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Necessary and sufficient conditions for the dynamic output feedback stabilization of fractional-order systems with order 0 < α < 1

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Science China(Information Sciences) 2019年第9期62卷 205-207页

作者： Ying GUO Chong LIN Bing CHEN qingguo wang Institute of Complexity Science Qingdao University School of Mathematics and Statistics Zaozhuang University Institute for Intelligent Systems Faculty of Engineering and the Built EnvironmentUniversity of Johannesburg

Dear editor,Fractional calculus is the generalization of integer order calculus that enables us to obtain a considerably accurate description of several real world systems because of its memory property and practical applications. The fractional-order systems(FOS) have attracted significant attention in recent years and have yielded several valuable results, especially with respect to stability and sta-

关键词： FOS Necessary and sufficient conditions for the dynamic output feedback stabilization of fractional-order systems with order 0

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A P2P Load Balancing-Supported ID Management Algorithm

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Wuhan University Journal of Natural Sciences 2011年第4期16卷 293-300页

作者： wang Bin SHEN qingguo Institute of Communications Engineering PLA University of Science and Technology Nanjing 210007 Jiangsu China

Load balancing is a critical issue in peer-to-peer networks. DHT （distributed hash tables） do not evenly partition the hash-function range, and some nodes get a larger portion of it. The loads of some nodes are as much as O（log n） times the average. In this paper, a low-cost, decentralized algorithm for ID allocation with complete knowledge in DHT-based system is proposed. It can adjust system load on nodes’ departure. It is proved that the ratio of longest arc to shortest arc is no more than 4 with high probability when network scale increases non-strictly. When network scale decreases from one stable state to another, algorithm can repair the unevenness of nodes distribution. The performance is analyzed in simulation. Simulating results show that updating messages only occupy a little of network bandwidth.

关键词： P2P load balance ID allocation DHT (distributed hash tables)

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Identification and PID Control for a Class of Delay Fractional-order Systems

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IEEE/CAA Journal of Automatica Sinica 2016年第4期3卷 463-476页

作者： Zhuoyun Nie qingguo wang Ruijuan Liu Yonghong Lan School of Information Science and Engineering Huaqiao University Institute for Intelligent Systems the University of Johannesburg School of Applied Mathematics Xiamen University of Technology School of Information Engineering Xiangtan University

In this paper, a new model identification method is developed for a class of delay fractional-order system based on the process step response. Four characteristic functions are defined to characterize the features of the normalized fractional-order model. Based on the time scaling technology, two identification schemes are proposed for parameters U+02BC estimation. The scheme one utilizes three exact points on the step response of the process to calculate model parameters directly. The other scheme employs optimal searching method to adjust the fractional order for the best model identification. The proposed two identification schemes are both applicable to any stable complex process, such as higher-order, under-damped U+002F over-damped, and minimum-phase U+002F nonminimum-phase processes. Furthermore, an optimal PID tuning method is proposed for the delay fractional-order systems. The requirements on the stability margins and the negative feedback are cast as real part constraints U+0028 RPC U+0029 and imaginary part constraints U+0028 IPC U+0029. The constraints are implemented by trigonometric inequalities on the phase variable, and the optimal PID controller is obtained by the minimization of the integral of time absolute error U+0028 ITAE U+0029 index. Identification and control of a Titanium billet heating process is given for the illustration. © 2014 Chinese Association of Automation.

关键词： Algebra Billets (metal bars) Delay control systems Identification (control systems) Proportional control systems Step response Three term control systems Time delay Titanium

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Combination of wound healing with 1-methylcyclopropene and wound detection by iodine solution to maintain the quality of sweet potato during long-term storage

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 241-246页

作者： Jixuan Cao Pei Liu Xuejiao wang qingguo wang Jingying Shi Key Laboratory of Food Processing Technology and Quality Control in Shandong Province College of Food Science and EngineeringShandong Agricultural UniversityTai’an 271018ShandongChina

Wound healing treatment after harvest is a critical step to protect sweet potatoes from *** method of phloroglucinol staining is commonly used for detecting ***,this method is not easy to identify the degree of callus as the color change is not obvious compared with non-curing roots for some cultivars.A new method based on the principle of starch test by iodine was developed for the detection of wound *** healing,the reducing sugar content increased while the starch content decreased to a lower level compared to that of the non-curing ***,the antioxidant capacity of the sweet potato after wound healing was higher than that in the *** healing combined with ethylene,1-methylcyclopropene(1-MCP),chlorpropham or abscisic acid were studied for inhibiting sprout of sweet potato root caused by high temperature during *** results showed ethylene and 1-MCP treatment had no negative effect on wound ***,1-MCP treatment was the most effective one on the suppression of sprouting and decay of sweet *** results indicate that iodine solution staining is a useful and rapid method to identify the wound healing extent,and 1-MCP treatment can effectively inhibit root sprouting during wound healing and the subsequent long-term storage.

关键词： sweet potato wound healing iodine staining sprouting inhibition decay rate

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Load-sharing Characteristic of Multiple Pinions Driving in Tunneling Boring Machine

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 532-540页

作者： WEI Jing SUN Qinchao SUN Wei DING Xin TU Wenping wang qingguo School of Mechanical Engineering Dalian University of Technology

The failure of the key parts, such as gears, in cutter head driving system of tunneling boring machine has not been properly solved under the interaction of driving motors asynchronously and wave tunneling torque load. A dynamic model of multi-gear driving system is established considering the inertia effects of driving mechanism and cutter head as well as the bending-torsional coupling. By taking into account the nonlinear coupling factors between ring gear and multiple pinions, the influence for meshing angle by bending-torsional coupling and the dynamic load-sharing characteristic of multiple pinions driving are analyzed. Load-sharing coefficients at different rotating cutter head speeds and input torques are presented. Numerical results indicate that the load-sharing coefficients can reach up to 1.2-1.3. A simulated experimental platform of the multiple pinions driving is carried out and the torque distributions under the step load in driving shaft of pinions are measured. The imbalance of torque distribution of pinions is verified and the load-sharing coefficients in each pinion can reach 1.262. The results of simulation and test are similar, which shows the correctness of theoretical model. A loop coupling control method is put forward based on current torque master slave control method. The imbalance of the multiple pinions driving in cutter head driving system of tunneling boring machine can be greatly decreased and the load-sharing coefficients can be reduced to 1.051 by using the loop coupling control method. The proposed research provides an effective solution to the imbalance of torque distribution and synchronous control method for multiple pinions driving of TBM.

关键词： load-sharing characteristic tunneling boring machine(TBM) multiple pinions driving nonlinear dynamic characteristic

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