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Oestrogen ameliorates blood-brain barrier damage after experimental subarachnoid haemorrhage via the SHH pathway in male rats

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Stroke & Vascular Neurology 2023年第3期8卷 217-228,I0060-I0073页

作者： Jie zhang Haiying Li Zhongmou Xu Jinxin Lu Chang Cao Haitao Shen Xiang Li wanchun You Gang Chen Department of Neurosurgery&Brain and Nerve Research Laboratory First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Institute of Stroke Research Soochow UniversitySuzhouChina

Background Sex differences affect the occurrence,progression and regression of subarachnoid haemorrhage(SAH).Oestrogen plays a protective role in alleviating the vasospasm and neuronal apoptosis induced by ***,whether oestrogen affects blood‒brain barrier(BBB)integrity has not been fully *** has been found to regulate the sonic hedgehog(SHH)signalling pathway through the oestrogen receptor in gastric cancer and adrenal glands,and the SHH signalling pathway has an important role in maintaining the BBB by upregulating the expression of tight junction *** this study,we investigated the relationship between oestrogen and the SHH signalling pathway using clinical data and established an experimental SAH model to explore whether oestrogen could ameliorate BBB damage after SAH through the SHH *** Correlations between oestrogen and the SHH pathway were analysed by patients’cerebrospinal fluid(CSF)samples and the Genotype-Tissue Expression database(GTEx).Then,an experimental rat SAH model was established using the endovascular perforation method and treated with oestrogen,oestrogen inhibitors and SHH signalling pathway ***,the effects of oestrogen on BBB damage were analysed by western blot,immunofluorescence and neurobehavioural *** ESLIA detection and correlation analysis showed that oestrogen levels in patients’CSF were positively correlated with the SHH pathway,which was further verified by GTEx gene-correlation *** was found to be mainly expressed in neurons and astrocytes in rats under physiological conditions and was upregulated by oestrogen *** the SAH model,oestrogen pretreatment was found to reverse SAH-induced decreases in the SHH pathway,which were counteracted by oestrogen receptor ***,oestrogen pretreatment reduced SAH-induced BBB damage,brain oedema and neurological dysfunction,which were eliminated by SHH pathway *** In conclusion,we

关键词： damage barrier SHH

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余德钊清热化湿法论治小儿慢性胃炎

中医康复 2024年第11期1卷 57-60页

作者：胡万春张畅畅郑杭余德钊刘星广州中医药大学第五临床医学院广东广州510405 广州中医药大学第四临床医学院广东深圳518000 广东省第二中医院(广东省中医药工程技术研究院) 广东广州510095

小儿慢性胃炎为临床常见病症,余德钊教授临证多年,认为小儿慢性胃炎多与不良饮食习惯损伤脾胃有关,饮食积滞气机不畅,脾胃易使水聚化湿,湿郁久化热更加影响脾胃运化水谷精微的功能,进一步影响小儿生长发育,同时免疫力低下更容易感受外... 详细信息

小儿慢性胃炎为临床常见病症,余德钊教授临证多年,认为小儿慢性胃炎多与不良饮食习惯损伤脾胃有关,饮食积滞气机不畅,脾胃易使水聚化湿,湿郁久化热更加影响脾胃运化水谷精微的功能,进一步影响小儿生长发育,同时免疫力低下更容易感受外来六淫邪气。因此,余德钊教授治疗小儿慢性胃炎尤重清热化湿之法,方以苏神汤、甘露消毒丹化裁,药性平和兼顾胃气,既能清脾胃湿热,又能调畅气机以助脾胃升清降浊之效;临床随证加减治疗小儿慢性胃炎,疗效显著。

关键词：小儿慢性胃炎苏神汤甘露消毒丹清热化湿余德钊

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一种改进型双L遮断式激光光幕靶

现代应用物理 2024年第3期15卷 50-57页

作者：姜万春杨军张德志刘文祥李进张敏赵天青强脉冲辐射环境模拟与效应全国重点实验室西北核技术研究所西安710024

针对现有光幕靶重量大、抗干扰能力弱、测量面积无法调整等问题,设计了1种改进型双L遮断式激光光幕靶,可同时测量垂直入射弹丸的速度与坐标。光幕靶电路板采用模块化方法设计,可根据用户需求灵活地拼接为0.5 m×0.5 m倍数的幕面。光幕... 详细信息

针对现有光幕靶重量大、抗干扰能力弱、测量面积无法调整等问题,设计了1种改进型双L遮断式激光光幕靶,可同时测量垂直入射弹丸的速度与坐标。光幕靶电路板采用模块化方法设计,可根据用户需求灵活地拼接为0.5 m×0.5 m倍数的幕面。光幕靶电路板集成了定制的抗光干扰芯片,可动态调整电路的放大倍数,避免光电二极管进入饱和状态,使光幕靶具有较强的抗光干扰能力。为检验光幕靶的实际性能,开展了强光干扰、坐标、手枪、步枪4类型实验,实验结果表明,光幕靶速度测量精度为5%、坐标测量精度为5 mm。

关键词：双L式光幕坐标速度模块化抗光干扰

血栓前状态易感基因变异与复发性流产的相关性分析

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武警医学 2024年第8期35卷 703-706页

作者：王敏潘菀淳张和平王鑫孙婷玉周玲解放军总医院第九医学中心妇产科北京100101

目的探讨血栓前状态易感基因变异与复发性流产的相关性.方法选择2021-12至2023-12在解放军总医院第九医学中心就诊的复发性流产患者103例,并选择同期就诊的无自然流产史患者91例作为对照.分别对两组人群的血栓前状态易感基因变异进行检... 详细信息

目的探讨血栓前状态易感基因变异与复发性流产的相关性.方法选择2021-12至2023-12在解放军总医院第九医学中心就诊的复发性流产患者103例,并选择同期就诊的无自然流产史患者91例作为对照.分别对两组人群的血栓前状态易感基因变异进行检测,包括FVL基因1691位点、FⅡ基因20210位点、PAI-1基因675位点、MTHFR基因677位点和1298位点.结果两组FVL基因1691位点、FⅡ基因20210位点均未见杂合变异与纯合变异;两组间PAI-1基因675位点变异(χ^(2)=0.429,P=0.452)、MTHFR基因677位点(χ^(2)=1.346,P=0.510)和1298位点(χ^(2)=2.866,P=0.245)基因变异频率无统计学差异.单因素回归分析显示,PAI-1基因675位点(OR=1.245,95%CI:0.624~2.482,P=0.533),MTHFR基因677位点(OR=1.071,95%CI:0.571~2.009,P=0.830)和1298位点(OR=1.6324,95%CI:0.883~3.017,P=0.117)的基因变异与复发性流产无关.结论FVL基因、FⅡ基因、PAI-1基因及MTHFR基因变异与复发性流产无相关性,不建议此类患者常规进行遗传性血栓前状态检测.

关键词：复发性流产血栓前状态 FVL基因 PAI-1基因 MTHFR基因

Tidal water exchanges can shape the phytoplankton community structure and reduce the risk of harmful cyanobacterial blooms in a semi-closed lake

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Journal of Oceanology and Limnology 2022年第5期40卷 1868-1880页

作者： Wenxu ZHENG Renhui LI Wenli QIN Binbin CHEN Min WANG wanchun GUAN Xiaoling zhang Qiao YANG Min ZHAO Zengling MA Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection Wenzhou UniversityWenzhou 325035China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou 325035China Department of Marine Biotechnology School of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China School of Petrochemical Engineering and Environment Zhejiang Ocean UniversityZhoushan 316022China

For estuaries,inland lakes play a vital role in the ecological balance under the impact of tide *** effect of tides-induced water exchange on phytoplankton community in a semi-closed lake was studied and compared with that of an adjacent closed lake in the Oujiang River mouth in Zhejiang,East China Sea,from June 29,2020 to June 14,*** show that the dominant species,abundance,dominance,and diversity of the phytoplankton species between the two lakes were significantly *** the closed lake,cyanobacteria were the dominant species during the study *** the semi-closed lake,the diversification of the dominant species was greater,and some species of diatoms and green algae became *** average phytoplankton abundance in the closed lake was 6 times of that in the semi-closed *** average dominance of cyanobacteria in the closed lake was 0.96,and those in the semi-closed lake and the Oujiang River were 0.51 and 0.22,*** blooms occurred throughout the study time in the closed lake but not in the semi-closed ***,the species diversity richness of the phytoplankton in the semi-closed lake was higher than that of the closed one,and the phytoplankton community between the closed lake and semi-closed lake could be divided into distinctly different groups based on non-metic multidimensional scaling analysis(NMDS)and analysis of similarities(ANOSIM)*** salinity of the water was significantly greater and the transparency significantly smaller in the semi-closed lake than those in the closed ***,water exchange driven by local tidal movement increased salinity and decreased transparency of water,which consequently shaped the community structures of different phytoplankton and reduced the risk of a cyanobacterial bloom outbreak in the semi-closed lake.

关键词： estuary harmful cyanobacterial blooms phytoplankton community water exchange tidal movement environmental parameters

Secondary biogenic coalbed gas in some coal fields of China

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Chinese Science Bulletin 2005年第S1期50卷 24-29页

作者： TAO Mingxin WANG wanchun XIE Guangxin LI Jinying WANG Yanlong zhang Xiaojun zhang Hong SHI Baoguang GAO Bo Key Laboratory of Gas Geochemistry Institute of Geology and GeophysicsChinese Academy of SciencesLanzhou 730000China College of Resources Science&Technology Beijing Normal UniversityBeijing 100875China Xi’an Branch of China Coal Research Institute Xi’an 710054China

The secondary biogenic coalbed gas, a new genetic and energy source type of coalbed gas in China, has been found in Xinji, Liyazhuang and Enhong areas. The essential characteristics of this type of gas are: (i) the major component of the gas is methane, with C1/C1-5 value higher than 0.99, indicating that the gas is part of dry gas; (ii) theδ13C1 value is in the range of -61.7‰to -47.9‰, mostly lower than -55‰, which is much lower than the estimatedδ13C1 value of thermogenic methane according to the thermal evolution degree of the coal rocks (with R0 value from 0.87% to 1.43%), showing the characteristics of the secondary biogenic gas; (iii) theδ5D value of methane ranges from -244‰to -196‰; (iv)δ13C 2 value ranges from -26.7‰to -15.9‰andδ13C 3 value ranges from -10.8‰to -25.3‰, indicating that the heavier hydrocarbons have a thermogenic origin; (v) the content of CO2 is very low, andδ13CCO2 value changes greatly, reflecting a characteristic of secondary change; (vi)δ15N2 value ranges mainly from -1‰to +1‰, indicating N2 derived significantly from air. The negative linear correlation between the contents of N2 and CH4 reflects the activity of bacteria bearing surface water infiltrating into coal beds. The comprehensive tracing indices show that the coalbed gas in the studied areas is the mixed gas of primarily secondary biogenic gas and a part of remnant thermogenic gas. The uplift of coal beds and the development of faults in the studied areas create favorable conditions for the formation of the secondary biogenic gas.

关键词： coalbed gas secondary biogenic gas thermogenic gas dry gas δ13C δD δ15N China.

页岩油气地质工程一体化建设下的产教融合与课程思政协同育人路径

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化工管理 2024年第21期 61-65页

作者：柳波马妍张云峰赵万春王博洋东北石油大学非常规油气研究院黑龙江大庆163318 东北石油大学地球科学学院黑龙江大庆163318

对于当前高校课程教学与思政教学协同育人模式而言,“各自为政”现象依然存在,专业课程思政教育功能的发挥程度不够。文章以页岩油气现代产业学院教学背景为例,深入剖析页岩油气地质工程一体化建设背景下的产教融合和课程思政协同育人... 详细信息

对于当前高校课程教学与思政教学协同育人模式而言,“各自为政”现象依然存在,专业课程思政教育功能的发挥程度不够。文章以页岩油气现代产业学院教学背景为例,深入剖析页岩油气地质工程一体化建设背景下的产教融合和课程思政协同育人路径。并分别从学生角度、教师角度以及授课内容角度出发,通过加强人才培育的顶层设计、强化思政课程教学设计和体系、校企共建“双师型”课程思政师资团队、打造多元化课程思政考核评价标准化体系等多维育人措施并举,突出学生的中心地位,激发学生学习动力和专业志趣,促进学生成为具有创新能力和思政素养的综合型人才,达到立德树人的目标。

关键词：课程思政产教融合油气类专业

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基于时域射线追踪算法的电场波形特性研究

南京师范大学学报（工程技术版） 2024年第2期24卷 28-33页

作者：王泽典顾剑锋段璐琦毛仲虎张陈旭唐万春南京师范大学计算机与电子信息学院江苏南京210023 南京师范大学南瑞电气与自动化学院江苏南京210023 南京师范大学江苏省三维打印装备与制造重点实验室江苏南京210023

利用时域射线追踪算法,构建出简化开关柜模型并模拟局部放电,仿真分析局放电磁波到达不同检测点的时域特性.由于多径传播,最短路径与其它路径存在到达时间差,通过叠加时间差相近路径的波形幅值,分析检测点时域波形混叠的原因,对比不同... 详细信息

利用时域射线追踪算法,构建出简化开关柜模型并模拟局部放电,仿真分析局放电磁波到达不同检测点的时域特性.由于多径传播,最短路径与其它路径存在到达时间差,通过叠加时间差相近路径的波形幅值,分析检测点时域波形混叠的原因,对比不同检测点的时域接收波形,分析波形畸变的原因.研究结果为开关柜内局部放电的电磁波传播规律提供新方法,为后续优化超高频检测天线的安装摆放提供参考依据.

关键词：局放检测射线追踪算法时域特性时间差波形混叠

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不同驱替介质在演23区延7储层中的应用

非常规油气 2024年第3期11卷 107-113页

作者：索步森卞小强曾永平王雪艳何万春张全培物华能源科技有限公司西安710061 西南石油大学成都610500 中国石油长庆油田分公司第十一采油厂甘肃庆阳745000 国家管网集团西气东输公司江苏储气库分公司南京210000

针对演23区油藏目前存在水驱油效率、单井产量及采出程度普遍较低的问题,急需开展控水稳油技术攻关,减缓含水上升速度,探索新注入介质,提高驱油效率,提高最终采收率。选取主力产油层位延7储层样品开展不同驱替介质的室内实验,并根据实... 详细信息

针对演23区油藏目前存在水驱油效率、单井产量及采出程度普遍较低的问题,急需开展控水稳油技术攻关,减缓含水上升速度,探索新注入介质,提高驱油效率,提高最终采收率。选取主力产油层位延7储层样品开展不同驱替介质的室内实验,并根据实验结果进行现场先导性试验论证。结果表明:纯水驱平均驱油效率为45.45%,驱油效率延7_(1)高于延7_(2),结合核磁共振实验可知孔喉半径及分布规律对驱油效率影响较大;相较单纯水驱,水驱后转氮气驱、聚合物驱或表面活性剂驱的驱油效率均有一定程度的增加,其中,聚合物驱油效率增加最高,为38.72%,氮气驱次之,增加16.20%,表面活性剂驱最低,只增加4.39%,且延7_(2)储层驱油效率提高大于延7_(1)储层;现场开展聚合物驱先导性试验,表现出地层压力上升、增产降水、见效比高,与驱油实验结果较相符,整体表现为研究区对聚合物驱的适应性较强。研究结论对于研究区后期现场高效开发具有指导性意义。

关键词：演23区驱替介质提高采收率驱油效率