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Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： GAO Chen-yan QIN Gao-feng ZHENG Ming-cui TIAN Mei-jing HE Yan-nan wang peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

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基于HEC-HMS模型的三峡区间洪水模拟

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长江科学院院报 2024年第6期41卷 76-83页

作者：王雨潇刘波王文鹏吴光东张天宇孙营营河海大学水文水资源学院南京210098 河海大学水利部水利大数据重点实验室南京211100 长江科学院水资源综合利用研究所武汉430010 重庆市气候中心重庆401147

三峡区间面积在长江上游的流域面积占比5.6%,但在三峡入库洪水组成中,区间形成的洪水占比可达10%以上,可见区间暴雨洪水是水库防洪安全必须考量的重要因素。采用2007—2011年三峡入库流量,上游边界寸滩和武隆站实测流量资料,建立了基于H... 详细信息

三峡区间面积在长江上游的流域面积占比5.6%,但在三峡入库洪水组成中,区间形成的洪水占比可达10%以上,可见区间暴雨洪水是水库防洪安全必须考量的重要因素。采用2007—2011年三峡入库流量,上游边界寸滩和武隆站实测流量资料,建立了基于HEC-HMS的三峡区间洪水模拟模型,用于分析区间暴雨洪水与入库洪水的关系。根据入库洪水来源组成分析和资料特点,提出分类调参、分期检验的区间洪水建模方案:对以上游来水为主型洪水,率定汇流参数;对区间降水贡献较大型洪水,率定产流参数;对2012年以后的模拟洪水过程,以三峡水库运行实录发布的洪水过程线为比对基准。结果表明:模型精度良好,率定期和验证期洪峰流量相对误差在±20%以内,峰现时间误差<3 h;经与长江三峡工程运行实录比对,模型适用于模拟2012年后的三峡入库洪水过程。以20160626场次洪水为典型,分析该场区间洪水对入库洪水的峰值贡献率达27.2%,使得峰现时间提前16 h。研究成果可用于三峡区间洪水的影响研究,也可作为区间流域洪水模拟模型建模方案的技术参考。

关键词：三峡区间洪水过程模拟 HEC-HMS模型参数率定

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Properties, hazards and valuable metal recovery technologies of red mud: A review

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Particuology 2024年第10期93卷 328-348页

作者： Peixin Du peng wang Xueqian Zhang Guangwu wen Yishan wang School of Materials Science and Engineering Shandong University of TechnologyZibo255000China

This review presents a summary of the research conducted thus far on the recovery of various types of valuable metals from red mud. The composition, properties, environmental hazards, and current status of comprehensive utilization of red mud were studied. A number of studies have been conducted on the use of red mud as a modifying additive for cement, the development of various catalysts based on red mud, and the recovery of various valuable metals from red mud. Furthermore, we examine several techniques for extracting various types of valuable metals from red mud, including pyrometallurgical recovery, wet leaching recovery, and emerging biobased technology recovery. We investigate the underlying principles, processes, research progress, and the potential for industrial application of these methods, and assess the advantages and disadvantages of each from the perspectives of economic and environmental benefits. Although these methods have certain disadvantages, in general, the recovery of various types of valuable metals from red mud is an effective way to solve the problem of red mud and the supply of metal raw materials. In conclusion, this paper presents an overview of the current state of red mud development and utilization, as well as the various methods employed for the recovery of valuable metals from red mud.

关键词： Red mud Utilization Environment hazard Valuable metal Recovery

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Local Hamilton type Gradient Estimates and Harnack Inequalities for Nonlinear Parabolic Equations on Riemannian Manifolds

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 539-546页

作者： wen wang Da-peng XIE Hui ZHOU School of Mathematics and Statistics Hefei Normal UniversityHefei 230601China

In this paper,we prove a local Hamilton type gradient estimate for positive solution of the nonlinear parabolic equation ut(x,t)=Δu(x,t)+au(x,t) ln u(x,t)+bu^(α)(x,t),on M×(-∞,∞) with α∈R,where a and b are *** ... 详细信息

关键词： nonlinear parabolic equation gradient estimate Harnack inequality

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Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma Bo wang Xiaodi Li Shuo wang wen wang Yongzhen peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen ***,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater *** this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of *** using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 *** long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,*** eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase *** in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and ***,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial ***,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification Mainstream wastewater

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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

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Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai Yu peng wen Hu Yi Liu Hui wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

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Stabilizing the Electrochemistry of Lithium-Selenium Battery via In situ Gelated Polymer Electrolyte: A Look from Anode

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Chemical Research in Chinese Universities 2021年第2期37卷 298-303页

作者： wang wen-peng ZHANG Juan LI Xue-Ting YIN Ya-Xia XIN Sen GUO Yu-Guo CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing100190P.R.China University of Chinese Academy of Sciences(UCAS) Beijing100049P.R.China

Li metal possesses a high theoretical specific capacity,high electronic conductivity,and a low electrochemical potential,making it a promising anode material for building next-generation rechargeable metal *** case conventional liquid electrolytes were used,and the anode using Li metal has been hindered by unstable(electro)chemistry at Li/electrolyte interface and the accompanied dendrite ***,for the Li-Se batteries,the dissolution and shuttle of polyselenide intermediates lead to the deposition of poorly-conductive species on the anode,which further aggravates the chemical environment at the *** this work,we proposed to stabilize the Li-Se electrochemistry by constructing a gel polymer electrolyte via in situ gelations of conventional ether-based electrolytes at room *** results demonstrate that the in situ gelated electrolyte helps to build electrochemically stable electrode/electrolyte interfaces and promote the efficient transfer of charge carriers across the *** with the liquid electrolytes,the gelated electrolyte shows improved chemical compatibility with the Li metal anode,which effectively alleviates the unfavorable side reactions and dendrite formation at the anode/electrolyte interface,and the polyselenide shuttle from the cathode to the *** a result,the Li-Se battery shows a higher Coulombic efficiency and improved cycling performance.

关键词： Lithium-metal anode Gel polymer electrolyte In situ polymerization Lithium-selenium battery

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A new insight into LPSO phase transformation and mechanical properties uniformity of large-scale Mg-Gd-Y-Zn-Zr alloy prepared by multi-pass friction stir processing

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Journal of Magnesium and Alloys 2024年第5期12卷 2041-2056页

作者： Xiaohu Guan wen wang Ting Zhang Pai peng Qiang Liu peng Han Ke Qiao Jun Cai Liqiang wang Kuaishe wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyNo.13 Yanta RoadXi’anShaanxi 710055China Xi’an Rare Metal Materials Institute Co.Ltd Xi’an 710016China State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityNo.800 Dongchuan RoadShanghai 200240China

A large-scale fine-grained Mg-Gd-Y-Zn-Zr alloy plate with high strength and ductility was successfully prepared by multi-pass friction stir processing(MFSP)technology in this *** structure of grains and long period stacking ordered(LPSO)phase were characterized,and the mechanical properties uniformity was ***,a quantitative relationship between the microstructure and tensile yield strength was *** results showed that the grains in the processed zone(PZ)and interfacial zone(IZ)were refined from 50μm to 3μm and 4μm,respectively,and numerous original LPSO phases were *** IZ,some block-shaped 18R LPSO phases were transformed into needle-like 14H LPSO phases due to stacking faults and the short-range diffusion of solute *** severe shear deformation in the form of kinetic energy caused profuse stacking fault to be generated and move rapidly,greatly increasing the transformation rate of LPSO *** MFSP,the ultimate tensile strength,yield strength and elongation to failure of the large-scale plate were 367 MPa,305 MPa and 18.0% *** refinement and LPSO phase strengthening were the major strengthening mechanisms for the MFSP *** particularly,the strength of IZ was comparable to that of PZ because the strength contribution of the 14H LPSO phase offsets the lack of grain refinement strengthening in *** result opposes the widely accepted notion that IZ is a weak region in MFSP-prepared large-scale fine-grained plate.

关键词： Friction stir processing Multi-pass Mg-Gd-Y-Zn-Zr alloy LPSO phase transformation Mechanical properties

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Temperature trends and its elevation-dependent warming over the Qilian Mountains

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Journal of Mountain Science 2024年第2期21卷 500-510页

作者： ZHAO peng HE Zhibin MA Dengke wang wen QIAN Lihui School of Computer Science Huainan Normal UniversityHuainan 232038China Linze Inland River Basin Research Station Key Laboratory of Inland River Basin ScienceNorthwest Institute of Eco-Environment and ResourceChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Understanding temperature variability especially elevation dependent warming(EDW)in high-elevation mountain regions is critical for assessing the impacts of climate change on water resources including glacier melt,degradation of soils,and active layer *** means that temperature is warming faster with the increase of *** this study,we used observed temperature data during 1979-2017 from 23 meteorological stations in the Qilian Mountains(QLM)to analyze temperature trend with Mann-Kendall(MK)test and Sen’s slope *** showed that the warming trends for the annual temperature followed the order of T_min>T_mean>T_max and with a shift both occurred in *** and summer temperature have a higher increasing trend than that in autumn and winter.T_mean shifts occurred in 1996 for spring and summer,in 1997 for autumn and winter.T_max shifts occurred in 1997 for spring and 1996 for summer.T_min shifts occurred in 1997 for spring,summer and winter as well as in 1999 for *** mean diurnal temperature range(DTR)shows a significant decreasing trend(-0.18°C/10a)from 1979 to *** mean DTR shows a significant decreasing trend(-0.26°C/10a)from 1979 to 2017 with a shift occurred in *** removing longitude and latitude factors,we can learn that the warming enhancement rate of average annual temperature is 0.0673°C/km/10a,indicating that the temperature warming trend is accelerating with the continuous increase of *** increase rate of elevation temperature is 0.0371°C/km/10a in spring,0.0457°C/km/10a in summer,0.0707°C/km/10a in autumn,and 0.0606°C/km/10a in winter,which indicates that there is a clear EDW in the *** main causes of warming in the Qilian Mountains are human activities,cloudiness,ice-snow feedback and El Nino phenomenon.

关键词： Climate change Qilian Mountains Warming rates DTR Elevation-dependent warming

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A High-Spectral-Resolution Laser Raman System and Its Application in Shock–Compressed Benzene

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Chinese Physics Letters 2013年第3期30卷 26-28页

作者： ZHAO Bei-Jing LIU Fu-Sheng ZHANG Ning-Chao FENG Li-peng wang wen-peng ZHANG Ming-Jian Institute of high temperature high pressure physics Southwest Jiaotong UniversityChengdu 610031

Raman measurements play an important role in examining the molecular changes associated with shock-induced structural and chemical changes in condensed *** combine a high spectra-resolution Raman system with a two-stage light gas gun to provide better quality data than the transient Raman system used *** measurements are presented for the shock compression of *** high spectral resolution data have provided an insight into molecular changes that could not be obtained from time-resolved methods.

关键词： materials. methods. shock

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