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Acta Geologica Sinica(English Edition) 2018年第1期92卷 400-401页

作者： wang yiyun TANG Juxing SONG Yang LIN Bin wang Qin College of Earth Science Chengdu University of Technology MLR Key Laboratory of Metallogeny and Mineral Resource Assessment Institute o Mineral ResourcesChinese Academy o Geological Science

Objective The Tiegelongnan deposit,located at Duolong ore district in western part of Bangong Co.-Nujiang metallogenic belt,is the first super-large Cu(Au,Ag)deposit with typical features of high-sulfidation epitherma...

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A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

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Frontiers of Medicine 2020年第6期14卷 711-725页

作者： Houli Zhao yiyun wang Elaine Tan Su Yin Kui Zhao Yongxian Hu He Huang Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Zhejiang Province Engineering Laboratory for Stem Cell and Immunotherapy Hangzhou 310000China Institute of Hematology Zhejiang UniversityHangzhou 310000China PET-CT Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China

The combination of the immunotherapy(i.e.,the use of monoclonal antibodies)and the conventional chemotherapy increases the long-term survival of patients with ***,for patients with relapsed or treatment-resistant lymphoma,a novel treatment approach is urgently *** antigen receptor T(CAR-T)cells were introduced as a treatment for these *** on recent clinical data,approximately 50%of patients with relapsed or refractory B-cell lymphoma achieved complete remission after receiving the CD19 CAR-T cell ***,clinical data revealed that some patients remained in remission for more than two years after the CAR-T cell *** than the CD19-targeted CAR-T,the novel target antigens,such as CD20,CD22,CD30,and CD37,which were greatly expressed on lymphoma cells,were studied under preclinical and clinical evaluations for use in the treatment of ***,the CAR-T therapy was usually associated with potentially lethal adverse effects,such as the cytokine release syndrome and the ***,optimizing the structure of CAR,creating new drugs,and combining CAR-T cell therapy with stem cell transplantation are potential solutions to increase the effectiveness of treatment and reduce the toxicity in patients with lymphoma after the CAR-T cell therapy.

关键词： chimeric antigen receptor T(CAR-T)cell lymphoma cytokine release syndrome(CRS) immune effector cell-associated neurotoxicity syndrome(ICANS)

Beyond fundamental resonance mode:high-order multi-band ALN PMUT for in vivo photoacoustic imaging

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Microsystems & Nanoengineering 2022年第6期8卷 205-216页

作者： Junxiang Cai yiyun wang Daohuai Jiang Songsong Zhang Yuandong Alex Gu Liang Lou Fei Gao Tao Wu School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Shanghai Institute of Microsystem and Information Technology ShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Microelectronics Shanghai UniversityShanghaiChina Shanghai IndustrialμTechnology Research Institute ShanghaiChina Shanghai Engineering Research Center of Energy Efficient and Custom AI IC ShanghaiChina

This paper reports on an aluminum nitride(AlN)piezoelectric micromachined ultrasound transducer(PMUT)array for photoacoustic(PA)imaging,where the high-order resonance modes of the PMUT are utilized to improve imaging resolution.A flexural vibration mode(FVM)PMUT is fabricated and applied in a photoacoustic imaging(PAI)***,the microelectromechanical system(MEMS)-based PMUT is suitable for PA endoscopic imaging of blood vessels and bronchi due to its miniature size and high *** importantly,AlN is a nontoxic material,which makes it harmless for biomedical *** the PAI system,the AlN PMUT array is used to detect PA signals,and the acousto–mechanical response is designed and optimized at the PMUT’s fundamental *** this work,we focus on the high-order resonance performance of the PMUT PAI beyond the fundamental *** acoustic and electrical responses of the PMUT’s high-order resonance modes are characterized and *** fundamental and three high-order resonance bandwidths are 2.2,8.8,18.5,and 48.2 *** with the resolution at the fundamental resonance mode,the resolutions at third-and fourth-order resonance modes increase by 38.7%and 76.9%in a phantom *** high-order resonance modes of the AlN PMUT sensor array provide higher central frequency and wider bandwidth for PA signal detection,which increase the resolution of PAI compared to the PMUT working at the fundamental resonance mode.

关键词： resonance fundamental photoacoustic

Genesis of the Nuri Cu-W-Mo Deposit,Tibet,China:Constraints from in situ Trace Elements and Sr Isotopic Analysis of Scheelite

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 117-131页

作者： wang yiyun WU Zhishan CHEN Wenqing DU Qing’an TANG Liwei SHI Hongzhao MA Guotao ZHANG Zhi LIANG Wei WU Bo MIAO Hengyi Chengdu Center China Geological Survey(Geoscience Innovation Center of Southwest China)Chengdu 610081China The Second Geological Institute of China’s Metallurgical Geology Bureau Fuzhou 351111China

The Nuri deposit is the only Cu-W-Mo polymetallic deposit with large-scale WO3 resources in the eastern section of the Gangdese metallogenic belt,Tibet,***,the genetic type of this deposit has been controversial since its *** on a study of the geological characteristics of the deposit,this study presents mineralization stages,focusing on the oxide stage and the quartz-sulfide stage where scheelite is mainly formed,referred to as Sch-A and Sch-B,*** LA-ICP-MS trace element and Sr isotope analyses,the origin,evolutionary process of the oreforming fluid and genesis of the ore deposit are *** Electron Microscope-Cathodoluminescence(SEMCL)observations reveal that Sch-A consists of three generations,with dark gray homogenous Sch-A1 being replaced by relatively lighter and homogeneous Sch-A2 and Sch-A3,with Sch-A2 displaying a gray CL image color with vague and uneven growth bands and Sch-A3 has a light gray CL image color with hardly any growth *** contrast,Sch-B exhibits a‘core-rim’structure,with the core part(Sch-B1)being dark gray and displaying a uniform growth band,while the rim part(Sch-B2)is light gray and *** normalized distribution pattern of rare earth elements in scheelite and Sr isotope data suggest that the early ore-forming fluid in the Nuri deposit originated from granodiorite porphyry and,later on,some country rock material was mixed in,due to strong water-rock *** the O-H isotope data further indicates that the ore-forming fluid in the Nuri deposit originated from magmatic-hydrothermal sources,with contributions from metamorphic water caused by water-rock interaction during the mineralization process,as well as later meteoric *** intense water-rock interaction likely played a crucial role in the precipitation of scheelite,leading to varying Eu anomalies in different generations of scheelite from the oxide stage to the quartz-sulfide stage,while also causing a

关键词： trace elements in situ Sr isotopes tungsten mineralization Gangdese metallogenic belt Tibet

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中国P2P网络借贷模式及风险研究

中国P2P网络借贷模式及风险研究

作者： yiyun wang 上海交通大学

学位级别：硕士

P2P网络借贷是一种金融创新产物,中小型企业和个人拓宽融资渠道,为投资者开辟新的投资方式,有其合理的存在价值。近年来我国网贷行业事件频发,受到监管部门、投资人和社会的广泛关注。本文通过定性和定量相结合的方式,对P2P网络借贷行... 详细信息

P2P网络借贷是一种金融创新产物,中小型企业和个人拓宽融资渠道,为投资者开辟新的投资方式,有其合理的存在价值。近年来我国网贷行业事件频发,受到监管部门、投资人和社会的广泛关注。本文通过定性和定量相结合的方式,对P2P网络借贷行业的风险进行识别,衡量,并最终提出风险控制的对策建议。首先对国内外P2P网络借贷平台采用的经营模式进行梳理。国内模式在国外的经验上进行了本土化改造,主要有两种模式:纯线上加无担保的信息中介模式和线上与线下相结合加担保的复合经营模式。概括分析了不同种模式的主要特点和风险特征。之后站在行业的角度,对我国P2P网络借贷行业内部和外部的风险进行识别。文章在对风险做出识别后用案例分析的方式,对e租宝这家经营失败平台进行分析。对其组织架构、经营模式、销售产品等方面进行研究,发现在平台内部存在:虚假交易问题、分散性问题、担保安全性问题、流动性问题,为下一步实证分析的数据指标选取和风险因素衡量提供思路和线索。通过因子分析法构建了网络借贷平台综合风险评价体系,用实证的方式,对网络借贷平台中的风险进行衡量。风险评价模型对25家正常经营平台和5家经营失败平台的15项数据指标进行数据处理。实证结果发现,平台人气因子、借款分散性因子、投资分散性因子、安全性因子、流动性因子的得分情况与平台的交易规模、运营模式、担保手段、内制度设置和信息披露程度等因素相关。5家经营失败平台得分结果与实际情况相符。实证研究结果能够从数据上对类似e租宝这类高风险平台进行识别。最后,结合前文对识别和衡量出的风险,探讨了P2P网络借贷风险控制的对策和建议。我国应该构建完善的法律和监管体系、完善社会征信体制、推进平台向信息中介模式转型、规范担保机制、建立信息披露制度五项建议。

关键词： P2P e租宝因子分析风险控制

An Exploration of Teaching Class of Mixed Ability

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Sino-US English Teaching 2020年第4期17卷 118-123页

作者： DUAN Lifang SHI Yun wang yiyun Dehong Teachers’College YunnanChina Chuxiong Teachers’College YunnanChina

There has been a long time of debate between the two teaching approaches of homogenous grouping and heterogeneous *** in the essay,we explored both of the two teaching approaches in Yunnan Province of China whereas the puzzle lies in the question of which method can achieve a relatively-better result in English classes of *** possible solutions are promoted based on the data and analysis collected from a survey.

关键词： mixed ability homogenous grouping heterogeneous grouping English teaching

A Preprocessing Method for Gait Recognition

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国际计算机前沿大会会议论文集 2016年第1期 23-24页

作者： Hong Shao yiyun wang Yang wang Weihao Hu School of Information Science and Engineering Shenyang University of TechnologyShenyang118070LiaoningChina

The results of image preprocessing may directly affect gait feature extraction in the area of gait recognition. Due to the influence of light, shelter and other external factors of gait image, some problems such as loss of information,image shadows, and improper threshold of image preprocessing may occur. In order to solve these problems, an image preprocessing method of gait recognition is proposed. Firstly, background image is extracted by background modeling, secondly, the target profile is extracted by the direct difference method; thirdly, the shadow elimination based on the HSV color model is carried out on the target profile map; Finally, the complete target profile is obtained by threshold segmentation. Experimental results on CASIA_A database demonstrate that this proposed method is quite effective on both target profile extraction and proportion comparison with the real area.

关键词： Gait recognition Image pre-processing Shadow elimination

PDGFRαreporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair

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Bone Research 2022年第1期10卷 122-136页

作者： Jiajia Xu yiyun wang Zhu Li Ye Tian Zhao Li Amy Lu Ching-Yun Hsu Stefano Negri Cammy Tang Robert J.Tower Carol Morris Aaron W.James Departments of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Orthopedics Johns Hopkins UniversityBaltimoreMD 21205USA Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningPR China

The outer coverings of the skeleton,which is also known as the periosteum,are arranged in concentric layers and act as a reservoir for tissue-specific bone *** cellular heterogeneity within this tissue depot is being increasingly ***,inducible PDGFRαreporter animals were found to mark a population of cells within the periosteum that act as a stem cell reservoir for periosteal appositional bone formation and fracture *** these processes,PDGFRαreporter^(+)progenitors give rise to Nestin+periosteal cells before becoming osteoblasts and *** diphtheria toxin-mediated ablation of PDGFRαreporter^(+)cells led to deficits in cortical bone formation during homeostasis and a diminutive hard callus during fracture *** ossicle transplantation,both mouse PDGFRαreporter^(+)periosteal cells and human Pdgfrα+periosteal progenitors expand,ossify,and recruit marrow to a greater extent than their counterpart periosteal cells,whereas PDGFRαreporter^(−)periosteal cells exhibit a predisposition to chondrogenesis in *** RNA sequencing identified enrichment of the secreted factors Fermt3 and Ptpn6 within PDGFRαreporter^(+)periosteal cells,which partly underlie the osteoblastogenic features of this cell population.

关键词： progenitor fracture reservoir

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Rapid and quantitative analysis of exosomes by a chemiluminescence immunoassay using superparamagnetic iron oxide particles

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Rapid and quantitative analysis of exosomes by a chemilumine...

2019年浙江省检验医学学术大会

作者： yiyun wang Zhenping Liu Xuchu wang Weiwei Liu Zhihua Tao The Second Affiliated Hospital of Zhejiang University School of Medicine

Since the discovery of exosomes, their potential diagnostic value has been the focus of considerable research. However, the lack of a rapid and simple technique for the quantitative analysis of exosomes greatly limits the application of exosomes in clinical research. In this study, we describe a newly developed one-step chemiluminescence immunoassay for the rapid quantitative analysis of exosomes from biofluids. Our new technique, named Exo NANO, adopts a double-antibody sandwich strategy using anti-CD63 antibodyconjugated superparamagnetic iron oxide particles(SIOPs) and acridinium ester(ACE)-labeled anti-CD9 antibodies. SIOPs have narrow size distribution and high magnetic susceptibility, and ACE has excellent chemiluminescent properties such as low background signal and no need for a catalyst. We demonstrated that Exo NANO allows the quantitative analysis of exosomes in the range of 2.92×10 to 2.80×10 particles/μL, with a limit of detection of 2.63×10 particles/μL. Using Exo NANO, we quantified exosomes incell culture medium and clinical biofluids such as serum, saliva, ascitic fluid, and cerebrospinal fluid. We believe that Exo NANO might pave the way for the rapid isolation and quantitative analysis of exosomes for routine clinical applications.

关键词： exosomes superparamagnetic iron oxide particles acridinium ester isolation chemiluminescence immunoassay

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《圣诞颂歌》对功利主义的批判

外国语文 2015年第2期31卷 45-49页

作者：王忆云天津商业大学大学外语教学部天津300134

查尔斯·狄更斯作为19世纪批判现实主义的大师,极力批判贫富两极分化和人内心善性泯灭的社会病症。《圣诞颂歌》是查尔斯·狄更斯于1843年所创作的具有非凡意义的作品,作者利用幽灵意象的表现手法不仅揭示了功利主义思想所带给英国资本... 详细信息

查尔斯·狄更斯作为19世纪批判现实主义的大师,极力批判贫富两极分化和人内心善性泯灭的社会病症。《圣诞颂歌》是查尔斯·狄更斯于1843年所创作的具有非凡意义的作品,作者利用幽灵意象的表现手法不仅揭示了功利主义思想所带给英国资本主义社会的极大不平等,同时也借用圣诞节这一特殊背景来呼唤善良人性的回归。论文着重分析《圣诞颂歌》中斯克鲁奇的自私人性和利己心态,从而剖析功利主义对这种人性堕落的推波助澜作用,同时分析《圣诞颂歌》中查尔斯·狄更斯对圣诞节的设置意图,以及作者借圣诞幽灵这一文学意象唤醒善良人性的积极用意。

关键词：功利主义圣诞节幽灵

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