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New Phase of Phase

Journal of Systems Science & Complexity 2021年第5期34卷 1821-1839页

作者： QIU Li CHEN wei wang dan Hong Kong University of Science and Technology Clear Water BayKowloonHong KongChina Peking University&Beijing Innovation Center for Engineering Science and Advanced Technology Beijing100871China

Year 2021 is *** sees the renaissance of concept of phase and the birth of a phase theory for matters much beyond complex numbers and single-input single-output(SISO)linear timeinvariant(LTI)systems while we celebrate the 60 th birthday of Lei Guo,an exemplary research leader of our *** we give a short tutorial of the newly developed phase theory,as a birthday present.

关键词： Phase response sectored real lemma small phase theorem

The First Five Years of a Phase Theory for Complex Systems and Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1728-1743页

作者： dan wang wei Chen Li Qiu Division of Decision and Control Systems KTH Royal Institute of TechnologyStockholm 10044Sweden Department of Mechanics and Engineering Science&the State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China Hong Kong University of Science and Technology Hong KongChinaand also with the Southern University of Science and TechnologyShenzhen 518055China

In this paper,we review the development of a phase theory for systems and networks in its first five years,represented by a trilogy:Matrix phases and their properties;The MIMO LTI system phase response,its physical interpretations,the small phase theorem,and the sectored real lemma;The synchronization of a multi-agent network using phase *** the end,we also summarize a list of ongoing research on the phase theory and speculate what will happen in the next five years.

关键词： Consensus and synchronization matrix phases multi-agent systems phase theory sectored real lemma small phase theorem.

辨体-辨病-辨证诊疗模式在甲状腺功能减退症防治中的应用

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中国中医基础医学杂志 2019年第9期25卷 1241-1243页

作者：赵静柏力萄王丹玮魏璠郑慧娟陈舒雅孙伯菊魏军平中国中医科学院广安门医院北京100053

甲状腺功能减退症是由于甲状腺激素合成和分泌减少或组织作用减弱导致的全身代谢减低综合征,严重危害人民健康。中医体质学说的发展为甲减的诊疗提供了新的方法。"辨体-辨病-辨证诊疗模式"是基于体病相关与体质可调理论的基础上,将辨体... 详细信息

甲状腺功能减退症是由于甲状腺激素合成和分泌减少或组织作用减弱导致的全身代谢减低综合征,严重危害人民健康。中医体质学说的发展为甲减的诊疗提供了新的方法。"辨体-辨病-辨证诊疗模式"是基于体病相关与体质可调理论的基础上,将辨体、辨病、辨证相结合应用于临床的中医诊疗方式。本文系统整理魏军平教授运用辨体-辨病-辨证诊疗模式诊断及治疗甲状腺功能减退症中的经验,主张临证时首先辨病确定其中西医病名,其次辨体预估疾病发展方向,然后辨证确立具体证型。治疗方面,注重在准确辨病的基础上,在甲减症状及体征明显的阶段以辨证论治为主兼以调体,症状基本缓解后转以调理偏颇体质为主,从而达到改善症状、调整体质进而防治甲减的目的。

关键词：辨体-辨病-辨证甲状腺功能减退症中医药诊断与治疗

[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 3-12页

作者： Lyu-Ye Zhang wei-Bing Zhang Hai-Lin wang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 China. State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China 3. University of Chinese Academy of Sciences Beijing 100049 China. University of Chinese Academy of Sciences Beijing 100049 China.

Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides. These modified nucleosides can act as signaling molecules that regulate downstream pathways once transported to the extracellular space; alternatively, they are metabolized in the bloodstream and excreted in urine. Metabolized modified nucleosides are altered by cellular stress responses and mediate abnormal physiological states. Changes in the urinary and blood levels of modified nucleosides associated with cancer can serve as biomarkers for disease. Therefore, identifying and accurately quantifying nucleosides is vital for understanding RNA degradation and associated patterns of nucleoside metabolism. Such analyses are helpful when studying the biological functions and potential clinical applications of modified nucleosides. In this regard, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) offers significant advantages in terms of sensitivity, selectivity, and efficiency, and has been widely used to analyze DNA and RNA nucleosides/nucleotides and their analogues. Multiple MS detection patterns and quantification methods have been established to detect nucleosides in biological samples, including cultured cells, urine, blood, and tissue samples. However, the development of an accurate HPLC-MS/MS method faces several challenges. Firstly, the presence of a complex biological matrix that contains macromolecules, small molecules, and salts can interfere with analysis. Salts and co-elu

关键词： RNA modifications high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) metabolite analysis methylated nucleosides

Best linear unbiased estimation algorithm with Doppler measurements in spherical coordinates

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Journal of Systems Engineering and Electronics 2016年第1期27卷 128-139页

作者： wei wang dan Li Liping Jiang School of Science Naval University of Engineering School of Science Wuhan University of Technology

In an active radar-tracking system,the target-motion model is usually modeled in the Cartesian coordinates,while the radar measurement usually is obtained in polar/spherical *** the target-tracking problem in the Cartesian coordinates becomes a nonlinear state estimation problem.A number of measurement-conversion techniques,which are based on position measurements,are widely used such that the Kalman filter can be used in the Cartesian ***,they have fundamental limitations to result in filtering performance *** fact,in addition to position measurements,the Doppler measurement or range rate,containing information of target velocity,has the potential capability to improve the tracking performance.A filter is proposed that can use converted Doppler measurements（*** product of the range measurements and Doppler measurements） in the Cartesian *** novel filter is theoretically optimal in the rule of the best linear unbiased estimation among all linear unbiased filters in the Cartesian coordinates,and is free of the fundamental limitations of the measurement-conversion *** on simulation experiments,an approximate,recursive implementation of the novel filter is compared with those obtained by four state-of-the-art conversion techniques *** results demonstrate the effectiveness of the proposed filter.

关键词： target tracking radar tracking state estimation converted measurement.

Partially known information attack on SM2 key exchange protocol

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Science China(Information Sciences) 2019年第3期62卷 61-74页

作者： wei wei Jiazhe CHEN dan LI Beibei wang China Information Technology Security Evaluation Center Institute for Advanced Study Tsinghua University

SM2 key exchange protocol is a part of the SM2 public key cryptographic algorithm based on elliptic curves which has been issued by Chinese State Cryptography Administration since 2010. Under the guide of Chinese government, SM2 has been widely used in Chinese commercial applications. This paper gives the first partially known information attack on SM2 key exchange protocol. Our attack is based on a technique modified from the hidden number problem(HNP) which was introduced originally to study the bit security of Diffie-Hellman and related schemes. We present a polynomial-time algorithm which could recover the user’s secret key when given about half least significant bits of the two unknown intermediate values in each congruence over about 30 to 40 instances. Compared with the standard HNP, our approach deals with congruence involved two independent unknown variables and each of them possesses the same size as the secret key. Moreover, our results almost coincide with the previous best result among the same field considering the extreme case in which one variant is completely revealed.

关键词： SM2 key exchange protocol cryptanalysis information leakage lattice attack extended hidden number problem

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing Li Xiufang Li Zi-Xiu Lu Linzhe Lü Jin Liu Luyao Liu Wenjing wang wei wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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Booming cancer immunotherapy fighting tumors

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Science China(Life Sciences) 2017年第12期60卷 1445-1449页

作者： dan Li wei wang Lab of Gene and Cell Therapy Cancer CenterCollaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu610041China.

In 2013,cancer immunotherapy led the annual breakthroughs in *** fact,immunotherapy is one of the hotspots in cancer therapy,and can date back to the Coley vaccine in *** in biotechnology and bio-engineering,especially research and development（R＆D）in the fields of therapeutic antibodies,checkpoint inhibitors,and engineered T cells,helped overcome the problems in tumor therapies,leading to increasing research focus on cancer immunotherapy.

关键词： Booming cancer immunotherapy fighting tumors

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颅脑外伤患者并发癫痫47例救治的探讨

中国医药导刊 2016年第11期18卷 1095-1096页

作者：殷春立张丹王兆伟中国人民解放军火箭军总医院神经内科北京100088

目的：探讨颅脑外伤并发癫痫患者的预防和治疗方法。方法：我院神经外科2012年2月-2014年1月期间收治的颅脑损伤继发癫痫患者47例,对原发疾病进行治疗,再给予预防和控制癫痫发作的保守治疗。结果：全部患者癫痫发作均得到有效控制,住院... 详细信息

目的：探讨颅脑外伤并发癫痫患者的预防和治疗方法。方法：我院神经外科2012年2月-2014年1月期间收治的颅脑损伤继发癫痫患者47例,对原发疾病进行治疗,再给予预防和控制癫痫发作的保守治疗。结果：全部患者癫痫发作均得到有效控制,住院期间均未出现跌倒、坠床等意外及再发癫痫。经1年随访复发2例（4.26%）。结论：积极处理原发疾病,积极预防、控制癫痫发作,是颅脑外伤后继发癫痫的重要处理原则。

关键词：宫腔镜手术剖宫产疤痕缺陷月经异常