检索结果-南通市图书馆

Dynamic Accuracy Design Method of Ultra-precision Machine Tool

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2018年第1期31卷 167-175页

作者： Guo-Da chen Ya-Zhou Sun Fei-Hu Zhang Li-Hua Lu wan-qun chen Nan Yu Center for Precision Engineering Harbin Institute of Technology Key Laboratory of E&M Ministry of Education & Zhejiang Province Zhejiang University of Technology Precision Engineering Institute Cranfield University

Ultra-precision machine tool is the most important physical tool to machining the workpiece with the frequency domain error requirement, in the design process of which the dynamic accuracy design(DAD) is indispensable and the related research is rarely available. In light of above reasons, a DAD method of ultra-precision machine tool is proposed in this paper, which is based on the frequency domain error *** basic procedure and enabling knowledge of the DAD method is introduced. The application case of DAD method in the ultra-precision flycutting machine tool for KDP crystal machining is described to show the procedure detailedly. In this case, the KDP workpiece surface has the requirements in four different spatial frequency bands, and the emphasis for this study is put on the middle-frequency band with the PSD specifications. The results of the application case basically show the feasibility of the proposed DAD method. The DAD method of ultra-precision machine tool can effectively minimize the technical risk and improve the machining reliability of the designed machine tool. This paper will play an important role in the design and manufacture of new ultra-precision machine tool.

关键词： Dynamic accuracy design Ultra-precision machine tool Frequency domain Error allocation

维普期刊数据库

Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptideexpressing metaplasia lesions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第11期13卷 1741-1754页

作者： wan-qun chen Feng-Liang Tian Jin-Wei Zhang Xiao-Jun Yang Yan-Ping Li Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China Department of Dermatology and Cosmetology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND Spasmolytic polypeptide-expressing metaplasia(SPEM)is a potential preneoplastic *** To elucidate the microRNA(miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules(YWXY)in SPEM *** Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed *** was administered to the mice with induced SPEM by tamoxifen,and the gastric mucosa was harvested on the tenth day of the *** immunohistochemistry and immunofluorescence were performed to validate the SPEM,lesions and the potential mechanism was *** transcripts were detected with reverse transcriptionquantitative polymerase chain *** The expression of miR-7 was downregulated in the SPEM lesions,and expression of trefoil factor 2(TFF2)and clusterin was high in the human gastric *** vivo experiments showed that YWXY could inhibit the cell proliferation in the tamoxifen-induced SPEM lesions by regulating ***,YWXY could restore the expression of miR-7 by regulating TFF2 by detection with immunofluorescence but not with reverse transcription-quantitative polymerase chain reaction,indicating its potential mechanism of targeting miR-7 by mediating *** expression of vascular endothelial growth factor-βand gastric intrinsic factor was restored within 3 d of YWXY administration for the SPEM lesions,speculating that the possible mechanism of YWXY is to inhibit the development and progression of SPEM by regulating vascular endothelial growth factor-βand gastric intrinsic *** miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric *** is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model.

关键词： Spasmolytic polypeptide-expressing metaplasia Yiwei Xiaoyu Granules MicroRNA-7 Chronic atrophic gastritis Trefoil factor 2 Gastric precancerous lesions

Yangzheng Sanjie decoction regulates proliferation and apoptosis of gastric cancer cells by enhancing let-7a expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第30期23卷 5538-5548页

作者： Hai-Xia Deng Ya-Ya Yu Ao-Qiang Zhou Jing-Li Zhu Li-Na Luo wan-qun chen Ling Hu Geng-Xin chen The Second Affiliated Hospital Guangzhou University of Chinese Medicine Institute of Gastroenterology Guangzhou University of Chinese Medicine The First Affiliated Hospital Guangzhou University of Chinese Medicine Discipline of Integrated Chinese and Western Medicine in Guangzhou University of Chinese Medicine

AIM To explore the let-7a-mediated anti-cancer effect of Yangzheng Sanjie decoction(YZSJD) in gastric cancer(GC) *** YZSJD-containing serum(YCS) was prepared using traditional Chinese medicine serum pharmacology methods. After YCS treatment, cell proliferation and apoptosis were assessed by cell counting kit-8 assay and flow cytometry, respectively, and mi RNA expression profiles were determined using q PCR arrays. Let-7a expression was examined by in situ hybridization in GC tissues and by q PCR in GC cells. c-Myc protein expression was detected by immunohistochemistry in GC tissues, and by Western blot in cell *** YZSJD significantly inhibited proliferation and induced apoptosis in AGS and HS-746 T GC cells. After treatment with YCS, the mi RNA expression profiles were altered and the reduced let-7a levels in both cell lines were up-regulated, accompanied by a decrease in c-Myc expression. Moreover, decreased let-7a expression and increased c-Myc expression were observed during the progression of gastric mucosa *** YZSJD inhibits proliferation and induces apoptosis of GC cells by restoring the aberrant expression of let-7a and c-Myc.

关键词： Gastric cancer let-7a c-Myc proliferation apoptosis Yangzheng Sanjie decoction

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： wan-qun chen Qing-Feng Fan Yuan-Jun He Fei Li Xin Wu Yan-Ping Li Xiao-Jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(***),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of *** only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic *** Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese ***,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of *** To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS *** We designed a double-blind,randomized,controlled *** study enrolled seventy-two ***-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 *** pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other *** visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh *** also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and *** Six patients did not complete the trial *** with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric fun

关键词： Chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

Quantum public-key crypto via EPR pairs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-qun Fu Hong-Wei Li Jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Vector meson's spin alignments in high energy reactions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui chen Zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng qun wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Identification, characteristic and phylogenetic analysis of type II DNA topoisomerase gene in Giardia lamblia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2005年第6期15卷 474-482页

作者： De HE1, 2, 3, Jian Fan WEN1,*, wan qun chen1, Si Qi LU4, De Dong XIN1, 21 Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China2 Gradulate School of the Chinese Academy of Sciences, Beijing 100039, China3 Southwest Forestry College, Kunming 650224, China4 Capital University of Medical Sciences, Beijing 100054, China Key Laboratory of Cellular and Molecular Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China Gradulate School of the Chinese Academy of Sciences Beijing China Southwest Forestry College Kunming China Capital University of Medical Sciences Beijing China

The genes encoding type II DNA topoisomerases were investigated in Giardia lamblia genome, and a type IIA gene,GlTop 2 was identified. It is a single copy gene with a 4476 bp long ORF without intron. The deduced amino acidsequence shows strong homology to eukaryotic DNA Top 2. However, some distortions were found, such as sixinsertions in the ATPase domain and the central domain, a ~100 aa longer central domain; a ~200 aa shorter C-terminaldomain containing rich charged residues. These features revealed by comparing with Top 2 of the host, human, mightbe helpful in exploiting drug selectivity for antigiardial therapy. Phylogenetic analysis of eukaryotic enzymes showedthat kinetoplastids, plants, fungi, and animals were monophyletic groups, and the animal and fungi lineages shared amore recent common ancestor than either did with the plant lineage; microsporidia grouped with fungi. However, unlikemany previous phylogenetic analyses, the “amitochondriate” G. lamblia was not the earliest branch but diverged aftermitochondriate kinetoplastids in our trees. Both the finding of typical eukaryotic type IIA topoisomerase and the phylo-genetic analysis suggest G. lamblia is not possibly as primitive as was regarded before and might diverge after theacquisition of mitochondria. This is consistent with the recent discovery of mitochondrial remnant organelles in G. lamblia.

关键词： evolutionary position GlTop2 gene Giardia lamblia identification phylogenetic analysis type II DNAtopoisomerase.

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胃癌前病变解痉多肽表达化生的研究进展

世界华人消化杂志 2020年第7期28卷 254-259页

作者：陈万群杨小军张金卫重庆市中医院消化科重庆市400037 重庆市中医院皮肤美容科重庆市400037

解痉多肽表达化生(spasmolytic polypeptide expressing metaplasia,SPEM)作为胃癌前病变的初始步骤,慢性炎症持续刺激可进展至异型增生甚至癌变.现有基于SPEM特性的动物模型研究显示,幽门螺杆菌感染所致的胃黏膜免疫应答失调可能为SPE... 详细信息

解痉多肽表达化生(spasmolytic polypeptide expressing metaplasia,SPEM)作为胃癌前病变的初始步骤,慢性炎症持续刺激可进展至异型增生甚至癌变.现有基于SPEM特性的动物模型研究显示,幽门螺杆菌感染所致的胃黏膜免疫应答失调可能为SPEM进展至肠化生直至胃癌的机制之一.因此,进一步研究SPEM的起源及进展机制,有望遏制SPEM病理形态的产生,阻断SPEM进展到肠化生,从而真正减少肠型胃癌的发病率.故本文将近10年来有关SPEM的研究进展进行简要综述.

关键词：解痉多肽表达化生胃癌前病变肠化生幽门螺杆菌胃癌异型增生

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le wang Wenwu Zhang Gang Li Xing cheng Peiqiang Su Yong wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

维普期刊数据库