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A comparison of the effect of alendronate and You-Gui-wan on osteoporosis in female rats with kidney-yang deficiency

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Traditional Medicine Research 2024年第6期9卷 31-41页

作者： Mei-Mei wu Xing-Peng He wan-ting wu Wen-Jie Lu Yan-Yang Mai Kun-Cai Xu Yao-Feng Zhi Hai-Xin Mo Jia-Di He Xin Zhang Peng-Fei Li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an ELISA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-wan alendronate

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Boosting thermal stability and crystallization of closed-loop-recyclable biodegradable poly(p-dioxanone) by end-group regulation

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Science China Chemistry 2024年第2期67卷 642-651页

作者： Jin Lei Zhu-Xin Gui wan-ting Xiong Gang wu Si-Chong Chen Yu-Zhong wang The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

A chemically closed-loop-recyclable biodegradable polymer,poly(p-dioxanone)(PPDO),is one of the ideal candidates for single-use plastic products due to its suitability for different application ***,when PPDO wastes can be collected,its monomer p-dioxanone(PDO) will be obtained through chemical recycling of these wastes;when cannot be collected,the wastes are able to be biodegraded into harmless ***,unsatisfied thermal stability and low crystallization rate of PPDO restrict its wider ***,based on end-group regulation,we simultaneously realized the significant enhancement of thermal stability and crystallization of PPDO through the simple melt processing with tributyl phosphite(TBP) or triphenyl phosphite(TPP).The model reactions were conducted to investigate the reaction mechanism and theoretical products during the preparation of PPDO/phosphite *** kinds of phosphites were proved to act as the end-capped reagent and chain extender in the melt processing,while TBP presented better *** a result,the activation energy of thermal decomposition was largely elevated,and the unprecedented T_(5%)(the temperature at a weight loss of 5%) and Tmax(the temperature at a maximum rate of weight loss) of PPDO were obtained,i.e.,T_(5%)of ~330 ℃ and Tmaxof ~385 ℃ in N_(2) atmosphere,T_(5%)of ~240 ℃ and Tmaxof ~317 ℃ in air atmosphere,***,the increased crystallization rate,crystallinity,crystalline orderliness,and realizable monomer recovery(yield >90%,purity >99.9%) of PPDO/phosphite compounds were confirmed.

关键词： poly(p-dioxanone) phosphite thermal stability crystallization end-group regulation

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Evolving roles of glycosylation in the tug-of-war between virus and host

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National Science Review 2024年第05期11卷 100-104页

作者： Xiaofeng Zhai Yanqiu Yuan wan-ting He Ying wu Yi Shi Shuo Su Quansheng Du Yang Mao Academy for Advanced Interdisciplinary Studies Engineering Laboratory of Animal Immunity of Jiangsu Province College of Veterinary MedicineNanjing Agricultural University State Key Laboratory of Anti-Infective Drug Discovery and Development School of Pharmaceutical SciencesSun Yat-sen University School of Pharmacy China Pharmaceutical University Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research School of Pharmaceutical Sciences Sun Yat-sen University CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Department of Interdisciplinary Sciences National Natural Science Foundation of China

Covering the surface of both host cells and enveloped viruses, glycans are inevitable biomolecules for investigating virus–host interactions. However, due to the intricate role of glycans in the viral–host relationship, few glycanrelated molecular mechanisms have been harnessed for antiviral therapies. The intricacy arises from multiple factors.

关键词： VACCINE BINDING PROTEIN

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Optimized Mask-RCNN model for particle chain segmentation based on improved online ferrograph sensor

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Friction 2024年第6期12卷 1194-1213页

作者： Shuo wanG Miao wan Tonghai wu Zichen BAI Kunpeng wanG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China

Ferrograph-based wear debris analysis(WDA)provides significant information for wear fault analysis of mechanical *** decades of offline application,this conventional technology is being driven by the online ferrograph sensor for real-time wear state ***,online ferrography has been greatly limited by the low imaging quality and segmentation accuracy of particle chains when analyzing degraded lubricant oils in practical *** address this issue,an integrated optimization method is developed that focuses on two aspects:the structural re-design of the online ferrograph sensor and the intelligent segmentation of particle *** enhancing the imaging quality of wear particles,the magnetic pole of the online ferrograph sensor is optimized to enable the imaging system directly observe wear particles without penetrating ***,a light source simulation model is established based on the light intensity distribution theory,and the LED installation parameters are determined for particle illumination uniformity in the online ferrograph *** this basis,a Mask-RCNN-based segmentation model of particle chains is constructed by specifically establishing the region of interest(ROI)generation layer and the ROI align layer for the irregular particle *** these measures,a new online ferrograph sensor is designed to enhance the image acquisition and information extraction of wear *** verification,the developed sensor is tested to collect particle images from different degraded oils,and the images are further handled with the Mask-RCNN-based model for particle feature *** results reveal that the optimized online ferrography can capture clear particle images even in highly-degraded lubricant oils,and the illumination uniformity reaches 90%in its imaging *** importantly,the statistical accuracy of wear particles has been improved from 67.2%to 94.1%.

关键词： wear particle analysis online ferrography particle image acquisition particle chain segmentation

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Selective oxidation using in-situ generated hydrogen peroxide over titanosilicates

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Chinese Journal of Structural Chemistry 2024年第6期43卷 12-14页

作者： Zhipeng wan Hao Xu Peng wu State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal UniversityShanghai200062China Institute of Eco-Chongming Shanghai202162China

Titanosilicates are a class of heteroatom-containing zeolitic materials with tetrahedrally coordinated Ti^(4+)ions incorporated into crystalline zeolite frameworks,with TS-1,Ti-MWW and Ti-MOR as representative and attractive selective oxidation *** liquid-phase oxidations of a variety of substrates such as olefins and ketones with the green oxidant of H_(2)O_(2)over titanosilicates under mild conditions have attracted considerable research interests in the clean production of fine and bulk chemicals,among which propylene epoxidation and cyclohexanone ammoximation have been industrialized[1].

关键词： silicate zeolite propylene

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High-temperature stability of retained austenite and plastic deformation mechanism of ultra-fine bainitic steel isothermally treated below Ms

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Journal of Iron and Steel Research International 2024年第8期31卷 2014-2030页

作者： ting-ting He Feng Hu Kun wang Wen Zhou Li Li Serhii Yershov Kai-ming wu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan 430081HubeiChina Zhejiang Tsingshan Iron and Steel Co. Ltd.Qingtian 323903ZhejiangChina

The mechanical properties of the sample and the stability of retained austenite were studied by designing two kinds of ultra-fine bainitic steel with different heat treatment methods austempering above and below Ms(martensite start tem-perature),which were subjected to tensile tests at 20 and 450℃,*** results show that compared to room temperature(20℃)tensile properties,the uniform elongation of the sample at high temperature(450℃)significantly ***,the uniform elongation of the sample austempered above Ms decreased from 8.0%to 3.5%,and the sample austempered below Ms decreased from 10.9%to 3.1%.Additionally,the tensile strength of the sample austempered above Ms significantly decreased(from 1281 to 912 MPa),and the sample austempered below Ms slightly decreased(from 1010 to 974 MPa).This was due to the high carbon content(1.60 wt.%),high mechanical stability,low thermal stability for the retained austenite of the sample austempered below ***,the retained austenite decomposed at high temper-atures,the carbon content and transformation driving force were significantly reduced,the transformation rate increased,and the phase transformation content reduced.

关键词： Ultra-fine bainite Isothermal treatment High-temperature tensile property Retained austenite stability Plastic deformation

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Agricultural Investment Project Decisions Based on an Interactive Preference Disaggregation Model Considering Inconsistency

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3125-3146页

作者： Xingli wu Huchang Liao Shuxian Sun Zhengjun wan Business School Sichuan UniversityChengdu610064China National Institute of Measurement and Testing Technology Chengdu610021China

Agricultural investment project selection is a complex multi-criteria decision-making problem,as agricultural projects are easily influenced by various risk factors,and the evaluation information provided by decisionmakers usually involves uncertainty and *** literature primarily employed direct preference elicitation methods to address such issues,necessitating a great cognitive effort on the part of decision-makers during evaluation,specifically,determining the weights of *** this study,we propose an indirect preference elicitation method,known as a preference disaggregation method,to learn decision-maker preference models fromdecision *** enhance evaluation ease,decision-makers merely need to compare pairs of alternatives with which they are familiar,also known as reference *** linguistic preference relations are employed to account for the presence of incomplete and uncertain information in such pairwise *** address the inconsistency among a group of decision-makers,we develop a pair of 0-1mixed integer programming models that consider both the semantics of linguistic terms and the belief degrees of ***,we conduct a case study and comparative *** reveal the effectiveness of the proposed model in solving agricultural investment project selection problems with uncertain and inconsistent decision information.

关键词： Multiple criteria analysis preference disaggregation inconsistency probability linguistic preference relation investment project selection

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Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance Li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru Zhang Qiong wu Yong Zhang Xi-Fei Li ting Xie Yu-Cheng wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer Li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in Li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible Li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in Li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials Lithium-ion batteries

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Hybrid Dynamic Variables-Dependent Event-Triggered Fuzzy Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 723-733页

作者： Xiongbo wan Chaoling Zhang Fan Wei Chuan-Ke Zhang Min wu IEEE the School of Automation China University of Geosciencesthe Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systemsand the Engineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationWuhan 430074China

This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative dynamic variable and an additive dynamic *** addressed DETM-based fuzzy MPC issue is described as a “min-max” optimization problem(OP).To facilitate the co-design of the MPC controller and the weighting matrix of the DETM,an auxiliary OP is proposed based on a new Lyapunov function and a new robust positive invariant(RPI) set that contain the membership functions and the hybrid dynamic variables.A dynamic event-triggered fuzzy MPC algorithm is developed accordingly,whose recursive feasibility is analysed by employing the RPI *** the designed controller,the involved fuzzy system is ensured to be asymptotically *** examples show that the new DETM and DETM-based MPC algorithm have the advantages of reducing resource consumption while yielding the anticipated performance.

关键词： Dynamic event-triggered mechanism(DETM) hybrid dynamic variables model predictive control(MPC) robust positive invariant(RPI)set T-S fuzzy systems

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A Cross-matching Service for Data Center of Xinjiang Astronomical Observatory

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Research in Astronomy and Astrophysics 2024年第1期24卷 119-127页

作者： Hai-Long Zhang Jie wang Xin-Chen Ye wan-Qiong wang Jia Li Ya-Zhou Zhang Xu Du Han wu ting Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Cross-matching is a key technique to achieve fusion of multi-band astronomical catalogs. Due to different equipment such as various astronomical telescopes, the existence of measurement errors, and proper motions of the celestial bodies, the same celestial object will have different positions in different catalogs, making it difficult to integrate multi-band or full-band astronomical data. In this study, we propose an online cross-matching method based on pseudo-spherical indexing techniques and develop a service combining with high performance computing system(Taurus) to improve cross-matching efficiency, which is designed for the Data Center of Xinjiang Astronomical Observatory. Specifically, we use Quad Tree Cube to divide the spherical blocks of the celestial object and map the 2D space composed of R.A. and decl. to 1D space and achieve correspondence between real celestial objects and spherical patches. Finally, we verify the performance of the service using Gaia 3 and PPMXL catalogs. Meanwhile, we send the matching results to VO tools-Topcat and Aladin respectively to get visual results. The experimental results show that the service effectively solves the speed bottleneck problem of crossmatching caused by frequent I/O, and significantly improves the retrieval and matching speed of massive astronomical data.

关键词： virtual observatory tools astronomical databases:miscellaneous catalogs

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