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Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie Cai Wen-Wen Fan Yun-Hui Zhong Cai-Lan Wen Xiao-Dan wei wan-chen wei wan-Yan Xiang Jin-Mao chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent Technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university ***:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical *** data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their *** analysis and logistic regression were used to examine the factors associated with these ***:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular *** insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,P<0.001).The linear correlations were observed between the difference of binocular spherical equivalent(SE)and the index of horizontal esotropia at a distance(r=0.231,P=0.004)and the asthenopia survey scale(ASS)score(r=0.346,P<0.001).Furthermore,the right eye's SE was inversely correlated with the convergence of positive and negative fusion images at close range(r=-0.321,P<0.001),the convergence of negative fusion images at close range(r=-0.294,P<0.001),the vergence facility(VF;r=-0.234,P=0.003),and the set of negative fusion images at far range(r=-0.237,P=0.003).Logistic regression analysis indicated that gender,age,and the difference in right and binocular SE did not influence the emergence of these ***:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent *** binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

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Is lymphatic invasion of microrectal neuroendocrine tumors an incidental event?:A case report

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World Journal of Clinical Cases 2023年第4期11卷 859-865页

作者： Jing-Xue Ran Liang-Bi Xu wan-wei chen Hao-Yi Yang Yan Weng Yong-Mei Peng Clinical Medical School Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Endoscopy Center Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND A rectal neuroendocrine tumor(rNET)is a malignant tumor originating from neuroendocrine ***,tumor size is the primary basis for assessing tumor *** SUMMARY This article reports the case of a 46-year-old male patient who underwent a colonoscopy that found a 3 mm rectal polypoid *** pathological examination of a sample collected with biopsy forceps revealed a neuroendocrine *** endoscopic submucosal dissection rescue therapy was *** presence of lymphatic vessels indicated that the tumor had infiltrated the negative resection *** lesion was located in the distal rectum near the anal ***,to ensure the patient’s quality of life,follow-up observation was conducted after full communication with the *** tumor recurrence or distant metastasis has been found during the 13-mo follow-up after *** Despite the presence of lymphatic invasion and extremely small diameter rNETs in our case,this phenomenon may not imply a higher risk of distant lymph node and organ metastasis.

关键词： Rectal neuroendocrine tumor Tumor size Lymphatic invasion Case report

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Molecular-scale co-assembly membranes derived from keplerate cluster:carbonic anhydrase-mimicking nanocapsules for enhanced CO_(2)/N_(2)separation

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Science China Chemistry 2024年第10期67卷 3271-3282页

作者： wan-Lei Zhao Hongqiang Li Ruoxuan Zheng Yixin Yang wei chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000China

The development of CO_(2)separation membranes with high permeability and high selectivity,as well as ultra-thin selective layers,has always been ***,a molecular-scaled co-assembly strategy is employed to fabricate the Pebax-Mo_(132)(Pebax=polyether-block-amide copolymer;Mo_(132)=(NH_(4))_(42)[Mo_(72)^(Ⅵ)Mo_(60)^(Ⅴ)O_(372)(CH_(3)COO)_(30)(H_(2)O)_(72)])*** optimal selfstanding membrane,Pebax-Mo_(132)-5%,shows a CO_(2)permeability of~384 Barrer and an ultra-high ideal CO_(2)/N_(2)selectivity of~244,outperforming most membranes reported in the *** CO_(2)permeability and ideal CO_(2)/N_(2)selectivity are increased by 70%and 367%,respectively,compared with the pristine Pebax membrane.A thin-film composite membrane prepared by spin-coating technique on a support membrane with gutter layers also exhibits a CO_(2)permeance of 838 GPU and a CO_(2)/N_(2)selectivity of *** excellent performance can be attributed to the following reasons:(1)strong hydrogen bonding interactions between{Mo_(132)}clusters and Pebax confer excellent interfacial compatibility to the mixed matrix membranes;(2)incorporation of hollow{Mo_(132)}clusters into the Pebax molecular chain decreases the crystallinity of Pebax,and thereby accelerates the chain dynamics and increases the free volume of the membrane;(3)in situ diffuse reflectance infrared Fouriertransform spectroscopy demonstrates that the{Mo_(132)}clusters can effectively catalyze the hydration reaction of CO_(2)and promote the transport of CO_(2);(4)furthermore,the 0.35 nm pores of the crown ether-type{Mo_(9)O_(9)}allow the accurate size sieving of CO_(2)(0.33 nm)and N_(2)(0.36 nm)molecules.

关键词： polyoxometalates molecular-scale assembly CO_(2)capture mixed matrix membranes

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A froth velocity measurement method based on improved U-Net++semantic segmentation in flotation process

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1816-1827页

作者： Yiwei chen Degang Xu Kun wan School of Automation Central South UniversityChangsha 410083China

During flotation,the features of the froth image are highly correlated with the concentrate grade and the corresponding working *** static features such as color and size of the bubbles and the dynamic features such as velocity have obvious differences between different working *** extraction of these features is typically relied on the outcomes of image segmentation at the froth edge,making the segmentation of froth image the basis for studying its visual ***,the absence of scientifically reliable training data with label and the necessity to manually construct dataset and label make the study difficult in the mineral *** solve this problem,this paper constructs a tungsten concentrate froth image dataset,and proposes a data augmentation network based on Conditional Generative Adversarial Nets(cGAN)and a U-Net++-based edge segmentation *** performance of this algorithm is also evaluated and contrasted with other algorithms in this *** the results of semantic segmentation,a phase-correlationbased velocity extraction method is finally suggested.

关键词： froth flotation froth segmentation froth image data augmentation velocity extraction image features

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Fe-N-C core-shell catalysts with single low-spin Fe(Ⅱ)-N_(4)species for oxygen reduction reaction and high-performance proton exchange membrane fuel cells

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Journal of Energy Chemistry 2024年第6期93卷 538-546,I0013页

作者： Yan wan Linhui Yu Bingxin Yang Caihong Li chen Fang wei Guo Fang-Xing Xiao Yangming Lin Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021FujianChina CAS Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021FujianChina Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002FujianChina College of Materials Science and Engineering Fuzhou UniversityNew CampusMinhou 350108FujianChina College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117FujianChina

Fe-N-doped carbon materials(Fe-N-C)are promising candidates for oxygen reduction reaction(ORR)relative to Pt-based catalysts in proton exchange membrane fuel cells(PEMFCs).However,the intrinsic contributions of Fe-N_(4)moiety with different chemical/spin states(e.g.D1,D2,D3)to ORR are unclear since various states coexist *** the present work,Fe-N-C core-shell nanocatalyst with single lowspin Fe(Ⅱ)-N_(4)species(D1)is synthesized and identified with ex-situ ultralow temperature Mossbauer spectroscopy(T=1.6 K)that could essentially differentiate various Fe-N_(4)states and invisible Fe-O *** quantifying with CO-pulse chemisorption,site density and turnover frequency of Fe-N-C catalysts reach 2.4×10^(-9)site g^(-1)and 23 e site~(-1)s^(-1)during the ORR,***-wave potential(0.915V_(RHE))of the Fe-N-C catalyst is more positive(approximately 54 mV)than that of Pt/***,we observe that the performance of PEMFCs on Fe-N-C almost achieves the 2025 target of the US Department of Energy by demonstrating a current density of 1.037 A cm^(-2)combined with the peak power density of 0,685 W cm^(-2),suggesting the critical role of Fe(Ⅱ)-N_(4)site(D1).After 500 h of running,PEMFCs still deliver a power density of 1.26 W cm^(-2)at 1.0 bar H_(2)-O_(2),An unexpected rate-determining step is figured out by isotopic labelling experiment and theoretical *** work not only offers valuable insights regarding the intrinsic contribution of Fe-N_(4)with a single spin state to alkaline/acidic ORR,but also provides great opportunities for developing high-performance stable PEMFCs.

关键词： Fuel cells Oxygen reduction reaction Non-platinum group metals(PGMs) Isotopic labelling Active site TOF

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Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

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World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： Le Ding Li-wan wei Tai-Song Li Jing chen Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)Translational Medical Research Center Co.Ltd.Beijing 101111China

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve *** in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language *** SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B *** individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were *** article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment *** the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had *** treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat *** exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(***1825trp),c.4120C>T(***1374*,593),c.14_15insC(***5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language *** the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of ***,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SETD1B gene Whole-exome sequencing New mutation Case report

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Cancer Incidence And Mortality in China,2006

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Chinese Journal of Cancer Research 2011年第1期23卷 3-9页

作者： wan-qing chen Si-wei Zhang Xiao-nong Zou Ping Zhao National Office for Cancer Prevention and Control/National Central Cancer Registry Cancer InstituteChinese Academy of Medical SciencesBeijing 100021China

Objective：To describe the cancer incidence and mortality rates in 2006 and evaluate the cancer burden in ***：Cancer registration data in 2006 from 34 cancer registries were collected,evaluated and pooled to calculate cancer incidence and mortality *** data analyses included mortality to incidence ratio（MI）,morphological verification percentage（MV%） and proportion of death certification only（DCO%）.Cumulative incidence and mortality rates were calculated using crude data,age-standardized data,and specific data for cancer site,age,sex and area（urban or rural）.Results：In 2006,34 registries with qualified registration data covered a total population of 59,567,322（46,558,108 in urban areas and 13,009,214 in rural areas）.The crude and age-standardized cancer incidence rates were 273.66 per 100,000 and 190.54 per 100,000,*** crude and age-standardized cancer mortality rates were 175.70 per 100,000 and 117.67 per 100,000,*** of lung,stomach,colon and rectum,liver,and breast in female were the five most common forms of cancer in China,which accounted for 58.99% of all new cancer *** cancer was the leading cause of cancer death,followed by stomach cancer,liver cancer,esophageal cancer and colorectal ***：Cancer is still an important public health issue in China with an increasing disease ***,the incidence rates for lung cancer,colorectal cancer and breast cancer were increasing,but those for stomach cancer and esophageal cancer were ***,age-specific incidence rate remained stable,indicating that the aging population was the major source of the increasing cancer burden.

关键词： Cancer Cancer registration Incidence Mortality

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Targeting stroma and tumor,silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2024年第1期14卷 292-303页

作者： Tahereh Setayesh Ying Hu Farzam Vaziri Xin chen Jinping Lai Dongguang wei Yu-Jui Yvonne wan Department of Medical Pathology and Laboratory Medicine University of CaliforniaDavisSacramentoCA 95817USA Cancer Biology Program the University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting *** data showed that Gal1 was highly expressed in human and mouse *** levels of Gal1 positively correlated with the stages of human HCC and negatively with *** roles of Gal1 in HCC were studied using overexpression(OE)or silencing using Igals1 siRNA delivered by *** to HCC initiation induced by RAS and AKT mutations,lgals1-OE and silencing had opposite impacts on tumor *** treatment effect of lgals1 siRNAwas further demonstrated by intersecting HCC at different time points when the tumor load had already reached 9%or even 42%of the body *** spatial transcriptomic profiles of Gal1 silenced and OE HCC,inhibiting matrix formation and recognition of foreign antigen in CD45t cell-enriched areas located at tumor-margin likely contributed to the anti-HCC effects of Gal1 *** the tumors,silencing Gal1 inhibited translational initiation,elongation,and ***,Gal1 silencing increased immune cells as well as expanded cytotoxic T cells within the tumor,and the anti-HCC effect of lgals1 siRNAwas ***,Gal1 silencing has a promising potential for HCC treatment.

关键词： Liver Hepatocellular carcinoma Carbohydrate-binding lectin Galectin 1 Extracellular matrix Translation Spatial transcriptomics Tumor-margin

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The breaking of spin symmetry in the single-particle resonances in deformed nuclei

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Nuclear Science and Techniques 2024年第3期35卷 237-245页

作者： Zhen-Yu Zheng Shou-wan chen Quan Liu School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China

The exploration of spin symmetry (SS) in nuclear physics has been instrumental in identifying atomic nucleus *** this study,we solve the Dirac equation from the relativistic mean field (RMF) in complex momentum *** investigated SS and its breaking in single-particle resonant states within deformed nuclei,with a focus on the illustrative *** was the initial discovery of a resonant spin doublet in a deformed nucleus,with the expectation of the SS approaching the continuum *** increasing single-particle energy,the splitting of the resonant spin doublets widened *** escalating splitting implies diminishing adherence to the SS,indicating a departure from the expected behavior as the energy levels *** also analyzed the width of the resonant states,showing that lower orbital angular momentum resonances possess shorter decay times and that SS is preserved within broad resonant doublets,as opposed to narrow resonant *** the radial density of the upper components for the bound-state and resonant-state doublets,it becomes evident that while SS is well-preserved in the bound states,it deteriorates in the resonant *** impact of nuclear deformation (β_(2)) on SS was examined,demonstrating that an increase in β_(2) resulted in higher energy and width splitting in the resonant spin doublets,which is attributed to increased component ***,the sensitivity of spin doublets to various potential parameters such as surface diffuseness (a),radius (R),and depth (Σ0) is discussed,emphasizing the role of these parameters in *** study provides valuable insights into the behavior of spin doublets in deformed nuclei and their interplay with the nuclear structure,thereby advancing our understanding of SS in the resonance state.

关键词： Spin symmetry Resonant states Deformed nuclei Complex-momentum representation

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Production performance analysis of a continental shale oil reservoir in Bohai Bay basin

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Petroleum 2024年第2期10卷 294-305页

作者： Quansheng Guan Changwei chen Xiugang Pu Yonggang wan Jing Xu Haiwei Zeng chen Jia Huanhuan Gao wei Yang Zesen Peng China University of Petroleum Exploration & Development Research Institute of Dagang Oilfield CNPC Unconventional Petroleum Research Institute China University of Petroleum

Due to the extremely low permeability of shale formations, the combination of horizontal well and volume fracturing has been proposed as an effective technique to improve the production of Dagang continental shale oil reservoirs. Based on the flow material balance method(FMB) and straight-line analysis(SLA) method, the stimulated reservoir volume(SRV) and drainage volume are determined to identify the flow regimes of the seepage mechanism of shale oil reservoirs. To resolve the challenges of multi-scaled flow regimes and bottom hole pressure(BHP) variation before and after pumping in shale oil wells, a multi-linear analytical flow model was established to predict the future production and the final expected ultimate recoverable oil(EURo) after fitting the historical production dynamics. Based on the results, it can be concluded that the flow regime of a shale oil well in production can be divided into two stages consisting of linear flow within SRV and composite flow from the un-stimulated area to *** effects of fracturing operation parameters, such as fracturing fluid volume and sand/liquid ratio, on shale oil productivity, are analyzed, and insightful suggestions are drawn for the future development of this pay zone.

关键词： Shale oil reservoirs Rate transient analysis Flow material balance Analytical multi-linear model Production performance

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