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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Experimental study on behavior of mortar-aggregate interface after elevated temperatures

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Frontiers of Structural and Civil Engineering 2017年第2期11卷 158-168页

作者： wan wang Jianzhuang XIAO Shiying XU Chunhui wang Department of Structural Engineering Tongji University Shanghai 200092 China

A push-out test program was designed and conducted to study the meso-scale behavior of mortaraggregate interface for concrete after elevated temperatures ranging from 20℃ to 600℃ with the concept of modeled concrete （MC） and modeled recycled aggregate concrete （MRAC）. The MCs and MRACs were designed with different strength grade of mortar and were exposed to different elevated temperatures. Following that the specimens were cooled to room temperature and push-out tests were conducted. Failure process and mechanical behaviors were analyzed based on failure modes, residual load-displacement curves, residual peak loads and peak displacements. It is found that failure modes significantly depended on specimen type, the elevated temperature and the strength grade of mortar. For MC, major cracks started to propagate along the initial cracks caused by elevated temperatures at about 80% of residual peak load. For MRAC, the cracks appeared at a lower level of load with the increasing elevated temperatures. The cracks connected with each other, formed a failure face and the specimens were split into several parts suddenly when reaching the residual peak load. Residual load-displacement curves of different specimens had similarities in shape. Besides, effect of temperatures and strength grade of mortar on residual peak load and peak displacement were analyzed. For MC and MRAC with higher strength of new hardened mortar, the residual peak load kept constant when the temperature is lower than 400℃ and dropped by 43.5% on average at 600℃. For MRAC with lower strength of new hardened mortar, the residual peak load began to reduce when the temperatures exceeded 200℃ and reduced by 27.4% and 60.8% respectively at 400℃ and 600℃. The properties of recycled aggregate concrete （RAC） may be more sensitive to elevated temperatures than those of natural aggregate concrete （NAC） due to the fact that the interracial properties of RAC are lower than those of NAC, and are deteriorated at lower

关键词： mortar-aggregate interface push-out test elevated temperatures modeled concrete (MC) modeled recycled aggregate concrete (MRAC)

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EFFECT OF A MOVING BOUNDARY ON THE FLUID TRANSIENT FLOW IN LOW PERMEABILITY RESERVOIRS

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Journal of Hydrodynamics 2012年第3期24卷 391-398页

作者： LUO wan-Jing wang Xiao-dong School of Energy Resources China University of Geosciences Beijing 100083 China

In a low permeability reservoir, the existence of a moving boundary is considered in the study of the transient porous flow with threshold pressure gradient. The transmission of the moving boundary directly indicates the size of the drainage area as well as the apparent influences on the pressure behavior. The nonlinear transient flow mathematical model in which the threshold pressure gradient and the moving boundary are incorporated is solved by advanced mathematical methods. This paper presents some new analytical solutions describing the pressure distribution at a constant rate and the production decline in a constant pressure production with the boundary propagation. It is shown that the greater the threshold pressure gradient, the slower the transmission of the moving boundary, the larger the pressure loss will be, and there is no radial flow in the middle and later phases of the wellface pressure for a well at a constant rate. We have the the maximum moving boundary at a specific drawdown pressure for a low permeability reservoir The greater the threshold pressure gradient, the smaller the maximum moving boundary distance, the quicker the production decline for a well in a constant pressure production will be. The type curve charts for the modern well test analysis and the rate transient analysis with a moving boundary are obtained and the field test and the production data are interpreted as examples to illustrate how to use our new results.

关键词： threshold pressure gradient moving boundary well test analysis low permeability reservoir rate transient analysis

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Stability and Hopf bifurcation of a delayed ratio-dependent predator-prey system

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Acta Mechanica Sinica 2011年第2期27卷 285-296页

作者： wan-Yong wang Li-Jun Pei School of Aerospace Engineering and Applied Mechanics Tongji University 200092 Shanghai China Department of Mathematics Zhengzhou University 450001 Zhengzhou China

Since the ratio-dependent theory reflects the fact that predators must share and compete for food, it is suitable for describing the relationship between predators and their preys and has recently become a very important theory put forward by biologists. In order to investigate the dynamical relationship between predators and their preys, a so-called Michaelis-Menten ratio-dependent predator-prey model is studied in this paper with gestation time delays of predators and preys taken into consideration. The stability of the positive equilibrium is investigated by the Nyquist criteria, and the existence of the local Hopf bifurcation is analyzed by employing the theory of Hopf bifurcation. By means of the center manifold and the normal form theories, explicit formulae are derived to determine the stability, direction and other properties of bifurcating periodic solutions. The above theoretical results are validated by numerical simulations with the help of dynamical software WinPP. The results show that if both the gestation delays are small enough, their sizes will keep stable in the long run, but if the gestation delays of predators are big enough, their sizes will periodically fluc-tuate in the long term. In order to reveal the effects of time delays on the ratio-dependent predator-prey model, a ratiodependent predator-prey model without time delays is considered. By Hurwitz criteria, the local stability of positive equilibrium of this model is investigated. The conditions under which the positive equilibrium is locally asymptotically stable are obtained. By comparing the results with those of the model with time delays, it shows that the dynamical behaviors of ratio-dependent predator-prey model with time delays are more complicated. Under the same conditions, namely, with the same parameters, the stability of positive equilibrium of ratio-dependent predator-prey model would change due to the introduction of gestation time delays for predators and preys. Moreover, w

关键词： Time delays · Stability · Hopf bifurcation · Normal form · Center manifold

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New family of piecewise smooth support vector machine

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Journal of Systems Engineering and Electronics 2015年第3期26卷 618-625页

作者： Qing Wu Leyou Zhang wan wang School of Automation Xi'an University of Posts and Telecommunications School of Mathematics and Statistics Xidian University School of Computer Science and Technology Xi'an University of Posts and Telecommunications

Support vector machines （SVMs） have been extensively studied and have shown remarkable success in many applications. A new family of twice continuously differentiable piecewise smooth functions are used to smooth the objective function of uncon- strained SVMs. The three-order piecewise smooth support vector machine （TPWSSVMd） is proposed. The piecewise functions can get higher and higher approximation accuracy as required with the increase of parameter d. The global convergence proof of TPWSSVMd is given with the rough set theory. TPWSSVMd can efficiently handle large scale and high dimensional problems. Nu- merical results demonstrate TPWSSVMa has better classification performance and learning efficiency than other competitive base- lines.

关键词： support vector machine (SVM) piecewise smooth function smooth technique bound of convergence.

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Desulfurization ability of refining slag with medium basicity

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International Journal of Minerals,Metallurgy and Materials 2014年第12期21卷 1160-1166页

作者： Hui-xiang Yu Xin-hua wang Mao wang wan-jun wang State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The desulfurization ability of refining slag with relative lower basicity （B） and Al2O3 content （B = 3.5-5.0; 20wt%-25wt% Al2O3） was studied. Firstly, the component activities and sulfide capacity （Cs） of the slag were calculated. Then slag-metal equilibrium experiments were carried out to measure the equilibrium sulfur distribution （Ls）. Based on the laboratorial experiments, slag composition was optimized for a better desulfurization ability, which was verified by industrial trials in a steel plant. The obtained results indicated that an MgO-saturated CaO-Al2O3-SiO2-MgO system with the basicity of about 3.5-5.0 and the Al2O3 content in the range of 20wt%-25wt% has high activity of CaO （αCaO）, with no deterioration of Cs compared with conventional desulfurization slag. The measured Ls between high-strength low-alloyed （HSLA） steel and slag with a basicity of about 3.5 and an Al2O3 content of about 20wt% and between HSLA steel and slag with a basicity of about 5.0 and an Al2O3 content of about 25wt% is 350 and 275, respectively. The new slag with a basicity of about 3.5-5.0 and an Al2O3 content of about 20wt% has strong desulfurization ability. In particular, the key for high-efficiency desulfurization is to keep oxygen potential in the reaction system as low as possible, which was also verified by industrial trials.

关键词： high-strength steel low alloyed steel refining slag basicity desulfurization thermodynamic calculations

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Painlevéanalysis,infinite dimensional symmetry group and symmetry reductions for the(2+1)-dimensional Korteweg-de Vries-Sawada-Kotera-Ramani equation

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Communications in Theoretical Physics 2023年第8期75卷 63-68页

作者： Bo Ren Ji Lin wan-Li wang Department of Mathematics Zhejiang University of TechnologyHangzhou 310014China Department of Physics Zhejiang Normal UniversityJinhua 321004China

The(2+1)-dimensional Korteweg–de Vries–Sawada–Kotera–Ramani(KdVSKR)equation is studied by the singularity structure *** is proven that it admits the Painlevé*** Lie algebras which depend on three arbitrary functions of time t are obtained by the Lie point symmetry *** is shown that the KdVSKR equation possesses an infinite-dimensional Kac–Moody–Virasoro symmetry *** selecting first-order polynomials in t,a finite-dimensional subalgebra of physical transformations is *** commutation relations of the subalgebra,which have been established by selecting the Laurent polynomials in t,are *** symmetry constitutes a centerless Virasoro algebra which has been widely used in the field of ***,the similarity reduction solutions of the model are studied by means of the Lie point symmetry theory.

关键词： KdVSKR equation Painleve analysis Lie point symmetry Kac-Moody-Virasoro algebra

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Review of non-reactive CaO-Al2O3-based mold fluxes for casting high-aluminum steel

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Journal of Iron and Steel Research International 2019年第4期26卷 336-344页

作者： Lei Zhang wan-lin wang Han-qing Shao School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina

Advanced high-strength steels (AHSSs) have been gradually applied to modern auto industry, as they have the advantages of improving the steel strength and lightening the car weight, which not only ensures the safety but also saves the energy. However, the high-aluminum (Al) content in AHSSs may react with SiO2 in conventional CaO-SiO2-based mold flux during the process of continuous casting, which leads to the deterioration of the mold flux properties and a poor slab quality. Then, the non-reactive CaO-Al2O3-based mold flux was proposed and has been developing for the casting process of high-Al steels, but there are some problems of low consumption and insufficient lubrication that need to be solved. Thus, previous researches on the effect of each component on the properties of CaO-Al2O3-based mold flux were systematically summarized, and the situation of plant trials on CaO-Al2O3-based mold flux was evaluated. The results indicated that the proposed CaO-Al2O3-based mold fluxes could avoid the slag-metal reaction problems;however, the problems of lubri-cation, crystallization and heat transfer issues still exist. Therefore, tremendous works still need to be conducted for the development of new generation of CaO-Al2O3-based mold flux system. The review was performed aiming to provide a technical guidance for designing and optimizing CaO-Al2O3-based mold flux system that meets the demand of the continuous casting process of high-Al steels.

关键词： High-Al steel CaO-Al2O3-based mold flux Thermophysical property Lubrication Crystallization

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Reproductive polyphenism and its advantages in aphids:Switching between sexual and asexual reproduction

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Journal of Integrative Agriculture 2020年第6期19卷 1447-1457页

作者： YAN Shuo wang wan-xing SHEN Jie Department of Entomology/MOA Key Lab of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193P.R.China Key Lab of Biology and Genetic Improvement of Root and Tuber Crops Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081P.R.China

Reproductive polyphenism,which allows one genotype to produce sexual and asexual morphs,is an extreme case of phenotypic plasticity and is commonly observed in *** are typical species that switch these reproductive modes,and the pathway orientation is triggered by the environmental conditions(mainly photoperiod and temperature).The typical arm ual life of aphids in eludes a successi on of parthenogenetic gen erations duri ng the spri ng and summer and a single sexual generation in *** this review,we describe how the environmental cues orientate the reproductive mode of aphids from photoperiodic perception to endocrine regulation,and how juvenile hormones may act on the target cells(oocytes)to initiate the gametogenesis and embryogenesis in sexual and asexual *** also discuss the paradox of sex,especially the advantages of sexual reproduction in *** the recent development of genomic resources in aphids,many potential genes involved in the reproductive polyphenism will enter the public's *** particular,we describe a novel RNAi method in aphids,which may provide a molecular technique for determining the developmental fate and multiple reproductive strategies.

关键词： aphids parthenogenesis embryogenesis gametogenesis photoperiodism

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Oxidation and interdiffusion behavior of a germanium-modified silicide coating on an Nb–Si-based alloy

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International Journal of Minerals,Metallurgy and Materials 2017年第3期24卷 289-296页

作者： Jin-long Li wan wang Chun-gen Zhou Department of Materials Science and Engineering Beihang University Beijing 100191 China

To investigate the interdiffusion behavior of Ge-modified silicide coatings on an Nb–Si-based alloy substrate,the coating was oxidized at 1250°C for 5,10,20,50,or 100 *** interfacial diffusion between the(Nb,X)(Si,Ge)_2(X = Ti,Cr,Hf) coating and the Nb–Si based alloy was also *** transitional layer is composed of(Ti,Nb)_5(Si,Ge)_4 and a small amount of(Nb,X)_5(Si,Ge)_*** increasing oxidation time,the thickness of the transitional layer increases because of the diffusion of Si from the outer layer to the substrate,which obeys a parabolic rate *** parabolic growth rate constant of the transitional layer under oxidation conditions is 2.018 μm×h^(-1/2).Moreover,the interdiffusion coefficients of Si in the transitional layer were determined from the interdiffusion fluxes calculated directly from experimental concentration profiles.

关键词： silicides coatings intermetallics oxidation interdiffusion

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