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What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments?

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Military Medical Research 2024年第2期11卷 268-286页

作者： Li-Tao Zhao Zhen-Yu Liu wan-Fang Xie Li-Zhi Shao jian Lu Jie Tian jian-Gang Liu School of Engineering Medicine Beihang UniversityBeijing 100191China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China CAS Key Laboratory of Molecular Imaging Institute of AutomationBeijing 100190China University of Chinese Academy of Sciences Beijing 100080China Department of Urology Peking University Third HospitalPeking UniversityBeijing 100191China Key Laboratory of Big Data‑Based Precision Medicine(Beihang University) Ministry of Industry and Information Technology of the People's Republic of ChinaBeijing 100191China Beijing Engineering Research Center of Cardiovascular Wisdom Diagnosis and Treatment Beijing 100029China

The present study aimed to explore the potential of artificial intelligence(AI)methodology based on magnetic resonance(MR)images to aid in the management of prostate cancer(PCa).To this end,we reviewed and summarized the studies comparing the diagnostic and predictive performance for PCa between AI and common clinical assessment methods based on MR images and/or clinical characteristics,thereby investigating whether AI methods are generally superior to common clinical assessment methods for the diagnosis and prediction fields of ***,we found that,in the included studies of the present study,AI methods were generally equal to or better than the clinical assessment methods for the risk assessment of PCa,such as risk stratification of prostate lesions and the prediction of therapeutic outcomes or PCa *** particular,for the diagnosis of clinically significant PCa,the AI methods achieved a higher summary receiver operator characteristic curve(SROC-AUC)than that of the clinical assessment methods(0.87 vs.0.82).For the prediction of adverse pathology,the AI methods also achieved a higher SROC-AUC than that of the clinical assessment methods(0.86 vs.0.75).Second,as revealed by the radiomics quality score(RQS),the studies included in the present study presented a relatively high total average RQS of 15.2(11.0–20.0).Further,the scores of the individual RQS elements implied that the AI models in these studies were constructed with relatively perfect and standard radiomics processes,but the exact generalizability and clinical practicality of the AI models should be further validated using higher levels of evidence,such as prospective studies and open-testing datasets.

关键词： Clinically significant prostate cancer Adverse pathology Radiomics quality score Artificial intelligence Magnetic resonance imaging

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Postoperative pneumocranium after endoscopic transnasal optic canal decompression

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 973-975页

作者： Sheng-jian Lu bo Yu Wen-Can Wu The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Dear Editor,We present the first time,a case of a patient developed cerebrospinal fluid(CSF)leak and pneumocranium following optic canal decompression(OCD).INTRODUCTION Indirect traumatic optic neuropathy(ITON)impairs visual functions and quality of *** transnasal optic canal decompression(ETOCD)is one of the standard treatment strategies for the *** the ETOCD,the optic nerve sheath are usually incised for sufficient decompression of optic nerve after removal of optic canal,which is associated with complications like CSF leakage,ophthalmic artery injury,and optic nerve injury[1].Generally,the mild CSF leak is common and can heal spontaneously using conventional treatment,the severe CSF leak requires surgical repair[2].

关键词： decompression nasal traumatic

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Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine

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Chinese Journal of Chemistry 2024年第8期42卷 873-878页

作者： jian Long Zhiwu Lu Xiao-Lin Li Peng Xue Wen-bo Liu Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)and College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving intermolecular regioselective arylation and intramolecular nitrile addition, enabling the synthesis of enantioenriched azepine derivatives. This reaction simultaneously installs an all-carbon quaternary stereocenter and introduces an unprotected imine functionality, showing great promise for subsequent transformations. The reaction exhibits good tolerance toward various functional groups, resulting in high yields and enantioselectivities. The synthetic utility of this methodology is further demonstrated through gram-scale synthesis and product derivatization. This research offers an efficient approach to the synthesis of seven-membered nitrogen heterocycles.

关键词： Nickel Asymmetric catalysis N-Heterocycles Alkyne functionalization Quaternary centers

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Adverse effect of niobium and boron on hot deformation behavior of sulfur-containing steel

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Journal of Iron and Steel Research International 2024年第1期31卷 252-263页

作者： Guo-ning He Shi-qi wan bo jiang Chao-lei Zhang Ya-zheng Liu Chun-jing Wu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China

The hot deformation behaviors of sulfur-containing gear steel 20MnCr5 containing three different contents of Nb and B(0,0.021%Nb,and 0.024%Nb-0.0022%B)were *** compression and tenssion tests were carried out by Gleeble3800 at the austenite region from 850 to 1150℃and the adverse effects of Nb and B were analyzed by the fracture,microstructure and precipitate *** compression tests showed that the proportions of instable area in hot processing maps of 0.021%Nb and Nb-B steels were higher and the deformability of Nb free steel was *** tensile deformation experiments showed that the reduction areas of Nb free,0.021%Nb and Nb-B steels were 92%-99%,84%-98%and 67%-97%,*** addition of Nb or Nb and B inhibited the dynamic recrystallization during hot deformation,and consequently,more deformed grains were then formed in 0.021%Nb and Nb-B steels thus to obtain the microstructure with worse uniformity and then deteriorate the *** addition,the interaction between inclusions and microalloyed elements was also *** particles of 0.021%Nb and Nb-B steels dynamically precipitated during deformation and precipitated together with MnS thus to worsen the deformability,resulting in the decrease of reduction area.

关键词： Hot deformation Gear steel Processing map Dynamic recrystallization Microalloying

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Impact Analysis of Microscopic Defect Types on the Macroscopic Crack Propagation in Sintered Silver Nanoparticles

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 441-458页

作者： Zhongqing Zhang bo wan Guicui Fu Yutai Su Zhaoxi Wu Xiangfen wang Xu Long School of Reliability and Systems Engineering Beihang UniversityBeijing100191China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China China Aerospace Components Engineering Center Beijing100098China

Sintered silver nanoparticles(AgNPs)arewidely used in high-power electronics due to their exceptional ***,the material reliability is significantly affected by various microscopic *** this work,the three primary micro-defect types at potential stress concentrations in sintered AgNPs are identified,categorized,and *** dynamics(MD)simulations are employed to observe the failure evolution of different microscopic *** dominant mechanisms responsible for this evolution are dislocation nucleation and dislocation *** the same time,this paper clarifies the quantitative relationship between the tensile strain amount and the failure mechanism transitions of the three defect types by defining key strain *** impact of defect types on the failure process is also ***,traction-separation curves extracted from microscopic defect evolutions serve as a bridge to connect the macro-scale *** validity of the crack propagation model is confirmed through tensile ***,we thoroughly analyze how micro-defect types influence macro-crack propagation and attempt to find supporting evidence from the MD *** findings provide a multi-perspective reference for the reliability analysis of sintered AgNPs.

关键词： Sintered silver nanoparticles defect types microscopic defect evolution macroscopic crack propagation molecular dynamics simulation cohesive zone model

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BaCe_(0.8)Fe_(0.1)Ni_(0.1)O_(3−δ)-impregnated Ni-GDC by phase-inversion as an anode of solid oxide fuel cells with on-cell dry methane reforming

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Journal of Advanced Ceramics 2024年第6期13卷 834-841页

作者： Yanya Liu Jun Luo Cheng Li bo Liu Dong Yan jian Li Lichao Jia School of Materials Science and Engineering State Key Laboratory of Materials Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074China

BaCe_(0.8)Fe_(0.1)Ni_(0.1)O_(3−δ)(BCFN)in a perovskite structure is impregnated consecutively by BCFN solution and BCFN suspension into a phase-inversion prepared NiO–Gd_(0.1)Ce_(0.9)O_(2−δ)(GDC)scaffold as an anode for solid oxide fuel cells(SOFCs)with on-cell dry reforming of methane(DRM).The whole pore surface of the scaffold is covered by small BCFN particles formed by BCFN solution impregnation;the large pores near the scaffold surface are filled by BCFN aerogels with a high specific surface area produced by BCFN suspension impregnation,which act as a catalytic layer for on-cell *** reduction,the anode consists of a Ni–GDC scaffold and BCFN particles with exsolved FeNi3 *** BCFN-impregnated Ni–GDC anode has higher electrical conductivity,electrochemical activity,and resistance to carbon deposition,with which the cell shows maximum power densities between 1.44 and 0.92 W·cm^(−2) when using H_(2) and between 1.09 and 0.50 W·cm^(−2) when using CO_(2)–CH_(4) at temperatures ranging from 750 to 600℃.A stable performance at 400 mA·cm^(−2) and 700℃is achieved using 45%CO_(2)–45%CH_(4)–10%N_(2) for more than 400 h without carbon deposition,benefiting from the impregnated BCFN aerogel with a high specific surface area and water adsorbability.

关键词： aerogel solid oxide fuel cells(SOFCs) phase-inversion dry reforming of methane(DRM) carbon resistance

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Prognostic value of ultrasound in early arterial complications post liver transplant

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 13-20页

作者： Ning-bo Zhao Yi Chen Rui Xia jian-bo Tang Dong Zhao Department of Ultrasound National Clinical Research Centre for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina Department of Thyroid and Hernia Surgery The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 51800Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina

Liver transplantation is the primary therapeutic intervention for end-stage liver ***,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** clinical manifestations associated with early arterial complications following liver transplantation are often *** timely intervention,these complications can result in graft fai-lure or patient ***,early diagnosis and the formulation of an op-timal treatment plan are *** examination remains the pre-dominant imaging modality for detecting complications post liver *** article comprehensively reviews common causes and clinical present-ations of early hepatic artery complications in the post-transplantation period and delineates abnormal sonographic findings for accurate diagnosis of these ***,ultrasound offers the advantages of convenience,safety,effect-iveness,and *** enables real-time,dynamic,and precise evalua-tion,making it the preferred diagnostic method for post-liver transplantation *** Liver transplantation stands as the primary therapeutic approach for end-stage liver *** advancements in surgical techniques and the application of novel immunosuppressive agents contribute to ongoing improvements in the success rate and overall survival in patients undergoing liver transplantation *** these advan-cements,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** the early stages following liver transplantation(within the first 30 d),proper hepatic artery function is crucial for hepatic arterial blood *** later stages,collateral circulation,including arteries such as the phrenic artery,right gastric artery,and gastroduodenal artery,becomes important for maintaining hepatic blood *** is now understood that the establishment of effective collat

关键词： Liver transplantation Vascular complication Arterial complication Ultrasound

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The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei Shi Yang Yan Chun-sheng Shao Kun Yu bo Zhang Liang-jian Chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1Y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5Y-2.5Nd was as a *** then investigated the effect of additions of Y and Mn on alloys'*** results show that Mn and Y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility bone regeneration bone defect repair

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Programmable repulsive potential for tight-binding from Chen-Möbius inversion theorem

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 71-83页

作者： jian-Gao Li Jin-Kun Tang Hong-Quan Song Gotthard Seifert Dong-bo Zhang College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China Department of Physics Beijing Normal UniversityBeijing 100875China College of Physics and Telecommunication Engineering Zhoukou Normal UniversityZhoukou 466001China Theoretische Chemie Technische Universität DresdenDresden D-01062Germany

An accurate total energy calculation is essential in materials *** date,many tight-binding(TB)approaches based on parameterized hopping can produce electronic structures comparable to those obtained using first-principles ***,TB approaches still have limited applicability for determining material properties derived from the total *** is,the predictive power of the TB total energy is impaired by an inaccurate evaluation of the repulsive *** complexity associated with the parametrization of TB repulsive potentials is the weak link in this *** this study,we propose a new method for obtaining the pairwise TB repulsive potential for crystalline materials by employing the Chen-Möbius inversion *** show that the TB-based phonon dispersions,calculated using the resulting repulsive potential,compare well with those obtained by first-principles calculations for various systems,including covalent and ionic bulk materials and twodimensional *** present approach only requires the first-principles total energy and TB electronic band energy as input and does not involve any *** striking feature enables us to generate repulsive potentials programmatically.

关键词： tight binding first-principles calculation total energy repulsive potential phonon dispersion

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Exosomal microRNAs in hepatocellular carcinoma,expanding research field

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World Journal of Gastroenterology 2024年第20期30卷 2618-2620页

作者： bo-Hao Zheng Xiao-jian Ni Hou-Bao Liu Department of Biliary Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Biliary Tract Disease Center of Zhongshan Hospital Fudan UniversityShanghai 200032China Biliary Tract Disease Institute Fudan UniversityShanghai 200032China Cancer Center Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Biliary Tract Minimal Invasive Surgery and Materials Engineering Research Center Shanghai 200032China

In this editorial we comment on the review by wang et al published in the recent issue of the World Journal of Gastroenterology in *** extracellular vesicles(exosomes)play important roles in the tumor *** this review,the authors introduce the following points:(1)The composition and function of exosomal microRNAs(miRNAs)of different cell origins in hepatocellular carcinoma(HCC);(2)the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC;and(3)the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of *** addition,the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was *** this review,the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC,which provides a deeper understanding of exosomal miRNAs to the readers.

关键词： Exosomes MicroRNA Hepatocellular carcinoma Liver cancer Tumor microenvironment

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