检索结果-南通市图书馆

The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第1期34卷 36-43页

作者： Ho-Eun Park Kyung-Hyo Do wan-Kyu lee College of Veterinary Medicine Chungbuk National UniversityCheongjuChungbuk 28644Republic of Korea.

The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15(JW15)isolated from Kimchi in RAW 264.7 *** immune effects were evaluated by measuring the production of NO,cytokines,inflammatory enzyme,and activation of NF-κ*** JW15 executed higher activity on stimulating the release of TNF-αas well as activating NF-κB compared to that of heatkilled ***,viable and heat-killed JW15 significantly increased the production of NO,IL-6 and TNF-αmore than that of Lactobacillus rhamnosus GG(LGG).Furthermore,viable JW15 induced higher production of i NOS compared with that of viable ***,our finding indicates that viable JW15 had similar,if not more,immune-enhancing activities as heat-killed *** addition,viable JW15 had higher immune-enhancing activity than commercial strain ***,viable JW15 has the potential to be used as a functional food to improve the host immune response.

关键词： Weissella cibaria JW15 probiotics immune-enhancing effect heat-killed probiotics viable probiotics

Tyrosine-mediated analog resistive switching for artificial neural networks

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung lee Jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-sik lee Jong-Seok lee Ki Tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun lee Min-Kyu lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon Na Chang-Bun Yoon SeKwon Oh Tae-sik Jang Hyun-Do Jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2022年第4期11卷 87-101页

作者： Jun sik Eom Da Som Park Sang Jin lee Bon-Hee Gu Shin Ja lee Sang-Suk lee Seon-Ho Kim Byeong-Woo Kim Sung Sill lee Myunghoo Kim Institute of Agriculture and Life Science Gyeongsang National UniversityJinju52828Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered Labs Gyeongsang National UniversityJinju52828Republic of Korea Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Heat stress(HS)damages livestock by adversely affecting physiological and immunological ***,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in *** understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed *** integrated approach allowed the discovery of HS-sensitive metabolic and immunological *** metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and ***,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related ***,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological *** would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers.

关键词： Heat stress Jersey steer Metabolome Transcriptome Immunity Metabolism

Lithospheric thinning and ignition of a Cordilleran magmatic flare-up:Geochemical and O-Hf isotopic constraints from Cretaceous plutons in southern Korea

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2023年第1期14卷 327-345页

作者： Albert Chang-sik Cheong Min-Ji Jung Hui JeJo Jeongmin Kim Shinae lee Youn-Joong Jeong Korea Basic Science Institute Ochang Center Cheongju 28119Republic of Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 34134Republic of Korea Korea Institute of Geoscience and Mineral Resources Daejeon 34132Republic of Korea

Northeast Asian continental margins contain the products of magma emplacement driven by prolonged subduction of the(paleo-)Pacific *** observed in many Cordilleran arcs,magmatic evolution in this area was punctuated by high-volume pulses amid background *** present study investigates the early evolution of the Cretaceous magmatic flare-up using new and published geochronological,geochemical,and O-Hf isotope data from plutonic rocks in the southern Korean *** a long(~50 m.y.)magmatic hiatus and the development of the Honam Shear Zone through flat-slab subduction,the Cretaceous flare-up began with the intrusion of monzonites,granodiorites,and granites in the inboard Gyeonggi Massif and the intervening Okcheon *** to Jurassic granitoids formed during the former flare-up,Albian(~111 Ma)monzonites found in the Eopyeong area of the Okcheon Belt have distinctly higher zirconε_(Hf)(t)(-7.5±1.3)andδ^(18)O(7.78‰±0.25‰)values and lower wholerock La/Yb and Sr/Y *** voluminous coeval granodiorite and granite plutons in the Gyeonggi Massif are further reduced in Sr/Y and to a lesser extent,in La/Yb,and have higher zirconε_(Hf)(t)values(-13 to-19)than the Precambrian basement(ca.-30).These chemical and isotopic features indicate that Early Cretaceous lithospheric thinning,most likely resulting from delamination of tectonically and magmatically overthickened lithospheric keel that was metasomatized during prior subduction episodes,and consequent asthenospheric upwelling played vital roles in igniting the magmatic *** O-Hf isotopic ranges of synmagmatic zircons from the Albian plutons and their Paleoproterozoic and Jurassic inheritance attest to the involvement of lithospheric mantle and crustal basement in magma generation during this decratonization *** magmatism then migrated trenchward and culminated in the Late Cretaceous,yielding widespread granitoid rocks emplaced at shallow crustal *** early Late Cretaceous(94-8

关键词： Cordilleran arc Cretaceous flare-up Korean Peninsula Lithospheric thinning Crustal rejuvenation

Development of a simple model for batch and boundary information updation for a similar ship's block model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2012年第5期55卷 1019-1031页

作者： lee Hyeon-deok SON Myeong-jo OH Min-jae lee Hyung-woo KIM Tae-wan Daewoo Shipbuilding & Marine Engineering Co. LTD.Geoje 656-714South Korea Department of Naval Architecture and Ocean Engineering Seoul National UniversitySeoul 151-744South Korea Research Institute of Marine Systems Engineering Seoul National UniversitySeoul 151-744South Korea

In early 2000,large domestic shipyards introduced shipbuilding 3D computer-aided design (CAD) to the hull production design process to define manufacturing and assembly *** production design process accounts for most of the man-hours (M/H) of the entire design process and is closely connected to yard production because designs must take into account the production schedule of the shipyard,the current state of the dock needed to mount the ship’s block,and supply ***,many shipyards are investigating the complete automation of the production design process to reduce the M/H for ***,these problems are still currently unresolved,and a clear direction is needed for research on the automatic design base of manufacturing rules,batches reflecting changed building specifications,batch updates of boundary information for hull members,and management of the hull model change history to automate the production design *** this study,a process was developed to aid production design engineers in designing a new ship’s hull block model from that of a similar ship previously built,based on AVEVA *** automation system that uses the similar ship’s hull block model is proposed to reduce M/H and human errors by the production design ***,scheme files holding important information were constructed in a database to automatically update hull block model ***,for batch updates,the database’s table,including building specifications and the referential integrity of a relational database were *** particular,this study focused on reflecting the frequent modification of building specifications and regeneration of boundary information of the adjacent panel due to changes in a specific ***,the rollback function is proposed in which the database (DB) is used to return to the previously designed panels.

关键词： ship design production design model reuse model history management referential integrity scheme file

Electrochemical behavior of Nd in its pyrometallurgical recovery from waste magnet

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2015年第2期34卷 111-117页

作者： Hong-Youl Ryu Jong-Hyeon lee wan-Gou Kim Hayk H.Nersisyan Go-Gi lee Sung-Koo Jo Huk-Hee lee Il-Soon Hwang Graduate School of Green Energy Technology Chungnam National University Department of Nano Materials Engineering Chungnam National University Rapidly Solidified Materials Research Institute Chungnam National University Research Institute of Industrial Science and Technology Korea Research Institute of Chemical Technology School of Energy Systems Engineering Seoul National University

High-purity Nd metal was recovered from waste Nd–Fe–B magnet by the molten salt electrowinning process with chemical pretreatment. X-ray diffraction（XRD）, scanning electron microscopy（SEM）, energy dispersive spectroscopy（EDS）, cyclic voltammetry（CV）,chronopotentiometry（CP）, and inductively coupled plasma-atomic emission spectrometer（ICP/AES） were used to characterize the deposit and electrochemical behaviors. The results show that NdF_3 is effectively synthesized from the Nd–Fe–B magnet using HCl solution and NH4F. During the chemical treatment of the waste magnet,iron impurity is eliminated as a soluble [NH4]3[FeF6]complex. Electrowinning using NdF_3 in LiF molten salt shows that Nd metal is deposited from the electrolyte onthe cathode at the reduction potentials ranging from-1.48to-1.35 V（vs. W） with the concentration change of NdF_*** final purity of Nd metal deposit is higher than99.78 %.

关键词： Electrowinning Neodymium Nd-Fe-Bmagnet Rare earth recycling

Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第9期14卷 1530-1535页

作者： Hae June lee Yeonghoon Son Minyoung lee Changjong Moon Sung Ho Kim In sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical Sciences(KIRMAS)SeoulRepublic of Korea National Primate Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)CheongjuRepublic of Korea College of Pharmacy Kyungpook National UniversityDaeguRepublic of Korea College of Veterinary Medicine Veterinary Medical Research InstituteChonnam National UniversityGwangjuRepublic of Korea School of Medicine Wonkwang UniversityJeonbukRepublic of Korea Research Center Dongnam Institute of Radiological&Medical Sciences(DIRAMS)BusanRepublic of Korea

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain *** investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial *** impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after *** also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic ***-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** butyrate pretreatment reversed these *** findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval ***16-0002)on December 30,2016.

关键词： sodium butyrate radioprotector ionizing radiation hippocampal damage cAMP response element binding brain-derived neurotrophic factor histone deacetylase inhibitor neurogenesis

Diagnostic criteria for autoimmune chronic pancreatitis revisited

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第16期12卷 2487-2496页

作者： Kyu-Pyo Kim Myung-Hwan Kim Jong Cheol Kim Sang Soo lee Dong wan Seo Sung Koo lee Department of Internal Medicine University of Ulsan College of MedicineAsan Medical CenterSeoulKorea

Autoimmune chronic pancreatitis （AIP） is increasingly being recognized worldwidely, as knowledge of this entity builds up. Above all, AIP is a very attractive disease to clinicians in terms of its dramatic response to the oral steroid therapy in contrast to ordinary chronic pancreatitis. Although many characteristic findings of AIP have been described, definite diagnostic criteria have not been fully established. In the year 2002, the Japan Pancreas Society published the diagnostic criteria of AIP and many clinicians around the world use these criteria for the diagnosis of AIP. The diagnostic criteria proposed by the Japan Pancreas Society, however, are not completely satisfactory and some groups use their own criteria in reporting AIP. This review discusses several potential limitations of current diagnostic criteria for this increasingly recognized condition. The manuscript is organized to emphasize the need for convening a consensus to develop improved diagnostic criteria.

关键词： Autoimmune chronic pancreatitis Diagnostic criteria