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Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： Wen-ning Liu Wei Zhang Peng-yue wang Yi-xian Liu Xiang-yi Jiao Ao-xiang wan Cheng-gang wang guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property

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蝶形耳廓畸形的分型与手术修复

中华整形外科杂志 2006年第5期22卷 356-358页

作者：蒋海越潘博国冬军郭万厚庄洪兴中国协和医科大学中国医学科学院整形外科医院外耳整形再造中心北京100041

目的对具有耳廓中、下1/3发育不良和先天性招风耳、贝壳耳综合特征的蝶形耳廓畸形进行分型及手术修复。方法Ⅰ型蝶形耳廓利用软骨翻转折叠缝合法修复;Ⅱ型蝶形耳廓采用局部皮瓣转移法修复;Ⅲ型蝶形耳廓运用软组织扩张器结合自体肋软骨... 详细信息

目的对具有耳廓中、下1/3发育不良和先天性招风耳、贝壳耳综合特征的蝶形耳廓畸形进行分型及手术修复。方法Ⅰ型蝶形耳廓利用软骨翻转折叠缝合法修复;Ⅱ型蝶形耳廓采用局部皮瓣转移法修复;Ⅲ型蝶形耳廓运用软组织扩张器结合自体肋软骨支架法修复。结果2001年10月至2005年3月,应用软骨翻转折叠缝合法修复Ⅰ型蝶形耳廓4例,完全纠正了耳颅角过大,重建了耳舟和对耳轮;利用局部皮瓣法修复Ⅱ型蝶形耳廓6例,术后耳廓较对侧略小,形态满意;采用软组织扩张器结合自体肋软骨支架法修复Ⅲ型蝶形耳廓9例,术后移植软骨、皮片成活良好,耳廓和对侧大小、形态一致。结论根据蝶形耳廓畸形的严重程度将其分为Ⅰ、Ⅱ、Ⅲ型,并分别运用软骨翻转折叠缝合法、局部皮瓣转移法、软组织扩张器结合自体肋软骨支架法修复,手术效果好,适于推广。

关键词：蝶形耳廓招风耳贝壳耳

先天性小耳畸形乳突区扩张皮肤血管分型及其临床意义

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中华整形外科杂志 2007年第5期23卷 389-390页

作者：蒋海越国冬军潘博郭万厚庄洪兴中国协和医科大学整形外科医院外耳整形再造中心北京100041

目的对先天性小耳畸形乳突区扩张皮肤血管分布情况进行分型，并依据分型进行扩张皮瓣设计，为充分、合理、安全利用扩张皮肤再造耳廓提供指导。方法在暗室内行乳突区完成皮肤扩张后的透光实验，观察扩张皮肤的血管分布情况，并依此设... 详细信息

目的对先天性小耳畸形乳突区扩张皮肤血管分布情况进行分型，并依据分型进行扩张皮瓣设计，为充分、合理、安全利用扩张皮肤再造耳廓提供指导。方法在暗室内行乳突区完成皮肤扩张后的透光实验，观察扩张皮肤的血管分布情况，并依此设计不同长宽比例的扩张皮瓣。结果根据血管分布情况，将403例扩张皮肤初步分为5种类型，并依此设计不同的扩张皮瓣，无一例发生皮瓣末端血运障碍。结论乳突区扩张皮肤血管分布的临床研究，可为耳廓再造术耳后扩张皮瓣的设计提供指导。

关键词：先天性小耳畸形扩张皮肤血管分布扩张皮瓣

Spatiotemporal variations in glacier area and surface velocity of the northern Antarctic Peninsula during 2018-2022

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Advances in Climate Change Research 2024年第2期15卷 297-311页

作者： Yu-Long KANG Shi-Chang KANG wan-Qin guo Tao CHE Zong-Li JIANG Zhen-Feng wanG Qiang-Qiang XU Cheng-De YANG State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100083China Key Laboratory of Remote Sensing of Gansu Province Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Earth Sciences and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China

Ice sheet serves as a crucial indicator for assessing climate *** loss in recent remote sensing-based studies indicated that the Antarctic Peninsula has rapid rates of glacier retreat and speed up of surface ***,observations of seasonal variability of ice speed are limited,and glacier-area changes require multi-temporal *** study investigated the changes in area and surface velocities of∼375 glaciers on the northern Antarctic Peninsula(NAP)utilizing satellite images acquired by the Sentinel 1&2 satellites during *** results indicate that the glacier area reduced by approximately 166.1±44.2 km^(2)(-0.2%±0.1%per year)during the study period,with an acceleration after 2020(-0.4%±0.3%per year),and the most dramatic reduction happened on the eastern *** maximum annual ice speeds on the NAP generally exceeded 3500 m per year,while the ice speeds in 2021 were the highest(exceeded 4210 m per year).The ice speed variability in austral autumn was higher than in other seasons,meanwhile the summer ice speeds showed an increasing *** glacier G012158E47018N,McNeile Glacier,glacier G299637E64094S and Drygalski Glacier showed the most remarkable ice speed variations represented by high daily velocities and strong fluctuations on their *** results demonstrated that the variations in glacier area and seasonal ice speed on the NAP were responsive to the ice-ocean-atmosphere ***,seasonal velocity and area variations should be considered when conducting accurate mass balance calculations,model validations and change mechanism analyses under climate warming scenarios.

关键词： Glacier area Seasonal ice speed Sentinel 1&2 Northern Antarctic Peninsula Ice-ocean-atmosphere processes

Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

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Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： guo-Jing Tang Xiao-Dong Chen Lu Sun Chao-Heng guo Meng-Yu Li Zhong-Tao Tian hou-Hong Chen Hong-Wei wang Qi-Yao Sun Ying-Di Pan Xin-Tao He Yi-Kai Su Jian-Wen Dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

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Genes & Diseases 2024年第1期11卷 397-412页

作者： Zhe Chen Qian guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML ***,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive *** metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of ***,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of *** a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA *** synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft *** results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR

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先天性小耳畸形危险因素的病例对照研究

中华耳鼻咽喉头颈外科杂志 2006年第2期41卷 107-111页

作者：杜佳梅郭万厚韩娟庄洪兴中国医学科学院整形外科医院外耳中心北京100041

目的探讨导致先天性小耳畸形发生的危险因素，为小耳畸形的预防提供理论依据。方法采用病例对照的研究方法，选取中国医学科学院整形外科医院外耳中心2004年2月到8月期间入院的207例6～11岁的单纯型小耳畸形患者的亲生父母为研究对象；... 详细信息

目的探讨导致先天性小耳畸形发生的危险因素，为小耳畸形的预防提供理论依据。方法采用病例对照的研究方法，选取中国医学科学院整形外科医院外耳中心2004年2月到8月期间入院的207例6～11岁的单纯型小耳畸形患者的亲生父母为研究对象；209例无先天性疾病的住院患者的亲生父母为对照，按年龄频数进行1：1的配比。根据自行制定的小耳畸形相关危险因素调查表对病例组及对照组进行问卷调查，调查主要内容包括：①患者及其父母基本信息；②怀孕时母亲的患病及用药情况；③母亲既往妊娠史；④家族史及父母的生活方式。采用卡方检验及非条件Logistic逐步回归法对各个变量进行单因素和多因素分析，并计算出优势比（oddsratio，OR）。结果性别为男性（OR=5．893）、母亲的受教育程度低（OR=2．275）、母亲孕早期患病史（OR=34．496）、怀孕初期用药史（OR=4．299）、多生史（OR=9．52）、母亲流产史（OR=1．723）、父亲吸烟史（OR=4．304）及父亲饮酒史（OR=4．347）为小耳畸形的危险因素；父母长期饮茶史（OR=0．179）为小耳畸形的保护因素。结论小耳畸形的发生是由多种因素相互作用、相互影响综合产生的，预防小耳畸形的发生应从危险因素的各个方面入手。

关键词：耳畸形病例对照研究危险因素

Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing

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Biomedical and Environmental Sciences 2024年第8期37卷 876-886页

作者： Yutong wang Jing Li Shirong Xu Shengli Lin Zhenchen hou Linlin wang Yali Huang Yue Sun Wei guo Lailai Yan Ying wang Chan Tian State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Medical Genetics Peking UniversityBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Central Laboratory of School of Public Health Peking UniversityBeijing 100191China School of Basic Medical Sciences Peking UniversityBeijing 100191China

Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from *** A total of 141 couples were *** and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,*** models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET *** Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization ***,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical *** Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy *** is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive ***,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity.

关键词： Rare earth elements In vitro fertilization Pregnancy outcomes Mixture exposure analysis

Decellularised extracellular matrix-based injectable hydrogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： wan-Ying guo Wei-Huang wang Pei-Yao Xu Ranjith Kumar Kankala Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian ProvinceChina Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian ProvinceChina

Decellularised extracellular matrix(dECM)is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its exceptional biocompatibility and malleability *** advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative *** to their excellent fluidity,the injectable hydrogels can be administered in a liquid state and subsequently formed into a gel state in vivo,stabilising the target area and serving in a variety of ways,such as support,repair,and drug release ***,dECM-based injectable hydrogels have broad prospects for application in complex organ structures and various tissue injury *** review focuses on exploring research advances in dECM-based injectable hydrogels,primarily focusing on the applications and prospects of dECM hydrogels in tissue ***,the recent developments of the dECM-based injectable hydrogels are explained,summarising the different preparation methods with the evaluation of injectable hydrogel ***,some specific examples of the applicability of dECM-based injectable hydrogels are ***,we summarise the article with interesting prospects and challenges of dECM-based injectable hydrogels,providing insights into the development of these composites in tissue engineering and regenerative medicine.

关键词： decellularisation methods decellularised extracellular matrix injectable hydrogels tissue engineering