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A Hyper-Heuristic Framework for Lifetime Maximization in Wireless Sensor Networks With A Mobile Sink

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 223-236页

作者： Jinghui Zhong Zhixing Huang Liang Feng wan du Ying Li School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China College of Computer Science Chongqing UniversityChongqing 400044China Department of Computer Science and Engineering School of EngineeringThe University of CaliforniaMerced USA Binxun Technology Co. LtdShenzhen 518000China

Maximizing the lifetime of wireless sensor networks(WSNs) is an important and challenging research problem. Properly scheduling the movements of mobile sinks to balance the energy consumption of wireless sensor network is one of the most effective approaches to prolong the lifetime of wireless sensor networks. However, the existing mobile sink scheduling methods either require a great amount of computational time or lack effectiveness in finding high-quality scheduling solutions. To address the above issues, this paper proposes a novel hyperheuristic framework, which can automatically construct high-level heuristics to schedule the sink movements and prolong the network lifetime. In the proposed framework, a set of low-level heuristics are defined as building blocks to construct high-level heuristics and a set of random networks with different features are designed for training. Further, a genetic programming algorithm is adopted to automatically evolve promising high-level heuristics based on the building blocks and the training networks. By using the genetic programming to evolve more effective heuristics and applying these heuristics in a greedy scheme, our proposed hyper-heuristic framework can prolong the network lifetime competitively with other methods, with small time consumption. A series of comprehensive experiments, including both static and dynamic networks,are designed. The simulation results have demonstrated that the proposed method can offer a very promising performance in terms of network lifetime and response time.

关键词： Genetic programming hyper-heuristics static and dynamic networks wireless sensor networks(WSNs)

A taxonomic framework for autonomous service management in Service-Oriented Architecture

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第5期13卷 339-354页

作者： du wan CHEUN Hyun Jung LA Soo Dong KIM Department of Computer Science Soongsil University

Since Service-Oriented Architecture (SOA) reveals the black box nature of services,heterogeneity,service dynamism,and service evolvability,managing services is known to be a challenging *** computing (AC) is a way of designing systems that can manage themselves without direct human ***,applying the key disciplines of AC to service management is appealing.A key task of service management is to identify probable causes for symptoms detected and to devise actuation methods that can remedy the *** SOA,there are a number of target elements for service remedies,and there can be a number of causes associated with each target ***,there is not yet a comprehensive taxonomy of causes that is widely *** lack of cause taxonomy results in the limited possibility of remedying the problems in an autonomic *** this paper,we first present a meta-model,extract all target elements for service fault management,and present a computing model for autonomously managing service *** we define fault taxonomy for each target element and inter-relationships among the ***,we show prototype implementation using cause taxonomy and conduct experiments with the prototype for validating its applicability and effectiveness.

关键词： Service-Oriented Architecture (SOA) Autonomic computing (AC) Cause taxonomy Services Faults Causes Adaptation

IFNγsignaling integrity in colorectal cancer immunity and immunotherapy

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Cellular & Molecular Immunology 2022年第1期19卷 23-32页

作者： wan du Timothy L.Frankel Michael Green Weiping Zou Department of Surgery University of Michigan School of MedicineAnn ArborMIUSA Center of Excellence for Cancer Immunology and Immunotherapy Rogel Cancer CenterUniversity of Michigan School of MedicineAnn ArborMIUSA Department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System University of Michigan School of MedicineAnn ArborMIUSA Graduate Programs in Immunology University of Michigan School of MedicineAnn ArborMIUSA Tumor Biology University of Michigan School of MedicineAnn ArborMIUSA Department of Pathology University of Michigan School of MedicineAnn ArborMIUSA

The majority of colorectal cancer patients are not responsive to immune checkpoint blockade(ICB).The interferon gamma(IFNγ)signaling pathway drives spontaneous and ICB-induced antitumor *** this review,we summarize recent advances in the epigenetic,genetic,and functional integrity of the IFNγsignaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ***,we discuss how to target IFNγsignaling to inform novel clinical trials to treat patients with colorectal cancer.

关键词： IFNGR Interferon MHC Palmitoylation T cell EZH2 ARID1A PD-1 PD-L1 Apoptosis Ferroptosis Colorectal cancer Immunity

First-principles study of multiple-site substitutions of alloying elements in Ni-based single crystal superalloys

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Science China(Technological Sciences) 2021年第6期64卷 1276-1284页

作者： SUN JunXi du wan XIAO Bin WU YuQin LIU Yi ZHANG TongYi State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China Materials Genome Institute Shanghai UniversityShanghai 200444China

The development of Ni-based single crystal superalloys relies heavily on the composition design with the addition of critical alloying elements,e.g.,Re and *** the role of alloying effects require to know the configurations of the alloying element distribution betweenγ-Ni andγ′-Ni3Al phases and among various non-equivalent *** work employed firstprinciples density functional theory calculations to study the preference of phase and site occupancy of 11 alloying elements including Al and transition metal elements:3d (Ti,Cr,Co,Ni),4d (Mo,Ru),and 5d (Hf,Ta,W,Re) in Ni and *** calculated the substitution energies of 1298 triple-site doping configurations including 286 Ni Ni Ni site doping of Ni,726 Al Ni Ni site doping,and 286 Ni Ni Ni site doping of Ni3Al with alloying elements Ni,Co,Ru,Cr,Re,Mo,W,Al,Ti,Ta,and *** the dual-site and triple-site doping of Ni and Ni3Al,all studied alloying elements preferred to occupy Ni phase rather than Ni3Al *** found that the most stable defect complexes often contained the favorable substitutions of Al,Ti,Ta,and Hf for the Ni sites that stabilized the alloying elements doping at the other one or two nearest neighbor *** co-substitutions of various alloying elements at multiple sites are critical to understanding the strengthening mechanism of alloying elements in Ni-based single crystal superalloys.

关键词： Ni-based single crystal superalloy first-principles density functional theory calculations phase and site occupancy substitution energy alloy design

Folate and fiber in the prevention of colorectal cancer:Between shadows and the light

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World Journal of Gastroenterology 2010年第8期16卷 921-926页

作者： du, wan Li, Wen-Ying Lu, Rong Fang, Jing-Yuan Shanghai Jiao Tong Univ Sch Med Renji Hosp Shanghai Inst Digest Dis Shanghai 200001 Peoples R China

Colorectal cancer (CRC) is one of the most common malignancies and causes of cancer deaths throughout the world. Endoscopy has its functional and finan-cial limitations; therefore,chemoprevention might be crucial in reducing the incidence of CRC. Although a number of studies have demonstrated the potential chemopreventive effects of folate (or folic acid),many challenges still remain. The relationship between fo-late intake and CRC risk is a complex association that might depend on many factors including gender,age,alcohol consumption,and smoking,all of which inter-fere with folate metabolism. The supplementary dose of fiber,the length of time required to observe the effects,and confounding factors exposed during the trial might also influence these findings. Therefore,more evidence from clinical studies is needed regarding the mechanisms that underlie the actions of bioactive food components in minimizing the risk of CRC.

关键词： Folate Fiber Butyrate Prevention Colorectal cancer

Nasal septal foreign body as a complication of dental root canal therapy: A case report

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World Journal of Clinical Cases 2021年第3期9卷 690-696页

作者： Xiao-wan du Jun-Bo Zhang Shui-Fang Xiao Department of Otolaryngology Head and Neck SurgeryPeking University First HospitalBeijing 100034China

BACKGROUND Currently,there have been no reports on foreign bodies found in the nasal septum after dental root canal ***,we present an unusual case of a foreign body found in the nasal septum,which occurred after dental root canal therapy and two unsuccessful *** SUMMARY A 55-year-old man was referred to our department due to slight nasal discomfort that persisted for about 1 *** consulting our department,the patient visited three different hospitals/clinics and underwent two surgeries that were not successful in removing a foreign body completely.A computed tomography scan was performed to detect the shift of the foreign body from dental root to the nasal septum,which resulted in the healing of oral inflammation and nasal septum *** endoscopic foreign body extraction surgery(3rd removal surgery)was then successfully performed,using a needle as the *** nasal reconstruction was required after the *** healing was *** Medical healthcare professionals should consider past medical history when dealing with foreign body *** septal foreign body extraction surgery,a needle could be used as a helpful reference.

关键词： Foreign body Nasal septum Endodontic complications Fractured instruments Case report

Silodosin is effective for treatment of LUTS in men wii BPH： a systematic review

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Asian Journal of Andrology 2013年第1期15卷 121-128页

作者： Hui Ding wan du Zi-Zhen Hou Han-Zhang wang Zhi-Ping wang Institute of Urology Key Laboratory of Diseases of Urological System Gansu Province Gansu Nephro-Urological Clinical Center The Second Hospital of Lanzhou University Lanzhou China 0tolaryngological Department The Second Hospital of Lanzhou University Lanzhou China The Medical College of Shandong University Jinan China

The aim of this study was to systematically review the evidence on the efficacy and safety of silodosin treatments on lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPH） from randomized controlled trials. We searched PubMed （1966- December 2011）, Embase （1974-December 2011） and the Cochrane Library Database （2011, Issue 12）. The assessed outcome measures were the change from baseline for the International Prostate Symptom Score （IPSS）, quality of life （QoL） score, peak urine maximum flow rate （Qmax）, QoL related to urinary symptoms and adverse effects. Two authors independently assessed the study quality and extracted data. All data were analysed using RevMan 5.1. The meta-analysis included four randomized controlled trials with a total of 2504 patients. The study durations were each 12 weeks. At the follow-up end points, the pooled results showed that the change from baseline for the silodosin group was significantly higher than the placebo group for the IPSS, QoL score and Qmax（mean difference （MD）=-2.78, P〈O.O0001; MD=-O.42, P--O.O04; MD= 1.17, P〈***,respectively） and patients felt more satisfied with QoL related to urinary symptoms in the silodosin group than the placebo group. Ejaculation disorder was the most commonly reported adverse effect. The pooled results also showed that the silodosin group was superior to the 0.2 mg tamsulosin group with respect to the IPSS and QoL score （IPSS： MD=- 1.14, P=O.02; QoL score： MD=-0.26, P=O.02） and inferior to the 0.2 mg tamsulosin group with respect to Qmax （MD=-0.85, P=O.01）. In contrast, there was no significant difference in the incidence of ejaculation disorder and dizziness between the silodosin and 0.2 mg tamsulosin groups. The current meta-analysis suggested that silodosin is an effective therapy for LUTS in men with BPH and is not inferior to 0.2 mg tamsulosin.

关键词： benign prostatic hyperplasia (BPH) KMD-3213 lower urinary tract symptoms (LUTS) silodosin tamsulosin systematic review meta-analysis

CuInSe_2 thin films obtained by pulse-plating electrodeposition technique with novel pulse wave

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Chinese Science Bulletin 2010年第18期55卷 1854-1858页

作者： wanG XiaoLi wanG GuangJun TIAN BaoLi wan ShaoMing du ZuLiang Key Laboratory for Special Functional Materials of Ministry of Education Henan University Kaifeng 475004 China

CuInSe2 films were electrodeposited onto indium tin oxide(ITO) substrate in constant current mode using bell-like wave modulated square wave in aqueous *** films obtained at different pulse frequencies were characterized by scanning electron microscopy(SEM),X-ray energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD).UV-Vis-NIR absorption spectro scopy was used to study the optical properties of these *** results showed that the chalcopyrite phase CuInSe2 films with a smooth surface and stoichiometric composition could be obtained at appropriate pulse *** crystallinity of CuInSe2 films could be further improved after annealing *** this,we also found that the films obtained using the pulse-plating electrodeposition technique had a faster deposition rate and better film adhesion ability than that using the traditional CIS electrodeposition technique,which is significant to the low-cost CIS thin film solar cell production.

关键词： CuInSe2薄膜脉冲电镀技术 CulnSe2 脉冲波扫描电子显微镜近红外吸收光谱脉冲频率铟锡氧化物

Sympathetic Nerve Mediated Spinal Glia Activation Underlies Itch in a Cutaneous T-Cell Lymphoma Model

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Neuroscience Bulletin 2022年第4期38卷 435-439页

作者： Fang Tong Qianru He wan-Jie du Huan Yang Dongping du Shaofeng Pu Qingjian Han State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200433China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairNantong UniversityNantong 226001China Pain Management Center Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Dear Editor,Cancer-associated itch can be described as pruritus associated with *** intractable itch associated with specific types of cancer afflicts patients badly,few effective treatments are available due to limit... 详细信息

关键词： malignancy cancer Cancer